• 제목/요약/키워드: Aging factor

검색결과 878건 처리시간 0.029초

일본의 인구학적 요인과 경제성장간의 관계에 대한 분석 (Analysis of Relations between Demographic Factors and Economic Growth in Japan)

  • 김호범;곽소희
    • 국제지역연구
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    • 제12권2호
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    • pp.125-145
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    • 2008
  • 일본은 동아시아 국가들 중 가장 먼저 인구 전환 과정을 마무리 지었으며, 소자고령화사회(小子高齡化社會)로 진입한 국가이다. 일본 인구문제 연구소에서 발표하는 인구통계자료집(2008)에 의하면, 일본의 인구증가율은 2000년에 0.21, 2005년 0.13, 2006년에 0.0으로, 인구감소 사회에 진입하고 있음을 알 수 있다. 이러한 급격한 인구학적 변화에 따라 경제성장에 어떤 영향을 미칠 것인가에 대한 관심이 증대되고 있다. 본 논문은 동아시아에서 가장 먼저 인구 전환 과정을 거친 일본에서의 인구전환 과정을 장기적 관점에서 살펴보고, 이를 실증분석을 하는 데 목적이 있다. 메이지 유신의 성공으로 가장 먼저 산업화를 달성한 일본의 인구전환은 동아시아 국가들 중에서 가장 빠르게 나타났다. 실증분석에서는 1952년에서 2005년 시계열 데이터를 사용한 분석 결과, 인구학적 요인과 경제성장간에 정(+)의 관계가 도출되었다. 그러므로 현재 일본의 상황을 고려할 때, 인구 감소는 노동력 감소에 의해 경제성장의 저해 요인이 될 수 있을 것이다. 이러한 문제는 일본뿐만 아니라 한국에서도 공통적인 문제이며, 이에 대한 다양한 정책이 요구되는 시점이라 할 수 있다.

저수지 붕괴예보 시스템의 수위기준 검증 연구 (A Study on the Verification of water level criteria for forecasting system of reservoir failure)

  • 이백;최병한
    • 한국구조물진단유지관리공학회 논문집
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    • 제23권3호
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    • pp.51-55
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    • 2019
  • 저수지의 붕괴 발생 시 인명 및 재산피해의 예방 및 저감을 위하여 붕괴예보 시스템의 필요성은 대두되고 있는 상황이다. 붕괴 예보시스템의 효율적 활용을 위해서는 실시간 계측한 이상거동 및 붕괴징후에 따라 대응할 수 있는 관리기준은 가장 중요한 요소이다. 기 연구된 수위 관리기준의 검증을 위하여 저수량에 따라 10여개의 저수지를 선정하고 수위변화 자료를 분석하여 적정성을 검토하였다. 1년 동안의 수위계측 자료에서 가장 급격한 변화구간을 선정하여 가중치 및 추세선을 적용하여 분석한 결과 3분위로 수립된 관리기준값은 7%이내의 표준편차를 보여주었다. 이는 수립된 관리기준값은 적정하다고 판단된다.

요실금 여성노인의 건강관련 삶의 질 영향요인 (The Influence Factors of Health-related Quality of Life on Urinary Incontinent Elderly Women)

  • 이진숙;이은주
    • 한국산학기술학회논문지
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    • 제20권5호
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    • pp.285-291
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    • 2019
  • 본 연구의 목적은 요실금 여성 노인의 건강관련 삶의 질에 영향 미치는 영향을 확인하기 위함이다. 본 연구에서는 질병관리본부에서 수행하고 있는 국민건강영양자료를 이용하여 활동 제한, 우울 증상 경험, 주관적 건강 인식이 요실금 여성 노인의 건강관련 삶의 질에 영향 미치는 정도를 파악하였다. 요실금 여성 노인은 요실금이 이환되지 않은 여성 노인에 비해 활동 제한, 우울 경험, 주관적 건강 인식, 삶의 질에 유의한 차이를 나타냈다. 반면 소득이나 교육은 요실금 여성 노인의 건강관련 삶의 질과 유의한 차이를 나타내지 않았다. 활동제한, 우울경험은 요실금 여성 노인의 건강관련 삶의 질에 유의한 영향을 미치지 못하였으며, 주관적 건강 인식만이 건강관련 삶의 질에 유의하게 영향을 미치는 것으로 확인되었다. 본 연구를 통해 그동안 노화의 한 과정으로 생각해 진료나 치료를 꺼려왔던 요실금 여성 노인 대상자들을 위한 중재 프로그램 개발이나 적극적인 치료 홍보와 관련된 기초자료를 제공하는데 의의가 있다.

