• Title/Summary/Keyword: Alclofenac

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Refinement of the Structure of Alclofenac, 4-Allyloxy-3-Chlorophenyl acetic acid ($C_{11}H_{11}O_{3}CI$)

  • Kim, Yang-Bae;Kim, Sung-Jae;Koo, Chung-Hoe
    • Archives of Pharmacal Research
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    • v.9 no.4
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    • pp.223-227
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    • 1986
  • The structure of alclofenac was determined by single crystal X-ray diffraction analysis. The compound was recrystallized from chloroform solution in monoclinic system space group $C_{2}$/c, with Z = 8, a = 8, a = 23.349(9), b =14.295 (3), c = 7.192 (2) $\AA$, $\beta$ = 111.32 (3)$^{\circ}$, and $d_{dbs}$ = 1.29, $d_{caic}$ = 1.30. The structure was solved by direct method and refined by least-squares procedure to the final R-value being 0.044 for 1055 reflections (F ${\geq}6${\sigma}$(F)). The molecules are dimerized by OH..O type hydrogen bonds related by two-fold axis.

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Determination of Carboxyl Drugs by Gas Chromatography-Flame Photometric Detector (가스크로마토그라피-염광광도 검출기에 의한 혈장중 카르복실기 함유 약물의 정량)

  • 박만기;조영현;유무영;강탁림
    • YAKHAK HOEJI
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    • v.30 no.4
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    • pp.180-184
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    • 1986
  • Such carboxyl drugs as mefenamic acid, alclofenac, ketoprofen, cicloxilic acid and tolfenainic acid in rat plasma were determined by the gas chromatography flame photometric detector (GC-FPD). After methylthiomethyl (MTM) esterification with MTM-chloride in 1, 8-diazabicyclo [5.4.0] undec-7-ene (DBU) catalyst, determination of these drugs by this method was tried and compared with that by the GC-flame ionization detector (FID) method in respect to sensitivity and effect of inteferences. The results showed it was possible to analyze with accuracy by this method because of specificity of the FPD, although these drugs were not separated from interferences in plasma on GC column. The GC-FPD method was more sensitive than GC-FID method and the minimum detectable amount of monocarboxylic drugs on 3%, QF-1 column was about 15fmol/injection.

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Pharmaceutical Studies on the Inclusion Complexes of Non-Steroidal Antiinflammatory Drugs with ${\beta}-Cyclodextrin$ (I) (비(非)Steroid 성소염약물(性消炎藥物)과 ${\beta}-Cyclodextrin$과의 Inclusion Complex에 관(關)한 약제학적(藥劑學的) 연구(硏究) (제1보)(第一報))

  • Han, Kun;Lee, Min-Hwa;Kim, Shin-Keun
    • Journal of Pharmaceutical Investigation
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    • v.13 no.1
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    • pp.10-22
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    • 1983
  • The interactions of ${\alpha}-cyclodextrin({\alpha}-CyD)$ and ${\beta}-cyclodextrin({\beta}-CyD)$ with several non-steroidal antiinflammatory drugs were studied on the effects of ${\alpha}-$ and ${\beta}-CyD$ on the solubility of the drugs in aqueous medium. Indoprofen, niflumic acid, alclofenac, and naproxen were chosen as representatives of antiinflammatory drugs. The solubility of all drugs studied increased with the addition of ${\beta}-CyD$, while not with glucose or ${\alpha}-CyD$. The increase of the solubility with ${\beta}-CyD$ was considered due mainly to the formation of inclusion complexes between ${\beta}-CyD$ and drugs. From the solubility data, the apparent stability constants K of the complex could be calculated. Ultraviolet absorption and circular dichroism confirmed the inclusion of indoprofen, niflumic acid and naproxen with ${\beta}-CyD$ in the molar ratio of 1 : 1. Inclusion complexes in solid powder form were obtained by the freeze-drying method and the inclusion formation was confirmed again by infrared, diffential thermal analysis, and X-ray diffraction measurements.

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