• Journal of Radiation Protection and Research
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• v.33 no.4
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• pp.167-172
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• 2008

Recently a high-quality voxel model of a Korean adult male was constructed at Hanyang University by using very high resolution serially-sectioned anatomical images of a cadaver, which was provided by the Korean Institute of Science and Technology Information (KISTI). Most existing voxel phantoms are developed based on an individual in the supine posture. This study converted the HDRK-Man voxel model into surface model and adjusted the flattened back of the HDRK-Man to a normal shape in the upright posture using 3D graphic softwares such as $3D-DOCTOR^{TM}$, $Rapidform^{(R)}$2006, $Rhinoceros^{(R)}$4.0, $MAYA^{(R)}$8.5. The effective doses of adjusted model were compared with those of unadjusted model for some standard irradiation geometries (i.e., AP, PA, LLAT, RLAT). In general, the differences were not very large and, among those, the largest difference was found for the PA radiation geometry, as expected. These methodologies can be used for the development of various deformed posture models of HDRK-Man in the later stage of this project.

• Journal of Forest and Environmental Science
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• v.14 no.1
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• pp.1-13
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• 1998

In this paper, it has been discussed on the relation between the anatomical features of woods and the penetration of methyl methacrylate monomer system into major Korean tree species, especially the Pinus koraiensis, Larix leptolepis, Quercus mongolica and Tilia amurensis. 1. There was some differences in penetration of polymers among different tree species, but generally the penetration of ring porous woods seems to be larger than that of diffuse porous woods and it was very difficult to penetrate to Larix leptolepis, especially to the that of heart wood. 2. The penetration on transeverse surface was relatively easy but radial and tangential impregnation were somewhat hard and differences between them were negligible. 3. The penetration of sapwood was larger than that of heartwood and its differences varied according to the existence of tyloses or contents in vessel. 4. Generally the polymer penetration of earlywood was larger than that of latewood in ring porous woods, but on the contrary, penetration of earlywood was small than that of latewood on diffuse porous woods. 5. Vessel diameter of wood had nearly no relation to polymers penetration. This seems to come from the reason that effective vessel diameter varies with the existence of tyloses or contents in vessel. 6. The penetration of ray tracheids was larger than that of ray parenchyma cells in softwoods, but penetration of hardwood rays seems to be small in comparison with softwood ray parenchyma cells. 7. Specific gravity and annual ring width had no relation to the penetration of polymer.

• Archives of Craniofacial Surgery
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• v.10 no.2
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• pp.67-70
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• 2009

Purpose: Anatomical basis around orbit can be helpful in periorbital surgery, and there are many articles about measurement between periorbital reference points. In 1967, Jones and Evans measured the orbital wall thickness of Asian cadavers and this article has been cited more than 50 times. But there is no research in orbital thickness in Vivo. Author's idea was based on difference between live human and human cadaver. Material & Method: We conducted this study from 63 consecutive blow out fracture patients between January, 2000 to june, 2005 by collecting the bone fragments and measured the thickness of that fragment using vernia calipers. Anatomically, orbital floor is separated two area by inferior orbital fissure and we measured each area. Three areas were zone I (medial wall), zone II (medial to inferior orbital fissure) and zone III (lateral to inferior orbital fissure). Result: When the overall results were considered, the thickness of Zone I (medial wall of orbit) was average $0.131{\pm}0.006mm$ in male and $0.129{\pm}0.007mm$ in female and Zone II (medial side of orbital floor) was $0.251{\pm}0.005mm$ in male and $0.245{\pm}0.006mm$ in female, Zone III (lateral side of orbital floor) was $0.237{\pm}0.006mm$ in male and $0.226{\pm}0.006mm$ in female. There were no statistical difference between orbital wall thickness of male and female. Also, orbital wall thickness of adults measured $0.130{\pm}0.005mm$, $0.250{\pm}0.005mm$, $0.232{\pm}0.006mm$ in Zone I, Zone II, Zone III and $0.128{\pm}0.006mm$, $0.233{\pm}0.005mm$, $0.215{\pm}0.007mm$ in Zone I, Zone II, Zone III from childs, and there were no statistical difference between adult and child. Conclusion: This article is the first study about Korean orbital wall thickness, and can be helpful to periocular surgery.

• Journal of Radiation Protection and Research
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• v.26 no.2
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• pp.93-99
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• 2001

Voxel head phantom for overcoming the limitation of mathematical phantom in depleting anatomical details was constructed and example dose calculation for BNCT was performed. The repeated structure algorithm of the general purpose Monte Carlo code, MCNP4B was applied for yokel Monte Carlo calculation. Simple binary yokel phantom and combinatorial geometry phantom composed of two materials were constructed for validating the voxel Monte Carlo calculation system. The tomographic images of VHP man provided by NLM(National Library of Medicine) were segmented and indexed to construct yokel head phantom. Comparison of doses for broad parallel gamma and neutron beams in AP and PA directions showed decrease of brain dose due to the attenuation of neutron in eye balls in case of yokel head phantom. The spherical tumor volume with diameter, 5cm was defined in the center of brain for BNCT dose calculation in which accurate 3 dimensional dose calculation is essential. As a result of BNCT dose calculation for downward neutron beam of 10keV and 40keV, the tumor dose is about doubled when boron concentration ratio between the tumor to the normal tissue is $30{\mu}g/g$ to $3{\mu}g/g$. This study established the voxel Monte Carlo calculation system and suggested the feasibility of precise dose calculation in therapeutic radiology.

