• Korean Journal of Acupuncture
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• 제24권4호
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• pp.181-200
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• 2007

Objevtives & Methods : Effects of cultivated wild ginseng pharmacopuncture at BL18 and LI11 on lipid composition, cytokine level, liver function, anti-oxidative capacity and histological characters were investigated in diet-induced obese rats. Forty male Sprague-Dawley rats weighing about 400g were divided into 4 groups of control, BL18, LI11 and BL18 plus LI11 pharmacopuncture groups and raised for 4 weeks. Results : 1. Plasma ${\beta}$-lipoprotein, free fatty acids level and TNF-${\alpha}$ levels significantly decreased in the pharmacopuncture groups compared to those of no treatment group. Plasma and liver total cholesterol, triglyceride, glucose and thiobarbituric acid reactive substance (TBARS) levels were also significantly lower than those of no treatment group. There was, however, no difference in TBARS level among pharmacopuncture groups. Liver total cholesterol level of BL18 pharmacopuncture group was lower than those of the other two pharmacopuncture groups. In LDL-cholesterol level, BL18 pharmacopuncture and BL18 plus LI11 pharmacopuncture groups only had significantly lower levels than that of no treatment group. 2. There was no significant difference between cultivated wild ginseng pharmacopuncture groups and no treatment group in IL-6, alanine transaminase (ALT), aspartic acid transaminase (AST) levels. 3. Compared with \ those of no treatment group, pharmacopuncture groups had significantly higher levels of HDL-cholesterol, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase activities. There was, however, no significant difference among pharmacopuncture groups. 4. Histological characters of heart, kidney and liver of BL18 pharmacopuncture group were similar to those of normal rats. Conclusions : These results indicate that cultivated wild ginseng pharmacopuncture at BL18 and LI11 may suppress adipose tissue mass and lipid peroxidation and activate antioxidant system.

• 한국의사학회지
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• 제23권2호
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• pp.1-13
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• 2010

The early Joseon era was a period when various medical systems were established and many medical literatures were published. Hwang Ja-hu(黃子厚) was a civil minister and medical professional who worked hard for maintaining government administrative system and medical regime during the Taejong and Sejong reign. Hwang Ja-hu followed his father and made MiReukWon(彌勒院) prosperous for the homeless people around Chungcheong-do Hoedeok. Hwang Ja-hu was talented in policy development as a government official. He was also learned in medicine, thus always doubled as head of JeonUiGam(典醫監). Hwang Ja-hu reformed the irrationalities in medical regime. He legalized JeonUiGam duties such as the presenting of the medicine or the preparation of the medicine and had the doctors take charge. He also suggested training acupuncture specialists(鍼灸專門醫). Hwang Ja-hu played a leading role in spreading HyangYak(鄕藥) throughout the country and reissuing [HyangYakGuGeupBang(鄕藥救急方)] due to personal philanthropism and service. He tried to defeat illnesses by letting the common people understand the symptoms and use medicine accordingly. Also he intended [HyangYakGuGeupBang(鄕藥救急方)] which was written focused on 'easiness book'(簡易方), 'experience book'(經驗方) to be used for the common people because [HyangYakJipSungBang(鄕藥集成方)] was made up a huge volume andused for training medical professionals and for accumulating knowledge. Hwang Ja-hu pursed subdivision of medical systems and specialization of medicine but also promoted medical rights. We should continue to discover and introduce medical figures who understood medicine and improved the medical systems.

• 한국의사학회지
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• 제23권2호
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• pp.81-87
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• 2010

