• The Korean Journal of Mycology
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• v.27 no.3 s.90
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• pp.237-241
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• 1999

To search for less toxic antiviral agents from Basidiomycetes, the water soluble components (=EA), were isolated from the carpophores of Elfvingia applanata (Pers.) Karst. Anti-varicella zoster virus (Oka strain; anti-VZV/Oka) activity of EA was examined in MRC-5 cells by plaque reduction assay in vitro. And the combined antiviral effects of EA with interferon (IFN) alpha or IFN gamma were examined on the multiplication of VZV/Oka. EA exhibited a dose-dependent reduction in the plaque formation of VZV/Oka with 50% effective concentration $(EC_{50})$ of $464.14\;{\mu}g/ml$. The results of the combination assay were evaluated by the combination index (CI) that was calculated by the multiple drug effect analysis. The combination of EA with IFN alpha showed partially synergistic or additive effects with CI values of $0.83{\sim}1.09$ for 50%, 70%, 90% effective levels, and those with IFN gamma showed antagonism with CI values of $1.20{\sim}1.24$.

• Nutrition Research and Practice
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• v.6 no.3
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• pp.195-200
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• 2012

The purpose of this study was to investigate the effects of ${\alpha}$-lipoic acid on body weight and lipid profiles in Sprague-Dawley rats fed a high fat diet (HFD). After 4 weeks of feeding, rats on the HFD were divided into three groups by randomized block design; the first group received the high-fat-diet (n = 10), and the second group received the HFD administered with 0.25% ${\alpha}$-lipoic acid (0.25LA), and the third group received the high-fat diet with 0.5% ${\alpha}$-lipoic acid (0.5LA). The high fat diet with ${\alpha}$-lipoic acid supplemented groups had significantly inhibited body weight gain, compared to that in the HFD group (P < 0.05). Organ weights of rats were also significantly reduced in liver, kidney, spleen, and visible fat tissues in rats supplemented with ${\alpha}$-lipoic acid (P < 0.05). Significant differences in plasma lipid profiles, such as total lipids, total cholesterol, triglycerides, low-density lipoprotein, and high-density lipoprotein, were observed between the HFD and 0.5LA groups. The atherogenic index and the plasma high density lipoprotein-cholesterol/total cholesterol ratio improved significantly with ${\alpha}$-lipoic acid supplementation in a dose-dependent manner (P < 0.05). Total hepatic cholesterol and total lipid concentration decreased significantly in high fat fed rats supplemented with ${\alpha}$-lipoic acid in a dose-dependent manner (P < 0.05), whereas liver triglyceride content was not affected. In conclusion, ${\alpha}$-lipoic acid supplementation had a positive effect on weight gain and plasma and liver lipid profiles in rats.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.4
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• pp.2436-2442
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• 2014

In this study, EEG, HRV, and Vibra image were compared and analyzed in the environmental test room due to variation of temperature. The condition of the environmental test room was in relative humidity 50[RH%], air current speed 0.02[m/s] and illuminance 1000[lux] with setting up different temperatures from $18[^{\circ}C]$ to $31[^{\circ}C]$. At temperature $25[^{\circ}C]$, relative $M{\alpha}$ wave, relative $M{\beta}$ wave, $\frac{SMR}{\theta}$, and SDNN were revitalized, and both sides ${\alpha}$ wave asymmetry index $A_2$, HRT, stress index, and fatigue degree were decreased. Therefore, it was found that temperature $25[^{\circ}C]$ effects to increase the Neuro-energy like amenity, productivity, and concentration.

