• Advances in Traditional Medicine
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• 제7권4호
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• pp.409-417
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• 2007

We investigated the effect of Arogh, a polyherbal formulation (PHF) on animal models of anxiety based on exploratory behavior. The anxiolytic activity of polyherbal formulation (30, 100, 300 and 500 mg/kg) was studied using various behavioural paradigms such as elevated plus maze (EPM), light/dark apparatus (LDA), open field apparatus (OFA), hole board apparatus (HBA). Diazepam (1 mg/kg) was used as a standard anxiolytic drug. The effect of PHF (100 and 300 mg/kg) on serotonin, dopamine and noradrenaline mediated behaviour was studied by lithium induced head twitches in rats, haloperidol induced catalepsy in mice and clonidine induced hypothermia in rats respectively. In EPM, PHF (100, 300 and 500 mg/kg) significantly (P < 0.05) increased the time spent in open arms and the number of entries in open arms. In LDA, PHF (100, 300 and 500 mg/kg) significantly (P < 0.05) increased the time spent in lit zone. In OFA, PHF (100, 300 and 500 mg/kg) significantly (P < 0.05) increased the number of assisted rearing and the number of squares traversed. In HBA, PHF (100, 300 and 500 mg/kg) significantly (P < 0.05) increased the number of head poking. In lithium induced head twitches, PHF (100 and 300 mg/kg) significantly (P < 0.05) decreased the number of head twitches. In haloperidol induced catalepsy, PHF (300 mg/kg) decreased the duration of catalepsy significantly (P < 0.05) at 60 min. In clonidine-induced hypothermia, PHF (300 mg/kg) did not modify the effect. Drugs must be carefully assessed on EPM test and therefore in the present study EPM is supported by other tests. Present study indicates that Arogh, a polyherbal formulation possess anxiolytic activity. It diminished serotonergic transmission and decreased the duration of catalepsy indicating potentiation of dopaminergic transmission. Thus, Arogh a polyherbal formulation contains bioactive principles which possess anxiolytic activity and modified 5-HT and DA mediated behaviour.

• 한국운동역학회지
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• 제22권1호
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• pp.43-53
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• 2012

The purpose of this study was to quantitatively examine the biomechanical variables of Fouette turns for expert and beginner ballet dancers and to determine the difference in the variables between the two groups. sixteen female ballet dancers participated in this study. They were divided into an expert group(age, $25.38{\pm}1.92$ years; height, $168.38{\pm}4.66$ cm; mass, $49.63{\pm}4.41$ kg) and a beginner group(age, $20.88{\pm}1.13$ years; height, $161.63{\pm}7.42$ cm; mass, $48.88{\pm}3.64$ kg) depending on their ballet experience. Descriptive data were expressed as mean ${\pm}$ standard deviation (SD) for all variables including the duration, displacement of the center of the body, velocity of the center of the body, angle of the body segments, angular velocity of the body segments, ground reaction force, lower extremity torque, muscle activity, body weight, age, and body mass. An independence t-test was conducted to determine how the following variables differed between the beginners and experts: duration, displacement of the center of the body, velocity of the center of the body, angle of the body segments, angular velocity of the body segments, ground reaction force, lower extremity torque, and muscle activity. All comparisons were made at the p<0.05 significance level. The results show that the experts scored high on the biomechanical variables, although all the variables were not significant. Significant differences were found in the angle of body segments, angular velocity of the body segments, lower extremity torque, and muscle activity(p<0.05). The findings of this study demonstrate that the experts have the required skill to make an improved Fouette turn. The findings may also help ballet dancers to learn and understand the Fouette turn.

