• BMB Reports
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• v.43 no.10
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• pp.664-669
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• 2010

The present study aimed to investigate the membrane stabilizing effect of Thymoquinone (TQ) on cell surface glycoconjugates and cytokeratin expression against DMBA induced hamster buccal pouch carcinogenesis. 0.5% DMBA painting (three times per week) in hamster buccal pouches for 14 weeks resulted in the formation of well developed oral squamous cell carcinoma. We observed 100% tumor formation with marked abnormalities of glycoconjugates status in tumor bearing hamsters as compared to control animals. Oral administration of TQ at a dose of 30 mg/kg body weight, to DMBA painted hamsters on alternate days for 14 weeks, reduced the tumor formation as well as protected the levels of cell surface glycoconjugates in DMBA painted hamsters. The present study thus suggests that TQ has potent chemopreventive efficacy as well as protected the abnormalities on cell surface glycoconjugates during DMBA induced hamster buccal pouch carcinogenesis.

• Steel and Composite Structures
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• v.25 no.5
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• pp.617-624
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• 2017

In this study, a new empirical method is presented to obtain Dynamic Increase Factor (DIF) in nonlinear static analysis of structures against sudden removal of a gravity load-bearing element. In this method, DIF is defined as a function of minimum ratio of difference between maximum moment capacity ($M_u$) and moment demand ($M_d$) to plastic moment capacity ($M_p$) under unamplified gravity loads of elements. This function determines the residual strength of a damaged building before amplified gravity loads. For each column removal location, a nonlinear dynamic analysis and a step-by-step nonlinear static analysis are carried out and the modified empirical DIF formulas are derived, which correspond to the ratio min $[(M_u-M_d)/M_p]$ of beams in the bays immediately adjacent to the removed column, and at all floors above it. Therefore, the new DIF can be used with nonlinear static analysis instead of nonlinear dynamic analysis to assess the progressive collapse potential of a moment frame structure. The proposed DIF formulas can estimate the real residual strength of a structure based on critical member.

• Smart Structures and Systems
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• v.6 no.8
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• pp.953-974
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• 2010

The performance of variable dampers for seismic protection of the benchmark highway bridge (phase I) under six real earthquake ground motions is presented. A simplified lumped mass finite-element model of the 91/5 highway bridge in Southern California is used for the investigation. A variable damper, developed from magnetorheological (MR) damper is used as a semi-active control device and its effectiveness with friction force schemes is investigated. A velocity-dependent damping model of variable damper is used. The effects of friction damping of the variable damper on the seismic response of the bridge are examined by taking different values of friction force, step-coefficient and transitional velocity of the damper. The seismic responses with variable dampers are compared with the corresponding uncontrolled case, and controlled by alternate sample control strategies. The results of investigation clearly indicate that the base shear, base moment and mid-span displacement are substantially reduced. In particular, the reduction in the bearing displacement is quite significant. The friction and the two-step friction force schemes of variable damper are found to be quite effective in reducing the peak response quantities of the bridge to a level similar to or better than that of the sample passive, semi-active and active controllers.

• Advances in aircraft and spacecraft science
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• v.3 no.1
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• pp.29-43
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• 2016

Composite materials are rapidly gaining popularity as an alternative to metals for structural and load bearing applications in the aerospace, automotive, alternate energy and consumer industries. With the advent of thermoplastic composites and advances in recycling technologies, fully recyclable composites are gaining ground over traditional thermoset composites. Stamp forming as an alternative processing technique for sheet products has proven to be effective in allowing the fast manufacturing rates required for mass production of components. This study investigates the feasibility of using the stamp forming technique for the processing of thermoplastic, recyclable composite materials. The material system used in this study is a self-reinforced polypropylene composite material (Curv$^{(R)}$). The investigation includes a detailed experimental study based on strain measurements using a non-contact optical measurement system in conjunction with stamping equipment to record and measure the formability of the thermoplastic composites in real time. A Design of Experiments (DOE) methodology was adopted to elucidate the effect of process parameters that included blank holder force, pre heat temperature and feed rate on stamp forming. DOE analyses indicate that feed rate had negligible influence on the strain evolution during stamp forming and blank holder force and preheat temperature had significant effect on strain evolution during forming.

