• Childhood Kidney Diseases
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• 제19권1호
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• pp.43-47
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• 2015

Hemolytic anemia and thrombocytopenia are rare clinical manifestations of acute glomerulonephritis. Initially, in all such cases, a diagnosis of hemolytic uremic syndrome, thrombotic thrombocytopenic purpura, systemic lupus erythematosus, and amyloidosis should be ruled out. The presence of hemolytic anemia and thrombocytopenia is rare, but possible, in a case of acute poststreptococcal glomerulonephritis, and may result in delayed diagnosis or misdiagnosis. Correct and timely diagnosis would ensure adequate treatment in such patients. We report of a 22-month-old boy with acute glomerulonephritis coexistent with hemolytic anemia and idiopathic thrombocytopenia.

• 동의생리병리학회지
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• 제22권1호
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• pp.212-215
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• 2008

This study was designed to evaluate of oriental treatment on the sinsimtong With Acute glomerulonephritis Patient. We used oriental treatment for a patient who have the sinsimtong which has been caused by the Acute glomerulonephritis. After treated with oriental treatment, the symptoms of the Acute glomerulonephritis are disappeared. Form the above result, it could be suggest that oriental treatment have good effect on the sinsimtong With Acute glomerulonephritis Patient.

• Childhood Kidney Diseases
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• 제4권2호
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• pp.154-160
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• 2000

IgA 신병증은 메산지움에 면역글로불린 A가 침착되는 질환으로 소아 연령에서 혈뇨의 흔한 원인 질환이며, 급성 감염후 사구체신염은 IgA 신병증 다음으로 소아 연령에서 흔한 혈뇨의 원인이다. IgA 신병증과 급성 감염후 사구체신염의 병태생리학적 기전은 아직 명확하게 밝혀지지 않고 있다. 그러므로 이 질환들 간의 병태생리학적 연관관계, 즉 연쇄상구균 감염이 IgA 신병증의 유발 혹은 악화 인자가 될 수 있는지, 또는 임상양상과 예후에도 어떤 영향을 미칠 수 있는지에 대해서는 더욱 알려진 것이 없다. 저자들은 임상적 및 병리학적 소견으로 IgA 신병증에 병발한 급성 연쇄상구균 감염후 사구체 신염으로 진단할 수 있는 증례 2례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• Childhood Kidney Diseases
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• 제7권2호
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• pp.217-222
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• 2003

저자들은 만성 육아종 질환에 동반된 APSGN을 경험하였기에 문헌 고찰과 함께 보고한다.

• Childhood Kidney Diseases
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• 제8권2호
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• pp.239-243
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• 2004

저자들은 두통, 안면 부종, 고열 및 옆구리 통증 등을 주소로 내원한 5세 여아에서 특징적인임상 양상과 검사 소견 등을 통하여 첫 발병시에 E. coli 감염에 의한 급성 신우신염이 병발한 급성 연쇄상구균 감염후 사구체신염으로 진단하고 치료한 증례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• Childhood Kidney Diseases
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• 제1권1호
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• pp.73-78
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• 1997

The hypertensive encephalopathy is one of sudden convulsive cause in patients with acute post-streptococcal glomerulonephritis, but commonly, after the episode we can observe only mild to moderately hypertension in APSGN at ER. So these remains some question of what causes the convulsion in patients with APSGN. In this article, we report 3 cases of convulsion in APSGN with only moderate hypertension, the etiology of which proved to be due to hypertensive encephalopathy by the brain MRI. We believe that the brain MRI is a very useful test to diagnose the etiology of convulsion in APSGN and if brain edema in occipital lobe is detected by brain MRI, the convulsion would be due to hypertensive encephalopathy and the prognosis will be very good.

• Childhood Kidney Diseases
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• 제1권1호
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• pp.82-85
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• 1997

The incidence of nephritis associated with Henoch-Sch nlein purpura varies, but glomerulonephritis consistently accounts for most of the associated morbidity and mortality. A very small number of Henoch-Sch nlein purpura develop rapidly progressive glomerulonephritis. A three-year old male patient who showed acute nephritic nephrotic syndrome developed abdominal pain, arthralgia and multiple purpurae on lower extremities later. Peritoneal dialysis was done at the 6th hospital day and continued for 7 months. Renal biopsy disclosed crescentic glomerulonephritis (with 81% crescent formation) and methylprednisolone pulse therapy was done. These days, his general condition is good, but serum creatinine levels are 1.2-1.3 mg/dL. This case was reviewed briefly with the literatures.