Induction of Angiogenesis by Malarial Infection through Hypoxia Dependent Manner

  • Park, Mi-Kyung;Ko, Eun-Ji;Jeon, Kyung-Yoon;Kim, Hyunsu;Jo, Jin-Ok;Baek, Kyung-Wan;Kang, Yun-Jeong;Choi, Yung Hyun;Hong, Yeonchul;Ock, Mee Sun;Cha, Hee-Jae
    • Parasites, Hosts and Diseases
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    • 제57권2호
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    • pp.117-125
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    • 2019
  • Malarial infection induces tissue hypoxia in the host through destruction of red blood cells. Tissue hypoxia in malarial infection may increase the activity of $HIF1{\alpha}$ through an intracellular oxygen-sensing pathway. Activation of $HIF1{\alpha}$ may also induce vascular endothelial growth factor (VEGF) to trigger angiogenesis. To investigate whether malarial infection actually generates hypoxia-induced angiogenesis, we analyzed severity of hypoxia, the expression of hypoxia-related angiogenic factors, and numbers of blood vessels in various tissues infected with Plasmodium berghei. Infection in mice was performed by intraperitoneal injection of $2{\times}10^6$ parasitized red blood cells. After infection, we studied parasitemia and survival. We analyzed hypoxia, numbers of blood vessels, and expression of hypoxia-related angiogenic factors including VEGF and $HIF1{\alpha}$. We used Western blot, immunofluorescence, and immunohistochemistry to analyze various tissues from Plasmodium berghei-infected mice. In malaria-infected mice, parasitemia was increased over the duration of infection and directly associated with mortality rate. Expression of VEGF and $HIF1{\alpha}$ increased with the parasitemia in various tissues. Additionally, numbers of blood vessels significantly increased in each tissue type of the malaria-infected group compared to the uninfected control group. These results suggest that malarial infection in mice activates hypoxiainduced angiogenesis by stimulation of $HIF1{\alpha}$ and VEGF in various tissues.

시니어 인지능력과 신기술 수용 행태 분석 : 웨어러블 디바이스 사용의도를 중심으로 (An Analysis of Cognitive Ability and Technology Acceptance Behavior for the Elderly : Towards the Use of Wearable Healthcare Devices)

  • 박지혜;문재윤;김진우;김건하;김보리;배현아;홍세준
    • Journal of Information Technology Applications and Management
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    • 제26권1호
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    • pp.21-38
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    • 2019
  • This study starts from the question, "Are people of the age 60 and over equally 'old?' "As the aging population has rapidly become a global issue, it is a timely question to think about whether it is appropriate to classify people aged 60 and over as senior citizens monolithically based on their chronological age. Thanks to the advancement of medical technology and ever-increasing life expectancy, there may be more differences than we thought in terms of cognitive and behavioral patterns among the elderly population. In order to further investigate this question, this study focuses on technology acceptance behavior of 132 participants over the age of 60 towards a wearable healthcare device. The results show that there were interesting behavioral differences among participants depending on their cognitive capabilities. More specifically, participants with high cognitive capability (Superagers) consider the usefulness and the social aspects (social norm and image) of using wearable healthcare technology. Whereas for those with relatively low cognitive capability (non-Superagers), usefulness of using the technology was not a significant factor, and they mainly considered social norm and image. Our findings imply that the current monolithic application of chronological age to classify the elderly population should be carefully reconsidered because people aged over 60 years old may not always share homogeneous cognitive and behavioral patterns.