• Asian review of World Histories
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• v.3 no.1
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• pp.81-112
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• 2015

This essay interrogates the category of the 'global' in the emerging domain of 'global intellectual history'. Through a case study of the Indian social-religious reformer Rammohun Roy (1772/4-1833), I argue that notions of global selfhood and rights-consciousness (which have been preoccupying concerns of recent debates in intellectual history) have multiple conceptual and practical points of origin. Thus in early colonial India a person like Rammohun Roy could invoke centuries-old Indic terms of globality (vishva, jagat, sarva, sarvabhuta, etc.), selfhood (atman/brahman), and notions of right (adhikara) to liberation/salvation (mukti/moksha) as well as late precolonial discourses on 'worldly' rights consciousness (to life, property, religious toleration) and models of participatory governance present in an Indo-Islamic society, and hybridize these with Western-origin notions of rights and liberties. Thereby Rammohun could challenge the racial and confessional assumptions of colonial authority and produce a more deterritorialized and non-sectarian idea of selfhood and governance. However, Rammohun's comparativist world-historical notions excluded other models of selfhood and globality, such as those produced by devotional Vaishnava, Shaiva, and Shakta-Tantric discourses under the influence of non-Brahmanical communities and women. Rammohun's puritan condemnation of non-Brahmanical sexual and gender relations created a homogenized and hierarchical model of globality, obscuring alternate subaltern-inflected notions of selfhood. Class, caste, and gender biases rendered Rammohun supportive of British colonial rule and distanced him from popular anti-colonial revolts and social mobility movements in India. This article argues that today's intellectual historians run the risk of repeating Rammohun's biases (or those of Hegel's Weltgeschichte) if they privilege the historicity and value of certain models of global selfhood and rights-consciousness (such as those derived from a constructed notion of the 'West' or from constructed notions of various 'elite' classicized 'cultures'), to the exclusion of models produced by disenfranchised actors across the world. Instead of operating through hierarchical assumptions about local/global polarity, intellectual historians should remain sensitive to and learn from the universalizable models of selfhood, rights, and justice produced by actors in different spatio-temporal locations and intersections.

• Korean Journal of Breeding Science
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• v.40 no.2
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• pp.184-187
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• 2008

A new early maturing satsuma mandarin (Citrus unshiu Marc.) 'Haryejosaeng' was developed as a nucellar seedling selection of 'Tachima Wase' (C. unshiu Marc.) that was crossed with C. natsudaidai Hayata at the National Institute of Subtropical Agriculture in Jeju island in 1992. The 'Jegam ga No. 2', a first selection from the seedlings fruited in 2001 was finally named "Haryejosaeng" through field evaluation trials at three locations in Jeju island from 2003 to 2004. 'Haryejosaeng' produces seedless fruit maturing in early November, and has higher soluble solids and lower acidity than 'Miyagawa Wase', the leading early-maturing satsuma mandarin cultivar in Jeju island. Fruit weight is moderate at about 80~90 g and its shape is compressed-oblate globose with a light orange color. The rind thickness of about 2 mm provides easy peeling. The flesh shows light orange colored and contains 10 to 11 Brix and 1 to 1.1% acidity when mature. Tree shows vigorous growth and spreading thornless twigs. Alternate bearing is similar to 'Miyagawa Wase'. 'Haryejosaeng' is susceptible to citrus scab disease and melanose, but resistant to citrus canker.

• Journal of the Mineralogical Society of Korea
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• v.17 no.3
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• pp.189-199
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• 2004

Cretaceous sedimentary rocks bearing dinosaur tracks in the Goseong interchange area were studied for their conservation and public display in the aspect of applied mineralogy. Black clay layers alternate with silt layers in the sedimentary rocks. The verical and horizontal fissures are commonly filled with calcite veinlets, supergenetic iron and manganese oxides. The rocks are composed of quartz, albite, K-feldspar, calcite, chlorite, illite, muscovite, and biotite, with minor apatite and rutile. Silt layers are relatively rich in calcite and albite, whereas clay layers are abundant in quartz, illite, and chlorite. Al, Fe, Mg, K, Ti, and P are enriched in the clay layers, while Ca, Na, and Mn in silt. Most of trace elements including V, Cr, Co, Ni, Cs, Zr, REE, Th, and U are enriched in clay layers. Inorganic carbon are present in silt layers as calcite, while organic carbon in black clay layers. The black clay layers were partly altered to yellow clay layers along the fissures, simultaneously with the decrease of organic carbon. Selective exfoliation of clay-rich black and yellow clay layers, calcite matrix of silt layers and calcite infillings of fissures are estimated as the major weakness potentially promoting chemical and physical degradation of the track-bearing rock specimens.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.9
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• pp.4597-4606
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• 2012

