• Archives of Plastic Surgery
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• 제44권6호
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• pp.496-501
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• 2017

Background Various surgical methods for repairing medial orbital wall fractures have been introduced. The conventional technique requires total separation of the displaced orbital bones from the orbital soft tissues. However, subperiosteal dissection around the fracture can cause additional damage. The aim of the present study is to introduce a method of reconstructing medial orbital wall fractures without subperiosteal dissection named the "push-out" technique. Methods Six patients with post-traumatic enophthalmos resulting from an old medial orbital wall fracture and 10 patients with an acute medial orbital wall fracture were included. All were treated with the push-out technique. Postoperative computed tomography (CT) was performed to assess the correct positioning of the implants. The Hertel scale and a comparison between preoperative and postoperative orbital volume were used to assess the surgical results. Results Restoration of the normal orbital cavity shape was confirmed by examining the postoperative CT scans. In the old fracture group, the median orbital volume of the fractured side was $29.22cm^3$ preoperatively, and significantly improved postoperatively to a value of $25.13cm^3$. In the acute fracture group, the median orbital volume of the fractured side was $28.73cm^3$ preoperatively, and significantly improved postoperatively to a value of $24.90cm^3$. Differences on the Hertel scale also improved, from 2.13 mm preoperatively to 0.25 mm postoperatively in the old fracture group and from 1.67 mm preoperatively to 0.33 mm postoperatively in the acute fracture group. Conclusions The push-out technique can be considered a good alternative choice for old medial orbital wall fractures with posttraumatic enophthalmos, acute medial orbital wall fractures including large fractured bone segments, and single-hinged greenstick fractures.

• Journal of Chest Surgery
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• 제31권4호
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• pp.402-408
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• 1998

1995년 3월 56세 여자환자가 계속 확장하는 만성 Debakey 1형 대동맥 박리증으로 대동맥궁 치환술을 시행하였다. 계속되는 박리의 전후 확장으로 대동맥궁의 혈류가 분리되었고, 가강이 복부대동맥까지 확장되어 있었다. 수술후 3시간 뒤에 갑작스러운 무뇨증이 발생하였고, 도플러 초음파와 대동맥촬영에서 신동맥으로의 혈류가 감소된 것이 발견되었다. 내막피판에 의한 급성 신부전으로 판단하고 대동맥 풍선확장술을 시행하였으나 실패하였다. 응급으로 복부대동맥 개창술을 시행하여 내막피판과 혈전을 제거하였다. 이후 환자는 경한 만성신부전 상태로 투석 치료없이 지내고 있다.

• Steel and Composite Structures
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• 제17권5호
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• pp.573-599
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• 2014

A new type of connection for steel-concrete composite bridges was developed by the Steel Structures Laboratory of Ecole Poytechinque $F{\acute{e}}d{\acute{e}}rale$ de Lausanne. Resistance to longitudinal shear is based on the development of shear stresses in the confined interfaces which form the connection. Confinement is provided by the reinforced concrete slab which encloses the connection and restrains the uplift (lateral separation) of the interfaces by developing normal stresses. The experimental investigation of the interfaces, under static and cyclic loading, enabled the development of the laws describing the structural behaviour of each interface. Those laws were presented by the authors in previous papers. The current paper focuses on the continuity of the research. It presents the experimental investigation on the new connection by means of push-out tests on specimens submitted to static and cyclic shear loading. Investigation revealed that the damage in the connection, due to cyclic loading, is expressed by the accumulation of a residual slip. A safe fatigue failure criterion is proposed for the connection which enabled the verification of the connection for the fatigue limit state with respect to the limit of fatigue. A numerical model is developed which takes into account the laws describing the interface behaviour and the analytical expressions for the confinement effect, the latter obtained by performing finite element analysis. This numerical model predicts the shear resistance of the connection and enables to assess its fatigue limit which is necessary for the fatigue design proposed.

• 한국식품과학회지
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• 제44권5호
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• pp.638-642
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• 2012

