• Title/Summary/Keyword: Aging Factor

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The Influence Factors of Health-related Quality of Life on Urinary Incontinent Elderly Women (요실금 여성노인의 건강관련 삶의 질 영향요인)

  • Lee, Jin-Sook;Lee, Eun-Ju
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.20 no.5
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    • pp.285-291
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    • 2019
  • This study was conducted to identify the factors influencing health-related quality of life of urinary incontinent elderly women. The Korea National Health and Nutrition Examination Survey (KNHANES) conducted by the Korea Centers for Disease Control and Prevention (KCDC) was used as baseline data to evaluate how activity limitation, depression experience and subjective health perception influence the health-related quality of life of urinary incontinent elderly women. The urinary incontinent elderly women differed significantly in terms of activity limitation, depression experience, subjective health perception influence and health-related quality of life compared to elderly women without incontinence. In contrast, income and education were not correlated with either of the aforementioned groups. The subjective health perception was identified as the only factor influencing the health-related quality of life of urinary incontinent elderly women. The results of this study will serve as basic data for positive treatment promotion and development of assessment programs for incontinence patients who recognize incontinence symptoms as part of the aging process and are therefore unwilling to receive care.

Induction of Angiogenesis by Malarial Infection through Hypoxia Dependent Manner

  • Park, Mi-Kyung;Ko, Eun-Ji;Jeon, Kyung-Yoon;Kim, Hyunsu;Jo, Jin-Ok;Baek, Kyung-Wan;Kang, Yun-Jeong;Choi, Yung Hyun;Hong, Yeonchul;Ock, Mee Sun;Cha, Hee-Jae
    • Parasites, Hosts and Diseases
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    • v.57 no.2
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    • pp.117-125
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    • 2019
  • Malarial infection induces tissue hypoxia in the host through destruction of red blood cells. Tissue hypoxia in malarial infection may increase the activity of $HIF1{\alpha}$ through an intracellular oxygen-sensing pathway. Activation of $HIF1{\alpha}$ may also induce vascular endothelial growth factor (VEGF) to trigger angiogenesis. To investigate whether malarial infection actually generates hypoxia-induced angiogenesis, we analyzed severity of hypoxia, the expression of hypoxia-related angiogenic factors, and numbers of blood vessels in various tissues infected with Plasmodium berghei. Infection in mice was performed by intraperitoneal injection of $2{\times}10^6$ parasitized red blood cells. After infection, we studied parasitemia and survival. We analyzed hypoxia, numbers of blood vessels, and expression of hypoxia-related angiogenic factors including VEGF and $HIF1{\alpha}$. We used Western blot, immunofluorescence, and immunohistochemistry to analyze various tissues from Plasmodium berghei-infected mice. In malaria-infected mice, parasitemia was increased over the duration of infection and directly associated with mortality rate. Expression of VEGF and $HIF1{\alpha}$ increased with the parasitemia in various tissues. Additionally, numbers of blood vessels significantly increased in each tissue type of the malaria-infected group compared to the uninfected control group. These results suggest that malarial infection in mice activates hypoxiainduced angiogenesis by stimulation of $HIF1{\alpha}$ and VEGF in various tissues.

An Analysis of Cognitive Ability and Technology Acceptance Behavior for the Elderly : Towards the Use of Wearable Healthcare Devices (시니어 인지능력과 신기술 수용 행태 분석 : 웨어러블 디바이스 사용의도를 중심으로)

  • Park, Ji Hye;Moon, Jae Yun;Kim, Jinwoo;Kim, Geon Ha;Kim, Bori R.;Bae, Hyun A;Hong, Se-Joon
    • Journal of Information Technology Applications and Management
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    • v.26 no.1
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    • pp.21-38
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    • 2019
  • This study starts from the question, "Are people of the age 60 and over equally 'old?' "As the aging population has rapidly become a global issue, it is a timely question to think about whether it is appropriate to classify people aged 60 and over as senior citizens monolithically based on their chronological age. Thanks to the advancement of medical technology and ever-increasing life expectancy, there may be more differences than we thought in terms of cognitive and behavioral patterns among the elderly population. In order to further investigate this question, this study focuses on technology acceptance behavior of 132 participants over the age of 60 towards a wearable healthcare device. The results show that there were interesting behavioral differences among participants depending on their cognitive capabilities. More specifically, participants with high cognitive capability (Superagers) consider the usefulness and the social aspects (social norm and image) of using wearable healthcare technology. Whereas for those with relatively low cognitive capability (non-Superagers), usefulness of using the technology was not a significant factor, and they mainly considered social norm and image. Our findings imply that the current monolithic application of chronological age to classify the elderly population should be carefully reconsidered because people aged over 60 years old may not always share homogeneous cognitive and behavioral patterns.

