• 대한음성학회지:말소리
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• 제51호
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• pp.57-69
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• 2004

Comprehension monitoring is a process of message evaluation and a very important skill of communication. Comprehension monitoring is a necessary language skill in classroom, as it is important for children to assess their own understanding of task instructions and teaching content. The present study investigated comprehension monitoring skill of children with Specific Language Impairment(SLI) compared to age-matched children and language-matched children. 18 vignettes and 6 displays were constructed. Children were asked to choose one object or 'DK' card from a display after the children listened to the vignettes. The results showed that children with SLI didn't have problem in comprehending unambiguous utterance and using prior statement. However, they had problem in monitoring comprehending ambiguous utterance compared age-matched children. Their performance were similar to language matched younger children. With respect to their performance, several possible explanations were discussed.

• 음성과학
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• 제12권1호
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• pp.15-25
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• 2005

The purpose of the present study was to investigate the characteristics of metalinguistic awareness of children with specific language impairment. Forty-five children participated in this study; 15 children with specific language impairment (SLI group) whose range of the language age was 4;6-6;6, 15 normal children chronological age matched (CA controls) and 15 normal children language age matched with the SLI group (CA controls). A metalinguistic task involving the identification and revision of syntactic, semantic, and phonologic errors was used. The SLI group performed significantly poorer than CA controls as well as LA controls in identifying and correcting error sentences, especially sentences with syntactic error. These results revealed the relation between language problems of children with SLI and metalinguistic abilities.

• BMB Reports
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• 제41권7호
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• pp.516-522
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• 2008

The glycation of BSA leads to protein/peptide modifications that result in the formation of AGEs. AGEs react with the amino groups of N-terminal amino acid residues, particularly arginine and lysine residues. Enhanced AGE formation exists in the blood and tissues of diabetics, as well as in aging and other disorders. The Identification of AGEs is of great importance. Mass spectrometry has been applied to identify and structurally elucidate AGEs. Here, we report on the identification of AGE-peptides and AGE precursors based on relative mass changes as a result of specific AGE formation. HPLC-ESIMS, ESI-MS/MS, and the Mascot database were used. The relative mass changes due to the specific type of AGE formation were added to the identified peptides followed by a manual search of the glycated samples, which resulted in the identification of seven peptides for the formation of five AGEs, namely CML, pyrraline, imidazolone A, imidazolone B, and AFGP. Four glycated peptides (FPK, ECCDKPLLEK, IETMR, and HLVDEPQNLIK) were identified in the formation of AGE-precursors.

• 한국인구학
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• 제32권1호
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• pp.1-23
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• 2009

본 논문에서는 설문조사자료를 이용하여 1940년대 이후 출생한 우리나라 여성들의 연령별 출산율, 연령별 누적출산율, 결혼연령을 5개의 출생코호트별로 살펴보고 위험도 모형을 이용하여 결혼연령 및 결혼 이후 초산까지의 간격에 영향을 미치는 요인을 각각 분석하였다. 먼저 연령별 출산율을 보면 출생시기가 늦은 코호트일수록 출산율이 최고수준에 이르는 연령이 높아지는 것으로 나타났다. 한편 연령별 누적출산율은 50년대 코호트와 60년대 코호트의 경우 각각 직전 코호트에 비해 누적출산율이 크게 하락하였으나 70년대 코호트나 80년대 코호트는 60년대 코호트에 비해 누적출산율에 있어서 별다른 차이를 보이지 않았다. 결혼연령을 보면 최근의 출생코호트로 올수록 결혼연령이 높아졌다. 한편, 결혼 위험도 모형을 추정한 결과에 의하면 여성의 출생시기가 늦을수록 그리고 교육수준이 높을수록 결혼연령이 높아지는 것으로 나타났으며 특히 출생시기의 영향은 그간 진행된 여성의 취업기회의 확대와 여성의 상대적 지위의 향상 등 경제적 및 사회문화적 변화를 종합적으로 반영하는 것으로 해석된다. 다음으로 결혼 이후 첫 자녀의 출산 위험도의 경우에는 출생시기나 결혼시기 모두 유의한 영향을 미치지 않는 것으로 분석되었다. 한편, 결혼 이후에도 상당기간 취업상태를 유지한 여성의 경우 출산 위험도가 크게 낮았으며 또한 중졸 이하 학력을 가진 여성은 여타 수준의 학력을 가진 여성에 비해 출산 위험도가 낮은 것으로 나타났다. 이는 여성의 취업이나 낮은 가구소득이 출산율을 낮추는 중요한 요인임을 의미하는 것으로 중요한 정책적 시사점을 가진다.

