• Clinical and Experimental Pediatrics
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• 제51권4호
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• pp.343-350
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• 2008

Asthma and allergic diseases are one of the most common disorders in children. Due to its increased prevalence, as well as the increased morbidity and mortality from these diseases, asthma and allergic diseases have come to be recognized as a major worldwide public health issue. In addition, socioeconomic burden of asthma and allergic diseases has increased in Korea also. The International Study of Asthma and Allergies in Childhood (ISAAC) investigated the worldwide prevalence of asthma and other allergic diseases using simple standardized methods because of the comparison of asthma and allergic diseases between the countries. In Korea, several epidemiologic studies have been conducted to determine the prevalence of asthma in children. Although these studies showed increased prevalence of asthma among Korean children (from 3.4% in 1964 to 10.1% in 1989), these findings were based on data from small numbers of subjects. The first Nationwide Study of Asthma and Allergies in Korean Children, which utilized the Korean version of ISAAC written and video questionnaire, was conducted in 1995 and the second Nationwide Study of Asthma and Allergies in Korean Children was conducted in 2000, directed by the Korean Academy of Pediatric Allergy and Respiratory Diseases. We report here the prevalence of asthma and other allergic diseases in Korean children and adolescents, and show the changes that occurred over this 5 year period. We also describe the risk factors for development of these diseases in Korean children. We developed Korean versions of the ISAAC written (WQ) and video (AVQ) questionnaires for allergic diseases. In 1995, the enrolled population consisted of 25,117 children selected from 34 elementary school and 14,946 children selected from 34 middle school across the nation, the response rate was 94.8%. In 2000, 27,831 children selected from 34 elementary school and 15,214 children selected from 34 middle school, and the response rate was 96.4%. From these studies, we can confirm that increase of the prevalences of asthma, allergic rhinitis, and atopic dermatitis in Korea, except the prevalence of food allergy. Especially, the video questionnaire showed increases in the lifetime and 12 month prevalence rates of wheeze at rest, exercise-induced wheeze, nocturnal wheeze, nocturnal cough, and severe wheeze over this period of time in middle school children. In addition, the increase of prevalences of symptoms, diagnosis and treatment of atopic dermatitis was noted significantly. Risk factor analysis showed that body mass index (BMI), passive smoking and living with a dog or cat were associated with higher risk of wheeze. Also the occurrence of fever during infancy and the frequent use of antibiotics were associated with the risk of wheeze. In conclusion, during the 5 year period from 1995 to 2000, the prevalences of asthma, allergic rhinitis, and atopic dermatitis has increased in Korean children. BMI, passive smoking, living with a dog or cat, the fever episodes in infancy, and the frequent use of antibiotics in infancy are important risk factors to development of asthma and atopic dermatitis. In the near future, the birth cohort study will be needed to investigate the causes of this increase and the natural course of allergic diseases, then we develop the methods to control asthma and allergic diseases.

• 대한의생명과학회지
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• 제20권4호
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• pp.244-249
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• 2014

Arazyme is a metalloprotease secreted by Aranicola proteolyticus that was previously shown to suppress cytokine expression of keratinocytes and endothelial cells and inhibit histopathological features in an atopic dermatitis-like animal model. However, the regulatory effects of arazyme in other allergic diseases have yet to be elucidated. In this study, we investigated whether arazyme is effective against neutrophil apoptosis in allergic diseases such as allergic rhinitis and asthma. Arazyme inhibited neutrophil apoptosis of normal subjects in a dose-dependent manner. However, the antiapoptotic effect of arazyme was reversed by LY294002, an inhibitor of PI3K, AKTi, an inhibitor of Akt, PD98059, an inhibitor of MEK, and BAY-11-7085, an inhibitor of NF-${\kappa}B$. Arazyme induced activation of NF-${\kappa}B$ via PI3K/Akt/ERK pathway. The anti-apoptotic effect of arazyme is associated with inhibition of cleavage of caspase 3 and caspase 9. Arazyme inhibited constitutive apoptosis of neutrophil in a dose-dependent manner in allergic subjects, and its mechanism was shown to be associated with PI3K/Akt/ERK/NF-${\kappa}B$. The results presented here improve our understanding of neutrophil apoptosis regulation and will facilitate development of drugs for treatment of allergic diseases.

