• Journal of Radiopharmaceuticals and Molecular Probes
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• v.9 no.1
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• pp.23-33
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• 2023

Prostate cancer ranks as the world's second most frequently diagnosed cancer among men, and is responsible for the fifth highest number of cancer-related deaths in this population. The development of effective diagnostic and therapeutic approaches for prostate cancer remains a major challenge in the field of oncology. Over the past few years, the prostate-specific membrane antigen (PSMA) has raised as a hopeful tracer for the diagnosis and treatment of prostate cancer.Various radioisotopes, such as ¹³¹I, ^99mTc, ⁶⁸Ga, and ¹⁷⁷Lu, have been used to label PSMA analogues, with varying degrees of success. Among these, ⁶⁸Ga-PSMA-11 and ¹⁷⁷Lu-PSMA-617 have emerged as the most promising radioligands for clinical use. Recently, researchers have been exploring the use of other radioisotopes, such as ²¹¹At, ⁸⁹Zr, ^64/67Cu, and ^203/212Pb, for the labeling of PSMA-targeted radioligands. These radioisotopes have unique properties that may offer advantages over existing radioligands, such as longer half-lives, higher specific activities, and different emission profiles. Efforts are currently underway to develop these radiopharmaceuticals and make them more widely available for clinical use. These exciting developments highlight the potential of PSMA-targeted radioligands for the diagnosis and treatment of prostate cancer, and provided significant implications for the management of this disease in the future. The current study aims to provide a comprehensive summary of the latest research and clinical applications of radiolabeled PSMA inhibitors for diagnoses and therapy of prostate cancer, emphasizing the exciting developments in the field and their potential impact on clinical practice.

• The Bulletin of The Korean Astronomical Society
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• v.46 no.2
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• pp.45.1-45.1
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• 2021

Horizon Run 5 (HR5) is a cosmological hydrodynamical simulation which captures the properties of the Universe on aGpc scale while achieving a resolution of 1kpc. This enormous dynamic range allows us to simultaneously capture the physics of the cosmic web on very large scales and account for the formation and evolution of dwarf galaxies on much smaller scales. On the back of a remarkable achievement of this, we have finished to run follow-up simulations which have 2 times larger volume than before and are expected to complementary to some limitations of previous HR simulations both for the study on the large scale features and the expansion history in a distant Universe. For these simulations, we consider the sub-grid physics of radiative heating/cooling, reionization, star formation, SN/AGN feedbacks, chemical evolution and the growth of super-massive blackholes. In order to do this project, we implemented a hybrid MPI-OpenMP version of the RAMSES code, 'RAMSES-OMP', which is specifically designed for modern many-core many thread parallel systems. These simulation successfully reproduce various observation result and provide a large amount of statistical samples of Lyman-alpha emitters and protoclusters which are important to understand the formation and expansion history of early universe. These are invaluable assets for the interpretation of current ΛCDM cosmology and current/upcoming deep surveys of the Universe, such as the world largest narrow band imaging survey, ODIN (One-hundred-square-degree Dark energy camera Imaging in Narrow band).

• The Bulletin of The Korean Astronomical Society
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• v.45 no.1
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• pp.69.3-69.3
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• 2020

우주개발과 활용이 주요 화두가 된 현대에 보다 빠르고 정확한 우주환경 예보는 전략적으로 매우 중요하다. 이에 우리는 광대역태양영상분광망원경(Wide-Field Solar Spectro-Imaging Telescope, Post SOlar Flare Telescope: PSOFT)을 활용한 태양전면 영상분광감시체계를 구성하고자 한다. 전세계 세 곳에 PSOFT를 배치하여 우주환경에 중대한 영향을 주는 요소인 태양의 플레어와 홍염 분출과 같은 현상과 표면의 다양한 활동들을 실시간으로 관측 분석하고자 한다. PSOFT는 30cm 구경의 광학계에 고속영상분광기를 결합하여 태양 전면의 분광영상을 약 1초각의 영상해상도와 5분의 시간해상도로 획득한다. 태양 전면을 슬릿으로 스캔하는 방식으로 H alpha와 Ca II 854.2nm선의 분광정보를 획득하는데 팁틸트 미러를 이용하여 1차적인 시상보정과 함께 스캔모션을 함께 구현함으로써 1)광학계 구조를 단순화하고, 2) 빠른 스캔이 가능하다. PSOFT로 얻은 태양전면 채층분광영상 데이터는 정밀한 우주환경 예보에 필요한 플레어나 홍염분출의 발생초기 정보를 제공할 뿐 아니라 태양 저층대기에서 발생하는 자기재연결, 파동 등에 대한 통계적 연구자료를 제공할 것으로 기대한다.