Spoken and Written Narrative in Persian-Speaking Students Who Received Cochlear Implant and/or Hearing Aid

  • Zamani, Peyman;Soleymani, Zahra;Rashedi, Vahid;Farahani, Farhad;Lotfi, Gohar;Rezaei, Mohammad
    • Clinical and Experimental Otorhinolaryngology
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    • v.11 no.4
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    • pp.250-258
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    • 2018
  • Objectives. To compare narrative skills between fourth and fifth grades of Persian-speaking students with hearing impairments and typical hearing students of the same grade and also to evaluate the effects of group, sex, hearing age, and educational grade of the students on their spoken/written narrative performance. Methods. The subjects were 174 students aged 10-13 years, 54 of whom wore cochlear implants, 60 suffered from moderate to severe hearing losses and wore hearing aids, with the remaining 60 students being typical hearing in terms of the sense of hearing. The micro- and macrostructure components of spoken and written narrative were elicited from a pictorial story (The Playful Little Elephant) and then scored by raters. Results. Compared to the typical hearing, the students with hearing impairments had significantly lower scores in all of the microstructure components of narratives. However, the findings showed no significant difference among different groups in macrostructure components of narratives. It was also revealed that the students had equal performance in spoken and written narrative. Finally, factor analysis manifested that group, sex, hearing age, and educational level of children might alter the outcome measures in various interactions. Conclusion. Although cochlear implantation was more effective than hearing aid on spoken and written narrative skills, the Persian-speaking students with hearing impairments were seen to need additional trainings on microstructure components of spoken/written narrative.

Risk and protective factors affecting sensory recovery after breast reconstruction

  • Bae, Jae Young;Shin, Ha Young;Song, Seung Yong;Lee, Dong Won
    • Archives of Plastic Surgery
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    • v.48 no.1
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    • pp.26-32
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    • 2021
  • Background Although loss of sensation in patients with breast cancer after mastectomy followed by breast reconstruction is an important factor affecting patients' quality of life, the mechanism of sensory recovery is still unclear. Our study aimed to identify variables that affect sensory recovery, especially pain, in reconstructed breasts. Methods All patients with breast cancer who underwent mastectomy followed by immediate breast reconstruction, including nipple reconstruction or areolar tattooing, were included in this study. Sensation was evaluated in the nipple as an endpoint of sensation recovery of the whole breast. Patients rated pain severity using a 3-point verbal rating scale (VRS): grade 0, no pain; grade 1, mild to moderate pain; and grade 2, severe pain. The VRS was assessed by a single experienced plastic surgeon. Results In the univariate analysis, the odds ratio (OR) for sensation recovery was 0.951 for age (P=0.014), 0.803 for body mass index (P=0.001), 0.996 for breast volume before surgery (P=0.001), 0.998 for specimen weight after mastectomy (P=0.040), and 1.066 for the period between mastectomy and sensory assessment (P=0.003). In the multivariate analysis, the variables that showed a significant effect were age (OR, 0.953; P=0.034), the period between mastectomy and sensory assessment (OR, 1.071; P=0.006), and reconstruction using abdominal tissue instead of prosthetic reconstruction (OR, 0.270; P=0.004). Conclusions Based on our results, it can be inferred that aging has a negative impact on the recovery of sensation, breast sensation improves with time after surgery, and the recovery of sensation is better in prosthetic reconstruction.