• Clinical and Experimental Pediatrics
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• 제59권3호
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• pp.145-148
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• 2016

Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is a rare and potentially fatal condition characterized by skin rash, fever, eosinophilia, and multiorgan involvement. Various drugs may be associated with this syndrome including carbamazepine, allopurinol, and sulfasalazine. Renal involvement in DRESS syndrome most commonly presents as acute kidney injury due to interstitial nephritis. An 11-year-old boy was referred to the Children's Hospital of Pusan National University because of persistent fever, rash, abdominal distension, generalized edema, lymphadenopathy, and eosinophilia. He previously received vancomycin and ceftriaxone for 10 days at another hospital. He developed acute kidney injury with nephrotic range proteinuria and hypocomplementemia. A subsequent renal biopsy indicated the presence of acute tubular necrosis (ATN) and late exudative phase of postinfectious glomerulonephritis (PIGN). Systemic symptoms and renal function improved with corticosteroid therapy after the discontinuation of vancomycin. Here, we describe a biopsy-proven case of severe ATN that manifested as a part of vancomycin-induced DRESS syndrome with coincident PIGN. It is important for clinicians to be aware of this syndrome due to its severity and potentially fatal nature.

• Childhood Kidney Diseases
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• 제10권2호
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• pp.119-124
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• 2006

Purpose : The prognosis of acute poststreptococcal glomerulonephritis(APSGN) has been reported to be favorable. However, several studies have reported that patients with nephrotic range proteinuria in the acute phase or persistent proteinuria may progress to chronic renal failure. To elucidate this further, we analyzed the features of proteinuria and its prognosis in pediatric patients with APSGN. Methods : A total of 48 children with APSGN admitted to our hospital between Jan. 2000 and Dec. 2004 were included. After discharge from the hospital, patients were regularly followed up every month by clinical evaluations and laboratory tests including routine urinalysis and quantification of proteinuria. Results : Age of the patients ranged from 3 to 15 years(median 5.8 years) at the time of disease onset. Proteinuria was present in 34(70.8%) patients and 5 of them showed heavy proteinuria. Proteinuria normalized within one month in most patients(82.3%) and there was no one with proteinuria after 6 months. Cyclosporine A(5 mg/kg/day in two divided doses) was given to 3 patients with massive proteinuria that lasted longer than 2 months and the result was complete remission within 4 months. Conclusions : Our data indicated that the prognosis of APSGN during childhood is excellent. Children with severe proteinuria or subnormal renal function in poststreptococcal glomerulonephritis had favorable prognosis without chronic renal failure, and children with crescentic formation also had favorable prognosis. Three patients who continued to have heavy proteinuria for more than 2 months received cyclosporine A and remission of proteinuria was achieved within a couple of months.

• Clinical and Experimental Pediatrics
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• 제48권6호
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• pp.606-613
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• 2005

목 적 : APSGN은 소아에서 흔히 볼 수 있는 급성 사구체 신염의 하나로, 대부분의 환자에서 급성기 이후 완전한 회복을 보이지만, 소수의 환자에서는 급성기 합병증으로 사망하거나, 이후에 만성 신부전으로 진행하기도 하는 것으로 알려져 있다. 최근 과거에 비하여 발생빈도가 줄어들었으나, 여전히 소아에서 흔히 볼 수 있는 신질환으로 최근 10년간의 임상 양상을 살펴보고, 과거의 보고들과의 차이를 알아보고자 하였다. 방 법 : 1994년 1월부터 2003년 12월까지 서울아산병원 소아과에서 APSGN으로 진단받고 입원 또는 외래 치료를 시행한 105명의 환아를 대상으로 후향적으로 의무기록을 검토하여 연구하였다. 결 과 : APSGN으로 진단받은 환아들의 남녀비는 2 : 1이었고, 평균연령은 $8.5{\pm}2.6$세였다. 연평균 발생 비율은 $10.5{\pm}4.9$였고, 연중 발생을 살펴보면 대부분(60.0%)의 환아가 10월에서 1월 사이에 발생하였다. 내원 당시 부종이 82명(78.1%), 육안적 혈뇨 70명(66.7%), 고혈압 50명(47.6%), 핍뇨 22명(20.9%)에서 나타났고, 현미경적 혈뇨 105명(100%), ASO 양성 99명(94%), C3 감소 96명(91.45), 단백뇨 67명(63.8%)에서 나타났고, BUN이 증가한 경우가 38명(26.2%)였다. C3가 감소하였던 96명 중 70명(75.3%)에서 8주째 정상으로 회복되었다. 22명의 환아에서 신장조직 검사를 시행하였다. 급성기 증상은 대부분의 환아에서 1-2주 사이에 소실되었다. 결 론 : APSGN의 임상양상은 과거의 연구들과 비교하여 큰 차이가 없었고, 급성기 회복률 및 단기예후는 우수하였다.