• Imaging Science in Dentistry
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• v.53 no.4
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• pp.375-381
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• 2023

Purpose: This study assessed the diagnostic performance of stitched and non-stitched cross-sectional cone-beam computed tomography (CBCT) images of non-displaced ovine mandibular fractures. Materials and Methods: In this ex vivo study, non-displaced fractures were artificially created in 10 ovine mandibles (20 hemi-mandibles) using a hammer. The control group comprised 8 hemi-mandibles. The non-displaced fracture lines were oblique or vertical, <0.5 mm wide, 10-20 mm long, and only in the buccal or lingual cortex. Fracture lines in the ramus and posterior mandible were created to be at the interface or borders of the 2 stitched images. CBCT images were obtained from the specimens with an 80 mm×80 mm field of view before and after fracture induction. OnDemand software (Cybermed, Seoul, Korea) was used for stitching the CBCT images. Four observers evaluated 56 (28 stitched and 28 non-stitched) images to detect fracture lines. The diagnostic performance of stitched and non-stitched images was assessed by calculating the area under the receiver operating characteristic curve (AUC). Sensitivity and specificity values were also calculated (alpha=0.05). Results: The AUC was calculated to be 0.862 and 0.825 for the stitched and non-stitched images, respectively (P=0.747). The sensitivity and specificity were 90% and 75% for the non-stitched images and 85% and 87% for the stitched images, respectively. The inter-observer reliability was shown by a Fleiss kappa coefficient of 0.79, indicating good agreement. Conclusion: No significant difference was found in the diagnostic performance of stitched and non-stitched cross-sectional CBCT images of non-displaced fractures of the ovine mandible.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.31 no.5
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• pp.370-378
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• 2005

The purpose of this study is that evaluate the distribution and biological roles of TNF-a, interleukin-1${\beta}$(IL-1${\beta}$), interleukin-6(IL-6) and tissue inhibitors of metalloproteinase-1(TIMP-1) in the synovial fliud of patients with non-inflammatory chronic temporomandibular joint(TMJ) disorders in relation to pain during joint movements and magnetic resonance imaging(MRI) findings. TMJ synovial fluids aspirates were obtained from 36 patients (36 joints) with chronic TMJ disorders and from 8 controls(8 joints). Patients were divided to four groups. The control group was from healthy volunteers(8 joints), group I(18 joints) was patients with anterior disc displacement with reduction, group II(5 joints) was patients with disc displacement without reduction and group III (5 joints) was osteoarthritis. The TNF-${\alpha}$, IL-1${\beta}$ and IL-6 levels in the aspirates were determined by using an enzyme-linked immunosorbent assay and the TIMP-1 level was measured by an enzyme immunoassay. Following examinations for pain during joint movements and MRI observations, these cytokines' level and frequencies of detection were compared. The level of IL-1${\beta}$was not significant different in all groups. but the level of TNF-${\alpha}$, IL-6 and TIMP-1 were significant different among groups. The level of IL-6 and TIMP-1 were correlated to pain during movement(p<0.01) and the level of TNF-a(p<0.05). Also, the level of IL-6 was correlated to the level of TIMP-1(p<0.01). Especially, The level of the TIMP-1 level was significantly correlated to the pain during movement and showed very high levle of Pearson's correlation coefficient (r=0.833)(p<0.001). The results indicated that the TNF-${\alpha}$, IL-6 and TIMP-1 levels in the TMJ aspirates of patients with chronic TMJ disorders have been raised. Especially, IL-6 and TIMP-1 were very high levels in the patients who were degraded in the TMJ. Also, TNF-${\alpha}$, IL-6 and TIMP-1 showed the significant correlation in the chronic temporomandibular joint disorders. Therefore I suggest that these cytokines were also correlated to the pain during movement in the chronic temporomandibular joint disorders.