돼지축사에서 채집해온 6개의 육성돈의 분변에서 식중독 유발 바이러스인 HAV와 HEV를 검출하였으며, HAV는 88.3%의 검출율을 보였으며, HEV는 33.3%의 검출율을 보였다. 결과에는 제시하지 않았으나, 염기서열 분석결과 HEV는 사람에게 전염이 가능한 유전자형인 III형이었으며, 실험적으로 사람의 간세포인 PLC/PRF/5에 접종하였을 때 증식이 됨을 확인하였다. 식중독 유발 바이러스인 HAV와 HEV는 오염된 식품이나 물을 섭취하거나 교차 오염에 의해 전염이 가능하기 때문에 돼지축사에서 위생상태의 개선뿐만 아니라 육류를 섭취하기 전인 운송 및 가공과정까지 식중독 유발 바이러스에 의한 교차오염을 막는 노력이 필요하다. HAV와 HEV 모두 검출된 분변에서 HAV를 순수분리하고 빠르게 검출하기 위해 IMS-RT-PCR을 적용하였으며, 항원-항체 반응에 의해 순수하게 HAV만을 분리할 수 있었다. 또한 HAV만이 순수분리 되었는지 재확인하기위해 세포감염을 통해 증식된 바이러스를 확보한 후 nested RT-PCR을 수행한 결과, HAV만을 순수 분리할 수 있음을 확인하였다. 이는 IMS 활용기술이 단순히 항체를 교체함으로써 다른 특정 식중독 유발 바이러스의 다양한 시료에서 바이러스 순수분리 및 검출에 활용 가능성이 있음을 확인하였다.

• Clinics in Shoulder and Elbow
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• 제24권4호
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• pp.209-214
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• 2021

Background: The treatment for acromioclavicular joint injuries (ACJI) ranges from a conservative approach to extensive surgical reconstruction, and the decision on how to manage these injuries depends on the grade of acromioclavicular (AC) joint separation, resources, and skill availability. After a thorough review of the literature, the researchers adopted a simple cost-effective technique of AC joint reconstruction for acute ACJI requiring surgery. Methods: This was a prospective single-center study conducted between April 2017 and April 2018. For patients with acute ACJI more than Rockwood grade 3, the researchers performed open coracoclavicular ligament reconstruction using synthetic sutures along with an Endobutton and a figure of 8 button plate. This was followed by AC ligament repair augmenting it with temporary percutaneous AC K-wires. Clinical outcomes were evaluated using the Constant Murley shoulder score. Results: Seventeen patients underwent surgery. The immediate postoperative radiograph showed an anatomical reduction of the AC joint dislocation in all patients. During follow-up, one patient developed subluxation but was asymptomatic. The mean follow-up period was 30 months (range, 24-35 months). The mean Constant score at 24 months was 95. No AC joint degeneration was noted in follow-up X-rays. The follow-up X-rays showed significant infra-clavicular calcification in 11 of the 17 patients, which was an evidence of a healed coracoclavicular ligament post-surgery. Conclusions: This study presents a simple cost-effective technique with a short learning curve for anatomic reconstruction of acute ACJI. The preliminary results have been very encouraging.

• 천문학회보
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• 제44권2호
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• pp.72.1-72.1
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• 2019

Symbiotic stars are wide binary systems of a white dwarf and a mass losing giant, exhibiting various activities mainly attributed to accretion of a fraction of slow stellar wind emanating from the giant. We perform 3 dimensional hydrodynamical simulations using the FLASH code to investigate the formation and physical structures of an accretion disk in symbiotic stars with binary separation in the range of 2-4 au. Radiative cooling is introduced in the flow in order to avoid acute pressure increase in the vicinity of the accretor that may prevent stable disk formation. By setting the same density condition in front of the bow shock generated in two different velocity fields, the role of ram pressure balancing between the disk and the wind is examined. We find that three main streams (direct stream from the giant, stream following the accretion wake, and stream passing through the bow shock front) all feed the disk, and their individual contributions on the mass accretion onto the white dwarf are explored.

• 한국식품저장유통학회지
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• 제21권2호
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• pp.170-174
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• 2014

식중독 유발 바이러스인 HAV는 제 1군 감염병원으로 규정되면서 감염 시 원인식품을 빠르게 분석하게 되었으며 그로 인해 정확하면서 빠른 검출기술을 요구하게 되었다. 본 연구에서는 HAV에 오염된 상추에서 신속하게 바이러스를 검사하기 위해서 IMS를 통하여 신속하게 HAV를 순수 분리 및 농축하였고, 형광물질인 quantum dot을 활용하여 형광검출을 실시하였다. 또한 일반적으로 바이러스 농축에 사용되는 PEG 농축방법과 비교하였을 때 검출능은 유사한 결과를 얻었으나, 농축시간 면에서는 IMS를 통한 방법이 효과적이었다. 또한 IMS 방법으로 확보된 항원을 Quantum dot을 활용하여 10분 이내에 바이러스를 검출할 수 있었다. 본 연구에서 제시된 검출기반은 식품 유통 과정 중 다양한 식중독 바이러스로부터 소비자를 보호 할 수 있는 검사방법으로 활용될 수 있다고 기대된다.

