• 통합자연과학논문집
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• 제5권2호
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• pp.107-119
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• 2012

Polymerization of monomeric amyloid-${\beta}$ peptides ($A{\beta}$) into soluble oligomers and insoluble fibrils is one of the major pathways triggering the pathogenesis of Alzheimer's disease (AD). Using small molecules to prevent the polymerization of $A{\beta}$ peptides can, therefore, be an effective therapeutic strategy for AD. In this study, we investigated the effects of mono- and bi-flavonoids on $A{\beta}42$ toxicity and fibrillogenesis and found that the bi-flavonoid, taiwaniaflavone (TF) effectively and specifically inhibits $A{\beta}$ toxicity and fibrillogenesis. Compared to TF, the mono-flavonoid apigenin (AP) is less effective and less specific. Our data showed that differential effects of the mono- and bi-flavonoids on $A{\beta}$ fibrillogenesis correlate with their varying cytoprotective efficacies. We also found that other bi-flavonoids, namely 2',8"-biapigenin, amentoflavone, and sumaflavone, can also effectively inhibit $A{\beta}$ toxicity and fibrillogenesis, implying that the participation of two mono-flavonoids in a single bi-flavonoid molecule enhanced their activity. Bi-flavonoids, while strongly inhibited $A{\beta}$ fibrillogenesis, accumulated nontoxic $A{\beta}$ oligomeric structures, suggesting that these are off-pathway-oligomers. Moreover, TF abrogated the toxicity of preformed $A{\beta}$ oligomers and fibrils, indicating that TF and other bi-flavonoids may also reduce the toxicity of toxic $A{\beta}$ species. Altogether, our data clearly show that bi-flavonoids, possibly due to the possession of two $A{\beta}$ binders separated by an appropriate size linker, are likely to be promising therapeutics to suppress $A{\beta}$ toxicity.

• Perspectives in Nursing Science
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• 제6권1호
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• pp.21-37
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• 2009

The purpose of this GWP project was two-fold:(1) to launch an organizational culture improvement for great workplace (2) to improve the perception of nursing personnel on communication and team work in a surgical nursing department of a teaching hospital in Seoul. Using one group pretest-posttest design, nursing personnel's perception on organizational culture related to communication and team work was evaluated. A 10-item, 5-point scale (1.5) survey was administered to 209 nursing personnel in January 2009 and again to 191 nursing personnel in October 2009. From January 2009, AMANNA team has taken activities focused on trust, pride, and fun. AMANNA is an abbreviation of Korean language, which means wonderful meeting and sharing in English. Monthly activities are as follows: choral concerts by nurse managers, welcome and farewell events, praising members for their services, explaining current circumstances, etc. Special activities are as follows: a New Year's greeting party, a spring picnic, beauty classes, a lecture on drug administration, cultural lectures using videos, and presentations of academic posters and another activity. The reliability of measurement was Cronbach's ${\alpha}$: 0.917(pretest), 0.954(posttest). Most nursing personnel's perception on organizational culture was improved (pretest mean=3.50 and posttest mean=3.78, p<.001). "A sense of belonging" showed the greatest improvement among the 10 items(3.18 vs. 3.56, p<.001). "Trust each other" showed the highest score (mean=3.98) in posttest. Frequency of participation and satisfaction showed a significant relationship(r=0.179, p=.021). We believe that this project has made a contribution towards a positive organizational culture. The keys to this initiative's preliminary success have been the leadership support and flexibility in implementing the interventions tailored to the hospital.

• 디지털융복합연구
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• 제14권12호
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• pp.515-524
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• 2016

연구의 목적은 문화예술교육 프로그램이 장애 청소년에게 미치는 영향을 알아보는 데 있다. 문화예술교육 프로그램 중 공예교육활동으로 구성하였으며 다학문간 융합교육을 지향하였다. 본 연구의 실행을 위해 고등학교 특수학급에 재학 중인 발달장애 청소년 7명을 대상으로 교육회기 이후 한 달간 심층인터뷰를 실시하였으며 연구결과는 다음과 같이 도출되었다. 첫째 일반학급에서는 경험하기 힘들었던 학문의 즐거움과 유쾌함, 흥미를 보였다. 둘째, 수업참여의 긴장감이 완화되며 교육활동을 통해 편안함을 느끼며, 공예교육에 대해 긍정적인 태도를 보였다. 셋째, 사회 정서적 영역에서는 협동 활동을 통한 함께 있음, 공존의 느낌을 받았으며, 친구와 교사로부터 지지와 도움의 경험을 하게 되었다. 넷째, 교육활동을 통해 자신의 생각을 나누고, 친구들의 이야기를 경청하고 함께 만들어낸 작품에 대해 이야기 하며 친밀한 관계의 경험을 나눌 수 있었다.

