• Journal of Oral Medicine and Pain
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• v.32 no.2
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• pp.151-156
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• 2007

Antimicrobial action of phytoncide in the mouth decrease odor-producing microorganisms. Also phytoncide has malodor effect by reaction with volatile sulfur compounds. Phytoncide has excellent malodor effect in microbiologically and chemically. This study prove the malodor effect of phytoncide by use ferrous sulfate. So I try to make new treatment method for halitosis. I get the results as follows. 1. The difference of mean value of absorbancy was 0.849 between the mean absorbancy of deposition by add phytoncide to saliva and the saliva only. 2. The difference of mean value of absorbancy was 0.701 between the mean absorbancy of deposition by add phytoncide to distilled water and the distilled water only. 3. The difference of mean value(0.849) in saliva by existence of phytoncide was larger than in double distilled water(0.701) by existence of phytoncide. Therefore, phytoncide make more deposition in saliva than double distilled water by reaction with sulfur compounds. As the results, phytoncide reaction with sulfur compounds in saliva. It take malodor action in liquid state effectively. It is thought, only the toothpaste it knows from in the limit which does not have a side effect by the human body it adds in the oral cavity of the mouth rinse and with the fact that it will be able to use positively in clinic.

• Journal of Korea Water Resources Association
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• v.56 no.9
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• pp.587-602
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• 2023

Due to climate change, population growth, and economic development, the demand for water in the urban water system (UWS) and the energy required for water use constantly increase. Therefore, beyond the traditional method of considering only the water sector, the Nexus approach, which considers synergies and trade-offs between the water and energy sectors, has begun to draw attention. In previous researches, the Nexus methodology was used to demonstrate that the UWS is an energy-intensive system, analyze the water-energy efficiency relationship surrogated by energy intensity, and identify climate (long-term climate change, drought, type), geographic characteristics (topography, flat ratio, location), system characteristics (total supply water amount, population density, pipeline length), and operational management level (water network pressure, leakage rate, water saving) effects on the UWS. Through this, it was possible to suggest the direction of policies and institutions to UWS managers. However, there was a limit to establishing and implementing specific action plans. This study built the energy intensity matrix of the UWS, quantified the impact of city conditions, external influences, and operational management levels on the UWS using the water-energy Nexus model, and introduced water-energy efficiency criteria. With this, UWS managers will be able to derive strategies and action plans for efficient operation management of the UWS and evaluate suitability and validity after implementation.

• Journal of Biomedical Engineering Research
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• v.24 no.2
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• pp.121-126
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• 2003

The purpose of this work was to assess and quantify whether the beneficial effects in long-term gas exchange at exciting frequency were obtained at different frequencies as well and then to develop a vibrating intravascular lung assist device(VIVLAD), for Patients suffering from acute respiratory distress syndrome(ARDS) or chronic respiratory problems. We investigate the optimal condition of the frequency band excited with new vibrator at state of limit hemolysis when blood hemolysis came to through a membrane vibration action. The experimental design and procedures were given for a device used to assess the effectiveness of membrane vibrations. Quantitative experimental measurements were performed to evaluate the performance of the device . and to identify membrane vibration dependence on blood hemolysis. We developed an analytical solution for the hydrodynamics of flow through a bundle of sinusoidally vibrated hollow fibers that is used to provide some insight into how wall vibrations might enhance the performance of the VIVLAD. In the result, it was measured that the effect of various excited frequencies in gas transfer rate and hemolysis from the maximum gas transfer rate at no vibration when the maximum gas transfer rates showed at module type 6, module type 6 consisted of 675 hollow fiber membranes The maximum oxygen transfer rate was caused by the occurrence of maximum amplitude and transfer of vibration to hollow fiber membranes when it was excited by the frequency band of 7Hz at each blood flow rate. because this frequency became the End mode resonance frequency of the flexible in blood flow. Also, when module type 6 was excited at an excited frequency of 7Hz. blood hemolysis was low. Therefore, we decided that the limit of hemolysis frequency is 7Hz . because maximum amplitude occurred at this frequency.

