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Comparison of Thermal Ablation and Surgery for Low-Risk Papillary Thyroid Microcarcinoma: A Systematic Review and Meta-Analysis

  • Hyun Jin Kim;Se Jin Cho;Jung Hwan Baek
    • Korean Journal of Radiology
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    • v.22 no.10
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    • pp.1730-1741
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    • 2021
  • Objective: Although thermal ablation is effective in treating low-risk papillary thyroid microcarcinomas (PTMCs), comparison of treatment outcomes between thermal ablation and surgery has not yet been systematically evaluated. This study aimed to compare the efficacy and safety of thermal ablation and surgery for the treatment of low-risk PTMCs. Materials and Methods: Ovid-MEDLINE and EMBASE databases were searched for studies reporting comparisons of treatment results between thermal ablation and surgery for patients with low-risk PTMC published up to April 6, 2020. The analysis evaluated the efficacy (local tumor recurrence, occurrence of new tumor, metastasis, and rescue surgery) and safety (complication rate) of thermal ablation and surgery. Results: This systematic review included four studies with a total of 339 PTMCs in 339 patients who underwent thermal ablation and 320 PTMCs in 314 patients who underwent surgery. There was no local tumor recurrence or distant metastasis in either group. There was no significant difference in the pooled proportion of lymph node metastasis (2.6% with thermal ablation vs. 3.3% with surgery, p = 0.65), occurrence of new tumors (1.4% with thermal ablation vs. 1.3% with surgery, p = 0.85), or rescue surgery (2.6% with thermal ablation vs. 1.6% with surgery, p = 0.62). However, the pooled complication rate was significantly higher in the surgery group than in the ablation group (3.3% with thermal ablation vs. 7.8% with surgery, p = 0.03). Conclusion: Both thermal ablation and surgery are effective and safe options for the management of low-risk PTMCs, with thermal ablation achieving a lower complication rate. Therefore, thermal ablation may be considered as an alternative treatment option for low-risk PTMC in patients who refuse surgery and active surveillance or are ineligible for surgery.

Development and Application of the Catchment Hydrologic Cycle Assessment Tool Considering Urbanization (I) - Model Development - (도시화에 따른 물순환 영향 평가 모형의 개발 및 적용(I) - 모형 개발 -)

  • Kim, Hyeon-Jun;Jang, Cheol-Hee;Noh, Seong-Jin
    • Journal of Korea Water Resources Association
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    • v.45 no.2
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    • pp.203-215
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    • 2012
  • The objective of this study is to develop a catchment hydrologic cycle assessment model which can assess the impact of urban development and designing water cycle improvement facilities. Developed model might contribute to minimize the damage caused by urban development and to establish sustainableurban environments. The existing conceptual lumped models have a potential limitation in their capacity to simulate the hydrologic impacts of land use changes and assess diverse urban design. The distributed physics-based models under active study are data demanding; and much time is required to gather and check input data; and the cost of setting up a simulation and computational demand are required. The Catchment Hydrologic Cycle Assessment Tool (hereinafter the CAT) is a water cycle analysis model based on physical parameters and it has a link-node model structure. The CAT model can assess the characteristics of the short/long-term changes in water cycles before and after urbanization in the catchment. It supports the effective design of water cycle improvement facilities by supplementing the strengths and weaknesses of existing conceptual parameter-based lumped hydrologic models and physical parameter-based distributed hydrologic models. the model was applied to Seolma-cheon catchment, also calibrated and validated using 6 years (2002~2007) hourly streamflow data in Jeonjeokbigyo station, and the Nash-Sutcliffe model efficiencies were 0.75 (2002~2004) and 0.89 (2005~2007).

