• Korean Journal of Acupuncture
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• v.18 no.1
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• pp.171-175
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• 2001

한의학에 있어서 음양의 조절은 매우 중요하다. 숙지황은 음허를 치료하는 주약이며, 부자는 양허를 치료하는 주약이다. 한의학에서 신성고혈압의 발생은 음허와 관련이 있다고 하였다. 본 연구는 실험적 신성고혈압과 자연발증고혈압 백서에 숙지황과 부자 전탕액을 투여 후 혈압의 변동과 혈장 renin 활성도, aldosterone 및 심방이뇨호르몬 (atrial natriuretic hormone)의 변동을 관찰하였다. 숙지황 투여후 실험적 신성고혈압 백서의 혈압은 감소하였다. 부자 전탕액 투여 후 자연발증고혈압 백서의 혈압 상승이 억제되었다. 숙지황 및 부자 전탕액 투여 후 자연발증고혈압 백서의 혈장 renin 활성도는 감소하였다. 부자 전탕액 투여 후 신성고혈압 백서의 혈장 ANP 농도는 감소하였다. 부자 전탕액의 혈압강하 작용은 ANP 및 aldosterone 농도의 변동과 관련이 있다고 사료된다.

• Korean Journal of Acupuncture
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• v.18 no.1
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• pp.143-156
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• 2001

Modulatory effect of cAMP-PKA system on inhibitory- and excitatory herbs-induced ion currents were investigated by nystatin-perforated patch clamp method under voltage-clamp condition. Ion currents induced by Bupleuri radix and Coptidis rhizoma were not affected by cAMP-PKA system. Ion current induced by Ecliptae herba was partially inhibited by cAMP-PKA system. Ion currents induced by Aconiti tuber and Boshniakiae herba were inhibitory modulated and ion current induced by Zingiberis rhizoma was excitatory modulated by cAMP-PKA system. Modulation of cAMP-PKA system on ion currents induced by Ginseng radix was fluctuated. In this results, it can be seen generally that excitatory herbs-induced ion currents were modulated by cAMP-PKA system while cAMP-PKA system did not affect inhibitory herbs-induced ion currents.

• The Journal of Korean Medical History
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• v.20 no.2
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• pp.116-132
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• 2007

In Yoshimasu Todo (吉益東洞)'s book, the doctors' commitment is said to attack the poison of illness and this can be realized only by using the poison of medicine. From this point of view, he had denied the preceding medicine books, since there was no distinction between the food that raise the body and the poison that attack the poison of illness in the preceding medicine books. In addition, Every medicine has the respective results and one medicine treats one disease, otherwise, in the preceding medicine books, one medicine deals with more than one illness and also they have denied that the characters of medicines are cold or hot because they couldn't be proven by tasting or seeing.

• Korean Journal of Pharmacognosy
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• v.44 no.2
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• pp.176-181
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• 2013

In order to search for protein tyrosine phosphatase 1B (PTP1B) inhibitors as therapy of type 2 diabetes and obesity from Korean traditional prescriptions, we selected 58 traditional prescriptions based on a review of the Korean traditional medicine books. The hot water extracts of Korean traditional prescriptions were screened for the inhibitory activity against PTP1B. Among the tested extracts, water extracts of Jakgamhwangsinbu-tang, Seonbanghwalmyung-eum, and Takreeonjoong-tang showed relatively good inhibitory activity against PTP1B at the concentration of $30{\mu}g/ml$. Additionally, we evaluated PTP1B inhibitory effect for each herbal ingredient and composition in Jakgamhwangsinbu-tang (芍甘黃辛附湯). Of the tested ingredients from this herbal medicine, water extracts of Paeoniae Radix rubra and Rhei Rhizoma, and ethanol extracts of Paeoniae Radix alba, Rhei Rhizoma, Asiasari Radix, and Aconiti Tuber showed good PTP1B inhibitory effect. Herbal compositions composed of these active herbal ingredients exhibited significant activity for PTP1B inhibition over 70% at $7.5{\mu}g/ml$.

• The Journal of Korean Obstetrics and Gynecology
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• v.18 no.4
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• pp.153-164
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• 2005

