• International Journal of Oral Biology
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• v.36 no.2
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• pp.51-57
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• 2011

Runx2 and Osterix, the transcription factors for osteoblast differentiation, are known as fundamental factors to regulate the development of calcified tissues. However, the biological functions of these factors in the development of the periodontal tissues remain unclear. In this study, we investigated the distribution of Runx2 and Osterix during periodontal tissue development of the mice. Mandibles from 14-day-old mice were prepared for paraffin section. Serial sections of the mandible containing $1^{st}$ molar tooth germs were obtained as a thickness of $7\;{\mu}m$. Some sections were stained with hematoxylin and eosin. Others were used for immunohistochemistry for PCNA, Runx2, and Osterix. Epithelial cells in growing end of Hertwig's epithelial root sheath (HERS) and mesenchymal cells adjacent to the growing end of HERS expressed PCNA. Undifferentiated mesenchymal cells and hard tissue forming cells like cementoblasts and osteoblasts in early stage of differentiation expressed Runx2. Fully differentiated cementoblasts and osteoblasts secreting matrix proteins expressed Osterix. However, the cells terminated the matrix formation did not express Osterix. Periodontal ligament cells expressed Runx2 and Osterix. Pulp cells expressed Runx2 only. These results suggest that Runx2 and Osterix might regulate the differentiation of cementoblasts in the same manner as osteoblasts. Runx2 might participate in the process of cementoblast differentiation in early stage, whether Osterix might regulate the maturation and matrix synthesis of the cells.

• Journal of Periodontal and Implant Science
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• v.51 no.2
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• pp.77-87
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• 2021

Purpose: The aim of this study was to compare the efficacy of the tunnel technique for root coverage using a new xenogeneic acellular dermal matrix vs. connective tissue grafting (CTG) for the treatment of multiple maxillary adjacent recessions (recession type 1) at 12 months postoperatively. Methods: This study enrolled 12 patients with at least 3 contiguous, bilateral, symmetrical maxillary gingival recessions (i.e., at least 6 recessions per patient). In total, 74 recessions were treated using the modified coronally advanced tunnel (MCAT) technique combined with a novel porcine-derived acellular dermal matrix (PADM) at 37 test sites or CTG at 37 control sites. The following clinical parameters were measured: recession height, clinical attachment level, width of keratinized tissue, probing depth, recession width, gingival thickness, mean root coverage (MRC), and complete root coverage (CRC). Comparisons between test and control groups were made for pain visual analog scale scores at 14 days. Results: At 12 months, the MCAT with PADM (test) yielded a statistically significant improvement in all clinical parameters studied. MRC was significantly higher on the control sides (80.6%±23.7%) than on the test sides (68.8%±23.4%). Similarly, CRC was 48.7%±6.8% on the control sides (CTG), in contrast to 24.3%±8.2% on the test sides (PADM). Statistically significant differences were observed in favor of the control sides for all clinical parameters studied. Nevertheless, the MCAT in adjunction with PADM was clearly superior at reducing mean and maximum patient-reported postoperative pain intensity and pain duration in the first week after surgery. Conclusions: The use of PADM to treat multiple recessions improved clinical parameters at 12 months, but these outcomes were nevertheless poorer than those observed for CTG. However, PADM reduced morbidity, particularly the pain experienced by patients.

• Journal of Periodontal and Implant Science
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• v.35 no.4
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• pp.823-837
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• 2005