Spoken and Written Narrative in Persian-Speaking Students Who Received Cochlear Implant and/or Hearing Aid

  • Zamani, Peyman;Soleymani, Zahra;Rashedi, Vahid;Farahani, Farhad;Lotfi, Gohar;Rezaei, Mohammad
    • Clinical and Experimental Otorhinolaryngology
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    • 제11권4호
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    • pp.250-258
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    • 2018
  • Objectives. To compare narrative skills between fourth and fifth grades of Persian-speaking students with hearing impairments and typical hearing students of the same grade and also to evaluate the effects of group, sex, hearing age, and educational grade of the students on their spoken/written narrative performance. Methods. The subjects were 174 students aged 10-13 years, 54 of whom wore cochlear implants, 60 suffered from moderate to severe hearing losses and wore hearing aids, with the remaining 60 students being typical hearing in terms of the sense of hearing. The micro- and macrostructure components of spoken and written narrative were elicited from a pictorial story (The Playful Little Elephant) and then scored by raters. Results. Compared to the typical hearing, the students with hearing impairments had significantly lower scores in all of the microstructure components of narratives. However, the findings showed no significant difference among different groups in macrostructure components of narratives. It was also revealed that the students had equal performance in spoken and written narrative. Finally, factor analysis manifested that group, sex, hearing age, and educational level of children might alter the outcome measures in various interactions. Conclusion. Although cochlear implantation was more effective than hearing aid on spoken and written narrative skills, the Persian-speaking students with hearing impairments were seen to need additional trainings on microstructure components of spoken/written narrative.

Risk and protective factors affecting sensory recovery after breast reconstruction

  • Bae, Jae Young;Shin, Ha Young;Song, Seung Yong;Lee, Dong Won
    • Archives of Plastic Surgery
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    • 제48권1호
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    • pp.26-32
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    • 2021
  • Background Although loss of sensation in patients with breast cancer after mastectomy followed by breast reconstruction is an important factor affecting patients' quality of life, the mechanism of sensory recovery is still unclear. Our study aimed to identify variables that affect sensory recovery, especially pain, in reconstructed breasts. Methods All patients with breast cancer who underwent mastectomy followed by immediate breast reconstruction, including nipple reconstruction or areolar tattooing, were included in this study. Sensation was evaluated in the nipple as an endpoint of sensation recovery of the whole breast. Patients rated pain severity using a 3-point verbal rating scale (VRS): grade 0, no pain; grade 1, mild to moderate pain; and grade 2, severe pain. The VRS was assessed by a single experienced plastic surgeon. Results In the univariate analysis, the odds ratio (OR) for sensation recovery was 0.951 for age (P=0.014), 0.803 for body mass index (P=0.001), 0.996 for breast volume before surgery (P=0.001), 0.998 for specimen weight after mastectomy (P=0.040), and 1.066 for the period between mastectomy and sensory assessment (P=0.003). In the multivariate analysis, the variables that showed a significant effect were age (OR, 0.953; P=0.034), the period between mastectomy and sensory assessment (OR, 1.071; P=0.006), and reconstruction using abdominal tissue instead of prosthetic reconstruction (OR, 0.270; P=0.004). Conclusions Based on our results, it can be inferred that aging has a negative impact on the recovery of sensation, breast sensation improves with time after surgery, and the recovery of sensation is better in prosthetic reconstruction.

Bridge Inspection and condition assessment using Unmanned Aerial Vehicles (UAVs): Major challenges and solutions from a practical perspective

  • Jung, Hyung-Jo;Lee, Jin-Hwan;Yoon, Sungsik;Kim, In-Ho
    • Smart Structures and Systems
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    • 제24권5호
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    • pp.669-681
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    • 2019
  • Bridge collapses may deliver a huge impact on our society in a very negative way. Out of many reasons why bridges collapse, poor maintenance is becoming a main contributing factor to many recent collapses. Furthermore, the aging of bridges is able to make the situation much worse. In order to prevent this unwanted event, it is indispensable to conduct continuous bridge monitoring and timely maintenance. Visual inspection is the most widely used method, but it is heavily dependent on the experience of the inspectors. It is also time-consuming, labor-intensive, costly, disruptive, and even unsafe for the inspectors. In order to address its limitations, in recent years increasing interests have been paid to the use of unmanned aerial vehicles (UAVs), which is expected to make the inspection process safer, faster and more cost-effective. In addition, it can cover the area where it is too hard to reach by inspectors. However, this strategy is still in a primitive stage because there are many things to be addressed for real implementation. In this paper, a typical procedure of bridge inspection using UAVs consisting of three phases (i.e., pre-inspection, inspection, and post-inspection phases) and the detailed tasks by phase are described. Also, three major challenges, which are related to a UAV's flight, image data acquisition, and damage identification, respectively, are identified from a practical perspective (e.g., localization of a UAV under the bridge, high-quality image capture, etc.) and their possible solutions are discussed by examining recently developed or currently developing techniques such as the graph-based localization algorithm, and the image quality assessment and enhancement strategy. In particular, deep learning based algorithms such as R-CNN and Mask R-CNN for classifying, localizing and quantifying several damage types (e.g., cracks, corrosion, spalling, efflorescence, etc.) in an automatic manner are discussed. This strategy is based on a huge amount of image data obtained from unmanned inspection equipment consisting of the UAV and imaging devices (vision and IR cameras).

