• Ecology and Resilient Infrastructure
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• 제2권2호
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• pp.147-153
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• 2015

독성 소재를 활용하여 하천생태복원 사업을 추진할 경우, 수생 생물이 직접적으로 독성물질에 노출되어 다양한 생물학적 문제를 야기할 수 있다. 따라서, 본 연구에서는 하천사업에 활용되는 콘크리트 소재의 독성을 분석하기 위해 한국산 무당개구리(Bombina orientalis)배아를 이용하여 생존율과 기형발생률 측면에서 발생독성 분석을 수행하였다. 콘크리트 바인더들의 독성을 평가한 결과, 무당개구리 배아의 생존율은 대조군 (control), 식물성 폴리우레탄(P1), 우레탄(P2), 시멘트(C) 실험군에서 각각 100%, 94-95%, 66-89%, 0%로 나타났다. 기형발생률은 대조군, P1, P2, C 실험군에서 각각 10.5%, 5.3-10.5%, 26.3-27.8%, 35.7%로 나타났다. 시멘트의 독성이 가장 강하게 나타났으며, 상대적으로 식물성 폴리우레탄의 독성이 가장 약한 것으로 나타났다. 또한, 충분한 양생시간을 가짐으로써 용출되는 독성물질이 저감되는 것을 확인하였다. 이상의 결과들로서 시멘트와 폴리우레탄은 양서류의 초기발생을 저해하는 것이 확인되었다. 본 연구는 하천복원을 위한 소재의 선택에 있어 생물학적 안전성을 검토하는 것이 매우 중요하며, 친환경 소재 및 친환경 공정 선택의 중요성을 보여준다.

• 한국임상약학회지
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• 제32권3호
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• pp.215-225
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• 2022

Background: Patients with hematologic cancers have a risk of drug-related problems (DRPs) from medications associated with chemotherapy and supportive care. Although the role of oncology pharmacists has been widely documented in the literature, few studies have reported its impact on cost reduction. This study aimed to describe the activities of oncology pharmacists with respect to hematologic diseases and evaluate the associated cost avoidance. Methods: From January to July 2021, patients admitted to the department of hemato-oncology at Seoul National University, Bundang Hospital were studied. The activities of oncology pharmacists were reported by DRP type following the Pharmaceutical Care Network version 9.1 guidelines, and the acceptance rate was calculated. The avoided cost was estimated based on the cost of the pharmacy intervention, pharmacist manpower, and prescriptions associated with the intervention. Results: Pharmacists intervened in 584 prescriptions from 208 patients during the study period. The most prevalent DRP was "adverse drug event (possibly) occurring" (32.4%), followed by "effect of drug treatment not optimal" (28.6%). "Drug selection" (42.5%) and "dose selection" (30.3%) were the most common causes of DRPs. The acceptance rate of the interventions was 97.1%. The total avoidance cost was KRW 149,468,321; the net profit of the avoidance cost, excluding labor costs, was KRW 121,051,690; and the estimated cost saving was KRW 37,223,748. Conclusion: Oncology pharmacists identified and resolved various types of DRPs from prescriptions for patients with hematologic disease, by reviewing the prescriptions. Their clinical service contributed to enhanced patient safety and the avoidance of associated costs.

• Journal of Acupuncture Research
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• 제31권2호
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• pp.145-152
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• 2014

Objectives : This study aimed to assess the effectiveness and safety of Taegeuk acupuncture for patients with chronic musculoskeletal pain. Methods : A retrospective analysis of the electronic medical records of Pusan National University Korean Medicine Hospital from March 2012 to March 2013 was performed. Eligible cases were outpatients who had received at least six sessions of Taegeuk acupuncture for their pain and had agreed to the use of their medical records for research purposes. Pain levels, heart rate variability, and patients' perceptions of the safety of acupuncture were investigated through the medical records and follow-up telephone interviews. Results : Fifteen cases were selected for analysis. All had suffered from musculoskeletal pain for at least one year. After six sessions of Taegeuk acupuncture, the average score on the pain numeric rating scale decreased from $6.7{\pm}2.0$ to $2.9{\pm}2.2$(a 43 % reduction). Follow-up telephone interviews revealed that patients experienced no adverse event after Taegeuk acupuncture. Conclusions : Patients with chronic musculoskeletal pain showed a reduction of more than half of the baseline pain after six sessions of Taegeuk acupuncture. However, the beneficial effects observed in this retrospective analysis should be interpreted with caution due to selection and recall bias. Further randomized controlled trials of Taegeuk acupuncture for chronic musculoskeletal pain are warranted.