• Journal of Animal Science and Technology
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• v.46 no.3
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• pp.307-314
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• 2004

Xenotransplantation of porcine organs has the potential to overcome the severe. shortage of human tissues and organs available for human transplantation. The swine represents an ideal source of such organs because of their plentiful supply and their numerous anatomical and physiological similarities to the human. However, this procedure also carries with a number of safety issues relating to the zoonotic infections. Porcine endogenous retrovinJses(PERVs), \Wich are germ line transmitted and persist without symptoms in the pigs, are most concerning zoonotic viroses. In order to analyze the prevalence of PERV in domestic pigs, four kinds of pigs'(Landrace, Berkshire, Yorkshire, and Duroc) genomic DNA were isolated from their hair follicles. PCR analysis was carried out for detection of PERVs using subgroup A/B/C and E pol sequence primers. All pigs (20 heads) tested had high copy number of PERVs within genomes. Subgroup A/B/C and E pol gene sequences from 20 isolates were determined by direct sequencing. Sequence analysis showed pol sequences are highly conserved among intra- and inter-subspecies(99.l and 98.8%, respectively). As a first report of PERV prevalence in Korea pigs, our data would be the basic concepts of PERV transmission study in xenotransplantation.

• Progress in Medical Physics
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• v.14 no.3
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• pp.196-202
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• 2003

In 3-dimensional conformal radiation therapy (3D-CRT) and intensity-modulated radiation therapy (IMRT), many studies on reducing setup error have been conducted in order to focus the irradiation on the tumors while sparing normal tissues as much as possible. As one of these efforts, we developed an image enhancement and registration tool for simulators and portal images that analyze setup errors in a quantitative manner. For setup verification, we used simulator (films and EC-L films (Kodak, USA) as portal images. In addition, digital-captured images during simulation, and digitally-reconstructed radiographs (DRR) can be used as reference images in the software, which is coded using IDL5.4 (Research Systems Inc., USA). To improve the poor contrast of portal images, histogram-equalization, and adaptive histogram equalization, CLAHE (contrast limited adaptive histogram equalization) was implemented in the software. For image registration between simulator and portal images, contours drawn on the simulator image were transferred into the portal image, and then aligned onto the same anatomical structures on the portal image. In conclusion, applying CLAHE considerably improved the contrast of portal images and also enabled the analysis of setup errors in a quantitative manner.

• Journal of Environmental Impact Assessment
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• v.26 no.1
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• pp.1-10
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• 2017

The study was carried out to understand the inhabiting status and biological features of nutria (Myocastor coypus) in the Jeju Island from May, 2013 to August, 2016. Five individuals were captured by traps and two individuals were collected in dead. Of the 7 individuals, those whose bio-information could not be known were excluded to perform autopsy of the rest of them. The results from morphological, cranial and anatomical analyses, it was found that the females achieved sexual maturation but had no breeding experience. An adult male showed similar sizes to those found in the Korean Peninsula. After collecting the 7 individuals in 2013, 1 nutria individual was filmed by the scouting camera in May, 2014 but not captured. The long-term investigation of the research area found no inhibiting individual. It is deemed the nutria was either died of natural death or migrated. In order to establish a proper nutria control, the environmental characteristics of Jeju Island should be considered where indigenous and introduced species coexist in a limited space. Our findings will provide helpful information for understanding biological features of nutria and planning protection program of natural ecosystems of Jeju Island.

• Journal of Biomedical Engineering Research
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• v.28 no.3
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• pp.397-409
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• 2007

