• The Journal of Korean Medicine
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• v.21 no.4
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• pp.104-111
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• 2000

Objectives: When stroke occurs, Korean people usually hope to be treated by traditional therapy and to be admitted to an oriental hospital. So this observation was done to make a small contribution toward stroke studies at oriental hospitals. Methods: This observation was made on 189 cases of stroke patients who were admitted to Kang Nam oriental medicine Hospital of Kyung Hee University from May, 1999 to August, 2000. Results and Conclusions : 1. The incidence of cerebral infarction was 3.6 times that of cerebral hemorrhage. 2. The incidence in females was 1.25 times of that in males. The incidence of stroke increased with aging and more cerebral hemorrhage occurred in lower age group than cerebral infarction. 3. There was higher morbidity in October and May, during the changing of the seasons, than any other months. 4. Hypertension the most common preceding disease, followed by heart disease, diabetes mellitus, hyperlipidemia. 5. Alcohol was the highest risk factor, followed by smoking, then obesity. 6. In cerebral infarction, MCA territory was the most frequent lesion site. 7. The change of Modefied Bathel Index(MBI) between MCA territory and others in cerebral infarction had no significance for 4weeks.(P>0.05)

• Clinical and Experimental Pediatrics
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• v.53 no.6
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• pp.680-687
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• 2010

Patients with congenital heart diseases (CHD) are confronted with early- and late-onset complications, such as conduction disorders, arrhythmias, myocardial dysfunction, altered coronary flow, and ischemia, throughout their lifetime despite successful hemodynamic and/or anatomical correction. Rhythm disturbance is a well-known and increasingly frequent cause of morbidity and mortality in patients with CHD. Predisposing factors to rhythm disturbances include underlying cardiac defects, hemodynamic changes as part of the natural history, surgical repair and related scarring, and residual hemodynamic abnormalities. Acquired factors such as aging, hypertension, diabetes, obesity, and others may also contribute to arrhythmogenesis in CHD. The first step in evaluating arrhythmias in CHD is to understand the complex anatomy and to find predisposing factors and hemodynamic abnormalities. A practical stepwise approach can lead to diagnosis and prompt appropriate interventions. Electrophysiological assessment and management should be done with integrated care of the underlying heart defects and hemodynamic abnormalities. Catheter ablation and arrhythmia surgery have been increasingly applied, showing increasing success rates with technological advancement despite complicated arrhythmia circuits in complex anatomy and the difficulty of access. Correction of residual hemodynamic abnormalities may be critical in the treatment of arrhythmia in patients with CHD.

• Journal of Nutrition and Health
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• v.21 no.5
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• pp.333-347
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• 1988

The purpose of the present study was to investigate the relationship between nutrient status, and bone mineral state which influenced by aging process. The subjects were 196 people over 65 years old(male 72, female124). The present dietary intake was estimated by the 24-hr, recall method, and individual dietary history concerning consumption of meat, fish and dairy products was obtained by questionaires. The syndrome of senility including seniliy was evaluated according to "Cornell Medical Index". The five subjects who showed 'Good' grade in bone senility, and five subjects who showed 'Risk' and 'Danger' grade were selected and their spine and femur bone density was measured by "Dual Photon Absorptiometry". The bone density measurement showed that the subjects with 'Good' grade in bone senility had bone density above that of normal person, and their nutrient status were satisfactory, whereas the subjects with 'Risk' and 'Danger' grade in bone senility had severe osteoporotic pattern, and their nutrient status were very poor. The food consumption score showed that the subject with higher intake of meat rather than milk had good grade in bone senility (p<0.05). Therefore, past meats consumption can be considered to be a significant factor in the present bone status. The nutrient intakes appeared to be significant factors in bone status in male, whereas there was little effect of nutrients intakes in female. Therefore, the risk of osteoporosis can increase as syndrome of bone senility and nutrient intakes were worse, and its is possible to evaluate bone status and predict osteoporosis simply from informations concerning syndrome of bone senility and nutrient intakes in old population over 65.

