• Proceedings of the Korean Society of Toxicology Conference
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• 2003.10b
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• pp.112-112
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• 2003

Air pollution is made up by complex mixture exhausted from cars, industries and incinerators etc. Those pollutants come from everywhere without border and contain phototoxic and photogenotoxic chemicals including PAHs exhausted in the air. We have published that the chemicals which show phototoxicity and photogenotoxicity are closely related in mechanistic and the PAHs react as a strong photocatalyzer by radical productions under UV exposure.(omitted)

• 대한예방의학회:학술대회논문집
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• 1998.10b
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• pp.335-336
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• 1998

• 대한예방의학회:학술대회논문집
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• 1998.10b
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• pp.202-203
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• 1998

• Toxicological Research
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• v.17 no.4
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• pp.255-265
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• 2001

Epidemiologic studies have demonstrated an association between short-term exposure to particulate air pollutants and increased mortality. However the biological mechanism underlying these associations have not been fully established and also the chemical and physical characteristics of the pollutant particles are not well understood. The metal constituents of air pollutant particles and their bioavailability are considered to Play an important role as possible mediators of Particle-induced airway injury and inflammation. Sprague-Dawley rat alveolar macrophage cells (NR8383) were exposed to airborne and acid-leached particulate matter (PM). Titanium oxide and nickel subsulfide were used as negative and positive controls. Particle-induced reactive oxygen species formation in cells was detected using the fluorescent probe 2',7'-dichlorofluorescin diacetate. Expression of TNF-$\alpha$ and IL-6 were measured by enzyme-linked immunosorbent assay, and PM-induced DNA double-strand breaks were determined with $\lambda$DNA/Hind III marker. Metals associated with air pollutant particles mediated intracellular oxidant production in alveolar macrophages, and the cytotoxicity and proinflammatory cytokine production induced by PM were associated with oxidative stress. The oxidants produced by air pollutant particles also are likely to induce DNA double-strand breaks. Our findings in alveolar macrophage cells exposed to PM and acid-leached PM support the hypothesis that metal components in urban air pollutants and their bioavailabilities might play an Important role in the induction of the adverse health effects.

• Asian Journal of Atmospheric Environment
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• v.5 no.3
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• pp.146-151
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• 2011

1-Nitropyrene (1-NP), 2-NP and 2-nitrofluoranthene (2-NFR) are useful markers for studying the atmospheric behaviors of polycyclic aromatic hydrocarbons (PAHs) and nitropolycyclic aromatic hydrocarbons (NPAHs). However, present methods for measuring trace levels of these compounds are lesssensitive and laborious. Here we describe several improvements to a previously reported high-performance liquid chromatography-chemiluminescence detection system that allows it to determine trace levels of 1-, 2-NPs and 2-NFR. The proposed system was equipped with a reducer column packed with Pt/Rh instead of zinc whose life-time was limited. The combination of Cosmosil MS-II (monomeric ODS) and AR-II (polymeric ODS) columns was used instead of polymeric ODS columns as the separator column to improve the separation. An ethanol mixture with acetate buffer (pH 5.5) was used in place of an acetonitrile mixture with the same buffer to activate the reducer column. The same ethanol mixture was used as the mobile phase for the clean-up column. The switching time of the column switching valve was optimized to concentrate the amino-derivatives of above NPAHs quantitatively on the concentrator column. The concentrations of bis(2,4,6-trichlorophenly) oxalate and hydrogen peroxide in the chemiluminescence reagent solution were optimized to 0.4 mM and 30 mM, respectively, to increase the sensitivity. Under the above conditions, the detection limits (S/N=3) of 1-, 2-NPs and 2-NFR were 1 fmol (0.25 pg), 10 fmol (2.5 pg) and 4 fmol (1 pg), respectively. The proposed system was effectively used to determine trace levels of 1-, 2-NPs and 2-NFR in airborne particulates collected at Noto Peninsula. The atmospheric concentrations of 1-, 2-NPs and 2-NFR were not more than sub pg $m^{-3}$ levels. They were higher in winter (January) than in summer (July). In both seasons, the concentrations were in decreasing order, [2-NFR]>[1-NP]>[2-NP].