• 지역사회간호학회지
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• 제30권4호
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• pp.426-436
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• 2019

Purpose: This study aimed to investigate the association between indoor environmental exposures and behavioral problems in children with allergic diseases. Methods: We used data from 2015 Panel Study of Korean Children (PSKC). The subjects of this study included 825 children aged 7 years with asthma, allergic rhinitis, or atopic dermatitis. The data was analyzed using hierarchical multiple regression. Results: Factors influencing behavioral problems in children with allergic diseases were passive smoking (β=.15, p<.001), painting from 1year after birth until 1 year ago (β=.13, p<.001), using of linoleum as floor materials (β=.09, p<.001), change of wallpaper From 2 years before pregnancy until 1year after birth (β=.08, p<.001), change of wallpaper from 1year after birth until 1 year ago (β=.07, p<.001), keeping hot food or water in plastic container (β=.06, p<.001), remodeling from 1 year after birth until 1year ago (β=.04, p<.001), using of plastic container (β=.03, p<.001), and change of floor materials from 1 year after birth until 1year ago (β=.01, p=.006) which explained about 10% of behavioral problems. Conclusion: This study showed that indoor environmental exposures were associated with behavioral problems in children with allergic diseases. Based on the findings of this study, programs focusing on controlling of indoor environmental exposures may help to prevent and reduce behavioral problems in children with allergic diseases.

• 한국학교보건학회지
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• 제33권2호
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• pp.125-138
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• 2020

Purpose: The study investigated the effect of adolescent health behavior on the prevalence of current allergic diseases. Methods: The subjects were 57,303 middle and high school youth. Data were analyzed using Rao-Scott χ² test and complex sample logistic regression analysis. Results: While controlling the affect of the general characteristics of the subjects, health behaviors affecting the current prevalence of allergic diseases were smoking, drinking, physical activity, eating habits, drug abuse, and mental health. Smoking behaviors affecting the current prevalence of allergic diseases were lifetime smoking experience, smoking days, liquid e-cigarette lifetime smoking experience, number of liquid electronic cigarette smoking days, e-cigarette lifetime smoking experience, e-cigarette smoking days, amount of smoking, second-hand smoking and drinking behaviors were lifetime drinking, drinking days, the amount of drinking, and severe drinking. Variables such as physical activity exceeding 60 minutes days, intake of energy and sweet drinks, water intake, habitual drug use and mental health behavior such as stress perception, weekday sleep time, subjective sleep satisfaction, depression, suicidal thoughts/ plan/ attempts affect current allergic diseases (p<.001). Conclusion: The results showed that current allergic disease related health behaviors in Korean adolescents. Therefore, considering these factors, it may be helpful to facilitate a health promotion plan for prevention and management of such diseases and to promote evidence-based health practices at school.

• 한방안이비인후피부과학회지
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• 제14권1호
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• pp.117-128
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• 2001