• IMMUNE NETWORK
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• 제4권3호
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• pp.131-142
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• 2004

In recent years, adjuvants have received much attention because of the development of purified subunit and synthetic vaccines which are poor immunogens and require adjuvants to evoke the immune response. Therefore, immunologic adjuvants have been developed and testing for most of this century. During the last years much progress has been made on development, isolation and chemical synthesis of alternative adjuvants such as derivatives of muramyl dipeptide, monophosphoryl lipid A, liposomes, QS-21, MF-59 and immunostimulating complexes (ISCOMS). Biodegradable polymer microspheres are being evaluated for targeting antigens on mucosal surfaces and for controlled release of vaccines with an aim to reduce the number of doses required for primary immunization. The most common adjuvants for human use today are aluminum hydroxide and aluminum phosphate. Calcium phosphate and oil emulsions have been also used in human vaccination. The biggest issue with the use of adjuvants for human vaccines is the toxicity and adverse side effects of most of the adjuvant formulations. Other problems with the development of adjuvants include restricted adjuvanticity of certain formulations to a few antigens, use of aluminum adjuvants as reference adjuvant preparations under suboptimal conditions, non-availability of reliable animal models, use of non-standard assays and biological differences between animal models and humans leading to the failure of promising formulations to show adjuvanticity in clinical trials. The availability of hundreds of different adjuvants has prompted a need for identifying rational standards for selection of adjuvant formulations based on safety and sound immunological principles for human vaccines. The aim of the present review is to put the recent findings into a broader perspective to facilitate the application of these adjuvants in general and experimental vaccinology.

• 한국작물학회지
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• 제43권4호
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• pp.259-263
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• 1998

High molecular weight glutenin (HMW-Glu) subunit compositions of 73 Korean wheat cultivars and experimental lines were evaluated by using one dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis. This method is suitable for obtaining a good resolution of 1Dx2 and 1Ax2$^*$ without adverse effects on separation of other HMW-Glu subunits. Korean wheats examined in this study could be divided into 15 different groups on the basis of HMW-Glu subunit compositions. From the wheat lines tested, it was identified that there were three alleles at the Glu-Al, five at the Glu-Bl and three at the Glu-D1 loci. The null allele of the Glu-Al was occurred in high frequency (79.4%), while low frequencies for 1Ax1 (12.3%) and 1Ax2$^*$(8.2%) were found. High frequency (75.3%) of the subunit pairs of 1Bx7+1By8 at the Glu-Bl loci compared with other subunits was found. The frequencies of subunits 1Dx2. 2+1Dy12 and 1Dx2+1Dy12 from the Glu-D1 loci were 54. 8% and 37.0%, respectively. However, a few Korean wheat lines (8.2%) carried 1Dx5 + 1Dy10 subunit pair which are responsible for good breadmaking quality. The information of HMW-Glu subunit compositions provide a useful tool to characterize wheat lines, and can be directly used in selection of breeding lines of different end-use properties.

• Journal of Plant Biotechnology
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• 제44권4호
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• pp.388-393
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• 2017

We report an Agrobacterium-mediated transformation procedure optimized for 'Kyoho' that is a major table grapevine cultivar in Korea, and its transgenic plants with antifreeze protein gene of carrot (DcAFP). The full length of DcAFP coding region in accordance with the previous report was isolated from young leaves of carrot and recombined into a plant transformation vector. Ethylene inhibitors such as silver nitrate and aminoethoxyvinylglycin (AVG) supplemented in a co-cultivation medium distinctly increased frequency of shoot regeneration when explants were sub-cultured in a selection medium: particularly ten-fold higher in treatment with 0.1 mg/L AVG than one without ethylene inhibitor. Among various antibiotics and their concentrations, the combination of 150 mg/L cefotaxime plus 150 mg/L $Clavamox^{TM}$ was selected for elimination of Agrobacterium cells in addition to minimization of adverse effect on shoot regeneration, while 50 mg/L kanamycin monosulfate effectively suppressed regeneration of non-transgenic shoots. Applying the elucidated culture condition, we finally obtained a total of 5 transgenic 'Kyoho' plantlets with DcAFP, of which integration with the grapevine genome and transcription was confirmed by nucleic acid analyses.

• 한국물환경학회지
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• 제26권4호
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• pp.614-621
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• 2010

A indigenous freshwater bivalve Unio douglasiae was introduced to compare the differences in the efficacy of algal bloom control and the appearances of mussel-mediated adverse effects between two different reservoirs such as mesotrophic (Shingu r.) and hypertrophic (Seokmun r.). We constructed the study mesocosm in the shore of each reservoir, stocked the mussel at density of $30indiv./m^3$ for 7 days, and measured daily the phytoplankton density and water quality. In mesotrophic reservoir, even though approximately 38% of suspended solids and chlorophyll-a was reduced by stocked bivalves for the first 3 days, algal density, ammonia and soluble reactive phosphorus gradually increased with increasing mussel death. In hypertrophic reservoir, mussels strongly inhibited suspended solids and chlorophyll-a by the termination of study with no increase of mussel death and nutrient, especially ammonia concentration. In both reservoirs, a strong selectivity showed mussels preferred to diatom rather than cyanobacteria and green algae without algal density and nutrient level. Our results indicate that an introduction of freshwater bivalve U. douglasiae is more strategic to improve water quality of hypertrophic than mesotrophic reservoir, but many preliminary studies on the treatment method and the selection of target water system are required.

