• Title/Summary/Keyword: Allenes

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Synthesis of 3-(2-Amino-1-Phenylethyl)-2-methylindole

  • Lee, Seong-Hwan
    • Applied Biological Chemistry
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    • v.1
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    • pp.43-47
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    • 1960
  • 1). By means of the F.H. Allene and James Allenes method of the ${\alpha}-methylindole$ synthesis, 2-methylindole was prepared with the Acetyl-o-toluidine and $NaNH_2$. yield; 88%, mp. $56.5{\sim}57^{\circ}C$. 2). 23.7 gr of 3-(-Nitro-1-phenylethyl)-2-melthylindole was prepared with 0.1 mol. of the 2-methylindole and 0.1 mol. of the ${\beta}-Nitrostyrene$. yield: 84.6%, mp. $104{\sim}105^{\circ}C$. 3). Analytical results. Calcd. for $C_{17}H_{16}N_2O_2$: C, 72.84; H, 5.63; N, 9.99. Found: C, 72.62; H, 5.63; N, 9.79.

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