1. An analysis of "GuGeupGanIBang(救急簡易方)" through Gwakran(霍亂) showed that the reference books are not concretely cited, but the symptoms are described in detail ed to let the common people understand and deal with Gwakran(霍亂) easily. It has the most detailed among Korean annotation emergency treatment books. It focuses on moxibustion and hot medicinal compress rather than acupuncture. The Korean annotation is translated in the order of the Korean language, so anyone can execute the treatments. The annotation used a lot of active verbs, so it is more of a book for the patient, not the doctor. So we can understand that this book is focused on the practical tips at an actual emergency situation. 2. "GuGeupGanIBang(救急簡易方)" is the most complete emergency treatment book and a Hangul medical book, which is scarce. It was published shortly after the invention of Hangul. It is an important material showing how terms related to medicine such as disease, prescriptions, symptoms were understood and expressed. As it is important in both medical book presswork study and Korean language study, it is designated as treasure. 3. The existing "GuGeupGanIBang(救急簡易方)" seem to be a reissued version. It is also not complete and scattered in several places. Volumes 1,2,3,6 and 7 survived, and volumes 4,5 and 8 have not been found yet.

• 대한약침학회지
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• 제5권2호
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• pp.52-62
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• 2002

Objectives : The purpose of this study was to investigate the effects of Bee Venom on NO, $H_2O_2$ expression induced by LPS in Raw 264.7 cells as a murine marcrophage cell line and on IL-1 expression induced by LPS in D10S cells. Methods : The expression of NO was measured by MTT Assay and IL-1 by MTS Assay. The expression of $H_2O_2$ was measured as ROS level within the cell using by FACS analysis. The non-toxic concentration(from $0.1\;{\mu}g/ml\;to\;5\;{\mu}g/ml$) of Bee Venom was determined by MTT Assay. Results : 1. Bee Venom inhibited the NO expression. The effective concentration of Bee Venom was $5\;{\mu}g/ml$ after 3 hours, 1 and $5\;{\mu}g/ml$ after 1 day and 2 days. The all concentration of Bee Venom inhibited the NO expression after 6, 12 hours and 3 days. 2. Bee Venom inhibited the $H_2O_2$ expression in a dose-dependent manner compared to the control. 3. Bee Venom could not significantly inhibit the IL-1 expression.

• 대한약침학회지
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• 제10권3호
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• pp.121-126
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• 2007

Objectives Hand paresthesia is common syndrome and the cause is more unknown than known reason. The Purpose of this study were investigated the effects of Myofacial Pain Syndrome theory to make diagnosis and treatment by Pharmacopuncture for the patients of hand paresthesia. Method This study was carried out to established the clinical criteria of hand parethesia. The patients who had past history of diabeics, neuropathy induced by alcohol or drug were excluded, and 86 patients who had hand paresthesia related with unknown-reason was selected by the interview process. And the effects of Pharmacopuncture theory were analyzed using VAS score before and after treatment. Results and conclusions 56.9% of unknown-reason patients are positive at diagnosis by MPS theory. While positive group decrease from $62.81{\pm}14.27$ to $25.28{\pm}15.97$, negative group decrease from $55.88{\pm}10.92$ to $48.28{\pm}14.01$ by VAS scores. Positive group was accordingly more effective than negative group. So diagnosis and treatment for hand numbness patients by MPS theory was useful in clinical.

• 대한약침학회지
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• 제11권3호
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• pp.5-16
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• 2008

Objective: We took intravascular threadlike structures from rat aortas to investigate their histological characteristics consistent with the intravascular Bonghan duct. Methods: Gomori s silver impregnation method, in addition to routine hematoxylin and eosin staining, was applied to demonstrate the characteristic feature of the intravascular threadlike structures. Results: These two staining methods clearly showed that the intravascular threadlike structures had unique features of argyrophilic reticular fibers and heavily stained oval or rod-shaped nuclei in them. Conclusion: The results are strong evidences for identifying threadlike structure as the intravascular Bonghan duct.

• 대한약침학회지
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• 제14권2호
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• pp.15-24
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• 2011

