• The korean journal of orthodontics
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• v.33 no.3 s.98
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• pp.169-183
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• 2003

Tooth movement by orthodontic force effects great tissue changes within the periodontium, especially by shifting the blood flow in the pressure side and resulting in a hypoxic state of low oxygen tension. The aim of this study is to elucidate the possible mechanism of apoptosis in response to hypoxia in MC3T3El osteoblasts, the main cells in bone remodeling during orthodontic tooth movement. MC3T3El osteoblasts under hypoxic conditions ($2\%$ orygen) resulted in apoptosis in a time-dependent manner as estimated by DNA fragmentation assay and nuclear morphology stained with fluorescent dye, Hoechst 33258. Pretreatment with Z-VAD-FMK, a pancaspase inhibitor, or Z-DEVD-CHO, a specific caspase-3 inhibitor, completely suppressed the DNA ladder in response to hypoxia. An increase in caspase-3-like protease (DEVDase) activity was observed during apoptosis, but no caspase-1 activity (YVADase) was detected. To confirm what caspases are involved in apoptosis, Western blot analysis was performed using anti-caspase-3 or -6 antibodies. The 10-kDa protein, corresponding to the active products of caspase-3, and the 10-kDa protein of the active protein of caspase-6 were generated in hypoxia-challenged cells in which the processing of the full length form of caspase-3 and -6 was evident. While a time course similar to this caspase-3 and -6 activation was evident, hypoxic stress caused the cleavage of lamin A, which was typical of caspase-6 activity. In addition, the stress elicited the release of cytochrome c into the cytosol during apoptosis. Furthermore, we observed that pre-treatment with SB203580, a selective p38 mitogen activated protein kinase inhibitor, attenuated the hypoxia-induced apoptosis. The addition of SB203S80 suppressed caspase-3 and -6-like protease activity by hypoxia up to $50\%$. In contrast, PD98059 had no effect on the hypoxia-induced apoptosis. To confirm the involvement of MAP kinase, JNK/SAPK, ERK, or p38 kinase assay was performed. Although p38 MAPK was activated in response to hypoxic treatment, the other MAPK -JNK/SAPK or ERK- was either only modestly activated or not at all. These results suggest that p38 MAPK is involved in hypoxia-induced apoptosis in MC3T3El osteoblasts.

• Journal of KIISE
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• v.44 no.12
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• pp.1245-1251
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• 2017

In this study we present a novel directory architecture that can dynamically allocate a directory entry for a cache block on demand at runtime only when the block is shared by more than one core. Thus, we do not maintain coherence for private blocks, substantially reducing the number of directory entries. Even for shared blocks, we allocate directory entry dynamically only when the block is actively shared, further reducing the number of directory entries at runtime. For this, we propose a new directory architecture called dynamic directory table (DDT), which is implemented as a cache of active directory entries. Through our detailed simulation on PARSEC benchmarks, we show that DDT can outperform the expensive full-map directory by a slight margin with only 17.84% of directory area across a variety of different workloads. This is achieved by its faster access and high hit rates in the small directory. In addition, we demonstrate that even smaller DDTs can give comparable or higher performance compared to recent directory optimization schemes such as SPACE and DGD with considerably less area.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.40 no.12
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• pp.9-17
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• 2003

In this paper we proposea method for estimating the bandwidth in next-generation If network. Especially, we concentrate on the edge routers accommodating the VoIP connections as well as a group of data connections. Bandwidth dimensioning is carried out at call level and packet level for voice traffic in the next-generation IP network. The model incorporates the statistical estimation approach at a call level for obtaining the number of voice connections simultaneously in the active mode. The call level model incorporates a statistical technique to compute the statistics of the number of active connections such as the mean and variance of the simultaneously connected calls in the network. The packet level model represents a load map for voice and data traffic by using non-preemptive M/G/1 queuing model with strict priority for voice over data buffer, From the proposed traffic model, we can derive a graph for upper bounds on the traffic load in terms of bandwidth for voice and data connections. Via numerical experiments we illustrate the implication of the work.

