• 생약학회지
• /
• 제45권4호
• /
• pp.332-337
• /
• 2014

The Salvia plebeia R. which is the biennial plant belonging to the labiatae department, grows widely in Korea. This study was performed to evaluate the antioxidant activities and anti-allergic effects of Salvia plebeia R. leaves (SPLE) or roots (SPRE). Using ethanol extracts, both leaves and roots induced significant radical scavenging activity against DPPH and ABTS radicals in a dose dependent manner (p<0.05). Superoxide dismutase (SOD)-like activity of SPLE was significantly higher than that of SPRE at all concentrations. Treatment of the RBL-2H3 cells with SPLE and SPRE in vitro decreased ${\beta}$-Hexosaminidase release and significantly inhibited IgE-antigen complex-mediated IL-4 and TNF-${\alpha}$ mRNA expression in RBL-2H3 cells. These findings suggest that Salvia plebeia R. can protect or reduce allergic asthma through high antioxidant and anti-allergic reactions.

• Journal of Nutrition and Health
• /
• 제31권5호
• /
• pp.949-956
• /
• 1998

Salicylate from plant foods and histamine from animal foods have been suggested to cause various food allergic symptoms. Salicylate regarded as one of the inducing agents f3r chronic urticaria and asthma in allergic patients was studied. There is much interest about the effects of salicylate in food allergy. It it recently suggested that the intake of salicylate from foods may have contributed to chronic urticaria and asthma. The purpose of this study is to analyze the salicylate content in various foods. 153 ingredients commonly used in Korean foods were analyzed by HPLC. Among the vegetables, chard(8.22$\mu\textrm{g}$/g), soybean sprout(5.13$\mu\textrm{g}$/g), perilla lean3.03$\mu\textrm{g}$/g), Chinese cabbage(2.25$\mu\textrm{g}$/g), carrot(2.16$\mu\textrm{g}$/g), and squash(1.33$\mu\textrm{g}$/g) con-rained higher amounts of salicylate as compared to other vegetables. Among fruits, oranges(5.13$\mu\textrm{g}$/g), grapefruits(2.90$\mu\textrm{g}$/g), and plums(1.65$\mu\textrm{g}$/g) contained the most. In animal foods, almost no salicylate was found except in chocolate milk(0.32$\mu\textrm{g}$/g). It was also found in black pepper(8.2$\mu\textrm{g}$/g), coffee(can)(5.00$\mu\textrm{g}$/g), mustard(4.16$\mu\textrm{g}$/g), curry powder(3.24$\mu\textrm{g}$/g), kochujang(2.37$\mu\textrm{g}$/g), cream powder(1.19$\mu\textrm{g}$/g), brown rice(1.04$\mu\textrm{g}$/g) and sesame oil(1.00$\mu\textrm{g}$/g). All information found in this study can be used as nutritional education materials in potentially allergic people for a prudent diet plan and can also provide proper dietary guidelines for these allergic patients. (Korean J Nutrition 31(5) 949-956, 1998)

• 한국콘텐츠학회논문지
• /
• 제19권11호
• /
• pp.434-444
• /
• 2019

최근 증가한 알레르기 질환의 유병률은 환경 및 식생활의 방식에 영향을 받는 것으로 나타났으며, 알레르기 질환을 완화하기 하려면 평소 식생활 개선이 중요하다. 식품 영양표시는 영양정보를 제공함으로써 알레르기 질환자의 식생활 개선에 도움을 준다. 본 연구는 영양표시의 인지에 영향을 미치는 다른 요인들을 통제한 상태에서 알레르기 질환 진단 경험 여부가 식품 영양표시 인지 여부에 미치는 영향을 파악하여 지원 방향에 대한 기초자료를 제시하고자 한다. 본 연구는 2016년 국민건강영양조사 자료를 활용하였으며 알레르기 비염, 천식, 아토피 피부염으로 진단 받은 경험이 있는 성인 4,928명을 최종 대상으로 선정하였다. 이분형 로지스틱 회귀 분석 결과, 알레르기 진단 경험과 식품 영양표시에 대한 인지도는 유의한 관련이 있었으며, 진단 경험 유무로 나누어 살펴보면 거주지역, 소득수준, 주관적 건강상태, 주관적 체형인식에서 차이가 있었다. 이들의 영양표시 활용을 지원하기 위해 영양교육 및 영양표시제에 대한 정책적 제도적 지원 방안이 마련되어야 할 것이다.

