• 한국지반공학회논문집
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• 제36권11호
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• pp.21-33
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• 2020

본 연구에서는 국내 내진설계기준 공통적용사항(MOIS, 2017)의 지반증폭계수를 활용하여 지표면 최대가속도를 산출하는 방법의 적절성을 검토하기 위해 포항지역 전역의 시추공을 대상으로 1차원 등가선형해석프로그램을 통해 지반응답해석을 수행하였다. 지반응답해석을 위한 지진파는 내진설계기준 공통적용사항에 따라 지진 재현주기 500년, 1000년, 2400년의 표준설계응답스펙트럼에 맞추었고, 지반데이터는 국토지반정보 포털시스템을 활용하여 확보하였다. 그 결과 내진설계기준 공통적용사항에서 제시하는 응답스펙트럼과 지반응답해석에서 얻어진 응답스펙트럼은 지반분류에 상관없이 대략적으로 일치하는 것을 알 수 있었다. 하지만, 증폭계수를 활용하여 지표면최대가속도를 산출할 경우 지반응답해석에서 얻어진 결과와 상당한 차이를 나타내는 것을 알 수 있었다.

• Earthquakes and Structures
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• 제12권6호
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• pp.713-723
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• 2017

Steel plate shear walls (SPSWs) are effective lateral systems which have high initial stiffness, appropriate ductility and energy dissipation capability. Recently, steel plate shear walls with low yield point strength (LYP), were introduced and they attracted the attention of designers. Structures with this new system, besides using less steel, are more stable. In the present study, the effects of plates with low yield strength on the seismic design parameters of steel frames with steel plate shear walls are investigated. For this purpose, a variety of this kind of structures with different heights including the 2, 5, 10, 14 and 18-story buildings are designed based on the AISC seismic provisions. The structures are modeled using ANSYS finite element software and subjected to monotonic lateral loading. Parameters such as ductility (${\mu}$), ductility reduction ($R_{\mu}$), over-strength (${\Omega}_0$), displacement amplification ($C_d$) and behavior factor (R) of these structures are evaluated by carrying out the pushover analysis. Analysis results indicate that the ductility, over-strength and behavior factors decrease by increasing the number of stories. Also, the displacement amplification factor decreases by increasing the number of stories. Finally, the results were compared with the suggestions provided in the AISC code for steel plate shear walls. The results indicate that the values for over-strength, behavior and displacement amplification factors of LYP steel plate shear wall systems, are larger than those proposed by the AISC code for typical steel plate shear wall systems.

• 한국지진공학회논문집
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• 제16권5호
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• pp.33-40
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• 2012

지진하중에 의해 발생하는 비정형 건물의 피해를 줄이기 위하여 내진설계기준에서는 비틀림 증폭계수를 도입하였다. 이 계수는 내진설계기준에 따라 다르게 적용되었으며 같은 시기의 설계기준에서조차 다르게 적용되었다. 본 연구에서는 서로 다른 설계편심으로 설계된 건물의 최종 정적편심의 크기, 연약단부의 횡강성과 비틀림 강성비를 비교하였다. 비틀림 증폭계수가 증가할수록 연약단부의 횡강성이 증가하여 건물의 최종 정적편심의 크기는 감소하였으나 이 계수가 최대값 3.0에 도달한 이후부터 건물의 최종 정적편심의 크기는 다시 증가하였다. 우발편심과 정적편심의 합에 비틀림 증폭계수를 곱하여 구한 설계편심으로 설계된 건물의 최종 정적편심의 크기는 수직부재의 위치에 따라 0 또는 음수로 측정되었다.

• Journal of Microbiology and Biotechnology
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• 제30권5호
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• pp.662-667
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• 2020

Epidermal growth factor receptor (EGFR) mutations are not only genetic markers for diagnosis but also biomarkers of clinical-response against tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC). Among the EGFR mutations, the in-frame deletion mutation in EGFR exon 19 kinase domain (EGFR exon 19-del) is the most frequent mutation, accounting for about 45% of EGFR mutations in NSCLCs. Development of sensitive method for detecting the EGFR mutation is highly required to make a better screening for drug-response in the treatment of NSCLC patients. Here, we developed a fluorometric tandem gene amplification assay for sensitive detection of low-abundance EGFR exon 19-del mutant genomic DNA. The method consists of pre-amplification with PCR, thermal cycling of ligation by Taq ligase, and subsequent rolling circle amplification (RCA). PCR-amplified DNA from genomic DNA samples was used as splint DNA to conjugate both ends of linear padlock DNA, generating circular padlock DNA template for RCA. Long stretches of ssDNA harboring multiple copies of G-quadruplex structure was generated in RCA and detected by thioflavin T (ThT) fluorescence, which is specifically intercalated into the G-quadruplex, emitting strong fluorescence. Sensitivity of tandem gene amplification assay for detection of the EGFR exon 19-del from gDNA was as low as 3.6 pg, and mutant gDNA present in the pooled normal plasma was readily detected as low as 1% fraction. Hence, fluorometric detection of low-abundance EGFR exon 19 deletion mutation using tandem gene amplification may be applicable to clinical diagnosis of NSCLC patients with appropriate TKI treatment.