• Journal of Korean Society of Steel Construction
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• v.19 no.6
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• pp.737-749
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• 2007

Flexural design of double composite box girder over the interior pier for three-span continuous bridge was performed by the LRFD method. The maximum span length of the continuous bridge ranged from 80m to 120m and the relative ratio of the span length was assumed to be 1:1.25:1. The girder section was designed for the strength limit state and service limit state with additional design check for constructibility. Before the bottom concrete and compression flange showed a complete composite action, the buckling of lower compression flange was checked. The flexural stiffness and flexural resistance characteristics for the section and for the constituent members such as tension flange, compression flange, and web were analyzed for different thicknesses of the bottom concrete on top of the compression flange. The effect of the distribution ratio of steel between the top and bottom flanges was investigated by analyzing ductility behavior and stress distribution through the girder's depth for several different relative area ratios of steel between the top and bottom flanges. It was found that a total amount of 15% of steel can be saved by applying the double composite system compared with that of the conventional composite system.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.2
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• pp.50-55
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• 2018

Earthquakes are almost impossible to predict and take place in a short time. In addition, there is little time to take aggressive action when an earthquake occurs. Therefore, there are more casualties and property damage than with other natural disasters. Recently, earthquakes have been occurring all over the world. As the number of earthquakes increase, studies on the safety of structures are being carried out. On the other hand, there are few studies on the electric facilities, which are relatively non - structural factors. Currently, electrical equipment in Korea is often not designed for earthquake safety and is quite vulnerable to damage when an earthquake occurs. Therefore, in this study, modeling was conducted through ABAQUS similar to an actual cabinet panel and 3D dynamic nonlinear analysis was performed using a natural seismic. According to seismic zone I and normal ground rock conditions of the power transmission and transmission facility seismic design practical guide, the maximum response acceleration of the performance level was 0.157g. In this study, however, it was not safe to reach the limit state of 30% of the analytical result at 0.1g for the general cabinet panel. From the results, the seismic fragility curve was derived and analyzed. The derived seismic fragility curve is presented as a quantitative basis for determining the limit state of the cabinet panel and can be utilized as basic data in related research.

• Proceedings of the PSK Conference
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• 2000.04a
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• pp.70-81
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• 2000

DA-5018 is a synthetic capsaicin derivative under development as a non-narcotic a analgesic ag$\varepsilon$nt. DA-50 18 showed a potent analgesic activity against acute and chronic pain m model(Tablel, 2.), but it had a narrow margin of safety. DA-5018 did not bind to opioid(${\kappa}, {\delta}, {\mu}$), NKl, CGRP receptors in vitro and its analgesic effect was not antagonized by naloxone, a and it did not develop analgesic tolerance. In addition DA-5018 had no inhibitory effects against c cyclooxygenase and 5-lipooxygenase activities. DA-5018 significantly increased the relcase of substance P from the slices of the rat spinal cord. These results suggest that DA-50 18 is not a narcotic nor aspirin-like analgesic and the release of substance P is one of analgesic mechanism of action of DA-5018. We found that DA-5018 was almost ten times more potent and was at l least IOO-times less irritable compared to capsaicin. Accordingly development of topical formula was adopted. Topical formula was desiged and screened by flux test of DA-5018 using hairless mouse skin and several formulas were selected. With these topical formulas we a assessed the analgesic efficacy and carried out the toxicity, skin irritation and pharmacokinetic studies. In streptozotocin-induced hyperalgesic rat and 50 % galactose-fed hyperalgesic rat as diabetic pain models, DA-5018 cream increased the pain thresh이ds up to 77.0% and 24.4% respectively, while Zostrix-HP(capsaicin cream) incr$\varepsilon$as cd by 65.9% and 21.0%. DA-5018 c cream showed a good analgesic effect as welI in FCA-induced arthritic rat. DA-5018 cream did not show any toxicological signs in acute and chronic toxicity test and had little skin irritation in car swclIing and scratching t$\varepsilon$st. Pharmacokinetics of DA-50 18 were studied after topical application of ${14}^C$-Iabelled or unlabelIed DA-5018 cream. Plasma and skin concentrations c except applied skin wcre below the dctection limit and after 7-day cummulative application, plasma concentrations were also below detection limit DA-50 18 may have an advantag$\varepsilon$ ov$\varepsilon$r c capsaicin and is now being developed as a topical agent for the treatment of pains. DA-50 18 cream was approved for Korean IND and is now under a Phase II clinical study for arthritic pain a after finising Phase I study. DA-50 18 was also liscensed out to Stiefel Company in America in

• Journal of Soil and Groundwater Environment
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• v.10 no.2
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• pp.12-19
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• 2005