• Journal of the Korean Society for Precision Engineering
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• v.26 no.6
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• pp.81-89
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• 2009

Dancer systems are typical equipment for attenuation of tension disturbances. Lately, demands for high speed roll-to-roll machines are rising but it is prior to attenuate the tension variation on the web entering into the printing zone to achieve the speed increment. Maintaining a constant tension before the first printing cylinder is the key of high speed, high quality printing. Dancer has been researched in two ways, whether it is controlled or not. The first one is active dancer and the other one is passive dancer. In the active dancer, a position of idle roll of dancer is measured and the roll is moved by external hydraulic cylinder to control tension disturbances. While the passive one composed with spring, damper and idle roll has no external actuator to position the idle roll. The tension disturbance causes movement of dancer roll and the displacement of the roll regulates the tension variation. On the other hand a composite type of dancer is applied for roll-to-roll printing machines. It has same apparatus as passive dancer. The displacement of roll is measured and front(or rear) driven roller is controlled to position the roll. In this paper, it is presented an analysis of pendulum dancer including position feedback PI control and logic for PI gain tuning in roll-to-roll machines. Pole-zero map and root locus with varying system parameters gives a design method for control of the dancer.

• Journal of Physiology & Pathology in Korean Medicine
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• v.36 no.6
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• pp.229-234
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• 2022

Lung cancer is the leading cause of cancer-related deaths worldwide. Indigo Naturalis (IN) is a dark blue powder obtained by processing leaves or stems of indigo plants, its anticancer effects have been reported in several studies. However, the pharmacological mechanism of IN in small cell lung cancer (SCLC) is not elucidated. In this study, to investigate the anticancer efficacy of IN for SCLC, we presented potential active ingredients, SCLC-related targets, and pharmacological mechanisms of IN that are expected to have anticancer activity for SCLC using a network pharmacological analysis. The phytochemical compounds of IN have been collected through TCMSP, SymMap, or HPLC documents. The active ingredients of IN such as indirubin, indican, isatin, and tryptanthrin were selected through ADME parameters or literature investigations for each compound. Using the Compounds, Disease-Target associations Databases, 124 common targets of IN and SCLC were obtained. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) Pathway enrichment analysis was carried out. GO biological processes are associated with response to xenobiotic stimulus, positive regulation of protein phosphorylation, regulation of mitotic cell cycle, and regulation of apoptotic signaling pathway. KEGG disease pathways included Gastric cancer, Bladder cancer, SCLC, and Melanoma. The main anticancer targets of the IN for SCLC were analyzed in 14 targets, including BCL2, MYC, and TP53. In conclusion, the results of this study based on the network pharmacology of IN can provide important data for the effective prevention and treatment of SCLC.

• Journal of KIISE:Computing Practices and Letters
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• v.7 no.6
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• pp.549-558
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• 2001

It is important to reuse existing motion capture data for reduction of the animation producing cost as well as efficiency of producing process. Because its motion curve has no control point, however, it is difficult to modify the captured data interactively. The motion transition is a useful method to reuse the existing motion data. It generates a seamless intermediate motion with two short motion sequences. In this paper, Uniform Posture Map (UPM) algorithm is proposed to perform the motion transition. Since the UPM is organized through quantization of various postures with an unsupervised learning algorithm, it places the output neurons with similar posture in adjacent position. Using this property, an intermediate posture of two active postures is generated; the generating posture is used as a key-frame to make an interpolating motion. The UPM algorithm needs much less computational cost, in comparison with other motion transition algorithms. It provides a control parameter; an animator could control the motion simply by adjusting the parameter. These merits of the UPM make an animator to produce the animation interactively. The UPM algorithm prevents from generating an unreal posture in learning phase. It not only makes more realistic motion curves, but also contributes to making more natural motions. The motion transition algorithm proposed in this paper could be applied to the various fields such as real time 3D games, virtual reality applications, web 3D applications, and etc.