• 한국강구조학회 논문집
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• 제22권1호
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• pp.87-97
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• 2010

본 연구는 비대칭 비가새 골조를 대상으로 강구조 설계기준에서 제시하고 있는 하중증폭계수를 적용한 2차 해석법의 타당성을 해석적 방법을 통해 평가하는데 그 목적이 있다. 이를 위해 KBC 2005에서 제안하고 있는 B1 및 B2 계수를 적용한 2차 해석과 KBC 2009에서 제안하고 있는 하중증폭계수를 적용한 직접해석을 5층 2스팬 및 5층 4스팬 비대칭 비가새 강구조 골조에 대해 실시하고, 그 해석 결과를 2차 비탄성 해석 결과와 비교하여 기준에서 제안된 2차 해석법들을 평가하였다. 해석의 주요 변수로는 골조 형상, 기둥 축력비, 해석방법, 기둥수평위치 등이 적용되었다. 연구 결과 구조물의 비대칭성은 B2 계수 및 제안된 해석법의 유효성에 영향을 미치는 것으로 나타났으며, 특히 기둥삭제 및 경사 기둥의 경우 오차의 범위가 증가하는 것으로 나타났다.

• 한국강구조학회 논문집
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• 제21권6호
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• pp.627-636
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• 2009

본 연구는 강구조 설계기준에서 제시하고 있는 하중증폭계수를 적용한 2차 해석법의 타당성을 해석적 방법을 통해 평가하는데 그 목적이 있다. 이를 위해 KBC 2005에서 제안하고 있는 B1 및 B2 계수를 적용한 2차 해석과 KBC 2009(안)에서 제안하고 있는 하중증폭계수를 적용한 직접해석을 3층 1스팬 및 5층 3스팬 비가새 강구조 골조에 대해 실시하고, 그 해석 결과를 2차 비선형 해석 결과와 비교하여 기준에서 제안된 2차 해석법들을 평가하였다. 해석의 주요 변수로는 골조의 규모, 기둥의 축력비, 해석방법 등이 적용되었다. 연구 결과 고축력 조건시 KBC 2005에서 제안된 하중증폭계수를 적용한 2차 해석은 2차 효과의 영향을 적절하게 고려하지 못하나 KBC 2009(안)에서 제안된 직접해석법의 경우 적절한 수준에서 2차 효과를 고려하고 있는 것으로 나타났다.

• 새물리
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• 제68권12호
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• pp.1378-1383
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• 2018

Multi-wavelength holography has a better axial range than single-wavelength holography, thus allowing unambiguous phase imaging. Noise amplification is the limiting factor in multi-wavelength holography as noise is amplified by a factor equivalent to the magnification of the wavelengths. Here, we propose a new algorithm to remove noise amplification in multi-wavelength holography. The proposed method does not use phase unwrapping and removes $2{\pi}$ ambiguities. Experiments and numerical simulations indicated that the proposed method is fast, has low noise, and is useful for measuring samples with arbitrary step heights.

• 전기의세계
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• 제30권9호
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• pp.582-588
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• 1981

The laser parameters such as a population inversion density, a stimulated emission cross section and loss factor in the glass laser amplifier medium were experimentally determined in order to analyse the properties of laser amplification. Using these parameters, the rate equations were approximately solved and the properties of laser amplification were analysed. An experiment of two-stage amplifier of Q-switching laser pulse was performed and the maximum output power was 1.1 GW, 33J. The several problems such as a laser solarization and a laser coupling in laser amplification were resolved.

• Wind and Structures
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• 제38권3호
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• pp.193-202
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• 2024

Modern high-rise tower designs incorporating recessed balcony cavity spaces can be prone to high-frequency and narrow-band Rossiter aerodynamic excitations under glancing incident winds that can harmonize and compete with recessed balcony volume acoustic Helmholtz modes and facade elastic responses. Resulting resonant inertial wind loading to balcony facades responding to these excitations is additive to the peak design wind pressures currently allowed for in wind codes and can present as excessive facade vibrations and sub-audible throbbing in the serviceability range of wind speeds. This paper presents a methodology to determine Cavity Amplification Factors to account for façade resonant inertial wind loads resulting from balcony cavity aero-acoustic-elastic resonances by drawing upon field observations and the results of full-scale monitoring and model-scale wind tunnel tests. Recessed balcony cavities with single orifice type openings and located within curved façade tower geometries appear particularly prone. A Cavity Amplification Factor of 1.8 is calculated in one example representing almost a doubling of local façade design wind pressures. Balcony façade and tower design recommendations to mitigate wind induced aero-acoustic-elastic resonances are provided.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 2007년도 정기 학술대회 논문집
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• pp.369-374
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• 2007

For a stability design of steel frames, AISC-LRFD specification recommend to use Alignment Chart and story-based methods in order to determine an effective budding length. Recently, elastic buckling analysis, which is the method that calculate the effective length of members using eigenvalue of the overall structure, has been widely used in practical design of steel frames because this method can be performed effectively and automatically by computers. However, it can in some cases lead to unexpectedly large effective length in column having small axial forces. Therefore, this paper propose a method using elastic buckling analysis, which estimate a proper effective buckling length for all members having a small axial force. For verification of proposed method, it is compared with system based approach and stiffness distribution factor method. As a result, proposed method can rationally solve a problem in some case of column having small axial force. Also, adoption range for proposed method is established.