Purpose : This study was designed to make a basis of in vivo or clinical study about colporrhea. Methods : This study is based on Yang's study, An investigation on the prescriptions of colporrhea(1999). We investigate the prescriptions in the Yang's study and examine the frequency of metioned single herb. Also we investigate the herb's classification. Results and Conclusion : 1) Single herb frequently used in the prescriptions was as follows. (()- Frequency) Paeoniae Radix Alba白芍藥(16), Glycyrrhizae Radix甘草(15), Poria白茯?(13),　Angelicae gigantis Radix當歸, Citri Pericapium陳皮(11), Atractylodis macrocephalae Rhizoma白朮(10), Zingiberis Rhizoma乾薑　, Atractylodis Rhizoma蒼朮, Ailanthi Cortex樗根白皮, Phellodendri Cortex黃柏, Ginseng Radix人蔘, Cyperi Rhizoma香附子(9),　Dioscoreae Rhizoma山藥, Corni Fructus山茱萸, Bupleuri Radix柴胡, Cnidii Rhizoma川芎, Gardeniae Fructus梔子(8), Rehmanniae Radix preparat熟地黃, Pinelliae Rhizoma半夏(7), Foeniculi Fructus小茴香, Scutellariae Radix黃芩, Angelicae dahuricae Radix白芷, Cinnamomi肉桂(5), CortexAlismatis Rhizoma澤瀉, Moutan Cortex牧丹皮, Aconiti iateralis preparata Radix附子, Plantaginis Semen車前子(4), Ostreae Concha牡蠣, Euphorbiae pekinensis Radix大戟, Aucklandiae Radix木香, Rhei Radix et Rhizoma大黃, Ledebouriellae Radix防風, Astragali Radix黃?, Rehmanniae Radix生地黃, Daphnis genkwa Flos莞花, Evodiae Fructus吳茱萸, Euphorbiae kansui Radix甘遂(3) 2) Herbs specifically frequently used in the prescriptions of colporrhea were as follows. Atractylodis Rhizoma蒼朮, Ailanthi Cortex樗根白皮, Phellodendri Cortex黃柏, Cyperi Rhizoma香附子, Bupleuri Radix柴胡, Gardeniae Fructus梔子　3)Herbs frequently used were classified by herbal medicine's classification. The　result was as follows. (()-The number of herbs)　補益藥（1９). 淸熱藥(18). 解表藥(10), 收澁藥(9), 溫裏藥(7), 理氣藥(6), 利水?濕藥(6), 瀉下藥（５)

• The Journal of Korean Medicine
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• v.42 no.4
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• pp.120-132
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• 2021

Objectives: The prevalence of Parkinson's disease is on an upward trend along with an increase in the aging population but there is no available treatment that halts the progression of neurodegeneration. This study reports a numerical analysis on Donguibogam and suggests novel herbal drugs, which have never been researched before but found to be deemed effective in this study. Methods: Referring to 71 Korean medicine symptom terms that represent the symptoms of Parkinson's disease, 4170 prescriptions described in Donguibogam were classified into two groups based on whether their main effects were effective for Parkinson's disease or not. Comparing the two groups, the chi-square test was performed to select statistically significant herbs, while the t-test, Wilcoxon test, and descriptive statistics were performed to determine the appropriate dose. Results: One hundred and twenty-seven prescriptions effective for Parkinson's disease were identified. The chi-square test determined 17 herbs that are effective for symptomatic treatment. Among the medicinal herbs, the authors suggest Osterici seu Notopterygii Radix et Rhizoma, Ephedrae Herba, Aconiti Tuber, Myrrha, Sinomeni Caulis et Rhizoma, and Aconiti Kusnezoffii Tuber as herbal candidates that have never been studied for Parkinson's disease. Through the statistical tests, it was judged that the mean value of the dose of the entire prescription was the appropriate dose for each herb. Conclusions: Seventeen herbs were selected for Parkinson's disease and the appropriate daily dose were calculated. Furthermore, this study presented a new process that applies a statistical method to traditional medical literature and preselecting herbs deemed effective for specific diseases.

• Journal of Korean Medicine Rehabilitation
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• v.24 no.4
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• pp.15-28
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• 2014

Objectives This study was carried out to find out the Antioxidant and Anti-inflammatory Effects of Components of Mahwangbujaseshin-tang in LPS-Stimulated RAW264.7 Macrophages. Methods There are 5 experimental groups. ; normal, control, EH (Ephedrae Herba), ALRP (Aconiti Lateralis Radix Preparata) and AR (Asiasari Radix). The extract of EH, ALRP and AR ($100{\mu}g/ml$) was added to each group. We examined cytotoxicity, total phenolic contents, DPPH and ABTS free radical scavenging activity, Intracellular ROS (reactive oxygen species) production, NO (Total Nitric oxide), iNOS (inducible nitric oxide synthase), PGE2 (prostaglandin E2), COX-2 (cyclooxygenase-2), $IL-1{\beta}$ ($interleukin-1{\beta}$), IL-6 (interleukin-6), $TNF-{\alpha}$ (tumor necrosis factor-${\alpha}$), MMP-9 (matrix metalloproteinase-9), TIMP-1 (tissue inhibitor of metalloproteinase-1) and HO-1 (heme oxygenase-1) expression level. Results 1. Total phenolic contents of EH were in the highest level. 2. DPPH and ABTS free radical scavenging activity of EH was in the highest level. 3. ROS production was significantly decreased in AR. 4. NO production was significantly decreased in EH, ALRP, AR and iNOS expression was decreased in EH, AR. 5. PGE2 and COX-2 expression was decreased in EH, AR. 6. $IL-1{\beta}$ production was significantly decreased in EH, AR and IL-6 production was significantly decreased in AR. $TNF-{\alpha}$ production was significantly decreased in ALRP, AR. 7. MMP-9 and TIMP-1 production were significantly decreased in EH. 8. HO-1 expression was significantly increased in EH. 9. With simultaneous usage of SnPP which is expression inhibitor of HO-1, NO, $IL-1{\beta}$, IL-6 and $TNF-{\alpha}$ production were partially increased in EH, ALRP, AR. Conclusions According to this study, Components of Mahwangbujaseshin-tang have anti-oxidants and anti-inflammation effects in LPS-Stimulated RAW264.7 Macrophages.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.29 no.3
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• pp.42-49
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• 2016