• Journal of Korean Society of Environmental Engineers
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• v.27 no.6
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• pp.657-662
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• 2005

Iron sulfide(FeS) is significantly produced through both abiotic and biotic processes in natural sediments and pore waters. In this study, chromium(VI) reaction with iron sulfide at various initial concentrations and at pH values of 4 and 8 was conducted to better understand the interactions between Cr(VI) and Fe(II) species dissolved from iron sulfide in both the aqueous and solid phases. Also, the removal efficiency of iron sulfide was compared with zero valent iron and other iron bearing oxides such as ${\alpha}-Fe_2O_3$, ${\alpha}-FeOOH$ and $Fe_3O_4$. The Cr(VI) removal rate by iron sulfide was higher at pH 4 than at pH 8 because more dissolved Fe(II) existed at pH 4 than at pH 8. Chromium and iron(oxyhydroxide) could be identified on the iron sulfide surface with transmission microscopy imaging and energy dispersive spectroscopy. The removal capacity of iron sulfide was much higher than zero valent iron and other iron oxide minerals due to the synergic effect of hydrogen sulfide and ferrous iron.

• Clinical and Experimental Pediatrics
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• v.53 no.1
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• pp.41-47
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• 2010

Purpose : Adiponectin is an endogenous modulator of vascular remodeling that suppresses vascular inflammation. However, the role of adiponectin in Kawasaki disease (KD) has not been elucidated. The purpose of this study is to investigate the correlation between serum adiponectin level and several parameters, such as interleukin (IL)-6, tumor necrosis factor $(TNF)-{\alpha}$, lipid profile, and C reactive protein (CRP), and to clarify the association between adiponectin and cardiac function. Methods : Twenty-two KD patients (22 patients in acute phase and 20 patients in subacute phase) were enrolled in the study group. The control group consisted of 31 subjects (13 febrile patients and 18 healthy children). Both groups underwent blood sampling and tissue Doppler imaging (TDI). Results : CRP was significantly increased in the KD group compared with the control group. There were no significant differences in serum $TNF-{\alpha}$, IL-6, and adiponectin levels between groups. However, a negative correlation was found between adiponectin level and CRP level or platelet count. Systolic myocardial velocity and A myocardial velocity measured by TDI were decreased significantly in the acute KD group compared with the subacute KD group and control group. Positive correlations were found between adiponectin level and systolic myocardial velocity or A myocardial velocity. Conclusion : In acute KD patients, low adiponectin level was related to severe inflammatory reactions and decreased left ventricular functions.

• Publications of The Korean Astronomical Society
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• v.23 no.2
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• pp.47-52
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• 2008

We have performed the flat-fielding correction for the $H{\alpha}$ full-disk monitoring system of KASI (Korea Astronomy and Space Science Institute), which is installed in the Solar Flare Telescope (SOFT) at the top of Bohyun Mountain. For this, we used a new method developed by Chae (2004), to determine the flat pattern from a set of relatively shifted images. Using this method, we successfully obtained the flat pattern for $H{\alpha}$ full-disk observations and compared our result with the image observed in Catania Astrophysical Observatory. The method that we used in this study seems to be quite powerful to obtain the flat image for solar observations. In near future, we will apply this method for the flat-fielding correction of all solar imaging instruments in KASI.