• Mycobiology
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• v.46 no.2
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• pp.159-167
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• 2018

This study evaluated the in vitro and in vivo hypolipidemic effects of the medicinal mushroom Phellinus pini. The methanol extract (ME) of the fruiting body of Ph. pini was active against pancreatic lipase and cholesterol esterase with 99.14% and 67.23% inhibited activity at 1.0 mg/mL, respectively. It also inhibited 81.81% and 55.33% of ${\alpha}$-glucosidase and ${\alpha}$-amylase activities, respectively, at 2.0 mg/mL. Hyperlipidemia as induced by feeding rats with a high fat and cholesterol diet (HFC). HFC supplemented with a 5% fruiting body powder of Ph. pini (HFC + PhP) significantly reduced plasma total cholesterol, low-density lipoprotein cholesterol, and triglycerides in rats compared with HFC. The reduced levels were comparable to rats fed the normal control diet (NC). The atherogenic index of HFC + PhP rats was significantly lower than that of the HFC rats. The excretion of fecal total lipid and cholesterol in the HFC + PhP rats was significantly higher than those in the NC and HFC rats. Histopathological examinations demonstrated scant deposition of lipids in the liver of rats fed HFC + PhP. The dietary supplementation with the fruiting body powder provided natural plasma lipid and glucose lowering effects in experimental rats without adverse effects on the plasma biochemical parameters and liver function related enzyme activities. Therefore, the hypolipidemic effects of Ph. pini may be due to the inhibitory effects on pancreatic lipase, cholesterol esterase, ${\alpha}$-glucosidase, and ${\alpha}$-amylase, and excretion of excess lipids and cholesterol in the feces.

• The Korean Journal of Mycology
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• v.27 no.2 s.89
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• pp.175-179
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• 1999

In order to find less toxic antiviral agents from Basidiomycetes, EA, the water soluble substance, was prepared from the carpophores of Elfvingia applanata (Pers.) Karst. Antiviral activity of EA against vesicular stomatitis virus [New Jersey serotype, VSV(NJ)] was examined in Vero cells using plaque reduction assay in vitro. And the combined antiviral effects of EA with interferon (IFN) alpha and gamma were examined on the multiplication of VSV(NJ). EA caused a concentration-dependent reduction in the plaque formation of VSV(NJ) with 50% effective concentration $(EC_{50})$ of 2.10 mg/ml. The results of combination assay were evaluated by the combination index (CI) that was analysed by the multiple drug effect analysis. The combination of EA with IFN alpha showed more potent effect with CI values of $0.87{\sim}1.59$ for 50%, 70% and 90% effective levels than that with INF gamma with CI values of $1.05{\sim}2.03$.

• Journal of the Korean Geotechnical Society
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• v.27 no.4
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• pp.21-32
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• 2011

A series of in-situ and laboratory tests were performed for the clayey soils of Busan area in order to develop the methods to evaluate the compressibility using CPT and DMT results. The laboratory tests show that the clayey layers of Busan areas are normally consolidated, and their compression indices are turned out to be 0.5~1.3. From the analysis of test results, correlation factors between the cone resistance and constrained modulus (${\alpha}_m$ and ${\alpha}_n$) are observed to decrease with increasing plasticity index, and the correlation factor between the dilatometer modulus and constrained modulus $(R_M)$ increases with $1/I_D$. Based on these relationships, the methods evaluating the constrained modulus from CPT and DMT results are suggested. It is shown that the prediction method by CPT underestimates the constrained modulus of improved ground, whereas the prediction method by DMT is suitable for evaluating the constrained modulus of improved and unimproved ground.

• Journal of Korean society of Dental Hygiene
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• v.12 no.4
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• pp.675-684
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• 2012

