• 한국노년학
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• v.29 no.3
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• pp.899-915
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• 2009

The purpose of this study was examined effect of physical fitness and exercise participation on healthy aging of the elderly. The subjecrts were a total 319 people that they were participate in the regular exercise, and go to welfare center in Seoul. Data were collected during the period from November 1 to November 30, 2006. The collected data were analyzed frequency, descriptive statistics, correlation and hierarchical regression analysis using the SPSS-Win 12.0 program. The results of hierarchical regression analysis were appeared as follows. According to the results of hierarchical regression analysis, significant factors influencing healthy aging were monthly income, monthly pocket money, self-perceived health status, leg muscle strength, exercise behavior and period of exercise. 2. According to the results, significant factors influencing physiological health were age, marital status, self-perceived health status, exercise behavior and period of exercise. 3. According to the results, significant factors influencing cognitive-mental health were monthly income, monthly pocket money, self-perceived health status, leg muscle strength, exercise behavior and period of exercise. 4. According to the results, significant factors influencing social-support health were monthly income, age, education, self-perceived health status, leg muscle strength, exercise behavior and period of exercise. In conclusion, First, this questionnaire demonstrates good reliability and validity and therefore it is an appropriate measurement of healthy aging for the elderly in Korea. Second, it is important that exercise behavior is main factor to healthy aging life on the elderly. Third, There is important mean values of the items for healthy aging.

• Journal of Preventive Medicine and Public Health
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• v.43 no.4
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• pp.292-300
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• 2010

Objectives: This study attempted to explore the aging phenomena that now characterize much of Korean society, and assessed issues associated with the life satisfaction experienced during the process of aging. Methods: By employing the National Survey on the State of Life and the Desire for Welfare of the Elderly, 2004 in South Korea this study attempted to identify the factors that determine subjective life satisfaction among the elderly. The data utilized herein consisted of 3278 elderly people aged 65 years or older, from 9308 households. Results: The results of analysis from the final model after the introduction of 19 variables in 8 factors showed statistically similar explanatory power in men (adj. $R^2=0.320$) and in women (adj. $R^2=0.346$). We found that economic condition was the most influential factor in both men (B = 0.278) and women (B = 0.336) except perceived health condition variables. The second most influential variable in life satisfaction was health checkups in men (B = 0.128) and degree of nutritional diet in women (B = 0.145). Those who had experience with chronic diseases also reported significantly lower perceived life satisfaction and this was particularly true of women. Conclusions: The aging society requires an understanding of the lives of elderly individuals. This study explored factors associated with life satisfaction in old age by using a life satisfaction model. The success of an aging society begins with an accurate understanding of the elderly, and thus political attention will need to be focused on this matter.

• Journal of the Ergonomics Society of Korea
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• v.33 no.5
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• pp.423-432
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• 2014

Objective and Background: The objective of this study was to evaluate the association of individual characteristics, work-related factors, lifestyle factors, and health problems with work ability among aging workers in Korea. Method: In this cross-sectional survey, the study population consisted of 1,594 workers who had participated in a voluntary health promotion center and private workplace. Participants completed the work ability index. Results: The mean WAI score was 37.4, while the mean age of the sample was 43.25. In the age group over 50 showed 36.26. The majority of participants rated their work ability as 'good' to 'excellent', one-third moderate and about 7.5% poor. Work ability decreased significantly with age among the men. The younger group had higher scores on the work ability index than the age group over 50, except for mental resources. By work characteristics, work ability was analyzed to be the lowest in the case of work handling heavy stuff. Lastly, as a result of health factors analysis, the good management and retention of current health status can be the measure helpful to the improvement of work ability. Conclusion and Application: According to the results, it can be a basic principle to devise and enforce preventive measures on the factors for which improvement or action is possible, together with workplace-level systematic approach, in order to improve work ability. For such measures to be realized, it is necessary to check trends in change for several years.

• Journal of the Korea Safety Management & Science
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• v.18 no.3
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• pp.109-116
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• 2016

The purpose of this study is to explore the research and development(R&D) programs for effectively response of population aging. We analyzed of aging-related R&D support status by National Science and Technology Information Services(NTIS) and reviewed of foreign aging-related R&D programs. It was found that the overall lack of support systems, the R&D support status for Korea's aging society is very low performance and the difference appears in the annual support status, etc. It is very important to enhance the effectiveness of R&D programs in order to effectively prepare for aging society. I suggested support measures of the R&D for aging society by survey research. The result of this study will help in planning of the R&D for aging society and contribute to increasing of welfare for the aged.

• Journal of the Korean Society of Safety
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• v.38 no.6
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• pp.1-8
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• 2023

The health state of the oil transformer is evaluated by the age of use and the state of internal defects. Mineral Oil, used as an insulator for oil transformers, creates specific gases and compounds through chemical reactions caused by heat, moisture, and partial discharge inside the transformer. It is possible to determine the aging and defect of the transformer through these gases and compounds. So, it is an important indicator to evaluate the health of a transformer. In this study, factors for assessing the health of transformers were hierarchically categorized, and key factors for each hierarchy were selected for design weighting. These weights were determined through surveys conducted with experts in the fields of transformer design, operation, and quality. For the health of a transformer, defect-related factors are approximately three times more important than factors related to aging. Additionally, defect-related factors showed a higher weighting for gases generated at high temperatures. Furthermore, Furan was determined to have a high weight, directly associated with insulating paper aging. Based on these findings, a health index was proposed, and a comparative analysis was conducted by categorizing 40 operational transformers into normal and comparison groups to evaluate and validate it.

