• The Journal of Korean Physical Therapy
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• 제33권3호
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• pp.136-141
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• 2021

Purpose: Dementia is a disease in which cognitive function declines, leading to deterioration of body functions and activities of daily living. The purpose of this study is to explore the effects of dual-task training, including cognitive tasks, on cognitive and body function and β-amyloid levels in Alzheimer's dementia patients. Methods: 34 inpatients diagnosed with Alzheimer's dementia at a nursing hospital located in South Korea. The patients were randomly divided into a dual-task group (n=16) and a single-task group (n=18). Each group was trained for 30 minutes three times a week for eight weeks. The MMSE-K was used to measure the patients' cognitive function. To assess the patients' static balance ability, their LOS was measured using BioRescue. while dynamic balance was measured using the BBS. The 10MWT were conducted to evaluate the patients' walking ability. Blood analysis was performed to measure levels of β-amyloid. Results: Both groups exhibited statistically significant improvements in gait function after the training (p<0.05). The dual-task group exhibited statistically significant differences in cognitive function, static and dynamic balance function, and β-amyloid levels after training (p<0.05). A significant difference was observed between the two groups (p<0.05). Conclusion: Dual-task training were found to be effective in improving cognitive and bodily functioning and reducing β-amyloid levels in Alzheimer's dementia patients. Thus, this may be suggested as an effective exercise method for the treatment and early prevention of Alzheimer's dementia.

• 대한핵의학회지
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• 제37권1호
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• pp.13-23
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• 2003

Neurodegenerative disorders cause a variety of dementia including Alzheimer disease, frontotemporal dementia, dementia with Lewy bodies, corticobasal degeneration, progressive supranuclear palsy, and Huntington's disease. PET scan is useful for early detection and differential diagnosis of these dementing disorders. Also, it provides valuable information about clinico-anatomical correlation, allowing better understanding of function of brain. Here we discuss recent achievements PET studies regarding these dementing disorders. Future progress in PET technology, new tracers, and image analysis will play an important role in further clarifying the disease pathophysiology and brain functions.

• Journal of Korean Biological Nursing Science
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• 제22권3호
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• pp.172-175
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• 2020

Purpose: The purpose of this paper is to provide nurses with a concise review on neurodegenrative dementias. This review includes pathophysiology, clinical course, and tips on management of dementias from Alzheimer's disease (AD), Parkinson disease (PD) and lewy body dementia (LBD). Considering increasing numbers of dementia cases among older adults, nurses who are cognizant about dementia care are instrumental in maximizing daily activities and quality of life of patients with cognitive impairment and dementia.

• ETRI Journal
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• 제46권1호
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• pp.96-105
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• 2024

We propose a method to automatically predict Alzheimer's disease from speech data using the ChatGPT large language model. Alzheimer's disease patients often exhibit distinctive characteristics when describing images, such as difficulties in recalling words, grammar errors, repetitive language, and incoherent narratives. For prediction, we initially employ a speech recognition system to transcribe participants' speech into text. We then gather opinions by inputting the transcribed text into ChatGPT as well as a prompt designed to solicit fluency evaluations. Subsequently, we extract embeddings from the speech, text, and opinions by the pretrained models. Finally, we use a classifier consisting of transformer blocks and linear layers to identify participants with this type of dementia. Experiments are conducted using the extensively used ADReSSo dataset. The results yield a maximum accuracy of 87.3% when speech, text, and opinions are used in conjunction. This finding suggests the potential of leveraging evaluation feedback from language models to address challenges in Alzheimer's disease recognition.

• Annals of Clinical Neurophysiology
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• 제23권1호
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• pp.7-16
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• 2021

Transcranial magnetic stimulation (TMS) is a safe and noninvasive tool for investigating the cortical excitability of the human brain and the neurophysiological functions of GABAergic, glutamatergic, and cholinergic neural circuits. Neurophysiological biomarkers based on TMS parameters can provide information on the pathophysiology of dementia, and be used to diagnose Alzheimer's disease and differentiate different types of dementia. This review introduces the basic principles of TMS, TMS devices and stimulating paradigms, several neurophysiological measurements, and the clinical implications of TMS for Alzheimer's disease.

