• Journal of the Korea Society of Computer and Information
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• v.25 no.3
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• pp.219-227
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• 2020

It is expected that Korea will be entering with super aged society with its rapid changing to aging society compare to other developed countries. Such phenomenon is recognized from a long time ago and government has enacted Elderly Long Term Convalescence Insurance Regulation back in 1999. However, different from its actual purpose, there are many problems and improvements to be made, leading to legislative revision for several times. Still, it is left with many issues. This is one example showing there has been a continuous problem with elderly long term convalescence insurance system. Even this system in Germany which have started 4 years before us is to continuously revising regulation by raising issues to make strong structure for elderly welfare and long term convalescence, aiming to enhance life of elderly people by providing detailed standard for convalescence. Elderly related legal systematization may not enhance their welfare service or daily life right away. However, if details in regulation and its theory is systematically arranged, this will greatly reduce administrative confusion as well as increasing understanding and use of this system for the nation.

• Journal of Agricultural Extension & Community Development
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• v.22 no.2
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• pp.159-173
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• 2015

The purpose of this study was to identify the conditions of neighborhood facilities for the elderly, paying special attention to the accelerated aging phenomenon in rural areas of Korea. We contrived a new index to measure spatial accessibility for people aged over 65 years, and we analyzed spatial accessibility by focusing on community facilities: public bath facilities, beauty shops, rural public facilities, markets, big stores, and large-scale retail shops. The most outstanding spatial accessibility among community facilities was found with the rural public facilities thanks to governmental installing adequate facilities in the past, followed by the beauty shops and the public bath facilities. In contrast, spatial accessibility of the markets was in the lowest. Spatial accessibility of community facilities for the elderly exhibited high variability among the rural areas. We confirmed significant inequality of spatial accessibility in all facilities we studied. The areas that had better spatial accessibility diverse combinations of the facilities. The areas that had worse spatial accessibility were, on the whole, consistent with traditional undeveloped regions. In the near future rational planning of facilities will be needed to supply adequate accessibility in targeted areas which currently had low accessibility. In order to improve the spatial accessibility of neighborhood facilities, the most essential factor is to take into account the geographical distribution patterns of rural settlements.

• Journal of Korean Academy of Nursing
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• v.26 no.4
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• pp.759-767
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• 1996

This study was done to provide an understanding of nursing in relation to the existential philosophy of the West and Buddhistic philosophy, It examined how human beings and death are interpreted and understood in existential philosophy as well as in Buddhistic philosophy. Then the study suggested that nursing should focus on helping the sufferer to find meaning and a sense of responsibility in his or her existence. When people have the opportunity to realize certain important but painful truths about their existence, they develop internal strength and control of their lives. Just as people learn to face their being, so can they come to terms with their non-being. According to the causal process in Buddhism, Human Being is not always annihilation of self. Therefore, birth, aging, disease and death go through the process of natural change and it is the appearance of human existence which is inherent in the health of every human being. To promote our health we must gain an insight about this phenomenon. This study viewed nurses' clients as 〈good friend〉 rather than 〈patient〉 which focuses on a disease-oriented concept. The concept of 〈good friend〉 views nurses' clients as active participants to create their life and as responsible persons in a constantly changing life. The study also examined the concept of recovery which means to come back to the previous healthy state and it suggested that the concept of recovery should be changed to 〈good change〉, because in existential philosophy, human beings are viewed as never going back to the past but moving on to the future by creating their existence. This study also suggested that nursing should help 〈good friend〉enlighten their existence to be free from pain and death and to get control over their existence.

• The Journal of the Korea Contents Association
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• v.16 no.2
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• pp.387-397
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• 2016

The purpose of this study is to suggest design characteristics of picture books for silver generation empirically through academic consideration of necessity and characteristics of picture books targeting silver generation. Through an analytical result of literature materials such as library and information science, pedagogy, and literature therapeutics, and aging phenomenon, picture books help mental and physical health of silver generation, but picture books for silver generation are insufficient in comparison with demand. Therefore, a theoretical basis of study and development of fairy tale books for silver generation is acutely needed. This study suggested that close attention for characteristics of silver generation is needed to solve a problem about dyslexia of silver generation in story, picture(expression, size, layout, structure, and color), and typography of characteristic factors of picture on designing fairy tale books for silver generation, suggesting needs to develop picture books reflecting characteristics such as visual organ, body function, and psychological factor of silver generation. In addition, design characteristics for composition of picture books for silver generation will be used as part of advanced data in a study on solid analytical data through an actual analysis on silver generation in the future.