• Korean Journal of Environment and Ecology
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• v.32 no.3
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• pp.274-288
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• 2018

This study investigated the environmental factors and fish assemblage in 42 wetlands between spring and autumn of 2017 to evaluate the fish distribution and deduce the management strategy for improving biodiversity in created wetlands located at the Nakdong River basin. The investigation identified a total of 30 fish species and found that the most of wetlands were dominated by exotic fishes such as Micropterus salmoides and Lepomis macrochirus. Fish species such as Rhinogobius brunneus, Opsariichthys uncirostris amurensis, Zacco platypus were less abundant in the area with high density of Micropterus salmoides (static area) because they preferred the environment with active water flow. The pattern analysis of fish distribution in each wetland using the self-organizing map (SOM) showed a total of 24 variables (14 fish species and 10 environmental variables). The comparison of variables indicated that the distribution of fish species varied according to water depth and plant cover rate and was less affected by water temperature, pH, and dissolved oxygen. The plant cover rate was strongly associated with high fish density and species diversity. However, wetlands with low plant biomass had diversity and density of fish species. The results showed that the microhabitat structure, created by macrophytes, was an important factor in determining the diversity and abundance of fish communities because the different species compositions of macrophytes supported diverse fish species in these habitats. Based on the results of this study, we conclude that macrophytes are the key components of lentic freshwater ecosystem heterogeneity, and the inclusion of diverse plant species in wetland construction or restoration schemes will result in ecologically healthy food webs.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.40 no.5
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• pp.413-419
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• 2022

As the development of the underground space becomes active, safety accidents related to the underground are frequently occurring in recent years. In this regard, the Ministry of Land, Infrastructure and Transport is enforcing the 『Special Act on Underground Safety Management』 (enforced on January 1, 2018, hereafter referred to as the Underground Safety Act). Among the core contents of the Underground Safety Act, underground facilities(water supply, sewage, gas, power, communication, heating) buried underground, underground structures(subway, underpass, underpass, underground parking lot, underground shopping mall, common area), ground (Drilling, wells, geology) of 15 types of underground information can be checked at a glance on a three-dimensional basis by constructing an integrated underground spatial map and using it. The purpose of this study is to develop a program that can quickly inspect the three-dimensional model after creating a three-dimensional underground structure data among the underground spatial integration maps. To this end, we first investigated and reviewed the domestic and foreign status of technology that generates and automatically inspects 3D underground structure data. A quality inspection program was developed. Through this study, it is judged that it will be meaningful as a basic research for improving the quality of underground structures on the integrated map of underground space by automating more than 98% of the 3D model inspection process, which is currently being conducted manually.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2008.05a
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• pp.171-174
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• 2008

As the mobile devices and the wireless networks have high-performance capabilities, it is possible to synchronize the spatio-temporal data of a server with the spatio-temporal data of a mobile device which are collected at a field. However, since the server process the synchronization which the model device requests the whole synchronizations of mass mobile devices take long time. In this paper, we propose the scheme to Process concurrently the synchronizations of mobile devices which does not conflict with others using the scheme of a multi-queue.

• 한국방재학회:학술대회논문집
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• 2007.02a
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• pp.231-237
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• 2007

To monitor process of vegetation rehabilitation at the damaged area after large-fire is required a lot of manpowers and budgets. However the analysis of vegetation recovery using satellite imagery can be obtaining rapid and objective result remotely in the large damaged area. Space and airbone sensors have been used to map area burned, assess characteristics of active fires, and characterize post-fire ecological effects. Burn severity incorporates both short- and long-term post-fire effects on the local and regional environment. Burn severity is defined by the degree to which an ecosystem has changed owing to the fire. To classify fire damaged area and analyze burn severity of Samcheok fire area occurred in 2000, Cheongyang fire 2002, and Yangyang fire 2005 was utilized Landsat TM and ETM+ imagery. Therefore the objective of the present paper is to quantitatively classify fire damaged area and analyze burn severity using normalized burn index(NBR) of pre- and post-fire's Landsat satellite imagery.