• Journal of the Korean Institute of Telematics and Electronics S
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• v.35S no.2
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• pp.40-49
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• 1998

In this paper, we propose an efficient per-Trunk interworking mechanism between PSTN and ATM network assuming the situation ATM network interworks with PSTN during the evolution period. The proposed mechanism improves the cell payload utilization by mapping only the active charnnels of PSTN frame into ATM cell payload. Also, we propose the frame recovery mechanism to guarantee the frame sequence integrity. The proposed mechanism is compared with other possible ones in terms of cell payload utilization, cell packetization delay. We present the implementation structure of the interworking unit. the correctness of the mechanism and the feasibility of the implementation are verifid through the CAD simulation.

• IMMUNE NETWORK
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• v.13 no.5
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• pp.168-176
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• 2013

In the last few years major progress has been made in better understanding the role of natural killer (NK) cells in hepatitis C virus (HCV) infection. This includes multiple pathways by which HCV impairs or limits NK cells activation. Based on current genetic and functional data, a picture is emerging where only a rapid and strong NK cell response early on during infection which results in strong T cell responses and possible subsequent clearance, whereas chronic HCV infection is associated with dysfunctional or biased NK cells phenotypes. The hallmark of this NK cell dysfunction is persistent activation promoting ongoing hepatitis and hepatocyte damage, while being unable to clear HCV due to impaired IFN-${\gamma}$ responses. Furthermore, some data suggests certain chronically activated subsets that are $NKp46^{high}$ may be particularly active against hepatic stellate cells, a key player in hepatic fibrogenesis. Finally, the role of NK cells during HCV therapy, HCV recurrence after liver transplant and hepatocellular carcinoma are discussed.

• KSBB Journal
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• v.15 no.3
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• pp.318-322
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• 2000

An oxygen-sensitive fumarate reductase has been purified from the cytosol fraction of the Enterococcus faecalis RKY1 grown anaerobically on a defined medium containing glycerol and fumarate. A major portion of the purification was performed with employing Triton X-100 and reducing agents by Phenyl-sepharose CL-4B DEAE-sepharose and Dephadex G-150 The final activity was 0.42 unit/mg. The deduced molecular mass of active band was 66 kDa. The optimal pH and temperature for the activity were 7.0 and 38$^{\circ}C$ respectively. The enzyme activity was not affected by 1mM metal ions such as bacl2 $.$2H2O HgCl2 MnCl2$.$4H2O ZnCl2 CuCl2$.$2H2O Mgcl2$.$6H2O FeSo4$.$7H2O and by EDTA. Partially purified enzyme ws yellow in color ; spectroscopic study indicated the presence of flavins as a cofactor.

• Journal of the Korean Society for Precision Engineering
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• v.23 no.1 s.178
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• pp.105-112
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• 2006

The nonlinear damping force model is made to identify the properties of the ER (electro-rheological) fluid suspension damper. The instrumentation is carried out to measure the damping force of the ER damper. The higher order spectral analysis method is used to investigate the nonlinear frequency coupling phenomena with the damping force signal according to the sinusoidal excitation of the damper. The distinctive higher order nonlinear characteristics are observed. The nonlinear damping force model, which has the higher order velocity terms, is proposed with the result of higher order spectrum analysis. The higher order terms coefficients, which vary according to the strength of the electric field, are calculated using the least square method.

• Korean Journal of Clinical Pharmacy
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• v.1 no.1
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• pp.1-7
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• 1991

Folates are involved in a variety of important biosynthesis by way of donating one carbon unit. Since folate metabolism was well understood a number of antifol have been developed. Among these antifols, aminopterin was first used in the treatment of childhood leukemia. However due to its toxicity and purity problems. it was immediately replaced by another antifols. methotrexate (MTX). MTX is shown to be active against various malignancies including leukemia breast cancer, osteogenic sarcoma, and head and neck cancer. Clinically, MTX therapy is divided into 3 categories. depeding on the dose administered; low-dose is defined as doses < $80\;mg/m^2$ intermediate-dose as doses $\geqq\;80\;mg/m^2$ and < $1000\;mg/m^2$ and high-dose as doses $\geqq\;1000\;mg/m^2$. Leucovorin should be administered to minimize MTX toxicities when MTX doses are greater than $80-100\;mg/m^2$. The clinical pharmacokinetics (ADME) of MTX is discussed in this text.