Objectives : The purpose of this study is to analyze research trends on tinea pedis in studies of Korean medicine.Methods : We searched papers using NDSL, KISS, RISS and KTKP(Korean Traditional Knowledge Portal). The first search used the keyword "Tinea pedis" in NDSL, KISS, RISS and KTKP. Used searching duration was not specified.Results : Studies found in NDSL, KISS and RISS were 122 and 118 studies were excluded. Studies found in KTKP were five papers and four studies of them were excluded. Finally five studies were selected and analyzed. Two studies of five selected ones were experimental researches and three studies were clinical researches. Among 2 researches of experimental researches, one of them was about antifungal efficacy of herbal medicines and ethahol extract of the mixture of Sophorae Subprostratae Radix, Aconiti Radix and Hibisci Syriaci Cortex and hot water extract of Phellodendri Cortex were effective. The other was about antifungal effect of the medicinal herb extraction method and vinegar extract was effective. Among 3 researches of clinical researches, there were one clinical study and two case studies. Functional soap containing herbal medicines and bee venom therapy were effective.Conclusions : As we looked for five researches, which were two experimental studies, one clinical study and two case studies. It is possible to treat tinea pedis with korean medical approach by conclusions of 5 researches. We expect that further researches will be proceeded and following results can be actively used as clinical treatments.

• Korean Journal of Oriental Medicine
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• v.17 no.2
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• pp.47-56
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• 2011

Objective : This study reviews the articles about 'Side effect' published in the Japanese Journal of Oriental Medicine to better understand about side effects of herbal medication and to encourage clinicians, the authorities and the public to establish side effects reporting system. Method : We searched articles published in the Japanese Journal of Oriental Medicine by using keyword '副作用(Side effect)' in the CiNii. Results : Among the 118 articles collected, 14 are clinical articles about side effect of prescriptions, 13 are reports about side effect of prescriptions presented from Japanese Ministry of Health, Labour and Welfare, 36 are clinical articles about relief of side effects derived from taking western medicine by taking a herbal prescription, 8 are studies about the effect of a herbal prescription combined with western medicine or comparative studies between a herbal prescription and western medicine, and so on. Conclusions : Lots of articles deal with side effects of Aconiti Lateralis Radix Preparata, Bupleuri Radix and so on. When side effects occurred, removing a certain herbal drug or quitting a herbal prescription is helpful to relieve or disappear the side effects. And Side effects reporting system should be established to guide safe medication use and treatment for patients. In order to establish side effects reporting system, the standardization of herbal drugs is needed.

• The Korea Journal of Herbology
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• v.33 no.1
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• pp.71-76
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• 2018

Objectives : This study was performed to investigate the single oral toxicity of HBX-6 in Sprague-Dawley (SD) rats. Methods : Twenty SD rats were randomly assigned to four groups of 5 rats each and were administrated singly to female and male SD rats, as an oral dose of 2000 mg/kg. HBX-6 is a newly combined Korean herbal medicine formula 30 % Ethanol extract derived from The Dongui Bogam. Now we are developing the prescription for the aim of improving benign prostatic hyperplasia (BPH) without undesirable side effects. HBX-6 is composed of nine medicinal herbs: Aconiti Lateralis Radix Preparata, Corni Fructus, Cistanchis Herba, Psoraleae Semen, Dendrobii Herba, Morindae Radix, Cuscutae Semen, Trigonellae Semen, Foeniculi Fructus. Animals were monitored for the mortality and changes in the body weight, clinical signs, gross observation and necropsy findings for the 14 days according to "Standard for Toxicity Study of Pharmaceuticals" of Korea Food and Drug Administration (KFDA) guideline and "Acute Oral Toxicity - Fixed Dose Procedure" of OECD Test Guideline. Results : We could not find any mortality. Compared with the control group, significant weight change was not observed in the experimental group. After administration, the more common symptoms were not observed. There were no gross abnormalities in all cases. Conclusions : Taken together, these results suggest that the approximate lethal dose of HBX-6 in both female and male SD rats were considered as over 2000 mg/kg.