• Journal of Environmental Impact Assessment
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• v.9 no.4
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• pp.271-276
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• 2000

The research centers on the health risk assessment of airborne toxic metals in Taejon third and fourth industrial complexes. Total suspended particulates were collected on glass microfibre filters by high volume air samplers. Fifteen toxic metals including 6 carcinogenic metals were analyzed by ICP-MS and ICP-AES after the pre-treatment of mixed acid extraction. The following results were summarized from the research : 1) the concentrations of TSPs were $17.7{\sim}219.6{\mu}g/m^3$ while the arithmetic mean concentration was $101.7{\mu}g/m^3$; 2) the arithmetic mean concentrations of human carcinogens such as arsenic, hexavalent chromium and nickel subsulfide were 10.22, 6.96 and 6.42 $ng/m^3$, respectively while those of probable human carcinogens such as beryllium, cadmium and lead were 0.13, 3.41, 97.65 $ng/m^3$, respectively; 3) the point risk estimate for the inhalation of carcinogenic metals was $1.5{\times}10^{-4}$, which was much higher than a risk standard of $10^{-5}$; 4) approximately 93% of the cancer risk were to the inhalation of human carcinogens, arsenic and hexavalent chromium, which should be properly managed in Taejon third and fourth industrial complexes.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.17 no.3
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• pp.245-253
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• 2007

This research was performed to evaluate the airborne personal concentration of hazardouse materials during the process of ship construction and surveyed from May 23 to June 30, 2007 in Kyungnam West Distirct, Korea. The subject was 94 ship construction workers exposed to welding fume and respirable particulate. The airborne concentrations of those were compared to Permissible Exposure Limit(PEL) from the Ministry of Labor in Korea. The airborne concentration of 23 samples(48.9%) of welding fumes was less than $5mg/m^3$, that of 16 (34.0%) was between 5 and $10mg/m^3$, and that of 8 (17.0%) was greater than $10mg/m^3$. The airborne concentration of 27 (57.4%) of respirable particulate masses was less than $5mg/m^3$ and the othere are greater than $5mg/m^3$. The welding fumes were identified containing the heavy metasl such as Fe, Mn, Zn, Mg, Ca, and Cu. The respirable particulates has similiar tendency with welding fumes in the component of heavy metals. But the concentration of Ca, Cu, Cr, and Ni turned out to be higher in welding fumes. Twenty (42.6%) of the 47 samples of welding fumes were exceeded PEL. In the heavy metals in welding fumes, ten (21.3%) of the 47 samples of Mn were exceeded PEL. Based on the results, the higher airborne hazardous materials were still exposed to wokers in ship construction process. It is suggested that the appropriate engineering control be applied to minimize the exposed cocnetration in ship building processes.

• Journal of Korean Society for Atmospheric Environment
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• v.4 no.2
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• pp.47-56
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• 1988

Polynuclear aromatic hydrocarbons $(PAH_s)$ in Seoul atmosphere were isolated and identified. PAH fraction was isolated from airborne suspended particulates by solvent extraction, fractionation and thin layer chromatography. PAHs were identified by GC-MS, capillary GC, retention index and so on. About 70 major $PAH_S$ were seperated in capillary GC and 41 $PAH_s$ of those were identified.

• Journal of Korean Society for Atmospheric Environment
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• v.2 no.3
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• pp.11-18
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• 1986

In order to evaluate the state of the environmental pollution by vehicle exhaust in Seoul area the correlation between lead in air and leaves of roadside trees has been investigated during August in 1985. The dust in the atmosphere was collected by high volume air sampler to measure the concentration of lead. On the other hand, lead as a pollution indicator was extracted from the leaves of roadside trees (Ginkgo biloba, Salix pseudo/lasiogyne, platanus occidentalis) by conventional method and their concentrations were determined. The following results were obtained : 1. Lead concentrations in the leaves of roadside trees varied with trees, for example, the average concentrations of lead in each of the leaves of Ginkgo biloba, Salix pseudo/lasiogyne and Platanus occidentalis were 20.66 ppm, 9.37 ppm, and 10.58 ppm, respectively. 2. The dust sampled along heavily traveled highways showed that lead content tended to increase with traffic volume. 3. The correlation coefficients between lead correlation in air and leaves of Gingo biloba, Salix pseudo/lasiogyne, and Platanus orientalis were 0.80, 0.85, and 0.87, respectively.

• Journal of Korean Society for Atmospheric Environment
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• v.6 no.2
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• pp.155-160
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• 1990

During the period from Mar. 1985 to Feb. 1988, airborne particulate matters were collected and size fractionated by the ANdersen high volume air sampler in Seoul. The concentrations of several heavy metals (Pb, Cu, Zn, Fe, Mn) and benzo(a)pyrene were determined to investigate the size distributions and seasonal variations. And with respect to seven components in the total suspended particulate (TSP), the factor analysis was performed for three groups such as the coarse particles (> 2 $\mu$m), fine particles (< $\mu$m) and TSP. As a result of factor analysis by using the varimax method, the chemical components in the TSP were able to characterize with two principal factors. The first factor, F1 was considered to be a factor indicating the contribution of natural sources and the second factor, F2 was a factor indicating the degree of artificial sources. Each components in the TSP was divided into two main groups of components originated from soil and/or road dust and pollutants originated from automobiles and/or human work.