Background: Type I allergy is involved in allergic asthma, allergic rhinitis, and atopic dermatitis which are accompanied by an acute and chronic allergic inflammatory responses. Rehmannia glutinosa is a traditional medicine in the East Asian region. This study examined whether a Rehmannia Glutinosa pharmacopuncture solution (RGPS) had anti-allergic or anti-inflammatory effects in antigen-stimulated-RBL-2H3 cells. Methods: We determined the effect of RGPS on cell viability using the 3-[4,5-dimethylthiazolyl]-2,5-diphenyltetrazolium bromide (MTT) assay. We also examined the effect of RGPS on the release of ${\beta}$-hexosaminidase and the secretion of IL-4 and TNF-${\alpha}$ using ELISA. In addition, we evaluated the effect of RGPS on the mRNA expression of various cytokines; IL-2, IL-3, IL-4, IL-5, IL-13 and TNF-${\alpha}$ using RT-PCR. Furthermore, we assessed the activation of mitogen-activated protein kinases (MAPKs) and nuclear factor (NF)-${\kappa}$B using Western blotting after RGPS treatment. Results: We found that RGPS ($10^{-4}$ to $10^{-1}$ dilution) did not cause any cytotoxicity. We observed significant inhibition of ${\beta}$-hexosaminidase release and suppression of the protein secretion of IL-4 and TNF-${\alpha}$ and mRNA expression of multiple cytokines in antigen-stimulated-RBL-2H3 cells after RGPS treatment. Additionally, RGPS suppressed not only the phosphorylation of MAPKs, but also the transcriptional activation of NF-${\kappa}$B in antigen-stimulated-RBL-2H3 cells. Conclusions: These results suggest that RGPS inhibits degranulation and expression of cytokines including IL-4 and TNF-${\alpha}$ via down-regulation of MAPKs and NF-${\kappa}$B activation in antigen-stimulated-RBL-2H3 cells. In conclusion, RGPS may have beneficial effects in the exerting anti-allergic or anti-inflammatory activities.

• 대한한방내과학회지
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• 제23권2호
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• pp.244-252
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• 2002

Functional dyspepsia refers to upper abdominal pain or discomfort with or without symptoms of early satiety, nausea, or vomiting with no definable organic cause. In this study, we recognized that dyspepsia was decreased with herbal medication (Banhabakchulchunma-tang) and acupuncture therapy. And we aimed to evaluate the Gastrointestinal Symptoms Rating Scale (GSRS) in these cases. The GSRS indicated that Oriental medicine treatment could be effective in the Functional dyspepsia. And it is helpful in decreasing symptoms of patients and in improving quality of life.

• 대한한방내과학회지
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• 제35권3호
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• pp.366-372
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• 2014

Objectives: This is a report of a case of a stage IV non-small-cell lung cancer (NSCLC) patient whose malignant pleural effusion & respiratory symptoms have been relieved with Korean medicinal prescription, modified Yieum-jeon. Methods: A 56-year-old male diagnosed with stage IV NSCLC suffering malignant pleural effusion with complaints of cough, sputum, bilateral leg edema, dysphagia, post neck and left scapular pain was treated with modified Yieum-jeon and acupuncture during 16days. After treatment, blood lab and chest X-ray were used to follow the condition of malignant pleural effusion & pulmonary symptoms. Results: Malignant pleural effusion and pulmonary symptoms were improved with modified Yieum-jeon intake without any related adverse side effects. Conclusions: This study suggests Yieum-jeon may play a positive role in improving the malignant pleural effusion symptoms in advanced lung cancer cases.

• 대한한방내과학회지
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• 제39권4호
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• pp.784-793
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• 2018

Objective: Chronic migraine is a headache syndrome accompanied by nausea, dyspepsia, depression, and insomnia and it reduces the quality of life. The present case revealed that Korean medicine treatment and Functional Cerebrospinal Therapy (FCST) can reduce headache and nausea in patients with chronic migraine. Method: A 39-year-old female patient with chronic migraine visited Dunsan Korean Medicine Hospital. She had headache combined with moderate nausea and wanted to reduce her dose of almotriptan. We treated her with Korean medicine, including acupuncture, herbal medicine, and a Chuna treatment based on FCST. We evaluated her symptoms using a Numeric Rating Scale (NRS) for headache and nausea every day. Result: After 22 days of treatment, the NRS of headache and nausea had reduced. Her dose of almotriptan was also reduced and the patient felt improvement of in her quality of life. Conclusion: We suggest that Korean medicine treatment combined with FCST can improve the headache and nausea of chronic migraine patients.