• 한국어병학회지
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• 제9권2호
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• pp.147-155
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• 1996

수온과 pH가 높은 조건에서 뱀장어에 미치는 암모니아 급성독성에 대하여 육안적인 면과 병리조직학적 변성을 관찰하였다. 육안 관찰 결과, 암모니아 무첨가구(0 mg/$\ell$)에서는 pH 8.5이상에서 아가미의 암갈색화가 진행되었고 암모니아 20 mg/$\ell$ 이상의 농도에서는 pH 7.5에서도 위와 같은 증상이 나타났다. pH 9.0에서는 암모니아 10 mg/$\ell$이상의 농도에서 1시간 이내에 전부 폐사했다. 아가미에 대한 조직학적 관찰 결과는 암모니아 무첨가구의 pH 7.5에서만 정상 조직이 관찰되었고 수온과 pH의 상승, 암모니아 농도의 증가 및 노출시간의 경과에 따라 조직의 변성이 심해지는 경향을 보였다. 암모니아 무첨가구의 pH 8.0, 8.5에서도 2차새변의 부종과 만곡증상이 보였고 pH 9.0에서는 2차새변 상피의 박리증상이 나타난 것으로 보아 높은 pH 조건만으로도 병변을 일으키는 요인이 될 수 있는 것으로 사료된다. 조직학적 변성의 초기에는 2차새변의 부종과 만곡증상이 보이다가 상피세포의 박리와 괴사로 진행 되었으며, 특히 2차새변상피의 박리증상은 육안적으로 관찰되는 아가미의 암갈색으로 변색시점과 비슷한 시기에 관찰되었다. 암모니아 20 mg/$\ell$이상에서는 pH 8.5, 수온 $27^{\circ}C$ 조건에서 2차새변상피의 괴사가 일어났고, 수온 $32^{\circ}C$에서는 노출시간이 경과하면서 폐사체가 생겼다.

• International Journal of Fluid Machinery and Systems
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• 제3권3호
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• pp.260-270
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• 2010

Reducing the losses of the tip clearance flow is one of the keys in an unshrouded centrifugal compressor design and development because tip clearances are large in relation to the span of the blades and also centrifugal compressors produce a sufficiently large pressure rise in single stage. This problem is more acute for a low flow high-pressure ratio impeller design. The large tip clearance would cause flow separations, and as a result it would drop both the efficiency and surge margin. Thus a design of a high efficiency and wide operation range low flow coefficient centrifugal compressor is a great challenge. This paper describes a recent development of high efficiency and wide surge margin low flow coefficient centrifugal compressor. A viscous turbomachinery optimal design method developed by the authors for axial flow machine was further extended and used in the centrifugal compressor design. The compressor has three main parts: impeller, a low solidity diffuser and volute. The tip clearance is under a special consideration in this design to allow impeller insensitiveness to the clearance. A patented three-dimensional low solidity diffuser design method is used and applied to this design. The compressor test results demonstrated to be successful to extend the low solidity diffusers to high-pressure ratio compressor. The compressor stage performance showed the total to static efficiency of the compressor being about 85% and stability range over 35%. The test results are in good agreement with the design.

• 한국자기공명학회논문지
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• 제15권1호
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• pp.54-68
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• 2011

$^1H$ nuclear magnetic resonance (NMR) spectroscopy of biological samples has been proven to be an effective and nondestructive approach to probe drug toxicity within an organism. In this study, ketoprofen toxicity was investigated using $^1H$-NMR spectroscopy coupled with multivariate statistical analysis. Histopathologic test of ketoprofen-induced acute gastrointestinal damage in rats demonstrated a significant dose-dependent effect. Furthermore, principal component analysis (PCA) derived from $^1H$-NMR spectra of urinary samples showed clear separation between the vehicle-treated control and ketoprofen-treated groups. Moreover, PCA derived from endogenous metabolite concentrations through targeted profiling revealed a dose-dependent metabolic shift between the vehicle-treated control, low-dose ketoprofen-treated (10 mg/kg body weight), and high-dose ketoprofen-treated (50 mg/kg) groups coinciding with their gastric damage scores after ketoprofen administration. The resultant metabolic profiles demonstrated that the ketoprofen-induced gastric damage exhibited energy metabolism perturbations that increased urinary levels of citrate, cis-aconitate, succinate, and phosphocreatine. In addition, ketoprofen administration induced an enhancement of xenobiotic activity in fatty oxidation, which caused increase levels of N-isovalerylglycine, adipate, phenylacetylglycine, dimethylamine, betaine, hippurate, 3-indoxylsulfate, N,N-dimethylglycine, trimethyl-N-oxide, and glycine. These findings demonstrate that $^1H$-NMR-based urinary metabolic profiling can be used for noninvasive and rapid way to diagnose adverse drug effects and is suitable for explaining the possible biological pathways perturbed by nonsteroidal anti-inflammatory drug toxicity.