• Proceedings of the Ginseng society Conference
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• 1998.06a
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• pp.216-223
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• 1998

Cyclic nucleotide phosphodiesterases (PDEs) represent the unique enzymatic system degrddinf cAMP and cGMP which play a major role in the regulation of cell physiology. To investigate a possible molecular mechanism of ginsenosides, their activities were evaluated on PDEs which are recently described is new therapeutic targets. PDEs are classified into 7 families according to their genes (PDEI to PDE7) and are differently distributed in tissues. The IC50 values of ginsenosides were determined on PDEI to PDE 5 chromatographically isolatetl from bovine aorta. The results show that total ginseng saponin extract preferentially inhibits PDE 1 and PDE4 at concentrations nearby 200 ug/ml. Protopanaxadiol (PPD) fraction acts preferentially on PDE4 with and IC50 value of 100 nlml and inhibits also PDEI and PDE5 at 14 to 2 fold higher concentrations, respectively. Protopanaxatriol (PPT) fraction preferentially inhibits PDE 1 with and IC50 value of 170 ug/ml. Compound Rgl, originated from PPT fraction, and RC3 (5) represent the most active compounds towards PDE 1 with IC50 values around 80 UM. However Rg3 (R), epimer of Rgl (5) has no effect on the various PDEs tested, excepted on PDE3 rich is sligthly sensitive Compound Rbl, originated from PPD, acts on both PDEI and PDE4. It if two fold less active than Rgl and Rg3 (5) on PDEI. Taken together, these results mainly suggest that PDEI and PDE4 inhibitions could be a molecular mechanism which would participate in ginsenoside mechanisms, especially the effect of PPD on blood vessel and on CNS.

• Journal of Ginseng Research
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• v.32 no.4
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• pp.390-396
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• 2008

For evaluating the quality of ginseng, simple and fast analysis methods are needed to determine the ginsenoside content of the ginseng products. The aim of this study was therefore to optimize conditions for fast analysis of the ginsenosides, the active ingredients in extracts of Korean red ginseng. When tandem HPLC mass spectrometry (HPLC-MS/MS) was used, four forms of ginsenoside, Rb1, Rb2, Rc, and Re, were readily separated in seven minutes using a gradient mobile phase (acetonitrile and water containing acetic acid). This is the shortest separation time reported among the studies of major ginsenoside analysis. When gradient HPLC with UV detection was used, the detection limit was high, but separation of these four ginsenosides required 25 minutes using acetonitrile and water containing formic acid as a mobile phase. HPLC-MS/MS was able to separate ginsenoside Rg1 easily regardless of the mobile phase condition, but the HPLC-UV could not separate Rg1 because acetonitrile concentration in the mobile phase had to be maintained below 20%. Ginsenoside peaks were clearer and had more sensitive detection limits when Korean red ginseng extract was analyzed by the HPLC-MS/MS, but the UV detection was useful for chromatographic fingerprinting of all four major ginsenosides of the extract: Rb1, Rb2, Rc, and Re. Extracts were found to contain 2.17 mg, 1.51 mg, 1.29 mg, and 0.46 mg of ginsenoside Rb1, Rb2, Rc, Re, respectively, per gram weight. The ratios of each ginsenoside in the extracts were 1.0 : 0.7 : 0.6 : 0.2, respectively. Taken together, the results indicate that HPLC-MS/MS spectrometry could be the most useful method for rapid analysis of even small amounts of major ginsenosides, while HPLC with UV detection could also be used for rapid analysis of major ginsenosides and for quality control of ginseng products.

• Journal of the Korea institute for structural maintenance and inspection
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• v.18 no.6
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• pp.41-49
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• 2014

In order to investigation splitting bond strength of the deformed longitudinal reinforcing bars in the R C members strengthened laterally with the external steel-band, a total 9 sets of test re-bars with and without active confining force given by the external steel-band are pulled monotonically until failure. Test results indicate that the bond strength becomes higher with the increase in number of steel-band sets and their initial stress magnitude. This is due to the active confining force given by the steel-band, and passive confining forces given by the steel-band and transverse reinforcements, in which the passive confinement effect varies depending on the magnitude of active confining force. An equation to estimate the splitting bond strengths for the R C members strengthened laterally with the external steel-band is developed based on the several experimental results of the present study.

• IEMEK Journal of Embedded Systems and Applications
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• v.3 no.2
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• pp.82-90
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• 2008

In this paper, we introduce a biped walking robot which can do static walking with 22 degree-of-freedoms. The developed biped walking robot is 480mm tall and 2500g, and is constructed by 22 RC servo motors. Before making an active algorithm, we generate the motions of robot with a motion simulator developed using C language. The two dimensional simulator is based on the inverse kinematics and D-H transform. The simulator implements various motions as we input the ankle's trajectory. Also the simulator is developed by applying the principle of inverted pendulum to acquisite the center of gravity. As we use this simulator, we can get the best appropriate angle of ankle or pelvic when the robot lifts up its one side leg during the walking. We implement the walking motions which is based on the data(angle) getting from both of simulators. The robot can be controlled by text shaped command through RF signal of wireless modem which is connected with laptop computer by serial cable.

