• 한국농공학회논문집
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• 제60권5호
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• pp.81-93
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• 2018

The Kajiyama formula, which is an empirical formula based on the maximum flood data at Korean watersheds, has been widely used for the design of hydraulic structures and management of watersheds. However, this formula was developed based on meteorological data and flow measured during early 1900s so that it could not consider the recently changed rainfall pattern due to climate changes. Moreover, the formula does not provide the monthly coefficients for 5 months including July and August (flood season), which causes the uncertainty to accurately interpret runoff characteristics at a watershed. Thus, the objective of this study is to enhance the monthly coefficients based on the recent meteorological data and flow data expanding the range of rainfall classification. The simulated runoff using the enhanced monthly coefficients showed better performance compared to that using the original coefficients. In addition, we evaluated the applicability of the enhanced monthly coefficient for future runoff prediction. Based on the results of this study, we found that the Kajiyame formula with the enhanced coefficients could be applied for the future prediction. Hence, the Kajiyama formula with enhanced monthly coefficient can be useful to support the policy and plan related to management of watersheds in Korea.

• Structural Engineering and Mechanics
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• 제69권3호
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• pp.257-268
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• 2019

Infills are as important members in structural design as beams, columns and braces. They have significant effect on structural behavior. Because of lots of variables in infills like material non-linear behavior, the interaction between frames and infill, etc., the infills performance during an earthquake is complicated, so have led designers do not consider the effect of infills in designing the structure. However, the experimental studies revealed that the infills have the remarkable effect on structure behavior. As if these effects ignored, it might occur soft-story phenomena, torsion or short-column effects on the structures. One simple and appropriate method for considering the infills effects in analyzing, is replacing the infills with diagonal compression strut with the same performance of real infill, instead of designing the whole infill. Because of too many uncertainties, codes and researchers gave many expressions that were not as the same as the others. The major intent of this paper is calculation the width of this diagonal strut, which has the most characteristics of infill. This paper by comprehensive on different parameters like the modulus of young or moment of inertia of columns presents a new formula for achieving the equivalent strut width. In fact, this new formula is extracted from about 60 FEM analyses models. It can be said that this formula is very efficient and accurate in estimating the equivalent strut width, considering the large number of effective parameters relative to similar relationships provided by other researchers. In most cases, the results are so close to the values obtained by the FEM. In this formula, the effect of out of plane buckling is neglected and this formula is used just in steel structures. Also, the thickness of infill panel, and the lateral force applied to frame are constant. In addition, this new formula is just for modeling the lateral stiffness. Obtaining the nearest response in analyzing is important to the designers, so this new formula can help them to reach more accurate response among a lot of experimental equations proposed by researchers.

• 대한본초학회지
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• 제30권4호
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• pp.57-64
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• 2015

Objectives : Oxidative stress is one of the most causes of hepatocyte injury. Gleditsia spina, the thorns ofGleditsia sinensisLam., has been known for its anti-cancer and anti-inflammatory effects in Korean medicine. The present study investigated hepatoprotective effect of Gleditsia spina water extract (GSE) against oxidative stress induced by arachidonic acid (AA) + iron in HepG2 cells.Methods : To investigate cytoprotective effect of GSE, cells were pretreated with GSE and then subsequently exposed to 10 μM AA for 12 h, followed by 5 μM iron. Cell viability was monitored by MTT assay, and expression of apoptosis-related proteins was examined by immunoblot analysis. To identify responsible molecular mechanisms, reactive oxygen species (ROS) production, GSH contents, and mitochondrial membrane potential were measured. In addition, effect of GSE on nuclear factor erythroid 2-related factor 2 (Nrf2) activation was determined by immunoblot and antioxidant response element (ARE)-driven reporter gene assays.Results : GSE pretreatment prevented AA + iron-mediated cytotoxicity in concentration dependent manner. In addition, ROS production, glutathione depletion, and mitochondrial impairment by AA + iron were significantly inhibited by GSE. Furthermore, GSE promoted translocation of Nrf2 to nucleus, which acts as essential transcription factor for induction of antioxidant genes. Increased nuclear Nrf2 that caused by GSE treatment promoted transcriptional activity of ARE. Finally, GSE up-regulated sestrin-2 which was widely recognized as target gene of Nrf2.Conclusions : This study demonstrates that GSE protects hepatocytes from oxidative stress via activation of Nrf2 signaling pathway.