• 대한지역사회영양학회지
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• 제9권6호
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• pp.725-733
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• 2004

It was well received that well grounded behavioral theories were important in the development of effective nutrition education programs, but there are only a few programs available for Korean women. The objective of this study was to develop nutrition education programs for childbearing-aged women in Korea. Based on the findings of the needs assessment for the program and theoretical backgrounds, we developed behaviorally oriented tailored nutrition education program including motivation (MT), modifying (MD) and maintenance (MA) stages. The key concepts of the stages were motivation promotion for MT, increasing behavioral capabilities for MD, and strengthening self-management and building favorable environmental condition for MA. The education program was intended to be need in individual nutrition counseling, but it could be well used for group education by developing materials using the relevant contents. The primary users of the program were nutrition educators, however it could be also used by clients as needed. The introductory chapter provided dietary assessment tools and nutrition education tips. MT chapter included subjects such as nutritional status screening, costs of inappropriate nutrition and weight management, benefits of eating right, and activities for motivation promotion. MD stage chapter dealt with topics of healthy weight, knowledges and skills for better eating habits and physical activity status, and activities related to setting tailored behavioral objectives. MA stage focused on facilitating self management skills and building helping relationships. Each stage underlined activities using various educational tools in order to promote active participation of the client (s). For better use of this program, it was recommended to conduct program validation study.

• 한국초등과학교육학회지:초등과학교육
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• 제22권1호
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• pp.109-120
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• 2003

The purpose of this study is to observe, to analyze of the preservice teachers' naive theories about the change of season. And it is to find a instruction strategy which can solve problem about this. The general idea about the change of season is observed by the 3 methods which are simply explaining with words, explaining with pictures and models. The author is to find the similarity. difference and relationship which the preservice teachers have about the general idea about the change of season. The important changable primary factors, which can effect to the general Idea formation, are naturally dragged out through the observation of preservice teachers participation. For this study, 4 first year preservice teachers of one of national university of education are used. Before the interview. the author tries to form rapport with the preservice teachers. Experiment materials, pencil. paper, camcorder, digital recorder and interview note were used for the study with reflection of them just way they are. As the result of the interview. all of 4 preservice teachers had not being understand the concept about the change of season and the three ways of explanation methods were not matched each other, so it is revealed that the general Idea of the change of season, which the preservice teachers have, is not strongly formed. In spite of the repeated study of the change of season from elementary school to university, it has many problem about recognition of the general idea about the change of season which pre-elementary teachers have. Therefore it is needed to improve the experiment in elementary science text book and naive theories by the activity which is explaining the change of season in three dimension space. to prevent the naive theories which the preservice teachers may have.

• 한국환경과학회지
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• 제19권1호
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• pp.69-80
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• 2010

Today's fundamental purpose of environmental education is to fulfill people's desire of living in a pleasant environment and at the same time promoting individualistic and collective environmentally friendly behaviors. In order to achieve these purposes, it is very important that each person holds an environmentally friendly mind that constantly tries to preserve and protect the environment which should be acquired through experiencing the importance of the environment. In order to increases the sense of attachment of people and the natural environment, the direction of environmental education should carry out education on environment related knowledge and the condition of environment damage side by side. The direction of environmental education should consider the cultivating student's awareness for active participation on matters related to the environment and to change their behaviors towards the environment. This study has tested the effect of reflective writing activities about the environment on the environmental sensitivity and willingness to act of 5th grade primary school students. For the sole purpose of this study, 70 students out of 141 5th graders of M Primary School were divided as the experimental group, and another 71 students were divided as the control group. The experimental group participated in 10 activities in where they were asked to express their thoughts and feelings in writing regarding 10 environmental problems occurring near the M Primary School. The control group participated in 10 environmental education lectures focusing on the lecturer. The results were as following. First, the reflective writing activities about the environment were effective in the environmental sensitivity of primary school students. Second, the reflective writing activities about the environment can affect the environmental willingness to act of primary school students. Third, there was a statistically significant correlation between environmental sensitivity and environmental willingness to act.

• 한국주거학회논문집
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• 제22권2호
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• pp.53-61
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• 2011

This study aims to examine the characteristics of the changes in residents' perception of neighborhood and sense of neighborhood according to the residential structural changes caused by city renewal projects such as old urban large redevelopment. Research findings benefits of the residential environment changes after the development are environment improvement, convenient traffic, leisure activity increase, and green area increase, whereas their drawbacks are encroachment of sunshine and view, However, with the regard to the relationship with neighbors, paired-sample t-test results showed there were no statistically significant differences between before and after the development. It appeared to be that the community residential complex development did not influence the relationship with neighbors. ANOVA was used to examine the differences in the neighborhood perception among age categories. The results showed that there were no differences between age groups but when there were changes in their life cycle, residents showed differences in their neighborhood perception among age groups. The neighborhood perception was measured on 5-point Likert Scale in four factors of intimacy, participation, reliability, and group identity. The perception decreased somewhat after the development and the group identity, especially, showed a significant difference (p<.001). This was considered to be caused by a sense of incongruity due to the influx of different social-economic groups.