Gamiseunggal-tang(G-tang) has long been used for the treatment of acute and chronic allergic diseases(especially, urticaria) in oriental medicine. But, It's mechanism of action is not well investigated. Anal therapy is another way of taking medicine, which is not used in common situation but available for the treatment of colon and anal diseases. It is also used in GI tract diseases, Gynecological diseases, and pediatric diseases and so on. It is especially benefitable for patients who are in such situations as coma, severe vomiting, and swallowing difficulty. In this study, the author investigated the effects of G-tang by anal therapy on acute and chronic allergic reactions in murine model. The results obtained are as follows: 1. G-tang(0.01, 0.1 g/kg) inhibited the compound 48/80-induced ear swelling response in mice. Inhibitory effects of G-tang was significant (P<0.05) at the dose of 0.01 g/kg. 2. G-tang(0.001-0.1 g/kg) inhibited the cutaneous allergic reaction activated by anti-dinitrophenyl(DNP) IgE in rats. Especially, G-tang 0.01, 0.1 g/kg inhibited the cutaneous allergic reaction significantly. 3. G-tang(0.01-1 g/L) dose-dependently inhibited the compound 48/80-induced histamine release from the peritoneal mast cells. 4. G-tang(0.001-0.1 g/L) had a inhibitory effect on anti-DNP IgE-induced tumor necrosis factor-${\alpha}$ production. Above results indicate that anal therapy of G-tang may be beneficial in the treatment of acute and chronic allergic diseases.

• 산업융합연구
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• 제20권1호
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• pp.87-96
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• 2022

본 연구는 알레르기 질환을 가진 청소년들의 실태와 정신건강과 관련된 요인을 파악 하고자 한다. 질환 관리를 위한 기초자료를 제공 하고자 함이다. 연구방법은 제16차 청소년 건강행태 조사 빅데이터를 이차분석 하였으며, SPSS 25 프로그램을 이용하여 x²-test를 사용하고 연관 정도를 파악하기 위해 오즈비와 95% 신뢰구간을 구하였으며, 다중 로지스틱 회귀분석을 시행하였다. 연구 결과 알레르기 질환을 가지고 있는 청소년의 37.1%가 스트레스 인지가 있는 것으로 나타났으며, 우울감 경험률이 27.6%, 자살 생각률이 12.5% 처럼 알레르기 질환을 가지고 있는 청소년의 스트레스 인지, 우울감 경험 및 자살생각의 가능성이 알레르기성 질환을 가지고 있지 않은 청소년에 비해 높았다. 본 연구 결과로 청소년의 알레르기 질환 유무에 따라 정신건강에 많은 영향을 미치는 것을 알 수 있었고 정신질환을 초래할 수 있는 질환 및 청소년 정신건강 관련 예방과 연구에 기초 자료로 삼고자 한다.

• 한국환경보건학회지
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• 제43권6호
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• pp.478-490
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• 2017

Objectives: The association of air pollution levels and land-use types with changes in the prevalence of allergic diseases (allergic conjunctivitis, allergic rhinitis, asthma, and atopic dermatitis) was investigated for seven metropolitan cities in Korea Methods: Data on daily hospital visits and admissions (of those under 19 years old) for 2003-2012 were obtained from the National Health Insurance Cooperation. Meteorological data on daily mean temperature, humidity, and air pressure were obtained from the Korea Meteorological Administration. Daily mean or maximum concentration data for five pollutants ($PM_{10}$, $O_3$, $NO_2$, $SO_2$, and CO) as measured at air quality monitoring sites operated by the Ministry of Environment were used. We estimated excess risk and 95% confidence intervals for the increasing interquatile range (IQR) of each air pollutant using Generalized Additive Models (GAM) appropriate for time series analysis. Results: In this study, we observed a significant association between the IQR increases of air pollutants and the prevalence risk of allergic diseases (allergic conjunctivitis, allergic rhinitis, asthma, and atopic dermatitis) in all metropolitan cities after adjusting for temperature, humidity, and air pressure at sea level. Among the air pollutants, $NO_2$ and $PM_{10}$ were associated with the prevalence of asthma, and $O_3$ was associated with only allergic conjunctivitis in regression analysis. However, in GAM analysis considering land-use, $O_3$ and $SO_2$ were associated with allergic conjunctivitis, PM10, O3, NO2, and CO were associated with allergic rhinitis, and $PM_{10}$, $O_3$ and $NO_2$ were associated with asthma in industrial area. Conclusion: This study found a significant association between air pollution and the prevalence of allergic related diseases in industrial areas. More detailed research considering mixed traffic-related air pollution (TRAP) and conducting meta-analyses combining data of the all cities is required.

