• Bulletin of the Korean Chemical Society
• /
• 제20권4호
• /
• pp.456-458
• /
• 1999

The synthesis of 6-amino-3-benzylpyrrolo[2,3-c]acridine (9) and its 8,9-dimethoxy derivative (10) from N-benzyl-4,5,6,7-tetrahydroindol-4-one and anthranilonitriles, via imine formation followed by cyclization and aromatisation, is described.

• 대한약학회:학술대회논문집
• /
• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
• /
• pp.180.1-180.1
• /
• 2002

• Archives of Pharmacal Research
• /
• 제10권3호
• /
• pp.153-157
• /
• 1987

Reaction of oxazolin-5-ones 1 with p-amino-diphenylamine was resulted in the formation of the corresponding imidazoline-5-ones 2 which on treatment with sulphur afforded phenothizaines 3. Acridine derivatives 5 were obtained from acetylaminodiphenyl amines derivatives 6 on heating with AnCl$_2$ at $200^{\circ}C.$3 reacted with chloroacetyl chloride to give 7 which reacted in turn with different amines to give 8. Antibacterial activity of the obtained products was studied.

• Bulletin of the Korean Chemical Society
• /
• 제18권5호
• /
• pp.528-534
• /
• 1997

The conformation and stabilization effects of acridine derivatives 9-aminoacridine, an acridine with an aminoalkyl side chain, bis acridine (two acridines linked by an aminoalkyl side chain), and proflavin in the triplex helical poly(dA)·[poly(dT)]2 were investigated by optical spectroscopies. Based on the negative LD and weak positive CD in the acridine absorption wavelength region, we concluded that the acridine moiety of all derivatives are intercalated. We also examined the melting temperatures. Of all the compounds examined, the acridine with an amino alkyl side chain had the strongest effect on the stabilization of the third strand of a poly (dA)·[poly(dT)]2 triplex. The role of the side chain, based on this observation, is discussed.