• Biomedical Science Letters
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• v.27 no.4
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• pp.231-238
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• 2021

Several structural proteins present in keratinocytes of the skin are known to play an important role in the formation of epidermal tissue and barrier function, and the absence of structural proteins in keratinocytes causes various skin diseases. In this study, 42 types of tetrapeptides derived from the sequence of Loricrin, a kind of terminally differentiating structural protein, were synthesized, and skin anti-aging properties were measured by measuring the elastase inhibition, proliferation of skin cells. The anti-aging efficacy was verified and, based on this, it succeeded in selecting one of the most excellent peptides. It is expected that the selected tetrapeptide can be used as a raw material for various cosmetics and quasi-drugs based on anti-aging and skin cell proliferation effects.

• Biomolecules & Therapeutics
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• v.30 no.6
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• pp.490-500
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• 2022

Aging is defined as physiological dysfunction of the body and a key risk factor for human diseases. During the aging process, cellular senescence occurs in response to various extrinsic and intrinsic factors such as radiation-induced DNA damage, the activation of oncogenes, and oxidative stress. These senescent cells accumulate in many tissues and exhibit diverse phenotypes, such as resistance to apoptosis, production of senescence-associated secretory phenotype, cellular flattening, and cellular hypertrophy. They also induce abnormal dysfunction of the microenvironment and damage neighboring cells, eventually causing harmful effects in the development of various chronic diseases such as diabetes, cancer, and neurodegenerative diseases. Thus, pharmacological interventions targeting senescent cells, called senotherapeutics, have been extensively studied. These senotherapeutics provide a novel strategy for extending the health span and improving age-related diseases. In this review, we discuss the current progress in understanding the molecular mechanisms of senotherapeutics and provide insights for developing senotherapeutics.

• The Journal of Korea Assosiation for Disability and Oral Health
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• v.7 no.2
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• pp.127-132
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• 2011

In Korea, the elderly is defined as the person aged over 65 and the disabled is defined as the person who is registered with Ministry of Health and Welfare. In 2008, the elderly with disabilities was about 770,000. Korea was already poised for an aging society in 2000 and is ahead of and aged society in 2018 and a super aged society in 2026. So, the number of the elderly with disabilities will continue to grow. Various oral diseases can be seen in the elderly with disabilities due to the systemic disease and impaired self oral care, in addition to the physiological aging. Particularly, we should be care for the aspiration pneumonia, which is the major cause of the death of the elderly. As a professional for the special care dentistry, we should understand the general and dental, individual characteristics of the elderly with disabilities and do proper oral care and treatment. Thereby, the quality of life of the patients might be improved.

• BMB Reports
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• v.40 no.1
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• pp.72-81
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• 2007

In order to screen the aging related proteins in human normal colon epithelia, the comparative proteomics analysis was applied to get the two-dimensional electrophoresis (2-DE) profiles with high resolution and reproducibility from normal colon epithelial tissues of young and aged people. Differential proteins between the colon epithelia of two age groups were found with PDQuest software. The thirty five differential protein-spots were identified by peptide mass fingerprint (PMF) based on matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) and database searching. Among them there are sixteen proteins which are significantly up-regulated in the colonic mucosal epithelia of young people group, which include ATP synthase beta chain, electron transfer flavoprotein alpha-subunit, catalase, glutathione peroxidase 1, annexin A2 and heat shock cognate 71 kDa protein, etc.; There are nineteen proteins which are significantly up-regulated in the colonic mucosal epithelia of aged people group, which include far upstream element-binding protein 1, nucleoside diphosphate kinase B, protein disulfide-isomerase precursor and VDAC-2, etc.. The identified differential proteins appear to be involved in metabolism, energy generation, chaperone, antioxidation, signal transduction, protein folding and apoptosis. The data will help to understand the molecular mechanisms of human colon epithelial aging.

• Environmental Analysis Health and Toxicology
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• v.23 no.2
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• pp.119-127
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• 2008

The purpose of this study was to investigate the effects of frankincense oil in a skin aging animal model. Skin aging was induced by both the irradiation of UVB and the application of squalene monohydroperoxide (Sq-OOH) to the back of experimental animals for 4 weeks. And at the same time experimental materials were applied topically. Six to seven weeks female SHR-1 hairless mice were divided into five groups including normal (N: saline), control (C: UVB+Sq-OOH+saline), vehicle control (VC: UVB+Sq-OOH+jojoba oil), positive control (PC: UVB+Sq-OOH+0.01% retinoic acid) and experimental (E: UVB+Sq-OOH+3% Frankincense oil) groups, five animals each group. The skin erythema index for the PC and E groups were lower than that of the C group. Whereas, both the lipid and water capacities for the PC and E groups were higher than those of the C group. Wrinkles for the C group were formed as a pattern of deep furrows and thick crests. Whereas, wrinkles for the PC and E groups were formed as a pattern of shallow furrows and thin crests which were similar to that of the N group. As for the both absolute and relative weight of the spleen, the PC group were significantly higher than the other groups. In conclusion, frankincense oil can be used practically for the prevention or improvement of skin aging in terms of health promotion and beauty for the people.