• 한방안이비인후피부과학회지
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• 제16권3호
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• pp.210-219
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• 2003

Objectives : This study is to suggest a kind of guide line of dietary therapy in allergic diseases. Methods : We investigated frequency, symptoms and implicating foods of food allergy, and experience, methods, periods, results and necessity of dietary therapy of 49 patients with allergic diseases by using self-report questionnaires. The data were analyzed by SPSS／PC+ program using frequency, Chi-square test(p〈0.05) and Pearson correlation coefficient(p〈0.01). Results : 1. The frequency of food allergy was 49% and skin symptoms were the most common. 2. The most implicating foods were chicken, flour, milk, pork and egg in order. 3. 36.7% of patients had experienced dietary therapy and 47.4% of them had stated mild improvement. 4. Over 80% of patients perceived necessity of dietary therapy and there is significant correlation between necessity of dietary therapy and sum of food allergens(r=368). Conclusions : Dietary therapy is recommended as supplementary therapy in allergic diseases and it needs to be established based on the real conditions and Korean Oriental medical theory.

• Clinical and Experimental Pediatrics
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• 제50권4호
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• pp.335-339
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• 2007

The link between upper airway disease (allergic rhinitis and sinusitis) and lower airway disease (asthma) has long been of interest to physicians. Many epidemiological and pharmacological studies have provided a better understanding of pathophysiologic interrelationship between allergic rhinitis and asthma. The vast majority of patients with asthma have allergic rhinitis, and rhinitis is a major independent risk factor for asthma in cross-sectional and longitudinal studies. The association between sinusitis and asthma has long been appreciated. Through the recent evidences, allergic rhinitis, sinusitis, and asthma may not be considered as different diseases but rather as the expression in different parts of the respiratory tract of same pathological process in nature. Various mechanisms have been proposed to explain the relationship between asthma and upper airway diseases, but the underlying mechanisms are not completely discovered. The implications for the one-airway hypothesis are important not only academically but also clinically for diagnostic and therapeutic purposes.

• Journal of the Korean Data and Information Science Society
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• 제27권1호
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• pp.155-168
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• 2016

본 연구는 청소년의 알레르기 질환 유병률과 관련 요인을 파악하기 위하여 2013년 청소년 건강행태 온라인조사 자료를 이용하여 분석하였다. 연구대상자는 중학생과 고등학생 72,435명이었다. 수집된 자료는 SPSS/Win 18.0 프로그램을 이용하여 천식, 알레르기비염 및 아토피피부염 유병률은 빈도와 백분율을 구하였고, 일반적 및 건강 관련 특성과 천식, 알레르기비염 및 아토피피부염과의 관련성은 카이제곱검정을 실시하였으며, 천식, 알레르기비염, 아토피피부염 관련 요인을 분석하기 위해 다중로지스틱 회귀분석을 하였다. 연구결과 청소년의 천식, 알레르기비염, 아토피피부염의 유병률은 9.3%, 30.6%, 23.4%로 나타났다. 회귀분석 결과 청소년의 천식은 성별, 연령, 경제적 상태, 비만도, 스트레스, 수면 충족도, 가정 내 간접흡연, 약물 사용, 다른 알레르기 질환, 신체활동과 관련성이 있었다. 알레르기비염은 연령, 경제적 상태, 거주지역, 거주형태, 비만도, 스트레스, 수면 충족도, 흡연 경험, 가정내 간접흡연, 음주 경험, 다른 알레르기 질환, 신체활동과 관련성이 있었다. 또한 아토피피부염은 성별, 연령, 경제적 상태, 거주지역, 비만도, 스트레스, 다른 알레르기 질환, 신체 활동과 관련성이 있었다. 이러한 결과는 알레르기 질환의 예방과 관리를 위한 기초자료로 활용될 수 있을 것이다.