Bridge Inspection and condition assessment using Unmanned Aerial Vehicles (UAVs): Major challenges and solutions from a practical perspective

  • Jung, Hyung-Jo;Lee, Jin-Hwan;Yoon, Sungsik;Kim, In-Ho
    • Smart Structures and Systems
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    • v.24 no.5
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    • pp.669-681
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    • 2019
  • Bridge collapses may deliver a huge impact on our society in a very negative way. Out of many reasons why bridges collapse, poor maintenance is becoming a main contributing factor to many recent collapses. Furthermore, the aging of bridges is able to make the situation much worse. In order to prevent this unwanted event, it is indispensable to conduct continuous bridge monitoring and timely maintenance. Visual inspection is the most widely used method, but it is heavily dependent on the experience of the inspectors. It is also time-consuming, labor-intensive, costly, disruptive, and even unsafe for the inspectors. In order to address its limitations, in recent years increasing interests have been paid to the use of unmanned aerial vehicles (UAVs), which is expected to make the inspection process safer, faster and more cost-effective. In addition, it can cover the area where it is too hard to reach by inspectors. However, this strategy is still in a primitive stage because there are many things to be addressed for real implementation. In this paper, a typical procedure of bridge inspection using UAVs consisting of three phases (i.e., pre-inspection, inspection, and post-inspection phases) and the detailed tasks by phase are described. Also, three major challenges, which are related to a UAV's flight, image data acquisition, and damage identification, respectively, are identified from a practical perspective (e.g., localization of a UAV under the bridge, high-quality image capture, etc.) and their possible solutions are discussed by examining recently developed or currently developing techniques such as the graph-based localization algorithm, and the image quality assessment and enhancement strategy. In particular, deep learning based algorithms such as R-CNN and Mask R-CNN for classifying, localizing and quantifying several damage types (e.g., cracks, corrosion, spalling, efflorescence, etc.) in an automatic manner are discussed. This strategy is based on a huge amount of image data obtained from unmanned inspection equipment consisting of the UAV and imaging devices (vision and IR cameras).

Effect of Deer Antler Extract on Muscle Differentiation and 5-Aminoimidazole-4-Carboxamide Ribonucleoside (AICAR)-Induced Muscle Atrophy in C2C12 Cells

  • Jo, Kyungae;Jang, Woo Young;Yun, Beom Sik;Kim, Jin Soo;Lee, Hyun-Sun;Chang, Yeok Boo;Suh, Hyung Joo
    • Food Science of Animal Resources
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    • v.41 no.4
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    • pp.623-635
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    • 2021
  • The effect of deer antler extract on muscle differentiation and muscle atrophy were evaluated to minimize muscle loss following aging. Various deer antler extracts (HWE, hot water extract of deer antler; FE, HWE of fermented deer antler; ET, enzyme-assisted extract of deer antler; UE, extract prepared by ultrasonication of deer antler) were evaluated for their effect on muscle differentiation and inhibition of 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR)-induced muscle atrophy in C2C12 cells. Morphological changes according to the effect of antler extracts on muscle differentiation were confirmed by Jenner-Giemsa staining. In addition, the expression levels of genes related to muscle differentiation and atrophy were confirmed through qRT-PCR. In the presence of antler extracts, the length and thickness of myotubes and myogenin differentiation 1 (MyoD1) and myogenic factor 5 (Myf5) gene expression were increased compared to those in the control group (CON). Gene expression of AMP-activated protein kinase (AMPK), MyoD1, and myogenin, along with the muscle atrophy factors muscle RING finger-1 (MuRF-1) and forkhead box O3a (FoxO3a) upon addition of deer antler extracts to muscle-atrophied C2C12 cells was determined by qRT-PCR after treatment with AICAR. The expression of MuRF-1 and FoxO3a decreased in the groups treated with antler extracts compared to that in the group treated with AICAR alone. In addition, gene expression of MyoD1 and myogenin in the muscle atrophy cell model was significantly increased compared that into the CON. Therefore, our findings indicate that antler extract can increase the expression of MyoD1, Myf5 and myogenin, inhibit muscle atrophy, and promote muscle differentiation.

