• Journal of Magnetics
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• v.20 no.1
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• pp.79-85
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• 2015

This paper presents a comparative study of a Tubular Linear Machine (TLM) with an Axially Magnetized Single-sided Permanent Magnet (AMSPM) and an Axially Magnetized Double-sided Permanent Magnet (AMDPM) based on analytical field calculations. Using a two-dimensional (2-D) polar coordinate system and a magnetic vector potential, analytical solutions for the flux density produced by the stator windings are derived. This technique is significant for the design and control implementation of electromagnetic machines. The field solution is obtained by solving Maxwell's equations in the simplified boundary value problem consisting of the air gap and coil. These analytical solutions are then used to estimate the self and mutual inductances. Two different types of machine are used to verify the validity of these model simplifications, and the analytical results are compared to results obtained using the finite element method (FEM) and experimental measurement.

• Analytical Science and Technology
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• v.32 no.3
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• pp.88-95
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• 2019

This study was conducted to establish the analytical method for the determination of cyanide in blood, urine, lung and skin tissues in rats. In order to detect or quantify the sodium cyanide in above biological matrixes, it was derivatized to Pentafluorobenzyl cyanide (PFB-CN) using pentafluorobenzyl bromide (PFB-Br) and then reaction substance was analyzed using gas chromatography mass spectrometer (GC/MS)-SIM (selected ion monitoring) mode. The analytical method for cyanide determination was validated with respect to parameters such as selectivity, system suitability, linearity, accuracy and precision. No interference peak was observed for the determination of cyanide in blank samples, zero samples and lower limit of quantification (LLOQ) samples. The lowest limit detection (LOD) for cyanide was $10{\mu}M$. The linear dynamic range was from 10 to $200{\mu}M$ for cyanide with correlation coefficients higher than 0.99. For quality control samples at four different concentrations including LLOQ that were analyzed in quintuplicate, on six separate occasions, the accuracy and precision range from -14.1 % to 14.5% and 2.7 % to 18.3 %, respectively. The GC/MS-based method of analysis established in this study could be applied to the toxicokinetic study of cyanide on biological matrix substrates such as blood, urine, lung and skin tissues.

• Mass Spectrometry Letters
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• v.12 no.3
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• pp.85-92
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• 2021

The therapeutic antibody drug market has experienced explosive growth as mAbs become the main therapeutic modality for a variety of diseases. Characterization of glycosylation that directly affects the efficacy and safety of therapeutic monoclonal antibodies (mAbs) is critical for therapeutics development, bioprocess system optimization, lot release, and comparability evaluation. The LC/MS approach has been widely used to structurally characterize mAbs, and recently attempts have been made to obtain comprehensive information on the primary structure and post-translational modifications (PTMs) of mAbs through intact protein analysis. In this study, we performed state-of-the-art LC/MS based intact protein analysis to readily identify and characterize glycoforms of various mAbs. Different glycoforms of mAbs produced in different expression cell lines including CHO, SP2/0 and HEK cells were monitored and compared. In addition, the comparability of protein molecular weight, glycoform pattern, and relative abundances of glycoforms between the commercialized trastuzumab biosimilar and the original product was determined in detail using the given platform. Intact mAb analysis allowed us to gain insight into the overall mAb structure, including the complexity and diversity of glycosylation. Furthermore, our analytical platform with high reproducibility is expected to be widely used for biopharmaceutical characterization required at all stages of drug development and manufacturing.

• Steel and Composite Structures
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• v.33 no.2
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• pp.209-224
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• 2019

This paper describes a study of the mapping relationship between the vertical deformation of bridge structures and rail deformation of high-speed railway, taking the interlayer interactions of the bridge subgrade CRTS II ballastless slab track system (HSRBST) into account. The differential equations and natural boundary conditions of the mapping relationship between the vertical deformation of bridge structures and rail deformation were deduced according to the principle of stationary potential energy. Then an analytical model for such relationship was proposed. Both the analytical method proposed in this paper and the finite element numerical method were used to calculate the rail deformations under three typical deformations of bridge structures and the evolution of rail geometry under these circumstances was analyzed. It was shown that numerical and analytical calculation results are well agreed with each other, demonstrating the effectiveness of the analytical model proposed in this paper. The mapping coefficient between bridge structure deformation and rail deformation showed a nonlinear increase with increasing amplitude of the bridge structure deformation. The rail deformation showed an obvious "following feature"; with the increase of bridge span and fastener stiffness, the curve of rail deformation became gentler, the track irregularity wavelength became longer, and the performance of the rail at following the bridge structure deformation was stronger.