Effect of Deer Antler Extract on Muscle Differentiation and 5-Aminoimidazole-4-Carboxamide Ribonucleoside (AICAR)-Induced Muscle Atrophy in C2C12 Cells

  • Jo, Kyungae;Jang, Woo Young;Yun, Beom Sik;Kim, Jin Soo;Lee, Hyun-Sun;Chang, Yeok Boo;Suh, Hyung Joo
    • 한국축산식품학회지
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    • 제41권4호
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    • pp.623-635
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    • 2021
  • The effect of deer antler extract on muscle differentiation and muscle atrophy were evaluated to minimize muscle loss following aging. Various deer antler extracts (HWE, hot water extract of deer antler; FE, HWE of fermented deer antler; ET, enzyme-assisted extract of deer antler; UE, extract prepared by ultrasonication of deer antler) were evaluated for their effect on muscle differentiation and inhibition of 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR)-induced muscle atrophy in C2C12 cells. Morphological changes according to the effect of antler extracts on muscle differentiation were confirmed by Jenner-Giemsa staining. In addition, the expression levels of genes related to muscle differentiation and atrophy were confirmed through qRT-PCR. In the presence of antler extracts, the length and thickness of myotubes and myogenin differentiation 1 (MyoD1) and myogenic factor 5 (Myf5) gene expression were increased compared to those in the control group (CON). Gene expression of AMP-activated protein kinase (AMPK), MyoD1, and myogenin, along with the muscle atrophy factors muscle RING finger-1 (MuRF-1) and forkhead box O3a (FoxO3a) upon addition of deer antler extracts to muscle-atrophied C2C12 cells was determined by qRT-PCR after treatment with AICAR. The expression of MuRF-1 and FoxO3a decreased in the groups treated with antler extracts compared to that in the group treated with AICAR alone. In addition, gene expression of MyoD1 and myogenin in the muscle atrophy cell model was significantly increased compared that into the CON. Therefore, our findings indicate that antler extract can increase the expression of MyoD1, Myf5 and myogenin, inhibit muscle atrophy, and promote muscle differentiation.

3T3-L1 및 B16F10 세포에서 청각 메탄올 추출물에 의한 지방 세포 분화 및 멜라닌 생성의 억제 효과 (Inhibition of adipogenesis and melanogenesis by methanol extract of Codium fragile (Suringar) Hariot in 3T3-L1 adipocytes and B16F10 melanocytes)

  • 최은옥;최영현;황혜진
    • 한국해양바이오학회지
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    • 제13권1호
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    • pp.1-9
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    • 2021
  • Codium fragile (Suringar) Hariot, a green alga of the Codiales family, has been reported to have several bioactive properties, including antioxidant and anti-inflammatory properties. However, its antiobesity and whitening effects and their underlying mechanisms are unclear. This study aimed to evaluate the antiobesity and melanogenesis inhibitory effects of C. fragile using methanol extracts of C. fragile (MECF). The results of this study revealed that MECF inhibited the accumulation of lipid droplets and triacylglycerol in differentiated 3T3-L1 adipocytes, which was associated with the inhibition of the expression of adipogenesis-related transcription factors, such as peroxisome proliferator-activated receptor γ, CCAAT/enhancer-binding protein-α (C/EBPα), and C/EBPβ, which function as the key regulators of adipogenesis. Also, MECF reduced tyrosinase activity and melanin content in B16F10 cells as well as the expression of tyrosinase, tyrosinase-related protein-1 (TRP-1), TRP-2, and microphthalmia-related transcription factor in the presence of α-melanocyte-stimulating hormone. Taken together, our findings suggest that the extract of C. fragile could be considered a promising functional ingredient for the prevention and treatment of obesity and skin pigmentation in the food and cosmetic industry.