The purpose of this study was to study the histopathological correlation between the use of platelet-rich plasma and enamel matrix protein used in conjunction with xenograft. compared to a control group with regards to bone regeneration at the grade III furcation area in beagle dogs. Control group was treated with bovine derived bone $powder(Biocera^{(R)})$, and experimental I group was treated with bovine derived bone powder and Platelet-rich plasma and experimental II group was treated with bovine derived bone powder and Enamel matrix $protein(Emdogain^{(R)})$. The regeneration rate of bone formation was observed and compared histopathologically at 2. 4, and 8 weeks after surgery. The results were as follows: 1. In control group and both experimental groups. inflammatory cells were observed but, new bone formation wasn't. 2. In control group, new cementum on the notch was found in 4 weeks, less mature periodontal ligament when compared to that of experimental group was found and cementum formation was great but, regeneration couldn't be seen in 8 weeks. 3. Experimental I group. new bone formation in the area adjacent to alveolar bone and graft material surrounded by more dense connective tissue were found in 4 weeks. New bone formation up to crown portion was found and periodontal ligament was aligned functionally and cementum more mature. 4. Experimental II group, new bone formation was found under the defect area in 4 weeks and new bone formation around graft material in 8 weeks, too, and there were a number of fibroblasts, blood vessels, acellular cementum, which was less mature when compared to that of experimental I group, and dense collagen fiber like which normal periodontal ligament has in periodontal ligament of experimental II group in 8 weeks. 5. As a result of histologic finding, bone formation rate were 18.0${\pm}$7.87%(control group), 34. 05${pm}$7.25%(experimental I group), 19.33 ${pm}$5.15%(experimental II group) in 4 weeks and 21.89${pm}$1.58%(control group), 38.82${pm}$3.2(experimental I group), 37.65${pm}$9.22%(experimental II group) in 8 weeks. 6. Statistically significant ratio of bone formation was observed in experimental I group in 4 weeks and in experimental II group in 8 weeks. When experimental I group was compared to experimental II group, the ratio of bone formation in experimental I group was higher than that in experimental II group in 4 weeks(p<0.05). This results suggest that platelet-rich plasma showed more new bone formation than enamel matrix protein within 4 weeks. And use of enamel matrix protein in the treatment of periodontal bone defects starts to enhance regeneration after 8 weeks in beagle dogs.

• ETRI Journal
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• v.26 no.6
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• pp.565-574
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• 2004

Differential unitary space-time modulation (DUSTM) has emerged as a promising technique to obtain spatial diversity without intractable channel estimation. This paper presents a study of the application of DUSTM on multiple-input multiple-output orthogonal frequency division multiplexing (MIMO-OFDM) systems with frequency-selective fading channels. From the view of a correlation analysis between subcarriers of OFDM, we obtain the maximum achievable diversity of DUSTM on MIMO-OFDM systems. Moreover, an efficient implementation strategy based on subcarrier reconstruction is proposed, which transmits all the signals of one signal matrix in one OFDM transmission and performs differential processing between two adjacent OFDM blocks. The proposed method is capable of obtaining both spatial and multipath diversity while reducing the effect of time variation of channels to a minimum. The performance improvement is confirmed by simulation results.

• BMB Reports
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• v.35 no.5
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• pp.513-517
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• 2002

We describe a new method for identifying the sequences that signal the start of translation, and the boundaries between exons and introns (donor and acceptor sites) in human mRNA. According to the mandatory keyword, ORGANISM, and feature key, CDS, a large set of standard data for each signal site was extracted from the ASCII flat file, gbpri.seq, in the GenBank release 108.0. This was used to generate the scoring matrices, which summarize the sequence information for each signal site. The scoring matrices take into account the independent nucleotide frequencies between adjacent bases in each position within the signal site regions, and the relative weight on each nucleotide in proportion to their probabilities in the known signal sites. Using a scoring scheme that is based on the nucleotide scoring matrices, the method has great sensitivity and specificity when used to locate signals in uncharacterized human genomic DNA. These matrices are especially effective at distinguishing true and false sites.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 1996.10a
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• pp.239-246
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• 1996

Very stiff floor system in a residential-commercial building causes some problems in the numerical analysis procedure due to significant difference in stiffness with adjacent structural elements. Static analysis of structure with a stiff transfer-floor can be peformed approximately in two steps for upper and lower pons for the structure. However, it is impossible to perform dynamic analysis in two steps with separate models. An efficient method for dynamic analysis of a structure with a rigid floor system is proposed in this study. The matrix condensation technique is employed to reduce the degree of freedom for upper and lower parts of the structure and a beam elements with rigid bodies of both ends are introduce to model the rigid floor system. Efficiency end accuracy of the proposed method ore verified through analysis of several example structures.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.64 no.1
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• pp.149-158
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• 2015