• 한국방재안전학회논문집
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• 제12권1호
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• pp.1-9
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• 2019

교량을 건설함에 있어 물의 흐름에 영향을 받는 교량 하부 구조물에 대한 토질 및 구조역학적 기초 분석은 충분하지만 수리현상으로 발생하는 세굴의 안정성 검토는 미흡한 실정이다. 또한 교각세굴심 산정에 있어 해외 교각세굴심 산정식을 활용하고 있기에 국내 하천의 유역 특성을 반영한 교각세굴심을 정도 높게 산정하는데 미흡하다. 본 연구에서는 현재 우리나라 하천설계 기준에 적용되고 있는 CSU(1993)공식 뿐만 아니라 세굴심 산정에 있어 불확실성을 고려하기 위하여 다른 교각 세굴심 산정식을 추가로 적용하여 세굴심을 산정한 후 각각의 공식들 간에 적용성을 검토하였다. 검토 결과 기존 사용되고 있는 9개의 교각세굴심 산정식으로 산정된 교각 세굴심 깊이와 수리 모형실험을 바탕으로 측정된 세굴심과 비교하였을 경우 SSE(%)는 최소 2.08%, 최대 91.23%, SSEn(%)은 최소 0.19%, 최대 415.91%의 차이를 보이고 있음을 확인하였다. 그 결과, 교각세굴심 산정식 간에도 많은 차이가 있음을 확인하였다. 본 연구의 결과는 향후 하천설계에 있어 정도 높은 세굴심을 산정함에 활용할 수 있을 것으로 기대된다.

• 대한수학회논문집
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• 제33권2호
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• pp.619-630
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• 2018

In this paper, we obtain a (p, q)-extension of the Whittaker function $M_{k,{\mu}}(z)$ together with its integral representations, by using the extended confluent hypergeometric function of the first kind ${\Phi}_{p,q}(b;c;z)$ [recently extended by J. Choi]. Also, we give some of its main properties, namely the summation formula, a transformation formula, a Mellin transform, a differential formula and inequalities. In addition, our extension on Whittaker function finds interesting connection with the Laguerre polynomials.

• Journal of Nutrition and Health
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• 제31권1호
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• pp.80-87
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• 1998

Intestinal microflora in 17 breast-fed(BF) and 14 formula-fed (FF) newborn infants at about 1 week after birth were investigated to determine the floral differences of the two lactation groups. The fecal conditions were significantly different between the two groups in that the number of subjects who showed watery feces, and the times of defecation per day, were higher in the BF group. In addition, the mean fecal PH of the BF group was lower than that of the FF group. The dominant species in the BF groups which showed the highest count among the species of microflora was bifidobacteria , while the dominant species in the FF group was streptococci. The frequency of staphylococci and the count of bifidobacteria were significantly higher in the BF group. However, the frquencies of streptococci and Peptococcaceae were higher in the FF group. Through the differences were not significant, the frequency of bvifidobacteria and the count of staphylococci were higher in BF group, whereas the frequencies of bacteriodes, clostridia, enterobacter and the count of clostridia were higher in FF group.

• 대한한의학방제학회지
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• 제20권1호
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• pp.13-24
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• 2012

Objectives : Yukmijihwang-tang(Wan), a well-known formula for invigorating yin-particular kidney yin, was first recorded in "Xiao er Yao Zheng Zhi Jue", consisting of Radix Rehmanniae Preparata, Fructus Macrocarpii, Rhizoma Dioscoreae Oppositae, Poria, Rhizoma Alismatis and Cortex Moutan Radicis with dose proportion of 8:4:4:3:3:3. Although clinical trials have been lacking, various pharmacological actions for Yukmijihwang-tang has been identified newly using animal models. In addition, it was reported that Yukmijihwang-tang increases structural chromosome aberrations significantly in Chinese hamster lung cells. In this article, it is purposed that new studies for pharmacology and toxicology of Yukmijihwang-tang are reviewed. Insight into new studies of Yukmijihwang-tang at the cellular and animal levels will enhance our understanding of Yukmijihwang-tang against various diseases will provide new tools to diagnose and treat patients. Methods : Recent researches for Yukmijihwang-tang were reviewed and summarized in terms of pharmacological action and toxicity. All sources for review were based on recent studies loaded on data base of web sites such as Science Direct and National Center for Biotechnology Information. Results and Conclusions : Recently, reports showed that YMJ had antiaging effects, antioxidant and free radical scavenging activities, anti-renal hypertension and prevented tumors, and diabetes mellitus. However, there is little information on its safety except general toxicity, acute and sub-chronic oral toxicity, or genotoxicity. In addition, clinical trial for Yukmijihwang-tang was limited even though Yukmijihwang-tang has been used extensively in Korean traditional medicine. Thus, further studies are necessary to focus on safety evaluation and clinical trial for Yukmijihwang-tang.

