• Toxicological Research
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• v.31 no.2
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• pp.151-156
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• 2015

5-Fluorouracil (5-FU) is commonly used for the therapy of colon cancer; however, acquired resistance to 5-FU is a critical barrier to successful treatment and the primary cause of chemotherapy failure. Epithelial-mesenchymal transition (EMT) is a process whereby cells undergo alterations in morphology and molecular characteristics promoting tumor progression and metastasis. Accumulating evidence shows that transition from epithelial to mesenchymal phenotype in cancer cells is associated with their resistance to chemotherapy. However, it is still poorly understood whether EMT is involved in acquired resistance to 5-FU. In this study, we developed an in vitro cell model, 5-FU-resistant HT-29 colon cancer cells, and characterized the differences in cellular morphology and molecular alterations between parental and resistant cells. In accord with mesenchymal-like morphology of 5-FU-resistant HT-29 cells, the expression of the mesenchymal marker fibronectin was significantly increased in these cells in comparision with that in the parental cells. Of interest, we also found a marked increase in the expression of EMT-inducing transcription factors Twist, Zeb1, and Zeb2. Finally, 5-FU-resistant cells showed enhanced migration in comparison with parental HT-29. Taken together, these results indicate that EMT could be associated with 5-FU resistance acquired by HT-29 cells. A specific role of each transcription factor found in this study will require further investigation.

• Journal of Korean Port Research
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• v.11 no.2
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• pp.145-156
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• 1997

The purpose in this study is development of model for the Container Terminals of Pusan Port, First of all, Quantitive and Qualititve factors are characterized which effects on Physical Distribution System in Container Terminals. The System Dynamics method is used to develope the model by using these factor. This model is able to present the timinig of investment in Container Terminals of Pusan Port. Six models are showed by change of parameters in System Dynamics, in this paper. In the model, Five feedback loop were found. Loop 1 : Number of Liners$\rightarrow$Number of Congested ships$\rightarrow$Port's Charges$\rightarrow$Export & Import Cargo Volumes$\rightarrow$Number of Liners$\rightarrow$The will to investment of government$\rightarrow$Length of berth→Number of Liners. Negative loop was acquired. Loop 2 : Port's Charge$\rightarrow$Economic of Port$\rightarrow$The will to Private management$\rightarrow$Efficiency for Port's Operation$\rightarrow$Port's Charges. Positive loop was acquired. Loop 3 : Number of Congested ships$\rightarrow$Planning for future development$\rightarrow$Information Service$\rightarrow$Support service for port's user$\rightarrow$Number of Congested ships. Negative loop was acquired. Loop 4 : Number of Congested ships$\rightarrow$Planning for future development$\rightarrow$Extent of stacking area$\rightarrow$Number of handling equipmint$\rightarrow$Number of Congested ships. Negative loop was acquired. Loop 5 : Export & Import Cargo Volumes$\rightarrow$Number of Liners$\rightarrow$Econmic of Port$\rightarrow$Support service for port's user$\rightarrow$Export & Import Cargo Volumes. Positive loop was acquired. System's level variables were selected as followings ; Number of Liners, Number of Congested ships, Export & Import Carge Volumes, Length of berth, and Port's Charges. As result of simmulation of model, fluctuation of respective year was found in level variables. This fluctuation can be used properly to present timing of investment.

• Tuberculosis and Respiratory Diseases
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• v.80 no.2
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• pp.201-209
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• 2017

