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A Program to Treat Hepatitis B in North Korea: A Model of Antiviral Therapy in a Resource-Poor Setting

  • Lee, Alice Unah;Linton, Heidi;Kilsby, Marcia;Hilmers, David C.
    • Gut and Liver
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    • v.12 no.6
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    • pp.615-622
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    • 2018
  • Despite the well-proven, safe and effective therapies for hepatitis B infection, delivery of treatment remains a significant challenge in resource-poor settings. Geopolitical and economic restrictions present additional difficulties in providing care in North Korea. However, treatment of patients with chronic hepatitis B remains a top priority for both the North Korean Ministry of Public Health and international agencies working in North Korean hepatitis healthcare facilities. Working in partnership, a path was created to institute this much-needed program. A consortium of United States and Australian humanitarian non-governmental organizations along with generous individual and corporate donors working in concert with local and national health authorities have succeeded in establishing the first hepatitis B treatment program in North Korea. The essential elements of this program include renovation of existing hepatitis hospitals, access to antiviral medications, establishment of laboratory facilities, creation of medical documentation and record-keeping, training of local health care professionals, and quarterly visits by international volunteer physicians and laboratory experts. Management and treatment decisions are made bilaterally. To date, nearly 1,500 patients have been evaluated, and over 800 have been started on long-term antiviral therapy. It is envisioned that this program will eventually be managed and funded by the Democratic People's Republic of Korea Ministry of Public Health. This program's success demonstrates a potential model for delivery of antiviral therapy for patients suffering from hepatitis B in other developing countries.

Model-based predictions for nuclear excitation functions of neutron-induced reactions on 64,66-68Zn targets

  • Yigit, M.;Kara, A.
    • Nuclear Engineering and Technology
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    • v.49 no.5
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    • pp.996-1005
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    • 2017
  • In this paper, nuclear data for cross sections of the $^{64}Zn(n,2n)^{63}Zn$, $^{64}Zn(n,3n)^{62}Zn$, $^{64}Zn(n,p)^{64}Cu$, $^{66}Zn(n,2n)^{65}Zn$, $^{66}Zn(n,p)^{66}Cu$, $^{67}Zn(n,p)^{67}Cu$, $^{68}Zn(n,p)^{68}Cu$, and $^{68}Zn(n,{\alpha})^{65}Ni$ reactions were studied for neutron energies up to 40 MeV. In the nuclear model calculations, TALYS 1.6, ALICE/ASH, and EMPIRE 3.2 codes were used. Furthermore, the nuclear data for the (n,2n) and (n,p) reaction channels were also calculated using various cross-section systematics at energies around 14-15 MeV. The code calculations were analyzed and obtained using the different level densities in the exciton model and the geometry-dependent hybrid model. The results obtained from the excitation function calculations are discussed and compared with literature experimental data, ENDF/B-VII.1, and the TENDL-2015 evaluated data.

Exploring the Factors That Influence Unexpected Change of E-Customer Behaviour and Perceived Cybercrime Risk during COVID-19 in Saudi Arabia

  • Ibrahim, Rehab;Li, Alice;Soh, Ben
    • International Journal of Computer Science & Network Security
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    • v.21 no.12
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    • pp.101-109
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    • 2021
  • Cybercrimes are the biggest threat that can influence the future of e-commerce, particularly in difficult times such as the COVID-19 pandemic. This pandemic has resulted in noticeable changes in e-customer behaviour represented in three types: spending rates, types of goods bought, and the number of purchasing times. Moreover, the percentage of cybercrime in many countries, including Saudi Arabia, has increased during the pandemic. The increase in the number of cybercrimes during the COVID-19 crisis and the changes in consumer behaviour shows that there is an urgent need to conduct research on the factors that have led to this. This study will explore the most significant factors that have an effect on the unexpected change of customer behaviour and cybercrime perceived risk during the COVID-19 pandemic in Saudi Arabia. The finding of the study will hopefully contribute to attempts in finding safer methods for shopping online during COVID-19 and similar crisis.