• Safety and Health at Work
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• 제14권1호
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• pp.66-70
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• 2023

Background: Online teaching and learning extend the duration of using gadgets such as mobile phones and tablets. A prolonged usage of these gadgets in a static position can lead to musculoskeletal disorders (MSD). Therefore, this study aims to identify the risk factors related to musculoskeletal symptoms while using gadgets during work from home due to the COVID-19 pandemic. Method: A cross-sectional survey with online-based questionnaires was collected from the University of Indonesia, consisting of lecturers, students, and managerial staff. The minimum number of respondents was 1,080 and was defined by stratified random sampling. Furthermore, the dependent variable was musculoskeletal symptoms, while the independent were age, gender, job position, duration, activity when using gadgets, and how to hold them. Result: Most of the respondents had mobile phones but only 16% had tablets. Furthermore, about 56.7% have used a mobile phone for more than 10 years, while about 89.7% have used a tablet for less than 10 years. A multivariate analysis found factors that were significantly associated with MSD symptoms while using a mobile phone, such as age, gender, web browsing activity, work, or college activities. These activities include doing assignments and holding the phone with two hands with two thumbs actively operating. The factors that were significantly associated with MSD symptoms when using tablets were gender, academic position, social media activity, and placing the tablet on a table with two actively working index fingers. Conclusion: Therefore, from the results of this study it is necessary to have WFH and e-learning policies to reduce MSD symptoms and enhance productivity at work.

• 생명과학회지
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• 제21권3호
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• pp.368-374
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• 2011

식물의 저온 적응 메카니즘에서 아스코브산과 관련된 효소 중 MDHA 환원효소의 활성도와 과산화수소, 아스코브산의 함량, mRNA의 발현수준과의 연관성을 연구한 결과는 다음과 같다. MDHA 환원효소의 활성도 변화는 저온에 노출되는 시간이 길어질수록 증가하였으며 6시간 이후에 엽록체분획과 세포질분획에서 급격하게 증가하는 경향을 보였으나 실온으로 회복시켰을 때 효소의 활성도가 상대적으로 감소하는 경향을 보였다. 저온에 노출된 동안 아스코브산의 함량은 비교적 일정한 경향을 보이다가 실온으로 회복시키면 그 이후에는 급격하게 증가하는 경향을 보였다. 반면 저온에 노출되는 동안 급격히 dehydroascorbate 함량이 감소하였다가 실온으로 회복되면 약간 증가하는 경향을 보였다. 아스코브산의 함량과 엽록체분획과 세포질분획의 MDHA 환원효소의 활성도와의 상관관계는 각각 정의 상관($R^2$=0.9240, 0.9108)을 나타내었으나 디하이드로아스코브산의 함량과 MDHA 환원효소의 활성도 사이에는 각각 부의 상관($R^2$=0.8638, 0.8980)을 나타내었다. MDHA 환원효소 활성도와 과산화수소의 함량과의 상관관계를 과산화수소의 생성량이 증가하면 MDHA 환원효소의 활성도가 증가하는 정의 상관($R^2$=0.9443, 0.9647)을 나타내었다. 저온스트레스 처리 시간이 증가할수록 MDHA 환원효소의 mRNA의 발현 수준과 총 MDHA 환원효소의 활성도가 증가하는 경향을 나타내었다.

• 한국학교보건학회지
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• 제27권3호
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• pp.121-129
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• 2014

Purpose: The purpose of this study were to compare general characteristic of high school girls according to menarcheal age and to investigate the factors associated with the menarcheal age of high school girls. Methods: This study utilized the data of the 2013 Korean Youth Risk Behavior Web-based Survey (KYRBWS). The sample included 18,077 high school girls who experienced menarche. The questionnaires used for this study assessed menacheal age, grade, place of residence, family affluence, height, weight, diet pattern, physical activity, sleep duration, and stress level. Data was analyzed using the complex sample analysis (${\chi}^2$-test, ANOVA and multiple regression analysis). Results: Higher BMI, frequent vegetable consumption, short sleep duration, and higher stress level were associated with an earlier menarcheal age among high school girls. Conclusion: The findings of this study indicate intervention strategies to control the timing of menarche.