Inhibition of adipogenesis and melanogenesis by methanol extract of Codium fragile (Suringar) Hariot in 3T3-L1 adipocytes and B16F10 melanocytes (3T3-L1 및 B16F10 세포에서 청각 메탄올 추출물에 의한 지방 세포 분화 및 멜라닌 생성의 억제 효과)

  • Choi, Eun-Ok;Choi, Yung Hyun;Hwang, Hye-Jin
    • Journal of Marine Bioscience and Biotechnology
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    • v.13 no.1
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    • pp.1-9
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    • 2021
  • Codium fragile (Suringar) Hariot, a green alga of the Codiales family, has been reported to have several bioactive properties, including antioxidant and anti-inflammatory properties. However, its antiobesity and whitening effects and their underlying mechanisms are unclear. This study aimed to evaluate the antiobesity and melanogenesis inhibitory effects of C. fragile using methanol extracts of C. fragile (MECF). The results of this study revealed that MECF inhibited the accumulation of lipid droplets and triacylglycerol in differentiated 3T3-L1 adipocytes, which was associated with the inhibition of the expression of adipogenesis-related transcription factors, such as peroxisome proliferator-activated receptor γ, CCAAT/enhancer-binding protein-α (C/EBPα), and C/EBPβ, which function as the key regulators of adipogenesis. Also, MECF reduced tyrosinase activity and melanin content in B16F10 cells as well as the expression of tyrosinase, tyrosinase-related protein-1 (TRP-1), TRP-2, and microphthalmia-related transcription factor in the presence of α-melanocyte-stimulating hormone. Taken together, our findings suggest that the extract of C. fragile could be considered a promising functional ingredient for the prevention and treatment of obesity and skin pigmentation in the food and cosmetic industry.

A Study of Fire Prevention Measures for Single-person Households (1인 가구의 화재예방 대책 연구)

  • Kim, Jong Kouk;Han, Dong-Ho
    • The Journal of the Convergence on Culture Technology
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    • v.7 no.1
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    • pp.424-431
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    • 2021
  • This study explores fire prevention measures for single-person households on the phenomenon of an increase in single-person households due to changes in the family structure due to low birthrate and aging population, full marriage, non-marriage, separation, bereavement, and returning to farming villages, and increased flexibility in the labor market. The factor that affects the fire of single-person households is the residential environment problem at the structural level. In terms of behavior, there is an increase in fire occurrence due to the rearing of companion animals. In order to prevent fires in single-person households, safety regulations without exceptions are needed to improve the residential environment at the structural level. At the behavioral level, it is necessary to expand the prevention and safety guidance of related organizations. In addition, as a measure to prevent fire caused by companion animals, manufacturers of electric ranges should develop safety devices to prevent fires caused by companion animals, such as an automatic power-off device or power supply using a timer. It can also be an important means to create and distribute promotional videos of measures necessary to safely raise companion animals, or to develop and distribute disaster preparedness programs implemented in virtual reality.

Analysis of the Effects of Job Policy Measures in Korea: Do the job policy measures impact the marriage and fertility of the youth in Korea?

  • Kang, Chang Ick;Lim, Kyung Eun;Kim, Junghak
    • Asian Journal for Public Opinion Research
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    • v.10 no.3
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    • pp.200-229
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    • 2022
  • The purpose of this study is to analyze the effects of youth job policy measures, set forth in Korea's 2016-2020 Third Basic Plan for Low Fertility and Aging Society (December 2015), on marriage and fertility among young people. Based on the results, we provide theoretical explanations for the findings and suggest policy alternatives to overcome the low fertility phenomenon in Korea. Previous studies have shown that employment is an important factor for marriage among youth, and a job policy could increase marriage and fertility rates. To test this assumption, we performed an exact matching between Statistics Korea's Employee-Enterprise Linkage DB and the Newlyweds DB from 2011 to 2019, in order to identify all young people aged 15-34. Then, linear spline regression analysis was used to examine the impact of the youth job policy on marriage and fertility. Comparing the period before the implementation of the employment policy (2011-2015) and after (2016-2019), the fertility rate increased as the number of young people looking for work increased. In addition, it was found that these impacts were greater after the implementation of the measures (2016-2019) than before (2011-2015). It is interesting to note that job growth among young people did not lead to an increase in marriage. However, the number of births significantly increased when young people who occupy jobs got married, which seems to be related to the delay in marriage among young people who are employed. Survey results about the intentions to marry and views on fertility are utilized for the explanation of the study results.