Background: Methicillin-resistant Staphylococcus aureus (MRSA) infection is a severe and life-threatening disease in patients with community-onset (CO) pneumonia. However, the current guidelines lack specificity for a screening test for MRSA infection. Methods: This study was retrospectively conducted in elderly patients aged ${\geq}65years$, who had contracted CO-pneumonia during hospitalization at the Jeju National University Hospital, between January 2012 and December 2014. We analyzed the risk factors of MRSA in these patients and developed a scoring system to predict MRSA infection. Results: A total of 762 patients were enrolled in this study, including 19 (2.4%) with MRSA infection. Healthcare-associated pneumonia (HCAP) showed more frequent MRSA infection compared to community-acquired pneumonia (4.4% vs. 1.5%, respectively; p=0.016). In a multivariate logistic regression analysis, admissions during the influenza season (odds ratio [OR], 2.896; 95% confidence interval [CI], 1.022-8.202; p=0.045), chronic kidney disease (OR, 3.555; 95% CI, 1.157-10.926; p=0.027), and intensive care unit admission (OR, 3.385; 95% CI, 1.035-11.075; p=0.044) were identified as predictive factors for MRSA infection. However, the presence of HCAP was not significantly associated with MRSA infection (OR, 1.991; 95% CI, 0.720-5.505; p=0.185). The scoring system consisted of three variables based on the multivariate analysis, and showed moderately accurate diagnostic prediction (area under curve, 0.790; 95% CI, 0.680-0.899; p<0.001). Conclusion: MRSA infection would be considered in elderly CO-pneumonia patients, with three risk factors identified herein. When managing elderly patients with pneumonia, clinicians might keep in mind that these risk factors are associated with MRSA infection, which may help in selecting appropriate antibiotics.

• Proceedings of the Korea Concrete Institute Conference
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• 1992.10a
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• pp.94-99
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• 1992

In this study , some factors such as mix proportion, type and dosage of high range water reducing admixture(HRWR) and natural pozzolanas influencing on the slump loss of high strength concrete(H.S.C) using HRWR were investigated for reducing the slump loss. The acquired results indicated that the slump loss of H.S.C was affected according to cement content, sand percentage and type and dosage of HRWR and fly ash was superior to ground granulated blast furance slag in reducing the slump loss of H.S.C.

• Archives of design research
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• v.20 no.2 s.70
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• pp.29-40
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• 2007

Human factors engineering has been taught in the design fields and considered as a necessary course for design students, We, ergonomists working with a design department, analyzed the current status of ergonomics curricula in the Korean design colleges. Sixty one percent of schools with design departments were offering ergonomics courses and most courses were electives. Comparatively more ergonomic courses were offered in industrial design and digital media departments. Ergonomic and human factors knowledge might not properly be acquired with this current status of the design curricula and systematic solutions should be considered and prepared for the future Korean designers.

• Parasites, Hosts and Diseases
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• v.52 no.5
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• pp.487-491
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• 2014

Toxoplasma gondii is an obligate intracellular protozoan that is distributed worldwide. Recently, several tests for avidity of Toxoplasma IgG antibodies have been introduced to help discriminate between recently acquired and distant infections. The study was conducted in Jawaharlal Nehru Medical College and Hospital, India from February 2011 to September 2012. Serum specimens were subjected to Toxoplasma IgM ELISA and IgG avidity ELISA test. Out of 48 patients with abortions, 17 (35.4%) were positive for IgM ELISA, and 8 (16.6%) had low IgG avidity antibodies. Out of 48 patients with other obstetric problems, 23 (47.9%) were positive for IgM ELISA, and 17 (35.4%) had low IgG avidity antibodies. Combining both groups on avidity test, only 25 of 40 (62.5 %) IgM-positive women had low-avidity IgG antibodies suggesting a recent T. gondii infection in these women. More importantly, 15 (37.5%) of the IgM-positive women had high-avidity antibodies suggesting that the infection was acquired before gestation The relation of IgM seropositivity with the following risk factors was not found to be statistically significant; contact with cats (0.13), non-vegetarian food habits (0.05), and low socio-economic status (0.49). While, for IgG avidity ELISA, only contact with cats (0.01) was significantly associated with seropositivity. All other risk factors have P-values of >0.05 (not significant). IgG avidity test when used in combination with IgM test was a valuable assay for diagnosis of ongoing or recently acquired T. gondii infection in India.