• 산업융합연구
• /
• 제18권5호
• /
• pp.70-76
• /
• 2020

본 연구는 청소년의 식이행태를 파악하고, 식이행태에 따른 알레르기 질환과의 관련성을 확인하여 추후 알레르기 질환 관리를 위한 기초자료를 제공하고자 함이다. 연구방법은 제15차 청소년건강행태조사 빅데이터를 이차분석하였으며, SPSS 25 프로그램을 이용하여 복합표본 빈도분석, 복합표본 교차분석을 시행하였다. 연구 결과 천식을 진단받은 청소년은 아침식사 빈도, 과일 섭취빈도, 탄산음료 섭취빈도, 에너지음료 섭취빈도, 단맛 나는 음료 섭취빈도, 패스트푸드 섭취빈도, 채소 섭취빈도, 편의점 식사 경험과 관련성이 있는 것으로 나타났다. 알레르기 비염을 진단받은 청소년은 아침식사 빈도, 과일 섭취빈도, 탄산음료 섭취빈도, 에너지음료 섭취빈도, 단맛 나는 음료 섭취빈도, 채소 섭취빈도, 우유 섭취빈도와 관련성을 있음을 보였다. 아토피피부염을 진단받은 청소년은 탄산음료 섭취빈도, 채소 섭취빈도, 우유 섭취 빈도, 편의점 식사경험과 관련성이 있었다. 따라서 알레르기 질환을 가진 청소년의 경우 올바른 식이행태를 교육하여 습관을 형성해 나갈 수 있도록 하는 것이 필요하다.

• 한방안이비인후피부과학회지
• /
• 제34권2호
• /
• pp.53-69
• /
• 2021

Objectives : The purpose of this study is to analyze the effects of treatment between Western medicine and Korean medicine on Allergic rhinitis patients using national population-based claim data from the Health Insurance Review and Assessment Service. Methods : The subjects of the study were 30,024 patients in the Korean medicine group and 30,024 in the Western medicine group who were diagnosed with Allergic rhinitis from September 1, 2018 to December 31, 2018. Propensity score analysis was used for matching age, sex, etc. at a ratio of 1:1. Cox regression and subgroup analysis were used to estimate the adjusted hazard ratio of recurrence, Asthma, and Atopic dermatitis in Korean medicine group and Western medicine group. In addition, the total treatment period, total treatment cost, and average cost per day of visit were compared and analyzed. Results : Compared to Korean medicine, Western medicine had a significantly higher risk of recurrence at 1.701 times, Asthma occurrence risk at 1.609 times and Atopic dermatitis occurrence risk at 1.098 times. Compared to Western medicine, the total treatment period of Korean medicine was 14.27 days longer, the total treatment cost was 53,591 won more, and the average cost per day was 7,539 won more. Conclusions : This study is a retrospective cohort study using the propensity score matching in Korea to compare the outcomes of Allergic rhinitis between Western medicine and Korean medicine. Further research is needed by considering patients characteristics, and linking with additional data.

• 산업융합연구
• /
• 제19권1호
• /
• pp.109-116
• /
• 2021

본 연구의 목적은 청소년의 천식과 알레르기 비염, 아토피 피부염, 고강도 운동량이 우울 증상과 자살사고에 미치는 영향을 확인하기 위함이다. 제15차(2019) 청소년 정신건강행태조사를 활용한 이차 자료분석연구이다. 자료 분석은 SPSS 22.0을 이용하여 복합표본 교차분석과 로지스틱 회귀분석을 시행하였다. 그 결과 우울 증상과 자살사고 모두 알레르기 질환과 고강도 운동, 흡연 경험, 음주 경험이 차이가 있었다. 흡연 경험과 음주 경험을 보정한 후 천식과 알레르기 비염, 아토피 피부염에 의해서는 우울 증상(OR:1.16, 95% CI:1.07-1.26; OR:1.16, 95% CI: 1.11-1.21; OR:1.17, 95% CI:1.11-1.23)과 자살사고(OR:1.32, 95% CI:1.20-1.47; OR:1.22, 95% CI:1.15-1.29; OR:1.21, 95% CI:1.14-1.29)가 증가하였으나 고강도 운동에 의해서는 우울 증상과 자살사고를 느끼는 정도가 감소하였다(OR:0.90, 95% CI:0.86-0.94; OR:0.85, 95% CI:0.80-0.90). 본 연구 결과로 청소년의 알레르기 질환과 고강도 운동량은 정신건강에 많은 영향을 미치는 것을 알 수 있었고 청소년의 정신건강 관련 예방과 연구에 기초자료로 삼고자 한다.