• Journal of Nutrition and Health
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• v.33 no.6
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• pp.660-667
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• 2000

Previous studies on the effect of age on intestinal taurine transport in animals have invariably shown a decline in the activity of the transport system with increasing age. In the present study changes in taurine transporter activity were observed during cell differentiation in the human colon carcinoma cell line HT-29 This cell line exhibits various enterocytic characteristics when differentiated and therefore has frequently been used to study the characteristcs and regulation of nutrient and drug absorption in the small intestine at the cellular level. Pre-treatment of the cells with $\beta$-alanine(10mM) reduced the taurine transport activity to 33% of the value for the control cells(p<0.05) which implies that taurine and $\beta$-alanine share a common $\beta$-amino acid transport system for their celluar uptake in the HI-29 was continued until 21 days post seeding. Kinetic studies of the taurine transporter were conducted in the HT-29 cell line with varying taurine concentration(5-60$\mu$M) in the uptake medium Both Vmax and the Michaelis-Menten constant(Km) of taurine transporter were decreased as differentiation of the HT-29 cell line was progressed ; Vmax of the taurine transporter in cells incubated for 4, 14 and 21 days post seeding was 2.79$\pm$3.4m 16.89$\pm$1.74, and 0.85$\pm$0.08 and 0.32$\pm$0.01nmol.mg protein-1 .30min-1 respectively(p<0.001) and Km was 42.3$\pm$3.4, 16.89$\pm$1.74, and 11.2$\pm$3.0$\mu$M respectively (p<0.01) These results indicate that the activity of sodium dependent active taurine transport system in the HT-29 cell line is decreased as confluent cells are differentiated. This phenomenon in cell culture system corresponds well with the earlier observation of lower intestinal taurine transport activity in suckling rats compared to that in adult animals although direct relationship of cell differentiation with in vivo aging process needs further verification.

• The Korean Journal of Physiology and Pharmacology
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• v.13 no.6
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• pp.491-496
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• 2009

Skeletal muscle atrophy is a common phenomenon during the prolonged muscle disuse caused by cast immobilization, extended aging states, bed rest, space flight, or other factors. However, the cellular mechanisms of the atrophic process are poorly understood. In this study, we investigated the involvement of mitogen-activated protein kinase (MAPK) in the expression of muscle-specific RING finger 1 (MuRF1) during atrophy of the rat gastrocnemius muscle. Histological analysis revealed that cast immobilization induced the atrophy of the gastrocnemius muscle, with diminution of muscle weight and cross-sectional area after 14 days. Cast immobilization significantly elevated the expression of MuRF1 and the phosphorylation of p38 MAPK. The starvation of L6 rat skeletal myoblasts under serum-free conditions induced the phosphorylation of p38 MAPK and the characteristics typical of cast-immobilized gastrocnemius muscle. The expression of MuRF1 was also elevated in serum-starved L6 myoblasts, but was significantly attenuated by SB203580, an inhibitor of p38 MAPK. Changes in the sizes of L6 myoblasts in response to starvation were also reversed by their transfection with MuRF1 small interfering RNA or treatment with SB203580. From these results, we suggest that the expression of MuRF1 in cast-immobilized atrophy is regulated by p38 MAPK in rat gastrocnemius muscles.

• Proceeding of Spring/Autumn Annual Conference of KHA
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• 2008.11a
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• pp.437-441
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• 2008

The community mixed-support facility in Japan is making efforts to try various approaches according to the changes made to allow the privatization of public facilities on the basis of Act on Special Measures for Urban Regeneration since 2004. Due to this change in policy, the community mixed-support facility is now taking further steps in trying to implement variety of approaches in the perspective of urban regeneration and urban maintenance and at the same time the trend of installation of community facility has gone through vivid changes for the last 20 years. The causes of this are from the social demand that claims for of new facilities and the change in the subsidy system in relation to equality in facility installation. Examples of the first cause can be the building of perpetuating educational society, an execution or a movement towards the society of gender equality, a countermovement for an aging society as well as a welfare society, and recently social phenomenon related to consumption is becoming an issue. And for the last, the number of construction of facilities is increasing that grow out of the traditional facility system. The complex of community mixed-support facility will provide public administrative and community mixed-support services to local people as well as to form a notion of community and a feeling of solidarity. Ultimately, this will develop local areas by regional interchanging of information. In this very research, we will analyze the community mixed-support facility and its characteristics as well as its implications and consider the types of complex through many preceding instances in Japanese community mixed-support facility.