• Journal of Preventive Medicine and Public Health
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• 제27권4호
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• pp.735-745
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• 1994

The incidence data (1991. 7. 1$\sim$1992. 6. 30) from the Implementation Study of Seoul Cancer Registry (ISSCR) were evaluated in terms of its completeness and validity. Two indicators for the completeness, Mortality/Incidence ratio (M/I ratio) and Age-specific Incidence Curve, showed fairy good registration throughout the age-sex specific strata, except the strata aged over 75 years old. The strata had very high M/I ratio (over 100%) and decreasing pattern of incidence, which suggested incomplete registration of cancer in this group. The active surveillance by a ISSCR staff improved the registration rate especially among elderlies. From the site specific M/I ratio, we found that liver cancer had oddly high M/I ratio. Since this high M/I ratio of liver cancer appears consistently in other reliable cancer registries, it is more like to be due to the high fatality of it rather than incomplete registration. The validity of the incidence data was assessed by three indicators; Histological Verification (HV%), Primary Site Unknown (PSU%), and Age Unknown (Age UNK%). The average HV% were 77% for men and 85% for women, which were slightly lower than those of other reliable cancer registries. This low HV% might be due to the considerable size of relative frequency of liver cancer in Korea, regarding the fact that the diagnosis of liver cancer is made mostly by non-biopsical radiologic methods (CT, Ultrasono, Angiography, MRI etc.). The level of PSU% and Age UNK% were in acceptable range, but not low enough, especially in terms of Age UNK%. Although ISSCR data had acceptable quality in general, it is needed to have more hospitals participate in the registry surveillance, to make registery data merged with death certificate data regulary, and educate the registration stans to be more competent and dedicated.

• Interdisciplinary Bio Central
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• 제4권4호
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• pp.13.1-13.6
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• 2012

The advanced glycation endproducts receptor (AGER) is a multiligand signal transduction receptor. One of its ligands, S100b molecules activates vascular smooth muscle cells and endothelial cells via its receptor, thus triggering activation of signaling cascades and generation of cytokines and proinflammatory molecules. Ubiquitin-conjugating enzyme Ubc9 is an E2 conjugating enzyme that transfers the activated small ubiquitin-related modifier to protein substrates, and thus it plays a critical role in SUR-Mylation-mediated cellular pathways. Previous studies have shown that both AGE-R and Ubc9 play roles in diverse cellular signaling pathways. However, until recently, little attention has been paid to interactions between AGE-R and Ubc9. In this study, sequence database searches allowed us to identify a potential interaction motif between AGE-R and Ubc9. The subsequent biochemical and molecular biological analysis suggested that there may be specificity in AGE-R and Ubc9 complex signaling in atherosclerosis and cancer cells in a cell-type specific manner. Although the determinant for specificity in AGE-R and Ubc9 complex signaling in cancer cells and atherosclerosis is yet to be determined, this study provides the basis to develop a specific therapeutic application of AGE-R, SURM (small ubiquitin-related modifier)-1, and Ubc9 complex activation pathways in atherosclerosis, diabetes, cancer and inflammatory diseases.