Jeju island is one of the highest rainfall areas in the Korean peninsular. However, variation in rainfall amount is much great with years, which resulted in substantial variation in annual groundwater recharge and sustainable yield. Therefore, to cope with groundwater hazard including sea water intrusion and water level decline in accordance with successive extreme drought, Jeju province established a stepwise action system, in which management of representative monitoring wells and corresponding actions to water level conditions was enforced. In this study, rainfall and groundwater monitoring data were analyzed to determine management groundwater level on Jeju island. First, rainfall data for last 30 years were analyzed, which yielded a lower limit of rainfall at a confidence level of 99% as a basis rainfall. Only when the rainfall less than the basis rainfall was sustained over 3 months, the water levels were targeted for the analysis. For the water level data selected using the above criteria, the lower limit of 99% confidence interval was determined as a reference groundwater level. Finally, some ratios of reference groundwater level was determined as stepwise management groundwater level on Jeju island.

• Parasites, Hosts and Diseases
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• v.27 no.3
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• pp.161-170
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• 1989

The proteases of Toxoplasma gcndii were purified partially and characterisrd for some biochemical properties including various chromatographic patterns, major catalytic classes, and conditions to promote the activity of these enzymes. When Toxoplasma extract was incubated with 3H-casein at various pH, peak hydrolysis of casein was observed at pH 6.0 and at pH 8.5. Proteasfs working at pH 6.0 and at pH 8.5 were purified partially by conventional methods of chromatographies of DE52 anion rxchange, Sephadex G-200 gel permeation, and hydroxylapatite chromatography. Partially purified enzymes were tested by site-specific inhibitors and promotorf. The protease working at pH 6.0 was inactivated by iodoacetamide with LDso of 10-5 M and promoted by dithiothreitol, while the protease working at pH 8.5 was inhibited by phenylmethylsulfonyl fluoride with LD50 of 10-5 M and was Promoted by ATP (excess ATP beyond 2 mM inhibited the activity reversely). The protease of pH 8.5 had the activity of ATPase which might exert the energy to its action. Therefore the former was referred to as a cysteinyl acid protease and the latter, ATP-dependent neutral serine protease.

• Journal of the Korea institute for structural maintenance and inspection
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• v.21 no.6
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• pp.106-112
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• 2017

This paper presents a mathematical model derived from the upper-bound theorem of concrete plasticity to rationally evaluate the shear friction strength of concrete interfaces with a construction joint. The upper limit of the shear friction strength was formulated from the limit state of concrete crushing failure on the strut-and-tie action along the construction joints to avoid overestimating the shear transfer capacity of a transverse reinforcement with a high clamping force. The present model approach proposed that the cohesion and coefficient of friction of concrete can be set to be $0.27(f_{ck})^{0.65}$ and 0.95, respectively, for rough construction joints and $0.11(f_{ck})^{0.65}$ and 0.64, respectively, for smooth ones, where $f_{ck}$ is the compressive strength of concrete. From the comparisons with 155 data compiled from the available literature, the proposed model gave lower values of standard deviation and coefficient of variation of the ratios between predictions and experiments than AASHTO and fib 2010 equations, indicating that the proposed model has consistent trends with test results, unlike the significant underestimation results of such code equations in evaluating the shear friction strength.

• Membrane Journal
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• v.15 no.3
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• pp.224-232
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• 2005

The use of the lung assist device (LAD) would be well suited for acute respiratory failure (ARF) patients, combining the simplicity of mechanical ventilation with the ability of extracoporeal membrane oxygenators (ECMO) to provide temporary relief for the natural lungs. This study's specific attention was focused on the effect of membrane vibration in the LAD. Quantitative experimental measurements were performed to evaluate the performance of the device, and to identify membrane vibration dependence on blood hemolysis. We tried to decide upon excited frequency band of limit hemolysis when blood hemolysis came to through a membrane vibration action. The excited frequency of the module type 5, consisted of 675 hollow fiber membranes, showed the maximum gas transfer rate. We concluded that the maximum oxygen transfer rate seemed to be caused by the occurrence of maximum amplitude and the transfer of vibration to hollow fiber membranes. It was excited up to $25{\pm}5$ Hz at each blood flow rate of module type 5. We found that this frequency became the 2nd mode resonance riequency of the flexible in blood flow. Blood hemolysis was low at the excited frequency of $25{\pm}5$ Hz. Therefore, we decided that limit hemolysis frequency of this LAD was $25{\pm}5$ Hz.