• 한국습지학회지
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• 제10권1호
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• pp.49-57
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• 2008

연안습지로 분류되는 갯벌은 육상과 해양을 연결하는 주요 전이대로서 다양하고도 고유한 생물상을 포함하면서 필수적인 생태적 기능을 수행하고 있다. 우리 인간을 포함하여 주변의 생물들이 누려왔던 갯벌의 생태계서비스 기능과 그것의 긍정적 효과를 유지 또는 강화하기 위해서는 갯벌의 보전이 매우 중요하나 국내의 경우 지금까지 보존보다는 개발이 우세하게 진행되어 왔다. 따라서 본 연구에서는 갯벌매립으로 인한 환경영향을 최소화할 수 있도록 해안개발사업으로 인한 갯벌훼손의 사례를 유형별로 분석하여 이를 토대로 저감방안을 수립하고자 하였다. 지금까지 해안개발사업을 추진하면서 입지선정단계에서 사업대상지가 갯벌로 구성되어 있다는 사실을 중요한 고려사항으로 인식하지 못하여 왔다. 이에 따라 1960년대 이래 우리나라 갯벌 면적의 거의 절반에 해당하는 갯벌이 매립되었고, 개발로 인해 주변 갯벌은 직 간접적으로 훼손되었으며, 모든 계획을 수립한 이후 환경영향평가의 협의단계에서 문제점이 지적되어 사업이 원래의 계획과는 다르게 수정해야 하는 경우도 나타나게 되었다. 이러한 문제점을 해결하기 위해서는 사업을 계획하는 초기단계에서 갯벌 환경에 대한 고려가 우선적으로 이루어져야 한다. 특히 입지선정단계에서 해양환경이 양호하여 다양한 생태계 기능을 수행하는 갯벌 (펄갯벌 및 모래갯벌)을 포함하여 암반 조간대, 사빈, 조하대 잘피숲 및 해중림 지역은 배제하도록 하여야 할 것이다.

• Advances in environmental research
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• 제6권4호
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• pp.265-279
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• 2017

The climate change has made adverse effects on land surface temperature for many regions of the world. Several climatic studies focused on different downscaling techniques for climatological parameters of different regions. For statistical downscaling of any hydrological parameters, conventional Neural Network Models were used in common. However, it seems that in any modeling study, uncertainty is a vital aspect when making any predictions about the performance. In this paper, Gamma Test is performed to determine the data length selection for training to minimize the uncertainty in model development. Another measure to improve the data quality and model development are wavelet transforms. Hence, Gamma Test with Wavelet decomposed Feedforward Neural Network (GT-WNN) model is developed and tested for downscaled land surface temperature of Patna Urban, Bihar. The results of GT-WNN model are compared with GT-FFNN and conventional Feedforward Neural Network (FFNN) model. The effectiveness of the developed models is illustrated by Root Mean Square Error and Coefficient of Correlation. Results showed that GT-WNN outperformed the GT-FFNN and conventional FFNN in downscaling the land surface temperature. The land surface temperature is forecasted for a period of 2015-2044 with GT-WNN model for Patna Urban in Bihar. In addition, the significance of the probable changes in the land surface temperature is also found through Mann-Kendall (M-K) Test for Summer, Winter, Monsoon and Post Monsoon seasons. Results showed an increasing surface temperature trend for summer and winter seasons and no significant trend for monsoon and post monsoon season over the study area for the period between 2015 and 2044. Overall, the M-K test analysis for the annual data shows an increasing trend in the land surface temperature of Patna Urban.

• 산업경영시스템학회지
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• 제12권20호
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• pp.123-138
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• 1989

The primary objective of the agency research in the game theory lives in the maintenance of Pareto is optimal condition for the optimal incentive contract. The basic concepts which are related to this objective are reviewed in connection with the general assumptions to model it, the moral hazard and adverse selection which arised from the information asymmetry, and finally the problem of risk distribution. The demand for auditing and the role of auditor have been addressed by ASOBAC. Issues which an auditor is explicitly introduced in a principal-agent framework have been addressed in this paper. These issues must be confronted to appropriately with the auditor, and to achieve an adequate understanding of optimal confronting arrangement with the auditor. The first step in introducing an auditor into this analysis is to examine the game-theoretic foundation of such a expended agency model. The Mathematical program formulated may not yield solution that are resonable. This arises because the program may call for the auditor and manager to play dominated Nash equilibra in some subgame. The nontrivial natures of the subgame implies that randomized strategies by the auditor and manager nay be of crucial importance. The possibilities for overcoming the randomized strategy problem were suggested; change the rule of the game and or impose covexity condition. The former seems unjustifiable in on auditing context, and the latter promising but difficult to achieve. The discussion ended with an extension of the revelation principle to the owner manager-auditor game, assuming strategies. An examination of the restriction and improvement direction of the basic concept of agency theory was addressed in the later part of this paper. Many important aspects of auditor incentives are inherently multiple-agent, multiple-period, multiple-objectine, phenomena and require further analyses and researches.