• BMB Reports
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• v.35 no.1
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• pp.106-115
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• 2002

The serine/threonine kinase Akt has been intensely studied for its role in growth factor-mediated cell survival for the past 5 years. On the other hand, the ongoing research effort has recently uncovered novel regulatory mechanisms and downstream effectors of Akt that demonstrate the involvement of Akt in other cellular functions such as cell cycle progression, angiogenesis, and cancer cell invasion/metastasis. Furthermore, recent studies using whole model organisms suggest additional roles for Akt in important diseases such as aging and diabetes. The following review addresses these recent advances in the understanding of Akt function.

• 한국전산유체공학회:학술대회논문집
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• 2010.05a
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• pp.233-238
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• 2010

A two-dimensional laminar flow past a vertical plate in a microchannel is investigated. At far upstream and downstream from the plate in the microchannel, the plane Poiseuille flow exists. The Stokes flow for this microchannel is investigated analytically and then the laminar flow by numerical method. For the Stokes flow analysis, the method of eigenfunction expansion is used. From the results, the streamline pattern and the pressure distribution are plotted, and the additional pressure drop induced by the plate and the force exerted on the plate are calculated as functions of the length of the plate. For the laminar flow, finite difference method (FDM) is used to obtain the vorticity and the stream function. When the Reynolds number exceeds a critical value, a pair of viscous eddies appears behind the plate.

• Plant Disease and Agriculture
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• v.5 no.1
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• pp.14-19
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• 1999

Cucumber mosaic cucumovirus (CMV) is an isometric plant virus with functionally divided genomic RNAs and a broad host range. RNA 1 and RNA 2 each encode one protein, both of which are essential for replication. RNA 3 encodes the viral coat protein and an additional protein thought to be involved in potentiating the cell-to-cell movement of the virus. Functions of the RNAs have been confirmed using a pseudorecombinant virus constructed with infectious cDNA-derived transcripts of the RNAs. Generally, CMV produces different symptoms in various host plants depending on the virus strains. In this mini-review, we describe the potential role of the genes associated with symptom expression of CMV RNAs.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2008.04a
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• pp.484-490
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• 2008

For CSLDV, the Chebyshev demodulation (or polynomial) technique and Hilbert transform approach have been used for mode shape reconstruction with harmonic excitation. In this paper, the Hilbert-Huang transform approach was applied as an alternative to impact excitation cases in terms of a numerical approach. The vibration of the tested structure is modeled using impulse response functions. In order to verify this technique, a simply supported beam was chosen as the test rig. With additional innovative steps which are the ideal-band pass filter and the nodal point determination, Hilbert-Huang transformation can be used for a good mode shape reconstruction even in the impact excitation case.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.32 no.1
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• pp.34-43
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• 2009

In this thesis, we explain developing processes of the power transmission system for lift truck. Conventional power transmission system had some problems such as spatial constraints or low speed and high torque problem. Because conventional power transmission system was mainly designed for high speed vehicles. In this paper we developed power shift drive axle specialized for $2.0{\sim}3.5$ ton lift truck. Innovative structure of transmission which is built in inside axle, enables to reduce system weight and size by 40% compared to the conventional power transmission system. Also, it is possible to do additional functions such as auto parking system and anti-roll back system.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2000.05a
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• pp.1016-1020
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• 2000

In this study, a structural characteristics analysis system for motor-integrated high-speed spindle systems, “SpindleX”, is developed based on the Timoshenko theory and the multi-layered finite element method. Since “SpindleX” has the various analysis modules related to static deflection analysis, modal analysis, frequency response analysis, unbalance response analysis and so on, it is useful in performing systematically and quantitatively the design and evaluation processes of spindle system under the windows GUI environment. Also, to enhance the user-friendliness, “SpindleX” possesses the various additional functions such as the DXF file interface for auto-importing the shape and geometric data of spindle system from the DXF file, the bearing database for auto-importing the mechanical properties and geometric data of bearing by the bearing number, and the graphical visualization for certificating the imported and analysed data of spindle system.

• Proceedings of the KIEE Conference
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• 2008.07a
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• pp.671-672
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• 2008

Hybrid intelligent technique is used in ship steering control. It can make full use of the advantage of all kinds of intelligent algorithms. This provides an efficient way for this paper. An RBF neural network and GA optimization are employed in a fuzzy neural controller to deal with the nonlinearity, time varying and uncertain factors. Utilizing the designed network to substitute the conventional fuzzy inference, the rule base and membership functions can be auto-adjusted by GA optimization. The parameters of neural network can be decreased by using union-rule configuration in the hidden layer of the network. The ship control quality is effectively improved in case of appending additional sea state disturbance. The performance of controller is evaluated by the system simulation using Matlab.

• Proceedings of the KSME Conference
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• 2000.04a
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• pp.286-291
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• 2000

The finite element analyses of mechanical rubber components are executed to predict the behavior of deformation and stress distribution in destgn step. The non-linear properties of rubber which are described as strain energy functions are important parameters to design and evaluate rubber components. These are determined by material tests which are tension, compression and shear test. The behaviors of loads-displacements of rubber components such as a roll tubber spring and resilient ring and additional spring for railway suspension system are evaluated by using commercial FEA code. It is shown that the results by FEA simulations are in close agreement with the test results.

• International Commerce and Information Review
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• v.12 no.4
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• pp.111-126
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• 2010

This paper provides an empirical investigation of the determinants of current accounts utilizing an exchange rate (ER), terms of trade (NET), industrial activity (IPI), world import volume (WIM), trade share of the China and Japan (CHJP), proportion of service trade (SERV). The period examined is 1991:1 through 2010:2. It is tested under different cases such as whether variables were cointegrated and whether there was an equilibrium relationship. The result showed that the hypothesis of no cointegrated vector could be rejected at the 5 percent level. The estimated error correction model showed that adjustment speed is fast. This paper also applies impulse-response functions to get additional information by considering the responses of the current account to the shocks of economic variables. The results indicate that current account responds negatively to industrial activity and proportion of service trade, and then decays very quickly.

• Journal of Korean Medical classics
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• v.29 no.3
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• pp.101-111
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• 2016

Objectives : In this study, the meaning of Movement Qi between kidneys(腎間動氣) in Huangdineijingtaisu(黃帝內經太素) is researched for the purpose of understanding the differences between Huangdineijingtaisu and Nanjing(難經). Methods : The annotations related to Movement Qi between kidneys in Huangdineijingtaisu were selected and analyzed to overview the historical changes of the definition. Results : The meaning of Movement Qi between kidneys in Huangdineijingtaisu is not different from that of Nanjing basically, however, Yang Shangshan(楊上善) suggested additional new meanings including penetration meridian(衝脈), pass way for vital energy(氣街), visceral exhaustion pulse(眞藏脈) and so on. Conclusions : The reason that Yang Shangshan explained the circulation of primordial energy(原氣) focusing on penetration meridian is that he tried to connect the actual functions about Movement Qi between kidneys to clinical treatment than the ideal concept in Nanjing.