• Korean Journal of Acupuncture
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• 제28권4호
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• pp.159-167
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• 2011

Objectives : This study was performed to find a desirable way for acupuncture treatment of Alzheimer Disease. Methods : The authors reviewed several literatures about 'Alzheimer Disease' and 'Dementia'. Based on the review, we interpreted the causes and symptoms on viewpoint of three yin and three yang, and also researched desirable way for acupuncture treatment of Alzheimer Disease. Results and Conclusions : The symptoms of Alzheimer Disease belong to the unbalance between reverting yin and lesser yang. The factors affecting attack rate of Alzheimer Disease are also related with the unbalance between reverting yin and lesser yang. It is necessary to inhibit the function of reverting yin and to activate the function of lesser yang for the acupuncture treatment of Alzheimer Disease.

• 대한통합의학회지
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• 제4권1호
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• pp.21-29
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• 2016

Purpose : The purpose of this study was to evaluate the influence of LOTCA-G and ADL by individualized cognitive program in elderly with vascular dementia, alzheimer dementia and mild cognitive impairment. Method : The subjects of this study, old man and woman diagnosed with vascular dementia, alzheimer dementia and mild cognitive impairment, 24 patients were picked up, who were agreed with this research and were having hospital care for 3weeks at nursing care centers. Individualized cognitive program was applied to 8 patients of vascular dementia, 8 patients of alzheimer dementia and 8 patients of mild cognitive impairment. Cognitive function measured by LOTCA-G and performance measured by FIM. The SPSS Ver. 22.0 statistical program was used for data processing. The significance level for statistical inspection was set as 0.05. Result : In comparison of LOTCA-G was significant increased after intervention and among three groups were significant difference. But FIM was no significant difference after intervention and among three groups were no significant difference. Conclusion : Therefore, the individualized cognitive program is useful to improve the cognitive function in elderly with dementia and mild cognitive impairment.

• 한국주거학회논문집
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• 제15권5호
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• pp.59-67
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• 2004

This study was intended to suggest the design guidelines of the space for the elderly with dementia. To achieve this, the behavioral characteristics of the elderly with dementia were grasped, and the design cases which were considered and reflected of the behavioral characteristics of the elderly with dementia were examined. Then, the effective space design guidelines which met the behavioral characteristcs of the elderly with dementia were suggested. The behaviors of the elderly with dementia were categorized into cognitive, emotional, and functional behavior. The positive influences of space design on dementia symptom were founded in the planned living environments, accessible and visible location of common space such as living room, soft and homelike interior finishes and lighting, and healing garden. Therefore, the space design for the elderly with dementia should be done on the basis of the dementia symptoms and healing effects.

• 디지털융복합연구
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• 제16권9호
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• pp.391-397
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• 2018

본 연구는 레크리에이션 치료 프로그램이 치매 노인들의 인지기능과 균형감각에 미치는 영향을 조사 분석하고자 실시되었다. 연구대상은 알츠하이머형 치매를 진단받은 노인 16명을 대상으로 6 개월 동안 레크리에이션 치료 프로그램을 제공하였으며, 실험군과 대조군 두 그룹의 프로그램 제공전과 후의 인지기능과 균형감각의 변화를 분석하였다. 연구결과 레크리에이션 치료 프로그램은 알츠하이머형 치매 노인의 인지기능과 균형감각을 유지시키거나 증진시키는 것으로 보고되었다. 연구 대상자 모집과 손실 및 레크리에이션 치료 프로그램 기간과 같은 변수 통제의 어려움을 제한점으로 볼 수 있으나 레크리에이션 치료와 같은 비약리적 방법의 개발과 효과성 검증의 측면에서 치매 노인의 재활치료 연구에 기여하였다고 판단된다.

• 대한핵의학회지
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• 제38권3호
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• pp.209-217
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• 2004

Evaluation of dementia in patients with early symptoms of cognitive decline is clinically challenging, but the need for early, accurate diagnosis has become more crucial, since several medication for the treatment of mild to moderate Alzheimer' disease are available. Many neurodegenerative diseases produce significant brain function alteration even when structural imaging (CT or MRI) reveal no specific abnormalities. The role of PET and SPECT brain imaging in the initial assessment and differential diagnosis of dementia is beginning to evolve vapidly and growing evidence indicates that appropriate incorporation of PET into the clinical work up can improve diagnostic and prognostic accuracy with respect to Alzheimer's disease, the most common cause of dementia in the geriatric population. in the fast few years, studios comparing neuropathologic examination with PET have established reliable and consistent accuracy for diagnostic evaluations using PET - accuracies substantially exceeding those of comparable studies of diagnostic value of SPECT or of both modalities assessed side by side, or of clinical evaluations done without nuclear imaging. This review deals the role of functional brain imaging techniques in the evaluation of dementias and the role of nuclear neuroimaging in the early detection and diagnosis of Alzheimer's disease.