• YAKHAK HOEJI
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• v.8 no.4
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• pp.94-95
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• 1964

Ether extract of the fruits of Angelica gigas NAKAI(Umbelliferae) growing wild and cultivating in Korea, afforded frocoumarin derivative, imperatorin which was identified through physical constants-I.R.spectrum, paper partition chromatography, and preparation of derivatives.

• YAKHAK HOEJI
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• v.11 no.3_4
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• pp.39-40
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• 1967

The saponificated part of the ethereal extract of the fruits of Angelica gigas N$_{AKAI}$ (Umbelliferae) afforded decursinol of pyranocoumarin derivative, which was already known in the same roots.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2000.10b
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• pp.42-45
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• 2000

• YAKHAK HOEJI
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• v.13 no.1
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• pp.47-50
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• 1969

The ether extract of Dang-Gui, the dried root of Angelica gigas N$_{AKAI}$, was placed into a column with aluminium oxide gel. The elution of it with a mixture of n-hexane and ethyl acetate afforded Nodakenetin (I) and the elution with a mixture of n-hexane, ethyl acetate, acetone and methyl alcohol yielded Umbelliferon (II) and Nodakenin (III). Three coumarin derivatives were identified by comparing with authentic samples. The existence of sucrose and glucose was also proved.

• YAKHAK HOEJI
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• v.11 no.3_4
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• pp.22-26
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• 1967

From the root of Angelica gigas $N_{AKAI}$ (Umbelliferae), known as "Tang Gui" in Korea, substance A (colorless needle crystal, $C_{14}H_{14}O_{4}$, m.p. $178^{\circ}$) and B (white plate crystal, $C_{19}H_{20}O_{5}$, m.p. $111^{\circ}$) were obtained. Acetylation of "A" gave its monoacetate, white needles, $C_{16}H_{16}O_{5}$. Saponification of "B" with 5% sodium hydroxide produced "A" and senecionic acid. Examination using I.R. and N.M.R. spectra shows that "A" is identical with decursinol and that "B" with decursin. The root also appears to contain five coumarin derivatives and two steroidal compounds.

• YAKHAK HOEJI
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• v.11 no.3_4
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• pp.33-35
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• 1967

The internal structures of "Chunho", "Kangwhal" and "Dangui" and their original plants had been compared with each other in the prior report. Coumarin derivatives, khellactone from the roots of Angelica purpuraefolia $C_{HUNG}$ and decursin and decursinol from A. gigas $N_{AKAI}$ were also isolated. In this report, we made a simple and convenient identification method for the powdered drugs of several Angelica genus by using a thin layer chromatogrophic technique. The ehter extract of the powdered drugs were applied to a silica gel plate, and was developed with n-hexane and ethyl acetate (1:1) mixture. The characteristic U.V. absorption patterns of each drug were shown.

• Korean Journal of Medicinal Crop Science
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• v.3 no.2
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• pp.84-90
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• 1995

These experiment were conducted to know the seedling growth pattern and to deter­mine the appropriate seeding amount for producing the small and middle sized uniform seedlings of which known to have low bolting in the cultivation of Angelica gigas. Cotyledons of seedling were emerged by 18 days after seeding and the first and the second leaf appeared at 5.0 days and 9.8 days respectively after the anterior leaf emergence. Leaf development from the 3rd to the 6th in order needs about 13 days respectively after the emergence of anterior leaf. Growth of small and middle sized seedling of which required $60{\sim}87days$ were 3.0 to 7.0mm in root head diameter, 6.3 to 10.3cm in root length, 0.4 to 1.3g in fresh root weight per plant with 3.9 to 5.0 leaves. The highest production ratio of small and middle sized seedlings was shown in $15,000seeds/m^2$ of seeding amount as 52.8% respectively.

• Herbal Formula Science
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• v.11 no.2
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• pp.125-134
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• 2003

We have examined the relaxational response to the water extract of Angelica gigas $N_{AKAI}$ (AG), Gingko biloba $L_{INNE}$ (GB), Acanthopanax senticosus $H_{ARMS}.$ (AP) and Augumented-Four-Substance Decoction (AG-FSD, GB-FSD, AP-FSD) in isolated thoracic aorta from sprague dawley(SD) rat. Rat thoracic aorta was investigated in vessel segments suspended for isometric tension recording by polygraph. Responses to AG, GB, AP and AG-FSD, GB-FSD, AP-FSD were investigated in vessels precontracted with 5-hydroxytryptamine(5-HT) were compared in vasodilation effect. We found that the thoracic aorta segments responded to AG, GB, AP and AG-FSD, GB-FSD, AP-FSD with a dose-dependent vasodilation. The 5-hydroxytryptamine induced contraction at $10^{-4}M$ were inhibited by 26.3%, 75.8%, 87.5% and 6.9%, 22.6%, 30.8% after addition of the 0.1 g/mL water extract of AG, GB, AP and AG-FSD, GB-FSD, AP-FSD. In conclusion, AG, GB, AP and AG-FSD, GB-FSD, AP-FSD induced relaxation in the isolated rat thoracic aorta were composed of dose-dependent relaxation. AP-FSD has very potent vasodilation.

• Korean Journal of Pharmacognosy
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• v.1 no.1
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• pp.25-32
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• 1970

Decursin, decursinol and nodakenin which were isolated from the root of Angelica gigas $N_{AKAI}$ (Umbelliferae) that is used as a botanical drug Dang-Gui (當歸) in Korea show following general pharmacologic activities. Decursin and decursinol increased the motility of the excised duodenum of the rabbit, but nodakenin did not. All of these three compounds depressed the heart contraction of the frog and blood pressure of the carotid artery and respiration of the rabbit. Decursin increased uterus contraction of the rabbit, but decursinol depressed it. And the tonus of the muscle of the earth worm was increased by decursinol, but was decreased by decursin.