• Radiation Oncology Journal
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• v.29 no.4
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• pp.219-227
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• 2011

Purpose: This study evaluated the treatment effectiveness and proper radiation dose of helical tomotherapy (HT) in spine oligometastases from gastrointestinal cancers. Materials and Methods: From 2006 to 2010, 20 gastrointestinal cancer patients were treated with HT for spine oligometastases (31 spine lesions). The gross tumor volume (GTV) was the tumor evident from magnetic resonance imaging images fused with simulation computed tomography images. Clinical target volume (CTV) encompassed involved vertebral bodies or dorsal elements. We assumed that the planning target volume was equal to the CTV. We assessed local control rate after HT for 31 spine metastases. Pain response was scored by using a numeric pain intensity scale (NPIS, from 0 to 10). Results: Spine metastatic lesions were treated with median dose of 40 Gy (range, 24 to 51 Gy) and median 5 Gy per fraction (range, 2.5 to 8 Gy) to GTV with median 8 fractions (range, 3 to 20 fraction). Median biologically equivalent dose (BED, ${\alpha}/{\beta}$ = 10 Gy) was 52 $Gy_{10}$ (range, 37.5 to 76.8 $Gy_{10}$) to GTV. Six month local control rate for spine metastasis was 90.3%. Overall infield failure rate was 15% and outfield failure rate was 75%. Most patients showed pain relief after HT (93.8%). Median local recurrence free survival was 3 months. BED over 57 $Gy_{10}$ and oligometastases were identified as prognostic factors associated with improved local progression free survival (p = 0.012, P = 0.041). Conclusion: HT was capable of delivering higher BED to metastatic lesions in close proximity of the spinal cord. Spine metastases from gastrointestinal tumors were sensitive to high dose radiation, and BED (${\alpha}/{\beta}$ = 10 Gy) higher than 57 $Gy_{10}$ could improve local control.

• The Bulletin of The Korean Astronomical Society
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• v.35 no.1
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• pp.39.2-39.2
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• 2010

In this paper, I present the domestic development of near infrared camera systems for the ground telescope and the space satellite. These systems are the first infrared instruments made for astronomical observation in Korea. KASINICS (KASI Near Infrared Camera System) was developed to be installed on the 1.8m telescope of the Bohyunsan Optical Astronomy Observatory (BOAO) in Korea. KASINICS is equipped with a $512{\times}512$ InSb array enable L band observations as well as J, H, and Ks bands. The field-of-view of the array is $3.3'{\times}3.3'$ with a resolution of 0.39"/pixel. It employs an Offner relay optical system providing a cold stop to eliminate thermal background emission from the telescope structures. From the test observation, limiting magnitudes are J=17.6, H=17.5, Ks=16.1 and L(narrow)=10.0 mag at a signal-to-noise ratio of 10 in an integration time of 100 s. MIRIS (Multi-purpose InfraRed Imaging System) is the main payload of the STSAT-3 in Korea. MIRIS Space Observation Camera (SOC) covers the observation wavelength from $0.9{\mu}m$ to $2.0{\mu}m$ with a wide field of view $3.67^{\circ}{\times}3.67^{\circ}$. The PICNIC HgCdTe detector in a cold box is cooled down below 100K by a micro Stirling cooler of which cooling capacity is 220mW at 77K. MIRIS SOC adopts passive cooling technique to chill the telescope below 200K by pointing to the deep space (3K). The cooling mechanism employs a radiator, a Winston cone baffle, a thermal shield, MLI of 30 layers, and GFRP pipe support in the system. Opto-mechanical analysis was made in order to estimate and compensate possible stresses from the thermal contraction of mounting parts at cryogenic temperatures. Finite Element Analysis (FEA) of mechanical structure was also conducted to ensure safety and stability in launching environments and in orbit. MIRIS SOC will mainly perform the Galactic plane survey with narrow band filters (Pa $\alpha$ and Pa $\alpha$ continuum) and CIB (Cosmic Infrared Background) observation with wide band filters (I and H) driven by a cryogenic stepping motor.