• Structural Engineering and Mechanics
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• v.86 no.1
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• pp.69-83
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• 2023

Analytical solutions to problems are crucial because they provide high-quality comparison data for assessing the accuracy of numerical solutions. Benchmark analytical solutions for the vibrations of cracked functionally graded material (FGM) plates are not available in the literature because of the high level of complexity of such solutions. On the basis of first-order shear deformation plate theory (FSDT), this study proposes analytical series solutions for the vibrations of FGM rectangular plates with side or internal cracks parallel to an edge of the plates by using Fourier cosine series and the domain decomposition technique. The distributions of FGM properties along the thickness direction are assumed to follow a simple power law. The proposed analytical series solutions are validated by performing comprehensive convergence studies on the vibration frequencies of cracked square plates with various crack lengths and under various boundary condition combinations and by performing comparisons with published results based on various plate theories and the theory of three-dimensional elasticity. The results reveal that the proposed solutions are in excellent agreement with literature results obtained using the Ritz method on the basis of FSDT. The paper also presents tabulations of the first six nondimensional frequencies of cracked rectangular Al/Al2O3 FGM plates with various aspect ratios, thickness-to-width ratios, crack lengths, and FGM power law indices under six boundary condition combinations, the tabulated frequencies can serve as benchmark data for assessing the accuracy of numerical approaches based on FSDT.

• Smart Structures and Systems
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• v.31 no.5
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• pp.517-529
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• 2023

Using a device composed of two lateral pressure plates (LPPs) and a steel reinforcement bar to apply horizontal pressure on slope surfaces, a newly developed prestress-reinforced embankment (PRE) is proposed, to which can be adopted in strengthening railway subgrades. In this study, an analytical model, which is available of calculating additional confining stress (σ_H) at any point in a PRE, was established based on the theory of elasticity. In addition, to verify the proposed analytical model, three dimensional (3D) finite element analyses were conducted and the feasibility in application was also identified and discussed. In order to study the performance of the PRE, the propagation of σ_H in a PRE was analyzed and discussed based on the analytical model. For the aim of convenience in application, calculation charts were developed in terms of three dimensionless parameters, and they can be used to accurately and efficiently predict the σ_H in a PRE regardless of the embankment slope ratio and LPP side length ratio. Finally, the potential applications of the proposed analytical model were discussed.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.23 no.3
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• pp.250-260
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• 2013

Objectives: The aim of this study is to analyze the current status of the possession of measurement and analytical instruments among work environment monitoring organizations that have been designated by the Ministry of Employment and Labor (MoEL) in Korea. Methods: Data for measurement and analytical instruments were gathered by inspectors who had been assigned by the Korea Occupational Safety and Health Agency (KOSHA) and MoEL during the evaluation program for designated work environment monitoring service providers in 2012. Data for 11 monitoring instruments and nine analytical instruments were collected from 108 organizations. Basic data such as the type of service provides and the size of employment were also recorded by the inspector. Results: The total number of personal air samplers including high and low flow rates operated in Korea was 5,418, with average of 50.2. Average operation number of noise dosimeters was 35.0, while 3,780 dosimeters were used in 108 work environment monitoring organizations. There were 10,488 monitoring instruments in total. All service providers possessed at least one AAS and GC in their analytical laboratory. Total number of HPLC/MS was five, followed by ICP/MS of seven, with an average of 0.07. Conclusions: Based on the data, domestic work environment monitoring service providers possessed relatively reasonable measurement and analytical instruments. Nearly all instruments had been imported from advanced countries such as USA, UK and Japan. Periodic gathering of data on these instruments may help maintain good workplace monitoring results and the health of workers at the sites.

• Analytical Science and Technology
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• v.27 no.3
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• pp.167-171
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• 2014

Hydrofluoric acid (HF), a typical inorganic acid, has been used in the industry for its various usage and classified as the toxic compound, because it can cause the pneumonia and pulmonary edema when it was exposed to respiratory organs. The official environmental analytical method for fluorine and its compound in waste has not been developed. For this reason, we have faced some problem to treat the contaminated wastes by the HF leakage from industrial process. In this study, prepared for analytical method for combustible waste (crop, trees, etc.) generated from HF leaking accident and to be applied as the official analytical method for fluorine contaminated waste when the fluorine and its compound will be regulated as a hazardous material by the waste management law later.

• Journal of Soil and Groundwater Environment
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• v.13 no.6
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• pp.50-61
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• 2008

In this study, new integrated particle tracking algorithm was developed to reduce the inherent problem of Eulerian- Lagrangian method, or adverse effect of particle tracking error on mass balance error. The new integrated particle tracking algorithm includes numerical method, semi-analytical method, and analytical method which consider both temporal and spatial changes of velocity field during time step. Detail of mathematical derivations is well illustrated and four examples are made to verify through the comparison of the new integrated particle tracking with analytical solution or Runge-Kutta method. Additionally, It was shown that the there is better superiority of the new integrated particle tracking algorithm over other existing particle tracking method such as Lu's method.

• Analytical Science and Technology
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• v.9 no.2
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• pp.145-160
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• 1996

Inorganic analytical laboratory of Korea Research Institute of Standards and Science participated in an interlaboratory comparison program operated by Quebec Toxicology Centre of Canada in 1994 and again in 1995. The objective of this program is to enable participating laboratories to assess reproducibility and accuracy of their analytical results for trace toxic elements in human biological fluids. This laboratory determined Cd and Pb concentrations in 3 levels of human blood samples by isotope dilution inductively coupled plasma mass spectrometry. 0.5mL of blood sample is added to the digestion bomb together with 2mL of nitric acid and enriched spike isotopes and then decomposed in the microwave digestion system. The decomposed sample is diluted to 10mL and nebulized into ICP-MS. The Cd and Pb values reported by all participating laboratories are presented and compared. The values reported by this laboratory are within the acceptable range of target values.