• Journal of the Korea Institute of Information and Communication Engineering
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• v.22 no.4
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• pp.648-655
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• 2018

Our government has concentrated its policy capabilities on Software industry in order to realize software-centric society. Through such efforts, software industry has developed continuously. As well, it has been a high-valued industry by the association with other various industries, so its importance has been great and its market has grown explosively. However, owing to the hasty support policies focused on software industry, various problems and adverse effects, such as the decline of construction quality due to the confusion of business operator selection and the business area conflict, has occurred. Therefore, in this thesis, I will find the problem and its cause about software support policies and relevant laws according to rapid market change, and will suggest the improvement plan about them. So, I intend to minimize the problems associated with the confusion of business operator selection, through the business area clarification(software industry and information communication construction industry) about complex ICT industry.

• The Korea Journal of Herbology
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• v.36 no.5
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• pp.37-46
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• 2021

Objective : This study aims to examine the effectiveness and safety of herbal medicines in upper respiratory tract infection by conducting systematic review against amoxicillin. Methods : Relevant randomized controlled trials (RCTs) published by December 2020 were searched in PubMED database. Study selection was conducted according to the PRISMA guideline. The Risk of Bias of the RCTs were evaluated based on the Cochrane criteria. Study selection and bias assessment were conducted independently by two researchers, and the third party was involved if there is a disagreement. Results : Three RCTs were included. Meta-analysis was not performed due to different specific disease and outcome measurements among the included studies. Herbal medicine showed statistically significant improvement in symptoms and endoscopic findings compared to amoxicillin in acute rhinosinusitis. In addition, herbal medicine showed statistically significant improvement in symptoms and a smaller dose of additional antibiotics in acute tonsillitis. However, herbal medicine showed no significant effects compared to amoxicillin in chronic sinusitis patients after functional endoscopic sinus surgery. In terms of adverse events, no significant difference was observed between the herbal medicine group and the amoxicillin group in all studies. Conclusion : Herbal medicine might be more effective than amoxicillin in the treatment of upper respiratory tract infection. Nevertheless, it is hard to clear that conclusion due to the fact that the collected studies were conducted on different specific diseases and herbal medicine, and that the included studies had flaws in the research methodology.

• Journal of Ginseng Research
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• v.43 no.3
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• pp.482-487
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• 2019

Background: The mixed-cultivation of different Panax ginseng cultivars can cause adverse effects on stability of yield and quality. K-1 is a superior cultivar with good root shape and stronger disease resistance. DNA markers mined from functional genes are clearly desirable for K-1, as they may associate with major traits and can be used for marker-assisted selection to maintain the high quality of Korean ginseng. Methods: Five genes encoding pathogenesis-related (PR) proteins of P. ginseng were amplified and compared for polymorphism mining. Primary, secondary, and tertiary structures of PR5 protein were analyzed by ExPASy-ProtParam, PSSpred, and I-TASSER methods, respectively. A coding single nucleotide polymorphism (SNP)-based specific primer was designed for K-1 by introducing a destabilizing mismatch within the 3' end. Allele-specific polymerase chain reaction (PCR) and real-time allele-specific PCR assays were conducted for molecular discrimination of K-1 from other cultivars and landraces. Results: A coding SNP leading to the modification of amino acid residue from aspartic acid to asparagine was exploited in PR5 gene of K-1 cultivar. Bioinformatics analysis showed that the modification of amino acid residue changed the secondary and tertiary structures of the PR5 protein. Primer KSR was designed for specific discrimination of K-1 from other ginseng cultivars and landraces. The developed real-time allele-specific PCR assay enabled easier automation and accurate genotyping of K-1 from a large number of ginseng samples. Conclusion: The SNP marker and the developed real-time allele-specific PCR assay will be useful not only for marker-assisted selection of K-1 cultivar but also for quality control in breeding and seed programs of P. ginseng.

• Toxicological Research
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• v.17
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• pp.41-45
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• 2001

The methods used for risk assessment from exposure to chemicals are well established. in most cases where toxicity other than carcinogenesis is being considered, the standard method relies on establishing the No Observed Adverse Effect Level (NOAEL) in the most sensitive animal toxicity study and using an appropriate safety factor (SF) to determine the exposure which would be associated with an acceptable risk. For carcinogens a different approach is used because it has been argued there is no threshold of effect. Thus mathematical equations are used to extrapolate from the high doses used in ani-mal experiments. These methods have been strongly criticised in recent years on several grounds. The most cogent criticisms are a) the equations are not based on a thorough understanding of the mechanisms of carcinogenesis and b) the outcome of a risk assessment based on such models varies more as a consequence of changes to the assumptions and equation used than it does from the data derived from carcinogenicity experiments. Other criticisms include the absence of any measure of the variance on the risk assessment and the selection of default values that are very conservative. Recent advances in the application of risk assessment emphasise that measures of both the exposure and the hazard should be considered as a distribution of values. The outcome of such a risk assessment provides an estimate of the distribution of the risks.