• 제어로봇시스템학회:학술대회논문집
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• 2005.06a
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• pp.2350-2355
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• 2005

In this paper, we introduce biped walking robot which can static walking with 22 degree-of-freedoms. The developed biped walking robot is 480mm tall and 2500g, and 22 RC servo motors are used to actuate. Before made an active algorithm, we generated the motions of robot with the motion simulator which developed using by C language. The two dimension simulator is Based on the inverse kinematics and D-H transform. The simulator implements various motions as inputted the ankle's trajectory. Also we developed a simulator which is applied the principle of inverted pendulum to acquires the center of gravity. As we use this simulator, we can get the best appropriate angle of ankle and pelvis when the robot lifts up its one side leg during the working. We implement the walking motions which is based on the data(angle) getting from both of simulators. The robot can be controlled by text shaped command through RF signal of wireless modem which connected with laptop computer by serial cable.

• Journal of the Korean Institute of Telematics and Electronics D
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• v.34D no.5
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• pp.61-66
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• 1997

In this paper we report the fabrication of an InGaAs metal-semiconductor-metal (MSM) photodiode(PD) which an InAlAs barrier enhancement layer that has very low dark current and high speed chracteristics. The detector using Cr/Au schottky metal fingers with 4um spacing on a large active area of 300*300um$^{2}$ offers a low dark current of 38nA at 10V, a low capacitance of 0.8pF, and a high 3-dB bandwidth of 2.4 GHz. To our knowledge, these characteristics are better than any previously published results obtained from large area InGaAs MSM PD's. The RC equivalent model and frequency domain current response model considering transit time were also used to analyze the frequency characteristic of the fabricated device.

• Journal of the Korean Institute of Telematics and Electronics B
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• v.32B no.12
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• pp.1572-1580
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• 1995

In this paper, a modified Chebyshev low-pass filter function is proposed. The modified Chebyshev filter function exhibits ripples diminishing toward .omega. = 0 in the passband. So, the modified filter function is realizable in the passive doubly-terminated ladder network for the order n even or odd, thus lending itself amenable to active RC or switched capacitor filters through the simulation techniques. Besides the passive doubly-terminated ladder realizability, lower pole-Q values of the modified function are accountable for improved phase and delay characteristics, as compared to classical function. We have designed the 6th order passive doubly-terminated network using the modified function. And then a continuous-time DDA(Differential Difference Amplifier) filter, which has no matching requirement, is realized by leap-frog simulation technique for fabrication. In the HSPICE simulation results, we confirmed that the designed continuous-time DDA filter characteristics are agreement with the passive filter.

• Proceedings of the Korea Concrete Institute Conference
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• 2000.04a
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• pp.527-532
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• 2000

Cracks in reinforced concrete members are important element in structural analysis and design. It is clear from the test results that shear strength of cracked member is remarkably degraded compared with uncracked one. However, considerable amount of shear resistance by such mechanisms as aggregate interlock and dowel action is still active. There are various approaches to shear transfer estimation including finite element analysis, fracture mechanics, upper bound theory of plasticity, etc., but working out comprehensive and consistent models and manageable equations is rather difficult and remains to be improved. Shear transfer problems under cyclic loading and effective compressive strength of cracked concrete have not been adequately investigated and need further systematic research.

• Advances in concrete construction
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• v.9 no.4
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• pp.407-412
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• 2020

Due to the influence of nonlinearity and time-variation, it is difficult to establish an accurate model of concrete frame structures that adopt active controllers. Fuzzy theory is a relatively appropriate method but susceptible to human subjective experience to decrease the performance. To guarantee the stability of multi-time delays complex system with multi-interconnections, a delay-dependent criterion of evolved design is proposed in this paper. Based on this criterion, the sector nonlinearity which converts the nonlinear model to multiple rule base of the linear model and a new sufficient condition to guarantee the asymptotic stability via Lyapunov function is implemented in terms of linear matrix inequalities (LMI). A numerical simulation for a three-layer reinforced concrete frame structure subjected to earthquakes is demonstrated that the proposed criterion is feasible for practical applications.

• Advances in concrete construction
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• v.8 no.4
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• pp.247-255
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• 2019

Several reinforced concrete structures that get deteriorated by rebar corrosion are retrofitted using Carbon Fiber Reinforced Polymer (CFRP). When rebar comes in direct contact with CFRP, rebar may corrode, as iron is more active than carbon. Progression of corrosion of rebar in strengthened RC structures has been carried out when rebar comes in direct contact with CFRP. The experimentation is carried out in two phases. In phase I, corrosion of bare steel bar is monitored by making its contact with CFRP. In phase II, concrete specimens with surface bonded CFRP were casted and subjected to the realistic exposure conditions keeping direct contact between rebar and CFRP. Progression of corrosion has been monitored by various parameters: Half-cell potential, Tafel extrapolation and Linear Polarisation Resistance. On termination of exposure, to find residual bond stress between rebar and concrete, pull-out test was performed. Rebar in contact with CFRP has shown substantially higher corrosion. The level of corrosion will be more with more area of contact.