• Journal of the Korean Institute of Rural Architecture
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• v.15 no.2
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• pp.41-51
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• 2013

In the midst of growing demand for rural life of urban dwellers, this study tried to investigate the difference in behavior and recognition about urban rural exchange between Korea and Japan. For this, this study utilized 2,000 total samples of the survey conducted by MLIT in Japan, because Japan has experienced a low birth rate and aging population earlier and actively promoting urban rural exchange program than South Korea. The result of the analysis is as follows. First, the needs for rural life of urban dwellers are similar both in Japan and South Korea. However, Japanese prioritize future efforts to current efforts. Second, urban dwellers' activities in rural areas were classified into three categories; field trips and hands-on activities, cruise and circulating activities, and leisure activities. Third, similarly three types of visit or intercourse of urban dwellers into rural areas were classified; repeatedly visit the same place as 'iterative type', visit a new place as 'new pioneer type', and not yet determined as 'undefined type'. Variables such as age of household, income, number of inmate, and number of children were analyzed linked to these three types of visit or intercourse in a Discriminant analysis. As a result, only 'age of household', however, turned out to be the crucial factor which influence decisively distinguishing characteristics of these three types of visit into rural areas.

• Journal of Integrative Natural Science
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• v.6 no.3
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• pp.125-137
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• 2013

Promising evidence suggests that amyloid beta peptide ($A{\beta}$), a key mediator in age-dependent neuronal and cerebrovascular degeneration, activates death signalling processes leading to neuronal as well as non-neuronal cell death in the central nervous system. A major cellular event in $A{\beta}$-induced apoptosis of non-neuronal cells, including cerebral endothelial cells, astrocytes and oligodendrocytes, is mitochondrial dysfunction. The apoptosis signalling cascade upstream of mitochondria entails $A{\beta}$ activation of neutral sphingomyelinase, resulting in the release of ceramide from membrane sphingomyelin. Ceramide then activates protein phosphatase 2A (PP2A), a member in the ceramide-activated protein phosphatase (CAPP) family. PP2A dephosphorylation of Akt and FKHRL1 plays a pivotal role in $A{\beta}$-induced Bad translocation to mitochondria and transactivation of Bim. Bad and Bim are pro-apoptotic proteins that cause mitochondrial dysfunction characterized by excessive ROS formation, mitochondrial DNA (mtDNA) damage, and release of mitochondrial apoptotic proteins including cytochrome c, apoptosis inducing factor (AIF), endonuclease G and Smac. The cellular events activated by $A{\beta}$ to induce death of non-neuronal cells are complex. Understanding these apoptosis signalling processes will aid in the development of more effective strategies to slow down age-dependent cerebrovascular degeneration caused by progressive cerebrovascular $A{\beta}$ deposition.

• KIEAE Journal
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• v.9 no.2
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• pp.99-106
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• 2009

The noise in apartment buildings are major factor that determine the quality of indoor noise environment. Particularly, the noise from children's running footsteps and plumbing noise have caused the residents who live in decrepit apartment houses to uncomfortable environment. And as time go by, sound performance are getting worse according to the aging of the facilities. So this study deals with the plans to improve the sound performance of decrepit apartment house. To compare the noise reduction, we measured the heavy-weight impact sound level and plumbing noise level before and after changes the measurement conditions. As the results of measurements, the heavy-weight impact sound level were decreased when stiffness reinforcement were installed on slab. Especially the sound level were decreased 2.1-7.6dB in 50-80Hz of low frequency range. Instead of PVC pipe system, cast iron pipe and triple elbow drain pipe systems were installed. Noise level were decreased 15dB(A) in 250Hz. Noise level of pipe system's on the slab is less than under slab one. On the contrary water saving stool showed increasing the noise level.