Bud Necrosis Characteristics of 'Hongisul' Grape ('홍이슬' 포도의 눈괴사 특성)

  • Kim, Eun-Joo;Lee, Byul-Ha-Na;Kwon, Yong-Hee;Shin, Kyoung-Hee;Chung, Kyu-Hwan;Park, Seo-Jun;Park, Hee-Seung
    • Horticultural Science & Technology
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    • v.29 no.5
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    • pp.407-412
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    • 2011
  • The germination of the buds in 'Hongisul' grapes is poor and especially the high ratio of shoots where the flowers failed to emerge it was difficult to secure a sufficient amount of harvest. Thus, in this study, the necrosis and the periodical change in the buds were observed morphologically and also the cause of necrosis of the bud was investigated in order to understand what was causing the low germination and flowering. There was no change in the size of the bud after June and based upon external observation, there wasn't any retrogression or withering. However, based on a microscopic examination, the ratio of whole bud and main bud necrosis of the 'Hongisul' grapes continued to increase after August, and specially the ratio of the main bud necrosis continued to increase up to October. As for the size of the buds on the shoots, the buds located on the $1^{st}-3^{rd}$ nodes from the basal part were small whereas the buds located on the $4-10^{th}$ nodes were comparatively larger in its size. The ratio of necrosis of the bud was the highest at the $1^{st}$ and $2^{nd}$ bud, meaning that the buds located at the basal part of the shoot were defective compared to those located at the end of the shoot. It was also found that when the growth of the shoot is active and the shoot diameter is thick, it hindered the development of the buds. Therefore, it was judged that long pruning of 'Hongisul' grapes would help the emergence of the flowers as you could use the buds that have comparatively developed better.

An Efficient Addressing Scheme Using (x, y) Coordinates in Environments of Smart Grid (스마트 그리드 환경에서 (x, y) 좌표값을 이용한 효율적인 주소 할당 방법)

  • Cho, Yang-Hyun;Lim, Song-Bin;Kim, Gyung-Mok
    • Journal of the Korea Society of Computer and Information
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    • v.17 no.1
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    • pp.61-69
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    • 2012
  • Smart Grid is the next-generation intelligent power grid that maximizes energy efficiency with the convergence of IT technologies and the existing power grid. Smart Grid is created solution for standardization and interoperability. Smart Grid industry enables consumers to check power rates in real time for active power consumption. It also enables suppliers to measure their expected power generation load, which stabilizes the operation of the power system. Smart industy was ecolved actively cause Wireless communication is being considered for AMI system and wireless communication using ZigBee sensor has been applied in various industly. In this paper, we proposed efficient addressing scheme for improving the performance of the routing algorithm using ZigBee in Smart Grid environment. A distributed address allocation scheme used an existing algorithm has wasted address space. Therefore proposing x, y coordinate axes from divide address space of 16 bit to solve this problem. Each node was reduced not only bitwise but also multi hop using the coordinate axes while routing than Cskip algorithm. I compared the performance between the standard and the proposed mechanism through the numerical analysis. Simulation verify performance about decrease averaging multi hop count that compare proposing algorithm and another. The numerical analysis results show that proposed algorithm reduce multi hop than ZigBee distributed address assignment and another.

Image segmentation using fuzzy worm searching and adaptive MIN-MAX clustering based on genetic algorithm (유전 알고리즘에 기반한 퍼지 벌레 검색과 자율 적응 최소-최대 군집화를 이용한 영상 영역화)

  • Ha, Seong-Wook;Kang, Dae-Seong;Kim, Dai-Jin
    • Journal of the Korean Institute of Telematics and Electronics S
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    • v.35S no.12
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    • pp.109-120
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    • 1998
  • An image segmentation approach based on the fuzzy worm searching and MIN-MAX clustering algorithm is proposed in this paper. This algorithm deals with fuzzy worm value and min-max node at a gross scene level, which investigates the edge information including fuzzy worm action and spatial relationship of the pixels as the parameters of its objective function. But the conventional segmentation methods for edge extraction generally need the mask information for the algebraic model, and take long run times at mask operation, whereas the proposed algorithm has single operation according to active searching of fuzzy worms. In addition, we also propose both genetic fuzzy worm searching and genetic min-max clustering using genetic algorithm to complete clustering and fuzzy searching on grey-histogram of image for the optimum solution, which can automatically determine the size of ranges and has both strong robust and speedy calculation. The simulation results showed that the proposed algorithm adaptively divided the quantized images in histogram region and performed single searching methods, significantly alleviating the increase of the computational load and the memory requirements.