• The Journal of Korean Medicine
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• v.41 no.3
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• pp.247-259
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• 2020

Objectives: This review aims to investigate clinical studies related to bee venom pharmacopuncture for cancer patients and to analyze the research trend for further study. Methods: We searched for clinical studies using bee venom pharmacopuncture therapy on patients with cancer through the electronic databases including Pubmed, Cochrane library, OASIS, KISS, NDSL, and KMBASE. There was no restriction on language and publication date, and after selection/exclusion process, the study design, target disease, intervention details including acupoints, treatment frequency and period, outcomes, study results and adverse events were extracted. Results: Thirteen clinical studies were finally selected. There were a randomized controlled trial RCT about the effect of sweet bee venom pharmacopuncture on cancer-related pain, and three case series about chemotherapy-induced peripheral neuropathy. In case reports, there were nine studies about oligodendroglioma, plexiform neurofibroma, breast cancer, prostate cancer, lung cancer, urachal adenocarcinoma, malignant melanoma, and atypical squamous cells of undetermined significance. The bee venom therapy affected the improvement of outcomes such as symptoms, quality of life, tumor response, and lab findings. Conclusions: The present study found that bee venom therapy is applicable to the treatment of cancer patients, and showed some effect on various symptoms. However, due to insufficient number and quality of studies, well designed and high-quality clinical trials are necessary to confirm the effectiveness and safety of bee venom pharmacopuncture therapy in patients with cancer.

• Computers and Concrete
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• v.17 no.5
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• pp.613-628
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• 2016

In this study, the influence of coarse aggregate size and type on chloride penetration of concrete was investigated, and the grey correlation analysis was applied to find the key influencing factor. Furthermore, the proposed 6-10-1 artificial neural network (ANN) model was constructed, and performed under the MATLAB program. Training, testing and validation of the model stages were performed using 81 experiment data sets. The results show that the aggregate type has less effect on the concrete permeability, compared with the size effect. For concrete with a lower w/b, the coarse aggregate with a larger particle size should be chose, however, for concrete with a higher w/c, the aggregate with a grading of 5-20 mm is preferred, too large or too small aggregates are adverse to concrete chloride diffusivity. A new idea for the optimum selection of aggregate to prepare concrete with a low penetration is provided. Moreover, the ANN model predicted values are compared with actual test results, and the average relative error of prediction is found to be 5.62%. ANN procedure provides guidelines to select appropriate coarse aggregate for required chloride penetration of concrete and will reduce number of trial and error, save cost and time.

• Asian-Australasian Journal of Animal Sciences
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• v.12 no.8
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• pp.1316-1323
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• 1999

Extensive emphasis on milk and milk fat yields with no diversion for beef performance increased the yield efficiency of North American dairy cattle. Heavy demand for North American genetics followed national strain comparison trials in Poland, and US and Canadian dairy cattle and germplasm still are an important source of genetics for many countries. Genetic improvement has accelerated in many countries because of the implementation of sampling programs for young bulls and improved evaluation procedures. Rapid access to information and more frequent calculation of genetic information also are having a positive impact on genetic improvement. Traits other than yield should be considered in a breeding program, but those traits mist have a reasonable opportunity for improvement and sufficient economic worth. Because of ever increasing efficiency, the world's milk supply comes from fewer cows each year. However, no decline in the rate of genetic improvement is apparent under current genetic practices; estimates of heritability are increasing, and a decline in yield efficiency is unlikely in the near future. As management improves, especially for subtropical conditions, many of the selection principles used in temperate climates will be adopted for more adverse environmental conditions.

• Clinical and Experimental Reproductive Medicine
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• v.41 no.2
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• pp.41-46
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• 2014

IVM refers to the maturation of immature oocytes in culture after their recovery from small antral follicles at the stage prior to selection and dominance. IVM requires little or no FSH in vivo and has been proposed as an alternative to conventional IVF, since it reduces the primary adverse effects caused by controlled ovarian stimulation, including the ovarian hyperstimulation syndrome. Moreover, IVM is a promising option for cases for which no standard protocol is suitable, such as FSH resistance, contraindications for ovarian stimulatory drugs, and the need for urgent fertility preservation. Recently, IVM has been used in women with regular cycles and normal ovaries. However, the pregnancy rate following IVM is suboptimal compared with that of conventional IVF, indicating that further studies to optimize the protocol and the culture conditions are warranted.

• Journal of the Korean housing association
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• v.25 no.2
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• pp.11-18
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• 2014

This study looked at designing, building and operating temporary camp, the first structures that South Korea built in the Antarctica. While there may be differences in accordance with the topography, ground surfaces in the Antarctica are covered broken stones, glaciers and snow. Hence, such topographical characteristics should be taken into account when conducting any construction work. To ensure successful assembly construction in the Antarctica using modules, prior trial assembly work should be done in Korea to identify any possible trouble in the actual construction process. Assuming that the workers will have to spend at least one winter in the temporary camp, the work will be more severely affected by adverse weather conditions and snow drift, resulting in the need to clear snow. This can be by designing roofs with curved surfaces. Also, quantitative effects will need to be verified through simulation and actual measurement. It will also be necessary to assess the camp's thermal environment and examine its air-conditioning methods. To identify the temporary camp's thermal system, the temperatures and humidities were measured, and the heating system was designed not to offer automatic control or desired value selection functions.

• Toxicological Research
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• v.26 no.1
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• pp.1-8
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• 2010

The process of new drug development consists of several stages; after identifying potential candidate compounds, preclinical studies using animal models link the laboratory and human clinical trials. Among many steps in preclinical studies, toxicology and safety assessments contribute to identify potential adverse events and provide rationale for setting the initial doses in clinical trials. Gene modulation is one of the important tools of modern biology, and is commonly employed to examine the function of genes of interest. Advances in new drug development have been achieved by exploding information on target selection and validation using genetically modified animal models as well as those of cells. In this review, a recent trend of genetically modified methods is discussed with reference to safety assessments, and the exemplary applications of gene-modulating tools to the tests in new drug development were summarized.