Objectives : The purpose of this study was to develop an instrument for Korean Scaling Fear (KSF)-1.1 in scaling patients. Methods : 402 sample size for scaling patients was studied in Daegu city in July and August of 2011. Mean and standard deviation was calculated in 3 dimensions(FWS: fear while scaling, DDH: distrust on dental hygienist, FAS: fear after scaling). Results : Age of 402 subjects was 36.5 years. In analyzing reliability for item-level, a range of correlation coefficient(${\alpha}$) on item-internal consistency(FWS, DDH, and FAS) was 0.58~0.88(${\alpha}$=0.90), 0.40~0.71(${\alpha}$=0.82), and 0.54~0.63(${\alpha}$=0.82), respectively. Floor(%) and ceiling(%) value on 3 dimensions were also 9.2% and 4.0%, 12.4% and 0.5%, and 17.7% and 1.2%, respectively, therefore, we found statistically high reliability for those(p<0.001). With explanatory factor analysis, this study could generate 3 dimensions(factor 1, eigenvalue 5.41, proportion 0.49; factor 2, eigenvalue 1.50, proportion 0.14; factor 3, eigenvalue 1.04, proportion 0.09) and 11 sub-scales. Also confirmatory factor analysis results showed that the KSF1.1 model was fitted very well in analysis of model fit($x^2$=112.94, df=41, p=0.000; goodness of fit index=0.95; adjusted goodness of fit index=0.92; root mean square residual=0.057). Conclusions : In conclusion, The findings of this study showed that developed reliable and valid instrument for measuring the KSF1.1 in the scaling patients.

• Journal of Convergence for Information Technology
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• v.10 no.11
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• pp.148-155
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• 2020

The purpose of the study was to test the reliability and validity of the Korean version of Pittsburgh Sleep Quality Index (PSQI-K) and to examine the cutoff point of the PSQI-K for screening insomnia among young adults. The subjective quality and patterns of sleep in 64 participants were measured using PSQI-K and Fitbit Charge 3^TM. The properties of the instrument were analyzed using Cronbach's alpha coefficient for the internal consistency reliability, factor analysis for the construct validity, and Spearman's rho correlation coefficient for the correlation between the PSQI-K total scores and Fitbit tracker scores. The Cronbach's alpha coefficient of the PSQI-K was 0.69. The Spearman's rho correlation coefficient between the PSQI-K and Fitbit tracker was higher than 0.67. A cutoff point of ≥6.0 had a sensitivity of 0.93 and a specificity of 0.84. In conclusion, the PSQI-K is a reliable and valid instrument to evaluate sleep disturbance in Korean young adults.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.1
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• pp.418-425
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• 2013

In this study, the three scents effects on subjects due to EEG type, and it researched to find optimal scent to increase their amenity and productivity. EEG and HRV were compared and analyzed in the environmental test room by classifying subjects into two type: A and B. The condition of the environmental test room was in temperature 31[$^{\circ}C$], relative humidity 50[RH%], air current speed 0.02[m/s] and illuminance 1000[lux] with setting up three different scents which are Rosemary, Jasmine and Hazelnut. The result of this study, at Jasmine scent for A and B type, relative ${\alpha}$ wave, SEF50, $\frac{SMR}{\theta}$ and SDNN were revitalized, and ${\alpha}$ wave asymmetry index, HRT, stress index and fatigue degree were decreased. It was found that favorite scent of A and B type is same as Jasmine scent, but A type was more sensitive than B type about scent. Therefore Jasmine scent is very effective to increase amenity, productivity and concentration, and to decrease stress and fatigue degree.

• Journal of the Korea Convergence Society
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• v.10 no.1
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• pp.7-12
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• 2019

The application of neural networks to stock forecasting has received a great deal of attention because no assumption about a suitable mathematical model has to be made prior to forecasting and they are capable of extracting useful information from data, which is required to describe nonlinear input-output relations of stock forecasting. The paper builds neural network models to forecast daily KOrea composite Stock Price Index (KOSPI), and their performance is demonstrated. MAPEs of NN1 model show 0.427 and 0.627 in its learning and test, respectively. Based on the predicted KOSPI price, the paper proposes an alpha trading for trades in Exchange Traded Funds (ETFs) that fluctuate with the KOSPI200. The alpha trading is tested with data from 125 trade days, and its trade return of 7.16 ~ 15.29 % suggests that the proposed alpha trading is effective.