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Analysis of Thymosin β4 and Vascular Endothelial Cell Growth Factor (VEGF) Expression in Normal Human Tissues Using Tissue Microarray (Tissue microarray를 이용한 사이모신 베타4(Thymosin β4)와 vascular endothelial cell growth factor (VEGF)의 정상 인간 조직 발현 양상 연구)

  • Ock, Mee-Sun;Cha, Hee-Jae
    • Journal of Life Science
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    • v.19 no.12
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    • pp.1777-1786
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    • 2009
  • Thymosin ${\beta}4$, a small protein containing 43 amino acids, has multi-functional roles in cell physiology. It was first identified as a thymic maturation factor and recently has been shown to accelerate wound healing, hair growth, angiogenesis, tumor growth, and metastasis. It was also reported to play a key role in developing organs, including the nervous system and heart. Thymosin ${\beta}4$ induces the expression of vascular endothelial cell growth factor (VEGF), laminin-5, and other important biologically active genes. Using tissue microarray analysis, we investigated the expression patterns of thymosin ${\beta}4$ and VEGF in various normal human adult tissues. Thymosin ${\beta}4$ was highly expressed in the liver, pancreas, ductal epithelium of the salivary gland, and heart, and moderately expressed in the skin, lung, spleen, lymph node, thymus, ureter, and blood endothelial cells in both the lung and adrenal gland. The expression of VEGF generally co-localized with thymosin ${\beta}4$ and VEGF was highly expressed in the pancreas, ureter, mammary gland, liver, esophagus, and blood endothelial cells in both the lung and adrenal gland. These results suggest that thymosin ${\beta}4$ plays an important role in the function of various organs and since the expression pattern of thymosin ${\beta}4$ co-localized with VEGF, part of that function may be to induce or maintain angiogenesis.

Physiobiochemical Characteristics of Hybrid Rice (1대 잡종벼의 생리생화학적 특성)

  • Tae, Hyun-Sook;Kim, Kil-Ung;Shin, Dong-Hyun;Wenxiong Lin;Moon, Huhn-Pal
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.40 no.5
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    • pp.608-618
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    • 1995
  • This study was conducted to determine physiobiochemical basis of heterosis using rice hybrids such as Shanyou 63 (Zhenshan 97As Minhui 63) and Teyou 63 (Longtepu A Minhui 63) as compared with inbred rice like Milyang 23. Seed protein patterns of rice hybrid showed complementary genetic characteristics inherited from their parents. Hybrid rice had larger embryo and higher $\alpha$-amylase activity than those of inbred rice. The larger embryo of hybrid was significantly correlated with tillering ability and high number of low node tillers jplant increased by 60~70% in Shanyou 63, leading to higher productive tillers/plant which directly influenced on grain yield of hybrid rice. These characters were further supported by high chlorophyll content in hybrids. Exogenous application of GA$_3$ (0.02 ppm) on inbred rice like Milyang 23, increased significantly $\alpha$-amylase activity, but no effect of GA$_3$ on hybrid rice was observed, indicating that sufficient amount of GA$_3$ is endogenously present in hybrid rice, showing 1 to 3.5 fold higher activity of $\alpha$-amylase in hybrid rice, which trigger heterosis from the germinating stage. Further, activity of cytochrome c oxidase was 2.66 to 5.52 fold higher in hybrid rice than that of inbred rice, indicating that rice hybrids have very active metabolism reflecting vigorous growth starting from the germinating stage, in turn leading to higher tillering ability.