• Journal of Korean Academy of Rural Health Nursing
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• v.3 no.2
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• pp.104-115
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• 2008

Purpose: A study of the family planning and Maternal-Child Health Services that disciplined itself in primary health care post form 1980 to 2009. Method: Investigation studies family planning in primary health care post and a change process of a Maternal-Child Health Services into case by case until 2009 from 1980. Results: Our country family planning business began at economic development dimensions in order to solve a poverty issue. This business goal were childbirth decrease of pregnancy possibility couple aged 19~49 and improve to mother and child health. For this goal, all kinds of health education included sex education and contraception education, contraception service, comprehensive maternal and child health service that management of front and back of childbirth etc. are provided. According to fail down a birthrate from 6.0(1962) to 1.25(2009), the nation reached to a dilemma called childbirth encouragement policy. Conclusions: Decrease of labor supply by low birthrate, decrease numerical an employed person by aging was brought a labor shortage and decrease of productivity of labor of industrial manpower. Deterioration phenomenon of financial income and expenditure by consumption and investment contraction caused decrease of slowdown of economic growth and potential growth rate, and a social cost burden is increased by deterioration financial old man support burden increase by this and pensions and health insurance, a sharp increase of social welfare cost etc. Now, in order to solve a low birth issue, the government establishes a whole nation forwarding system and establishes basic plan social low birth and advanced age, and to prepare for childbirth fault factors removal and advanced age society shall endeavor.

• Biomedical Science Letters
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• v.21 no.4
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• pp.181-187
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• 2015

Osteoporosis is one of the diseases caused by accumulation of effects from complex interactions between genetic and environmental factors. Aging is the major cause for osteoporosis, which normally increases skeletal fragility and bone fracture especially among the elder. "Omics" refers to a specialized research field dealing with high-throughput biological data, such as genomics, transcriptomics, proteomics or metabolomics. Integration of data from multi-omics has been approved to be a powerful strategy to colligate biological phenomenon with multiple aspects. Actually, integrative analyses of "omics" datasets were used to present pathogenesis of specific diseases or casual biomarkers including susceptible genes. In this study, we evaluated the proposed relationship of novel susceptible genes (TREML2, HTR1E, and GLO1) with osteoporosis, which genes were obtained using multi-omics integration analyses. To this end, SNPs of the susceptible genes in the Korean female cohort were analyzed. As a result, one SNP of HTR1E and five SNPs of TREML2 were identified to associate with osteoporosis. The highest significant SNP was $rs6938076^*$ of TREML2 (OR=0.63, CI: 0.45~0.89, recessive P=0.009). Consequently, the susceptible genes identified through the multi-omics analyses were confirmed to have association with osteoporosis. Therefore, multi-omics analysis might be a powerful tool to find new genes associated with a disease. We further identified that TREML2 has more associated with osteoporosis in females than did HTR1E.

• Journal of Preventive Medicine and Public Health
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• v.7 no.2
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• pp.395-401
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• 1974

In order to figure out the normal range, lower limit of hypertension and upper limit of hypotension of the blood pressure of Korean, authors had measured blood pressure according to Korotkow's method for 31,897 healthy persons as samples who were occupied different levels of the social class except cases who would seem to be the essential hypertension and had the diseases affecting to secondary hypertension. A following conclusion was induced by actual measurement and statistical reasoning. 1. The normal range and limits of hypo- and hypertension by sex and age groups of Korean were demonstrated in Table 1 and Figure 1. 2. The more aging the higher value of blood pressure in both sexes, especially women rather than men and systolic as to diastolic. 3. Generally, blood pressure values of female were lower than male, after 55 years of age, however, the crossing phenomenon was recognizable. 4. To settle the normal and abnormal ranges of the blood pressure of Korean, it was attempted that $M{\pm}1.282{\sigma}$ as normal range, $M+2{\sigma}$ as lower limit of hypertension and $M-2{\sigma}$ as upper limit of hypotension were calculated, and regression lines were drawn to adjust the biological variables and derive continuity from each age class. (Fig. 2 and 3) 5. The blood pressure levels were becoming elevated as to getting increased of the body weight, particularly diastolic value at 40-49 age group in male and systolic value at 30-39 age group in female.