Early-life exposure to endocrine disrupting chemicals associates with childhood obesity

  • Yang, Chunxue;Lee, Hin Kiu;Kong, Alice Pik Shan;Lim, Lee Ling;Cai, Zongwei;Chung, Arthur C.K.
    • Annals of Pediatric Endocrinology and Metabolism
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    • v.23 no.4
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    • pp.182-195
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    • 2018
  • Increasing prevalence of childhood obesity poses threats to the global health burden. Because this rising prevalence cannot be fully explained by traditional risk factors such as unhealthy diet and physical inactivity, early-life exposure to endocrine disrupting chemicals (EDCs) is recognized as emerging novel risk factors for childhood obesity. EDCs can disrupt the hormone-mediated metabolic pathways, affect children's growth and mediate the development of childhood obesity. Many organic pollutants are recently classified to be EDCs. In this review, we summarized the epidemiological and laboratory evidence related to EDCs and childhood obesity, and discussed the possible mechanisms underpinning childhood obesity and early-life exposure to non-persistent organic pollutants (phthalates, bisphenol A, triclosan) and persistent organic pollutants (dichlorodip henyltrichloroethane, polychlorinated biphenyls, polybrominated diphenyl ethers, per- and polyfluoroalkyl substances). Understanding the relationship between EDCs and childhood obesity helps to raise public awareness and formulate public health policy to protect the youth from exposure to the harmful effects of EDCs.

The Correlation between Online Comments before Broadcasting and Television Content Viewers' Behavior Pattern: The Anchoring Effect Perspective

  • Ma, Alice Kyoungran;Ahn, Jongchang
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.13 no.6
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    • pp.3023-3036
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    • 2019
  • This study investigated the television (TV) content viewers' behavior influenced by online communication at the choice of new TV series on a terrestrial streaming platform. For exploring the impact of the anchoring effect on the TV content consumption, this study analyzed the correlation between the first episode's TV ratings and the data of online comments or reactions. These data were potential audiences' communication, which were generated on the online article three weeks before the first broadcasting began. To avoid the crucial influence by external factors, such as season and social issue, the test was done with eight (8) TV series which have same genre (drama), similar core audience targeting (20-49's women), similar broadcasting period (Jun-Oct 2016), same scheduling (10.00 to 11.00 pm, weekdays) and aired on terrestrial TV platforms. This research found that not only the amount of comments and reactions, but also the attitude about the comments created before broadcasting, positively influence the audiences' decision-making behavior for new TV content choices. This investigation contributes to the literature on media economics and management by exploring the media content users' consuming behavior with behavioral economics perspectives (anchoring effect) and making a first step for finding a new effect on the media content consumption.

A Study on the Media Consumers' Behavior Related to Online Communications: Behavioral Economics Perspective

  • Ma, Alice Kyoungran;Kim, Takhun;Ahn, Jongchang
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.13 no.5
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    • pp.2491-2508
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    • 2019
  • This research investigates the media consumers' behavior with behavioral economics perspective, especially regarding TV content viewers' behavior; how do online communications influence TV viewers' decision when choosing a new TV content among options. We focus on quantity and attribute of comments or reactions on the online news articles. We analyze that online communications data, which were generated before the first broadcast, affect the TV content consumers' choice for a new TV series. Here we identify a predicted utility, experienced utility and distinction bias in TV media consumption to find the effectiveness of the first viewing choice on whole TV series' episodes. To avoid the crucial influence by exogenous factors, such as season and social issue, the test was done with specific conditions. This research found that the total number of reactions to the comments by itself positively affects the audiences' decision-making behavior for a new TV content choice. This influence was regardless of favor/ non-flavor reactions. This study contributes to the literature on media economics and management by exploring the media content users' consuming behavior and making a first step for finding an important influencer on the media content consumption.

Spatial spectrum approach for pilot spoofing attack detection in MIMO systems

  • Ning, Lina;Li, Bin;Wang, Xiang;Liu, Xiaoming;Zhao, Chenglin
    • ETRI Journal
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    • v.43 no.5
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    • pp.941-949
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    • 2021
  • In this study, a spatial spectrum method is proposed to cope with the pilot spoofing attack (PSA) problem by exploiting the of uplink-downlink channel reciprocity in time-division-duplex multiple-input multiple-output systems. First, the spoofing attack in the uplink stage is detected by a threshold derived from the predefined false alarm based on the estimated spatial spectrum. When the PSA occurs, the transmitter (That is Alice) can detect either one or two spatial spectrum peaks. Then, the legitimate user (That is Bob) and Eve are recognized in the downlink stage via the channel reciprocity property based on the difference between the spatial spectra if PSA occurs. This way, the presence of Eve and the direction of arrival of Eve and Bob can be identified at the transmitter end. Because noise is suppressed by a spatial spectrum, the detection performance is reliable even for low signal-noise ratios and a short training length. Consequently, Bob can use beamforming to transmit secure information during the data transmission stage. Theoretical analysis and numerical simulations are performed to evaluate the performance of the proposed scheme compared with conventional methods.