• The Korean Journal of Community Living Science
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• v.24 no.1
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• pp.37-49
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• 2013

The purpose of this study is to explore how health and health behavior factors moderate the relation between socio-economic position(SEP) and Korean elderly people's self-rated health status. The data sources are from the Korean Longitudinal Study of Aging(2008). The analysis sample consists of 4,040 cases. Analysis of the results shows that health characteristics such as ADL, MMSE, geriatric depression, and pain are significant predictors of self-rated health status. In addition, exercise and drinking alcohol also prove to be factors influencing self-rated health status. Health factor such as MMSE and health behavior factors such as drinking alcohol served as moderators of the influences of SEP on one's self-rated health status. For example, higher MMSE provides a slight increase to the positive relationship between SEP and self-rated health status. In addition, those who responded yes to drinking alcohol, compared to those who responded no, provides an increase to the positive relationship between SEP and one's self-rated health status.

• Molecules and Cells
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• v.40 no.9
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• pp.613-620
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• 2017

The most common form of senile dementia is Alzheimer's disease (AD), which is characterized by the extracellular deposition of amyloid ${\beta}-peptide$ ($A{\beta}$) plaques and the intracellular formation of neurofibrillary tangles (NFTs) in the cerebral cortex. Tau abnormalities are commonly observed in many neurodegenerative diseases including AD, Parkinson's disease, and Pick's disease. Interestingly, tau-mediated formation of NFTs in AD brains shows better correlation with cognitive impairment than $A{\beta}$ plaque accumulation; pathological tau alone is sufficient to elicit frontotemporal dementia, but it does not cause AD. A growing amount of evidence suggests that soluble $A{\beta}$ oligomers in concert with hyperphosphorylated tau (pTau) serve as the major pathogenic drivers of neurodegeneration in AD. Increased $A{\beta}$ oligomers trigger neuronal dysfunction and network alternations in learning and memory circuitry prior to clinical onset of AD, leading to cognitive decline. Furthermore, accumulated damage to mitochondria in the course of aging, which is the best-known nongenetic risk factor for AD, may collaborate with soluble $A{\beta}$ and pTau to induce synapse loss and cognitive impairment in AD. In this review, I summarize and discuss the current knowledge of the molecular and cellular biology of AD and also the mechanisms that underlie $A{\beta}-mediated$ neurodegeneration.

• Journal of Agricultural Extension & Community Development
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• v.22 no.4
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• pp.405-421
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• 2015

Agro-fishing villages of agriculture and fishery are suffering deepening gap with urban areas due to depreciation from their products market opening pressure. They are facing problems of decreasing and aging population, poor settlement environment, etc. and losing their vitality for their low productivity and lack of young labor force. These issues of agro-fishing villages of agriculture and fishery are divided in so various items and classes that it is plausible to approach in a way to connect each issue in a small frame of each by selecting sub topics according to each item and each class rather than to solve the issues in a large frame. Chungchungnam-do is approaching the issues through 3 agro innovations(agro fishery, agro fishing villages, agro fishing people) in local government level and Durae enterprises are solving local problems through the self supporting residents' community business by utilizing local resources. This study is to draw clues and solutions to vitalize agro fishery villages through community businesses by detailed reviews and research on cases of Durae enterprises' characteristics and their vitalizations and provide a new alternative plan to agro fishery villages losing their vitality and demolishing their communities.

• Journal of dental hygiene science
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• v.17 no.3
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• pp.218-225
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• 2017

The purpose of this study was to determine the association between drinking behaviors and the need for periodontal treatment. The data of 5,995 adults from the 2012 Korea National Health and Nutrition Examination Survey were categorized into young adulthood (19~39 years), middle age (40~64 years), and old age (${\geq}65$ years) and analyzed. Chi-square test was performed to determine those who needed periodontal treatment by the respondents' general characteristics and drinking behaviors, and logistic regression analysis was carried out to determine the impact of each drinking behavior on the need for periodontal treatment. The results of this study have confirmed that alcohol intake is a factor adversely affecting periodontal status; therefore, patients should know the fact that excessive alcohol intake and increased frequency of drinking may affect the prevalence rate of periodontal diseases. Moreover, moderate-drinking programs that can reinforce prevention of drinking so that dental hygienists can provide good oral health care should be developed. A systematic oral health promotion program should be introduced for constant prevention with the objective of activating oral health education that focused on middle-aged and young-adult people in pursuit of healthy aging society.