• Child Health Nursing Research
• /
• 제24권1호
• /
• pp.101-108
• /
• 2018

Purpose: This study aimed to identify the effects of the mother-medical staff partnership on mothers' condition management ability for children with chronic allergic diseases. Methods: A total of 109 Korean mothers caring for a child with a chronic allergic diseases, identified according to the allergic march, such as food allergy, atopic dermatitis, allergic rhinitis, and allergic asthma, were recruited from the pediatric department of a general hospital in Seoul through convenience sampling. Data were collected using structured self-reported questionnaires from August 1, 2017 to October 31, 2017. and analyzed by descriptive statistics and multiple regression using SPSS version 22.0. Results: The Mother-medical staff partnership had a statistically significant effect on mothers' condition management ability for children with chronic allergic diseases (p<.05). Among the general characteristics, satisfaction with nursing services had a statistically significant effect on mothers' condition management ability (p<.05). Conclusion: In conclusion, strategies to support children with chronic allergic diseases, as well as their caregivers, should consider the mother-medical staff partnership as part of a family-centered approach.

• 한국지역지리학회지
• /
• 제21권4호
• /
• pp.728-738
• /
• 2015

본 연구는 상수도 사용량과 환경성 질환의 관계를 밝힘으로써 환경성 질환(아토피 피부염, 알레르기 비염, 천식)이 공간적 특성에 영향을 받고 있음을 확인하는 것을 목적으로 한다. 본 연구의 결과를 요약하면 아래와 같다. 첫째, 가정용 물 사용량이 많을수록 아토피 피부염 환자 수가 증가하는 것으로 나타났다. 둘째, 폐수 발생량이 많을수록 알레르기 비염 환자 수가 증가하는 것으로 나타났다. 셋째, 천식 환자 수는 가정용 물 사용량, 산업용 물 사용량, 폐수 발생량 중 어떤 변수에도 영향을 받지 않는 것으로 나타났다. 본 연구는 물 사용량이 환경성 질환, 그 중에서도 아토피 피부염과 밀접한 관련이 있음을 통계적으로 밝혔으며, 이 결과는 향후 환경성 질환 연구의 중요한 기초자료가 될 것으로 기대된다.

• Korean Journal of Acupuncture
• /
• 제25권2호
• /
• pp.87-94
• /
• 2008

Objectives : The aim of this study was to find out some rationales for using Hominis placental extract(HPE) pharmaco-acupuncture on asthmatic patients, and to suggest an appropriate clinical research of HPE pharmaco-acupuncture on asthma. Methods : Articles regarding immunologic experiments about HPE and clinical reports about HPE-contained pharmaco-acupuncture on asthmatic patients were reviewed by on-line and off-line searching. Results and Conclusions : HPE is suggested to have several pharmacological effects on allergic diseases including asthma as well as autoimmune diseases. There are some observational studies of HPE-contained pharmaco-acupuncture on asthmatic patients. However, the designs of these studies are not sufficient to investigate the exact effect of HPE pharmaco-acupuncture on asthma. To investigate HPE pharmaco- acupuncture as a novel asthma therapy, it will be needed to perform further experiments about HPE's pharmacological mechanism on asthma and to try further advanced clinical researches such as well-designed randomized controlled trial of HPE pharmaco-acupuncture.

• Clinical and Experimental Pediatrics
• /
• 제64권8호
• /
• pp.408-414
• /
• 2021

Background: Complementary food in infancy is necessary for human growth, neurodevelopment, and health. However, the role of allergen consumption in early infancy and its effects on the development of food allergy or tolerance remain unclear. Purpose: To investigate the influence of age at the time of complementary food introduction on the development of asthma and atopic dermatitis in Korean children aged 1-3 years. Methods: We combined data from the Korea National Health and Nutrition Examination Survey collected from 2010 to 2014 and analyzed 1619 children aged 1-3 years who were included in the survey. Multivariate regression analysis was used to identify associations among type of feeding, age at the time of complementary food introduction, and doctor-diagnosed atopic dermatitis and asthma. Results: Age at the time of complementary food introduction was not significantly associated with doctor-diagnosed atopic dermatitis and asthma in children aged 1-3 years. In the univariate analysis, children with asthma showed higher water and sodium intake levels than nonasthmatic children. However, this relationship was not significant in the multivariate regression analysis. Conclusion: The present study revealed no statistically significant relationship between age at the time of complementary food introduction and the risk of atopic dermatitis and asthma in young Korean children. A national prospective study is needed to clarify the influence of age at the time of complementary food introduction on the development of allergic diseases.