Understanding of Holding Environment Through the Trajectory of Donald Woods Winnicott

  • Bahn, Geon Ho
    • Journal of the Korean Academy of Child and Adolescent Psychiatry
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    • v.33 no.4
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    • pp.84-90
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    • 2022
  • Personal life and achievements are the process and result of a person's past, present, and future interacting with each other. In this regard, if one fully understands the life and background of the person who developed the theory of psychoanalysis, one can understand and use the theory more appropriately. The holding environment theory developed by Donald Woods Winnicott is useful for understanding the process by which infants grow healthy under the care of a mother who is good enough. In this paper, the background of the birth of the holding environment theory is reviewed based on Winnicott's developmental background and marital life. He grew up with a holding environment from good enough 'multiple mothers'. Born with excellent athletic ability and musical talent, he was more curious than anyone else and particularly active in discovering new things. After the unhappy first marriage, Claire Britton's second marriage was happy academically and personally. Claire was a fellow paediatric psychoanalyst who published Winnicott's research and theories after his death. Psychoanalysis or psychotherapy itself can be a holding environment, and the holding environment theory can be applied to various fields in the digital era.

Beyond Net Zero - SOM's Urban Sequoia Building Concept and Technologies for Future, Regenerative Cities

  • Mina Hasman;Jiejing Zhou;Alice Guarisco;Nicholas Chan;Alessandro Beghini;Zhaofan Li;Michael Cascio;Yasemin Kologlu
    • International Journal of High-Rise Buildings
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    • v.12 no.2
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    • pp.121-128
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    • 2023
  • Cities cover only 3% of the planet's surface, yet they are responsible for more than 75% of the global emissions. Given the projected urban built area will double by 2060, the carbon emitted from cities will further increase. SOM proposes the Urban Sequoia concept, for buildings that go beyond 'net zero' and absorb carbon from the atmosphere. This concept combines multiple strategies, including the use of an optimised building form with a highly efficient structural system, modularized prefabrication techniques, holistic integration of facade, MEP and interiors' components, bio-based materials, and Direct Air Capture (DAC) technology, to reduce a 40-storey building's whole life cycle carbon emissions by more than 300% over a 100-year lifespan. Calculations of embodied carbon emissions are performed with SOM's in-house Environmental Analysis (EA) Tool to demonstrate the effectiveness of employing Urban Sequoia's design strategies in the design of new buildings using current technologies.

A Study of English Fantasy Novels in the 19th Century: Focus on Lewis Carroll and George MacDonald (19세기 영국 판타지소설 연구 -루이스 캐럴과 조지 맥도널드를 중심으로)

  • Yang, Yun-Jeong
    • Journal of English Language & Literature
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    • v.56 no.5
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    • pp.999-1026
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    • 2010
  • There was a Golden Age of Fantasy novels in the United Kingdom in the 19th Century, which had the major writers, Lewis Carroll and George MacDonald. These writers pushed the boundaries of imagination and created a new world in which explore their own selves and societies. Fantasy novels flowered in the 1860s when a group of writers including Carroll and MacDonald published their works. These writers used the trait of dream framing to create their own fantasy world in which they took the action against the complicated and oppressive Victorian reality. Carroll's fantasy worlds of Alice in Wonderland and Through the Looking-Glass were an insane and chaotic world where the certainty of the real world was overturned. MacDonald's dream worlds of At the Back of the North Wind and the Princess books including The Princess and the Goblin and The Princess and Curdie were ideal societies in which imaginative characters could create harmony between fantasy and reality. Fantasy writers engaged in making journey to other lands to do philosophical and moral discussion critiquing Victorian society and to find insights into those problems in their works. Thus, their fantasy journey traverses time and place can produce some suggestive answers to the questions that lie in other times and realities as well as theirs.