• 동서간호학연구지
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• 제11권1호
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• pp.42-50
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• 2005

Purpose: The purpose this research was to provide with basic data in the control of the fatiguer found in the patients with fibromyalgia by analysing the factors that predict that. Method: At three university medical center, appointed 245 out-patients diagnosed of fibromyalgia according to the conditions by American College of Rheumatology (1990). The research instruments used in this study were graphic rating scale(Anxiety, sleep disturbance, pain, joint stiffness and depression), physical activity, the number of tender points, life satisfaction and Self-efficacy scale. In data analysis, SPSS 12.0 program was utilized and data were analyzed using descriptive statistics, Pearson's correlation coefficient and multiple regression. Result: The factors that predict the fatigue of patients with fibromyalgia were sleep disturbance, life satisfaction, pain, joint stiffness, illness duration, and anxiety which explained 50.1% of the fatigue. Conclusion: It has been confirmed that the regression equation model of this research may serve as a fatigue prediction factors in patients with fibromyalgia.

• 한국생활과학회지
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• 제15권2호
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• pp.227-237
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• 2006

The purpose of this study is to find out midaged women's crisis and ways to overcome it. Another purpose is to improve their qualities of life and to provide basic data to develop their potentials. The results are as follows: First, it shows that socio-demographic characteristics have a significant influence on midaged women's crisis. Those variables include religion, jobs, family-life cycle, income, marriage duration, age, and supporting parents. Second, the variables significantly influencing the coping behavior with the crisis include age, income, religion, marriage patterns, region, marriage duration, family-life cycle, and supporting parents. Third, as a result of this research, their negative expression of action or emotion was higher as they were getting old. The general tendency was that an emotional crisis level was low when rational coping behaviors were high. Therefore, self-esteem or social activity improvement programs should be developed for midaged women.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1997년도 추계학술대회
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• pp.443-446
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• 1997

HRV(heart rate variability) is the time series data of R-R interval time duration based on ECGs. Power spectral analysis of HRV has recently been used to define the activity of ANS(autonomic nervous system). In this study, 14 rats were divided into two groups, sympathectomy and vagotomy. During the experiments, ECGs of rats were collected three times at each experimental conditions or the duration of 5 minutes, where sampling frequency was set at 2KHz. After the application of the Berger's Serires algorithm to ECG raw data, power spectrum of HRV was obtained via FFT. Results showed that HF/LF were increased or the sympathectomy group and decreased or the vagotomy group. It implies that the variations in HF/LF components could be used or the ANS function classification.

• 한국독성학회:학술대회논문집
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• 한국독성학회 2001년도 International Symposium on Dietary and Medicinal Antimutgens and Anticarcinogens
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• pp.111-111
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• 2001

The relationship between selenium and signal molecules is not well elucidated yet. It was found that physiological concentration of selenite, less than 3 $\mu$M, reduced ASKl activity and induced of PI3-Kinase/Akt pathways in HT1080 cells. Duration of these signal molecules by selenite was much longer than that by growth factors and other stresses. The longer duration time of these signal molecules may be important to maintain normal functions against stresses.(omitted)

• Archives of Pharmacal Research
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• 제17권6호
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• pp.398-404
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• 1994

The behavioral response, depamine metabolism, and characteristics of dopamine subtypes after developing the hyperlycemia were studied in the striata of rats. In animals developed hyperglycemia, the on-set duration of cataleptic behavior responded to SCH 23390 injection was delayed abd shortened, respectively. However, the cataleptic response to spiperone occurred significantly earlier in on-set and prolonged in duration. Dopamine metabolites, dihydroxyphenylacetic acid (DDPAC) and homovanillic acid (HVA), were significantly reduced in teh striata of hyeprglycemic rats. However, level of DA was significantly increased. It is noted that the ratios of DOPAC and HVA to DA were decreased, suggesting decreased tumover of DA. The affinity of striatal D-1 receptors was significantly increased without changes in the number of binding sites, while the maximum binding number of D-2 recptors was significantly increased without affecting its affinity in the diabetic rats. These results indicate that the dopaminergic activity in striatia was altered in hyperglycemic rats. Furthermore, it suggests that the upregulation of dopamine receptors might be due to the decreased dopamine matabolism.