Cholangiocarcinoma (CCA) is an uncommon adenocarcinoma which arises from the epithelial cells of the bile ducts. The aim of the study was to investigate the cytotoxicity, toxicity, and anticancer activity of a crude ethanolic extract of ginger (Zingiber officinale Roscoe) against CCA. Cytotoxic activity against a CCA cell line (CL-6) was assessed by calcein-AM and Hoechst 33342 assays and anti-oxidant activity was evaluated using the DPPH assay. Investigation of apoptotic activity was performed by DNA fragmentation assay and induction of genes that may be involved in the resistance of CCA to anticancer drugs (MDR1, MRP1, MRP2, and MRP3) was examined by real-time PCR. To investigate anti-CCA activity in vivo, a total of 80 OV and nitrosamine (OV/DMN)-induced CCA hamsters were fed with the ginger extract at doses of 1000, 3000, and 5000 mg/kg body weight daily or every alternate day for 30 days. Control groups consisting of 10 hamsters for each group were fed with 5-fluorouracil (positive control) or distilled water (untreated control). Median $IC_{50}$ (concentration that inhibits cell growth by 50%) values for cytotoxicity and anti-oxidant activities of the crude ethanolic extract of ginger were 10.95, 53.15, and $27.86{\mu}g/ml$, respectively. More than ten DNA fragments were visualized and up to 7-9 fold up-regulation of MDR1 and MRP3 genes was observed following exposure to the ethanolic extract of ginger. Acute and subacute toxicity tests indicated absence of any significant toxicity at the maximum dose of 5,000 mg/kg body weight given by intragastric gavage. The survival time and survival rate of the CCA-bearing hamsters were significantly prolonged compared to the control group (median of 54 vs 17 weeks). Results from these in vitro and in vivo studies thus indicate promising anticancer activity of the crude ethanolic extract of ginger against CCA with the absence of any significant toxicity. Moreover, MDR1 and MRP3 may be involved in conferring resistance of CCA to the ginger extract.

• Journal of the Korean Institute of Intelligent Systems
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• v.12 no.6
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• pp.517-523
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• 2002

In this paper, we propose system that apply VIBL method to add speech recognition to LIBL method based on human s studying method to use natural language to steering system of ship, MERCS and winch appliances and use VIBL method to alternate process that linguistic instruction such as officer s steering instruction is achieved via ableman and control steering gear, MERCS and winch appliances. By specific method of study, ableman s suitable steering manufacturing model embodies intelligent steering gear controlling system that embody and language direction base studying method to present proper meaning element and evaluation rule to steering system of ship apply and respond more efficiently on voice instruction of commander using fuzzy inference rule. Also we embody system that recognize voice direction of commander and control MERCS and winch appliances. We embodied steering manufacturing model based on ableman s experience and presented rudder angle for intelligent steering system, compass bearing arrival time, evaluation rule to propose meaning element of stationary state and correct steerman manufacturing model rule using technique to recognize voice instruction of commander and change to text and fuzzy inference. Also we apply VIBL method to speech recognition ship control simulator and confirmed the effectiveness.

• Journal of Korean Society of Steel Construction
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• v.21 no.1
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• pp.63-70
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• 2009

Failure modes result in fracture or tearing, which may cause deterioration of resistance and reduction of inelastic deformation capacity. The potential failure modes for Special Concentrically Braced Frames (SCBFs) include fracture or tearing of the brace, net section fracture of the brace or gusset plate, fracture of the gusset plate welds, shear fracture of the bolts, block shear, excessive bolt bearing deformation, and buckling of the gusset plate. HSS tubular braces are commonly used in SCBFs, and net section fracture of the tubular brace may also occur through the brace net section at the end of the slot cut into the tube to slip over the gusset plate. This failure mode is categorized as a tension failure mode, and may cause dramatic loss of resistance and brittle behavior. Net section reinforcement is required according to AISC design specifications (AISC 2001). In this paper, the need to reinforce the net section area was discussed. Initially, the results of the net section fracture tests done by the University of California in Berkeley were presented with the modeling of these tests using FE models. To investigate the possibility of net section fracture in an actual frame, the slot end hole model was adapted to the frame FE model, and alternate near-fault histories were applied with tension-dominated cycles, since previous analyses showed that loading history was the most critical factor in net section fracture. The need for this reinforcement (cover plate) and the tension-dominated near-fault history were investigated.