• 보건교육건강증진학회지
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• 제33권5호
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• pp.37-46
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• 2016

Objectives: This study examines the awareness of hypertension and its age-specific characteristics among Korean adults. Methods: Data were derived from the fourth Korean National Health Examination and Nutrition Survey (KNHANES IV, 2007-2009) of 14,637 subjects aged 30 and older. Self-reported prevalence of hypertension (HTN) was compared with measured arterial systolic/diastolic blood pressure, employing Kappa index, sensitivity, and specificity. Multiple logistic regression analysis was used to determine factors in hypertension awareness by age groups. Results: Kappa agreement between self-reported and measured data in hypertension was high (0.70, 95% CI 0.68-0.71). Awareness by sensitivity was relatively high (65.3%) and specificity was very high (98.8%) for all ages. After age stratification, the results revealed the very lowest level of hypertension awareness among the youngest age group: 29.1% of adults aged 30-49 years, 57.5% of adults aged 45-59 years, and 76.9% of those aged ${\geq}60years$. Predictors for awareness differed by age group. Among adults aged 30-49 years, men exhibited lower awareness to HTN than women. Among middle-aged adults, workers showed lower awareness than non-workers. Among those aged ${\geq}60years$, men and the less educated showed lower awareness to HTN than their counterparts. Conclusions: Age-specific prevention strategies are needed for hypertension management.

• 임상간호연구
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• 제27권1호
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• pp.77-84
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• 2021

Purpose: Malnutrition affects all age groups, but older adults are particularly more vulnerable to nutritional deficiencies. This study evaluated the age-specific factors affecting malnutrition in hospitalized older adults. Methods: A retrospective study was conducted on inpatient elderly people who received artificial nutrition from 2010 to 2017. Data of demographics, diagnosis, type of nutrition therapy, number of comorbidity, fall risk assessment, Acute Physiologic Assessment and Chronic Health Evaluation (APACHE) score, and intensive care unit admission were collected. Malnutrition was defined as a body mass index (BMI) of less than 18.5 kg/m². Patients were classified as the young-old (65~74 years old), the old-old (75~84 years old), or the oldest-old (85 years old or older). Results: A total of 7,130 older adults were included, and 4,028 patients were classified as the young-old, 2,506 into the old-old, and 596 into the oldest-old. Proportion of malnutrition was higher in the oldest-old compared to the other groups. In multivariate analysis, parenteral nutrition, alcohol, and high risk of falls were factors affecting malnutrition in all groups. Parenteral nutrition and alcohol in the young-old, high risk of falls in the old-old, and male sex in the oldest-old were the factors affecting malnutrition by the age group. Conclusion: Older age was the most significant factor affecting malnutrition. Specific strategies by age are needed to improve nutritional status in hospitalized older adults as influencing factors for malnutrition vary among different age groups.

• Communications for Statistical Applications and Methods
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• 제28권2호
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• pp.119-134
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• 2021

Lung cancer is one of the leading causes of cancer deaths in the world. Investigation of mortality rates is pivotal to adequately understand the determinants causing this disease, allocate public health resources, and apply different control measures. Our study aims to analyze and forecast age-specific US lung cancer mortality trends. We report functions of mortality rates for different age groups by incorporating functional principal component analysis to understand the underlying mortality trend with respect to time. The mortality rates of lung cancer have been higher in men than in women. These rates have been decreasing for all age groups since 1990 in men. The same pattern is observed for women since 2000 except for the age group 85 and above. No significant changes in mortality rates in lower age groups have been reported for both gender. Lung cancer mortality rates for males are relatively higher than females. Ten-year predictions of mortality rates depict a continuous decline for both gender with no apparent change for lower age groups (below 40).

• 말소리와 음성과학
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• 제15권3호
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• pp.9-16
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• 2023

The current study investigated the influence of age of L2 acquisition (AOA) and length of residence (LOR) in the L2 setting country on the production of voicing-conditioned vowel duration and spectral qualities in English by Korean learners. The primary aim was to explore the ways in which the language-specific phonetic features are acquired by the age of onset and L2 experience. Analyses of the archived corpus data produced by 45 native speakers of Korean showed that, regardless of AOA or LOR, absolute vowel duration was used as a salient correlate of voicing contrast in English for Korean learners. The accuracy of relative vowel duration was influenced more by onset age than by L2 experience, suggesting that being exposed to English at an early age may benefit the acquisition of temporal dimension. On the other hand, the spectral characteristics of English vowels were more consistently influenced by L2 experience, indicating that immersive experience in the L2 speaking environment are likely to improve the accurate production of vowel quality. The distinct influence of the onset age and L2 experience on the specific phonetic cues in L2 vowel production provides insight into the intricate relationship between the two factors on the manifestation of L2 phonological knowledge.