Owing to needs of biomechanical comprehension and analysis to obtain various medical treatment designs which are related with the spine in order to cure and diagnose LBP patients, the FE modeling and nonlinear analysis of lumbosacrum including a partial ilium and iliolumbar ligaments, were carried out. First, we investigated whether the geometrical configuration of vertebrae displayed by DICOM slice files is regular and normal condition. After constructing spinal vertebrae including a partial ilium, a sacrum and five lumbars (from L1 to L5)with anatomical shape reconstructed using softwares such as image modeler and CAD modeler, we added iliolumbar ligaments, lumbar ligaments, discs and facet joints, etc.. And also, we assigned material property and discretized the model using proper finite element types, thus it was completely modeled through the above procedure. For the verification of each segment, average sagittal ROM, average coronal ROM and average transversal ROM under various loading conditions(${\pm}10Nm$), average vertical displacement under compression(400N), ALL(Anterior Longitudinal Ligament) and PLL(Posterior Longitudinal Ligament) force at L12 level, strains of seven ligaments on sagittal plane at L45 level and maximal strain of disc fibers according to various loading conditions at L45 level, etc., they were compared with experimental results. For the verification of multilevel-lumbosacrum spine including partial ilium and iliolumbar ligaments, the cases with and without iliolumbar ligaments were compared with ROM of experiment. The results were obtained from analysis of the verified FE model as follows: I) Iliolumbar ligaments played a stabilizing role as mainly posterior iliolumbar ligaments under flexion and as both posterior and anterior iliolumbar ligaments of one side under lateral bending. 2) The iliolumbar ligaments decreased total ROM of 1-8% in total model according to various motion conditions, which changed facet contact forces of L5S level by approximately 0.8-1.4 times and disc forces of L5S level by approximately 0.8-1.5 times more than casewithout ilioligaments, under various loading conditions. 3) The force of lower discs such as L45 and L5S was bigger than upper discs under flexion, left and right bending and left and right twisting, except extension. 4) It was predicted that strains of posterior ligaments among iliolumbar ligaments would produce the maximum 16% under flexion and the maximum 10% under twisting. 5) It's expected that this present model applies to the development and design of artificial disc, since it was comparatively in agreement with the experimental datum.

• Journal of Korean Society of Forest Science
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• v.79 no.1
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• pp.33-41
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• 1990

The purpose of this study is to investigate the developmental process of plant community during the secondary succession through the analysis of floristic composition, life form etcectra in burned site, and the structure of forest stand before forest fire occurrence was estimated by the method of anatomical wood identification for dead trees in burned site, Cheisuk-bong in Mt. Chiri of Korea. Plant community before forest fire occurrence was estimated the high mountain conifer stand of the last successional stage to consist of Pinus koraiensis(75%), Abies koreana(15%) and Picea jezoensis(10%), and Betula costata was survived only one species after forest fire occurrence. The total number of plant species in the investigated area was 19 families and 23 species that was identified. The dominate species in burned site were Festuca ovina and Arrhenatherum elatius, Carex humilis, Ligularia fischeri etcectra in the investigated area flora. The life form of plant in burned site was the erect from 47.8%, the tufted from 30.4%, the branched and the prostrate from was both 8.7%, It was assumed that dominant species in the burned sites were Gramineae (Festuca ovina, Arrhenatherum elatius), Carex humilis ${\rightarrow}$Sorbus commixta, Rhododendron schrippenbachii, Sambucus williamsii var. coreana, Tripterygium regelii ${\rightarrow}$Acer pseudo-sieboldianum var. koreanum, Betula costata, Quercus mongolica${\rightarrow}$Pinaceae forest(Pinus koraiensis, Abies koreana, Picea jezoznsis).

• Journal of Acupuncture Research
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• v.28 no.5
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• pp.39-55
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• 2011

Objectives : Inchinohryungsan has been used for treatment of hepatobiliary diseases. This study was designed to investigate the effect of Inchinohryungsan pharmacopuncture on hepatocellular carcinoma in rats. Sprague Dawley(SD) rats of the control and experimental groups received intraperitoneal injection of 50 mg/kg DEN, weekly for 12 weeks. Methods : Rats were divided into 5 groups. Normal group was not induced hepatocellular carcinoma and not treated. Control group was induced hepatocellular carcinoma and injected with Inchinohryungsan pharmacopuncture into the root of tail. Experimental groups were induced hepatocellular carcinoma. BL group was injected with Inchinohryungsan pharmacopuncture into the $BL_{18}$ and $LR_{14}$, BG group was injected into the $BL_{19}$ and $GB_{24}$ and CSC group was injected into the $CV_{12}$, $ST_{25}$ and $CV_4$. Thereafter, the changes of the body weight, the liver weight and the weight of liver/100g body weight, WBC, neutrophil, lymphocyte and the activities of AST, ALT, ALP, LDH, AFP and SOD were measured. And gross anatomy, light and electron microscopy were performed. Results : The significant results were as follows, 1. The activities of LDH were significantly decreased in CSC group compared with control group. 2. The activities of AFP were significantly decreased in the BL, BG, CSC groups compared with control group. 3. The activities of SOD were increased in the BL, BG, CSC groups compared with control group and CSC group was significantly increased than normal group. 4. According to the gross anatomical observation, the control and BL, BG, CSC groups showed multi-nodular hepatocellular carcinoma. But the size and numbers of the hepatocellular carcinoma in experimental groups were smaller than control group. 5. The numbers of hepatic p53 positive cells were decreased in the BL, BG groups compared with control group. 6. According to the light and electron microscopical observation, the BL, BG and CSC groups were mildly improved than control group in morphological and histopathological changes. Conclusions : These results suggested that Inchinohryungsan pharmacopuncture may have some effects on hepatocellular carcinoma induced by DEN in rats.