• 한국태양에너지학회 논문집
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• 제38권5호
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• pp.11-25
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• 2018

The Ln-least method is commonly used to estimate the Weibull parameters from the observed wind speed data. In previous studies, the bin method has been used to calculate the cumulative frequency distribution for the Ln-least method. The purpose of this study is to obtain better performance in the Ln-least method by applying probability plotting position(PPP) instead of the bin method. Two types of the wind speed data were used for the analysis. One was the observed wind speed data taken from three sites with different topographical conditions. The other was the virtual wind speed data which were statistically generated by a random variable with known Weibull parameters. Also, ten types of PPP formulas were applied which were Hazen, California, Weibull, Blom, Gringorten, Chegodayev, Cunnane, Tukey, Beard and Median. In addition, in order to suggest the most suitable PPP formula for estimating Weibull parameters, two accuracy tests, the root mean square error(RMSE) and $R^2$ tests, were performed. As a result, all of PPPs showed better performances than the bin method and the best PPP was the Hazen formula. In the RMSE test, compared with the bin method, the Hazen formula increased estimation performance by 38.2% for the observed wind speed data and by 37.0% for the virtual wind speed data. For the $R^2$ test, the Hazen formula improved the performance by 1.2% and 2.7%, respectively. In addition, the performance of the PPP depended on the frequency of low wind speeds and wind speed variability.

• 한국수자원학회논문집
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• 제49권12호
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• pp.1007-1014
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• 2016

영국에서는 지역구분이 필요없고 상대적으로 긴 재현기간에 대해서도 안정적인 확률강우량 추정이 가능한 FORGEX (Focused Rainfall Growth Extension) 기법을 개발하여 강우자료의 지역빈도해석을 수행하고 있으며, 지역빈도해석에 적합한 모집단 성장곡선으로부터 네트워크 최대값(network maximum, netmax) 자료의 분포위치를 고려하기 위하여 영국 강우자료를 이용한 공간상관식(ln $N_e$)을 유도하였다. 이런 이유로 영국에서 개발된 공간상관식을 우리나라에 적용할 경우 부정확한 확률강우량을 산정하는 문제점이 발생한다. 이를 보완하기 위하여 본 연구에서는 우리나라 기상청 산하 유인관측소 지점 중 30년 이상의 긴 강우자료를 보유한 64개 지점의 강우자료를 이용하여 공간상관식을 유도하였다. 지점 간의 합리적인 비교를 위해 1973년부터 2014까지를 기준기간(reference period)으로 정하였고, 강우지속시간, 지점 수, 네트워크 면적 등 3가지 변수를 고려하여 공간상관식을 유도하였다. 유도된 공간상관식을 FORGEX 기법에 적용하여 지역빈도해석을 수행하였고, 기존의 영국식을 이용하여 산정한 확률강우량 값과 비교 분석하였다. 그 결과 우리나라 강우자료를 이용하여 새롭게 유도한 공간상관식은 기존의 영국식 보다 정확한 것으로 나타났고, 이를 FORGEX 기법에 적용한 결과 영국 공간상관식은 새롭게 개발한 공간상관식보다 확률강우량을 과소 추정하는 것으로 나타났다. 본 연구를 통하여 기존 FORGEX 기법에서 내포하고 있는 부정확성을 보완할 수 있고, 긴 재현기간에 대한 확률강우량을 보다 정확하게 추정할 수 있을 것으로 판단된다.

• 대한의용생체공학회:의공학회지
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• 제30권2호
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• pp.169-178
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• 2009

In this study, we suggest Korean nonlinear fitting formula (KNFF) to maximize speech intelligibility for digital hearing aids based on NAL-NL1 (NAL-nonlinear, version 1). KNFF was derived from the same procedure which is used for deriving NAL-NL1. KNFF consider the long-term average speech spectrum of Korean instead of English because the frequency characteristic of Korean is different from that of English. New insertion gains of KNFF were derived using the SII (speech intelligibility index) program provided by ANSI. In addition, the insertion gains were modified to maximize the intelligibility of high frequency words. To verify effect of the new fitting gain, we performed speech discrimination test (SDT) and preference test using the hearing loss simulator from NOISH. In the SDT, a word set as test material consists of 50 1-syllable word generally used in hearing clinic. As a result of the test, in case of moderate hearing loss with severe loss on high frequency, the SDT scores of KNFF was more improved about 3.2% than NAL-NLl and about 6% in case of the sever hearing loss. Finally we have obtained the result that it was the effective way to increase gain of mid-high frequency bands and to decrease gain of low frequency bands in order to maximize speech intelligibility of Korean.