This paper proposes a subband filtering technique to the MUSIC and the ESPRIT algorithm for estimating the magnitude and frequency of the harmonics of power signal. In proposed method, the input power signal is decomposed to the odd harmonics and the even harmonics respectively by the filter bank system. The amplitude and the frequency estimation of the decomposed harmonics are carried out using the MUSIC and the ESPRIT method. Subband filtering can reduce the autocorrelation matrix size of input data, and spectrum leakage between adjacent harmonics. Therefore, this subband technique has advantage in computational cost and estimation accuracy compared to fullband MUSIC and ESPRIT. To demonstrate the performance of the method, computer simulations are performed to the synthesized input signal, and experiment results are compared in subband and fullband cases.

• ETRI Journal
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• v.34 no.4
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• pp.503-510
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• 2012

We analyze the relationship between channel coherence bandwidth and two complexity-reduced lattice reduction aided detection (LRAD) algorithms for multiple-input multiple-output (MIMO) orthogonal frequency division multiplexing (OFDM) systems in correlated fading channels. In both the adaptive LR algorithm and the fixed interval LR algorithm, we exploit the inherent feature of unimodular transformation matrix P that remains the same for the adjacent highly correlated subcarriers. Complexity simulations demonstrate that the adaptive LR algorithm could eliminate up to approximately 90 percent of the multiplications and 95 percent of the divisions of the brute-force LR algorithm with large coherence bandwidth. The results also show that the adaptive algorithm with both optimum and globally suboptimum initial interval settings could significantly reduce the LR complexity, compared with the brute-force LR and fixed interval LR algorithms, while maintaining the system performance.

• Proceedings of the Korean Society For Composite Materials Conference
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• 1999.11a
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• pp.258-263
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• 1999

In this study, the numerical and experimental investigations were conducted to understand ultrasonic wave propagation and to evaluate the degree of fiber waviness in thick composites nondestructively. The path, energy and traveling time of insonified wave were predicted by adopting the ray and plane wave theories. In the analysis, the composites were assumed to have continuous fiber with sinusoidal waviness in a matrix and were modeled as stacks of infinitesimally short length off-axis elements with varying fiber orientation along the length direction. From the experiments on the specially fabricated thick composite specimens with various degrees of uniform fiber waviness, the energy distributions of received wave were obtain for the various positions of transmitter. It was observed that the energy of wave was converged to the adjacent peaks of fiber waviness. The location where maximum energy of wave was detected from the experiments showed good agreement with the location obtained from theoretical predictions. Finally, the test procedure was Proposed to evaluate fiber waviness in thick composites by considering the energy of wave and relative distance between transmitter and receiver.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 1992.10a
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• pp.101-105
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• 1992

Machined graphite/epoxy composite surfaces were studied by using SEM(Scanning Electron Microscopy). surface profilometry and its analysis to determine suitable surface describing parameters for machined unidirectional and laminate composite surface. The surface roughness and profile are found to be highly dependent on the fiber layup direction and the measurement direction. Machined unidirectional and 0.deg. 45 .deg. 90 .deg. plies in laminate composite surface profiles are found to be Gaussian in the direction of machining. Since there exist bare fibers without matrix smearing in 0 .deg. ply, higher surface roughness values were found in this orientation. It was possible to machine 90 .deg. and -45 .deg. plies due to the adjacent plies, which were holding those plies. It was found that the microgeometrical variations in terms of roughness parameters Ra without Dy (maximum Damage Depth) region and Dy are better descriptors of the machined laminate composite surface than commonly used roughness parameters Ra and Ra. The characteristics of surface profiles in laminate composite are well represented in CHD (Cumulative Height Distribution) plot and PPD (Percentage Probability Density) plot. Also, the power spectral density function is shown to be capable of identifying the wavelength distribution of the machining damage.