• 한국정보시스템학회지:정보시스템연구
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• 제17권3호
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• pp.205-233
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• 2008

This study suggests the dynamic value chain model, that will be able to not only show changing processes to organization's significant capital by integrating an individual, implicit, and explicit knowledge which affect organizational decision making, but also distinguish the key driver for raising organizational competitive power because it makes possible to analyze sensitivity of performance along with decision making alternatives and policy changes from dynamic view by connecting knowledge management capability, knowledge management activity, and relations with organizational performance with specific strategic map. Recently, a lot of organizations show interest in measuring and evaluating their performance synthetically. In organizations taking knowledge management, they introduce effective value chain model like a dynamic balanced scorecard (DBSC), and therefore they can reflect their knowledge management condition as well as show their changes by checking performance of established vision and strategy periodically. Furthermore, they can ask for their inner members' understanding and participation by communicating with and inspiring their members with awareness that members are one of their group, present a base of benchmarking, and offer significant information for later decision making. The BSC has been a successful framework for measuring an organization's performance in various perspectives through translating an organization's vision and strategy into an interrelated set of key performance indicators and specific actions. The BSC, while having significant strengths over traditional performance measurement methods, however, has its own limitations, due to its static nature, such as overlooking two-way causation between performance indicators and neglecting the impact of delayed feedback flowing from the adoption of new strategies or policy changes. To overcome these limitations, this study employs SD, a methodology for understanding complex systems where dynamic feedback among the interrelated system components significantly impact on the system outcomes. The SD simulation model in the form of DBSC would serve as a useful strategic teaming tool for facilitating an organization's communication process through various scenario analyses as well as predicting the dynamic behavior pattern of their key performance measures over a future time frame. For the demonstration purpose, this study applied the DBSC model to Prototype of Korea manufacturing and service firm.

• 한국사회복지학
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• 제63권1호
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• pp.137-158
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• 2011

본 연구는 사회정서적선택이론을 바탕으로 노년기 자원봉사시간과 심리사회적 안녕감의 비선형성을 탐색하고, 노인의 성별, 고령화정도 및 건강상태에 따라 어떠한 특징을 보이는지를 분석한다. 분석은 2009년도 전국노인자원봉사실태조사 자료 645사례에 대한 2차 분석이며, 단순선도표 및 다중선도표를 활용한 기술적 분석을 수행한다. 연구결과, 자원봉사에 참여하지 않은 상태(0시간)의 노인은 낮은 심리사회적 안녕감을 보이며, 보통수준에서 자원봉사에 참여한 노인은 높은 수준의 안녕감을, 이후 높은 강도의 참여시간부터는 다시 낮아지는 U자형의 비선형적 관계를 보인다. 남성노인, 75세이상 고령노인, 주관적 건강상태가 좋지 않은 노인이 보다 낮은 시간대에서 긍정적혜택을 경험한다. 본 연구를 통해 노년기 자원봉사 참여가 비참여에 비해 심리사회적 안녕감을 향상시키는데 기여하나, 활동은 년 100-200시간 미만의 보통수준으로, 700시간 이상을 넘지 않아야 함을 발견한다.

• The Journal of Advanced Prosthodontics
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• 제5권2호
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• pp.204-208
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• 2013

PURPOSE. The purpose of this study was to evaluate the effectiveness of a promotion campaign for subject recruitment and selection, and reasons of withdrawal from a prospective clinical trial of mandibular two-implant supported overdenture. MATERIALS AND METHODS. The subjects of this study were participants in a randomized controlled clinical trial for investigating prognosis of implants and overdentures with attachments. Recruited subjects were classified by gender, age, and participation motives. Withdrawal rate of the participants before and after enrollment were evaluated. RESULTS. 177 patients were recruited and 51 patients were enrolled for the trial. Among them, 40 participants eventually took part in the trial. 116 subjects (65.5%) were recruited by advertisement and 61 (34.5%) were referred by patients of the hospital or local clinics. Regarding recruitment effectiveness, newspaper recruited the largest number of participants. With respect to referral patients, the proportion of our hospital patients was higher (37/61). Subjects in their 70s comprised the largest proportion (22/51). The male to female ratio was similar (25:26). Final withdrawal rate of all subjects were 74.0%. Among the reasons for withdrawal from enrollment (n=126) presence of remaining teeth and lack of motivation were the most common reasons. CONCLUSION. To facilitate recruitment of clinical trial subjects and improve enrollment rate, it is important to obtain a sufficient number of researchers, perform promotion activity with diverse strategies, cooperate with local dentists, increase the research funding, and alleviate subjects' fear against clinical trials by thorough consultation.