• Journal of Power Electronics
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• v.4 no.3
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• pp.152-160
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• 2004

This paper presents analysis, modeling, and design of a low-harmonic, isolated, active-clamped SEPIC for future avionics applications. Simpler converter dynamics, high switching frequency, zero voltage-Transition-PWM switching, and a single-layer transformer construction result. This paper describes complete design of a digital controller for a high-frequency switching power supply. Guidelines for the minimum required resolution of the analog-to-digital converter, the pulse-width modulator, and the fixed-point computational unit is derived. A design example based on a SEPIC converter operating at the high switching frequency is presented. The controller design is based on direct digital design approach and standard root-locus techniques.

• Journal of the Korean School Mathematics Society
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• v.3 no.1
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• pp.59-67
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• 2000

This study has been done to help teach mathematics on the spot of education by providing the history of mathematics and illustrations concerning mathematics, which were rearranged for the level of the second grade students in highschool and intented to interest students in mathematics classes. The contents of teaching, according to each unit (Matrix, Sequence, Limit, Differentiation, Integration, Probability, Statistics) include the life of the representative mathematician, the historical background centered on episodes, questions linked with reality, questions making sensations in history and something for maxim in mathematics. If such contents are properly used, they are expected to be able to stimulate students' curiosity, and to be effective in improving students' learning ability in mathematics by causing them to show their active attitudes toward learning mathematics.

• Toxicological Research
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• v.17
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• pp.89-96
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• 2001

Recently, considerable attention has been focused on the role of cyclooxygenase-2 (COX-2) in the carcinogenesis as well as in inflammation. Improperly overexpressed COX-2 has been observed in many types of human cancers and transformed cells in culture. Thus, it is conceivable that targeted inhibition of abnormally or improperly up-regulated COX-2 provides one of the most effective and promising strategies for cancer prevention. A ubiquitous eukaryotic transcription factor, NF-kB is considered to be involved in regulation of COX-2 expression. Furthermore, extracellular-regulated protein kinase and p38 mitogen-activated protein (MAP) kinase appear to be key elements of the intracellular signaling cascades involved in NF-kB activation in response to a wide array of external stimuli. Certain chemopreventive phytochemicals suppress activation of NF-kB by blocking one or more of the MAP kinases, which may contribute to their inhibitory effects on COX-2 induction. One of the plausible mechanisms by which chemopreventive phytochemicals inhibit NF-kB activation involves suppression of degradation of the inhibitory unit I kB, which hampers subsequent translocation of p65, the functionally active subunit of NF-kB.

• Journal of the Korean Professional Engineers Association
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• v.25 no.4
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• pp.52-58
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• 1992

In korea, since November 1982 these two small group activity (QC circle convension and Factory Saemaul activity small group convension) has been united, many problems have been disclosed that are aganist the basic principle more or less. Worker's small group within their working place to improve the surroundings creatively. In practice, however, many group are so typical and impetuous of the material effect that it is worried to be inclined to outform rather than contents. Effective small group activities are presumed to be successful only with labour management cooperation on the basis of human-orient management philosophy. The small group activities are also prevalent in service sector. More derivative methods have been developed and more members are willingly participation in training programs. The small group which is basically a horizontal organization unit, promptes communication within the whole organization, In consideration of social circumstances and traditions, the flexible model of the small group activities suitable to the corporate environment, will contribute to industrial development.

• Journal of Conservation Science
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• v.36 no.1
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• pp.28-36
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• 2020

The storage environment of a Japanese woodblock print collection was assessed for organic acids. The active air sampling method was used to collect organic acid emissions in the low microgram range from areas of a selected woodblock print with different pigments, following which an off-gassing mitigation strategy based on the fan filter unit(FFU) system was investigated. Research findings revealed that the off-gassing behavior of woodblock prints is significantly impacted by storage practices and to a lesser degree by the pigments. The FFU system can be used as a mitigation strategy, but the permanence of the results depends on the storage conditions.