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The Beacon Frame-Based Node Grouping Algorithm for Improving the Performance between MCT devices in the Home Wireless Network (가정 무선 네트워크 내 MCT 디바이스 간 성능 향상을 위한 Beacon frame 기반 노드 그룹화 알고리즘)

  • Kim, Gyu-Do;Kown, Young-Ho;Rhee, Byung-Ho
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2015.10a
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    • pp.787-790
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    • 2015
  • Recently, M2M (Machine to Machine) communication is possible the development of MTC (Machine Type Communication) devices becomes active. MCT devices in the form of home appliances have a low power consumption, low cost, short-range wireless communication in wireless home network. For purpose, MTC devices based on IEEE 802.15.4/Zigbee are composed in the form of cluster-tree topology, which consists of one PAN (Personal Area Network), one or other router and end of nodes. It happens that transmission delay, packet drop, and lacking data resulted from collision originated by a competition for allocating channels among MTC devices that greatly increased. At last performance of entire network can be degradated. This paper proposes that the beacon frame-based grouping algorithm using multiple channels in a MTC devices in the presence of wireless home network interference. The proposed algorithm decreases the transmission delay, dropped packet and throughput is more increase, so the proposal algorithm is more efficient than the IEEE 802.15.4/ Zigbee standard.

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Active Adjustment: An Approach for Improving the Search Performance of the TPR*-tree (능동적 재조정: TPR*-트리의 검색 성능 개선 방안)

  • Kim, Sang-Wook;Jang, Min-Hee;Lim, Sung-Chae
    • The KIPS Transactions:PartD
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    • v.15D no.4
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    • pp.451-462
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    • 2008
  • Recently, with the advent of applications using locations of moving objects, it becomes crucial to develop efficient index schemes for spatio-temporal databases. The $TPR^*$-tree is most popularly accepted as an index structure for processing future-time queries. In the $TPR^*$-tree, the future locations of moving objects are predicted based on the CBR(Conservative Bounding Rectangle). Since the areas predicted from CBRs tend to grow rapidly over time, CBRs thus enlarged lead to serious performance degradation in query processing. Against the problem, we propose a new method to adjust CBRs to be tight, thereby improving the performance of query processing. Our method examines whether the adjustment of a CBR is necessary when accessing a leaf node for processing a user query. Thus, it does not incur extra disk I/Os in this examination. Also, in order to make a correct decision, we devise a cost model that considers both the I/O overhead for the CBR adjustment and the performance gain in the future-time owing to the CBR adjustment. With the cost model, we can prevent unusual expansions of BRs even when updates on nodes are infrequent and also avoid unnecessary execution of the CBR adjustment. For performance evaluation, we conducted a variety of experiments. The results show that our method improves the performance of the original $TPR^*$-tree significantly.

Address-Internetworking Scheme between Wireless Sensor Network and Internet Using TCP Port-Numbers (TCP 포트번호를 이용한 센서 네트워크와 인터넷(IPv4/IPv6)의 주소 연동)

  • Kim, Jeong-Hee;Kwon, Hoon;Kim, Do-Hyeu;Kwak, Ho-Young;Do, Yang-Hoi;Kim, Dae-Young;Byun, Yung-Cheol
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.11 no.1
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    • pp.114-123
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    • 2007
  • As a promising technology that enables ubiquitous computing and will lead the information technology industries of the next generation, the new field of sensor networks is one of the most active research topics today. From now on, each node, the network formation, and even the sensor network itself will interact with the generic network and evolve dynamically according to environmental changes, in a process of continual creation and extinction. In this paper, we propose a address-Internetworking scheme for interactive networking between a sensor network and the Internet based on the TCP port-numbers. The proposed scheme enables internetworking between a sensor network address scheme based on Zigbee and the Internet address scheme based on the Internet Protocol version 6 (IPv6). We implement the proposed address-Internetworking scheme using Berkeley TinyOS, Mica Motes, and IP. In addition we verify the proposed scheme by an interconnection experiment, which involves wireless sensor networks and the Internet, using IPv4/IPv6.