• Korean Journal of Biological Psychiatry
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• v.21 no.4
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• pp.118-127
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• 2014

Along with language, socialization is a unique feature of the human being. There is a continuous debate regarding whether the development of socialization is innate, and conducted by the environment in the growing process, or the result of the interaction of both aspects. If socialization is the result of the interaction with the environment or is an acquired developmental process, the following question rises. "Is there a 'critical period' for the development of socialization?" Although there are a huge number of studies seeking for treatment and solutions for developmental delay or deficits of socialization, it is very complicated question to answer. Historical figures such as 'Hugh Blair' of Borgue in England, and 'the wild boy of Aveyron' in France, seem to have innate socialization deficits. Nowadays patients with non-verbal learning disorder, social communication disorder, or autism spectrum disorder seem to have genetic defects. On the other hand, Harry Harlow's monkey experiments, hikikomori of Japan, Romanian orphans and patients with reactive attachment disorder seem to display social deficits due to environmental factors. However, it is not easy to clearly draw a line between innate or acquired factors. Therefore, rather than subdividing the diseases for etiological and pathophysiological approach to heterogenous groups with the common denominator of social deficit, and for the research of pathophysiology and treatment development, the authors suggest a comprehensive concept of "social dysfunction spectrum."

• Journal of Animal Environmental Science
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• v.6 no.1
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• pp.15-22
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• 2000

A monitoring and the forecasting system for the swine delivery was developed using CCD camera multi-function board microphone and data-recorder equipped on a personal computer. For the swine delivery monitoring and forecasting factors four factors were selected such as genitalia swine body shape breast color and sound. Image of physical variation of body shape, shape and color of genitalia area and color of breast of pregnant sow were grabbed using the CCD color camera and multi-function board and variation of voice of pregnant sow was acquired using microphone and data recorder. Acquired information of image and voice were analyzed using a custom developed algorithm and program. The result of the forecasting efficiency of swine delivery was 89%, 71% and 100% using the variation of genitalia are the body shape and the voice of pregnant sow. respectively. The efficiency of image processing was 100% for the delivery detection when the piglet was delivered half of its body from genitalia of pregnant sow, The monitoring and forecasting system informed the estimated time of the delivery of swine to a farm manager immediately if an estimated and established time set by the farm manager was the same and/or the estimated time ws earlier than the established time and the system detected the delivery.

• Smart Media Journal
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• v.6 no.3
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• pp.57-63
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• 2017

The most important, essential prerequisite for the improvement of vehicle license plate recognition is the acquisition of high-quality vehicle images. Because typical images acquired from roads are affected by different environmental factors including the time of day, sunlight, and the weather, the brightness and the shape of the license plates in the images are inconsistent. To this end, many image corrections are performed, resulting in slower recognition and lower recognition rate. Therefore, in this study, we used the images acquired from roads to test the proposed method for fast capturing of vivid, high-quality vehicle images by measuring the brightness around license plates during real-time image capturing to control in real time the factors, such as shutter speed, brightness, and gain of the camera, that affect the brightness and the quality of the images.

• Earthquakes and Structures
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• v.16 no.6
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• pp.655-664
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• 2019

Behavior factor of a structure plays a crucial role in designing and predicting the inelastic responses of it. Recently, irregular buildings have been interested in many designers. To design irregular structures, recognizing the inelastic behavior of them is necessary. The main objective of this study is to determine the behavior factor of irregular Reinforced Concrete Moment Resisting Frames (RCMRFs) via nonlinear Incremental Dynamic Analysis (IDA). To do so, first, several frames are designed according to the regulations of the Iranian national building code. Then the nonlinear incremental dynamic analysis is performed on these structures and the behavior factors are achieved. The acquired results are compared with those obtained using pushover analysis and it is shown that the behavior factors acquired from the nonlinear incremental dynamic analysis are somewhat larger than those obtained from pushover analysis. Eventually, two practical relations are proposed to predict the behavior factor of irregular RCMRFs. Since these relations are based on the simple characteristics of frames such as: irregularity indices, the height and fundamental period, the behavior factor of irregular RCMRFs can be achieved efficiently using these relations. The proposed relations are applied to design of four new irregular RCMRFs and the outcomes confirm the accuracy of the aforementioned relations.