• Journal of Yeungnam Medical Science
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• 제1권1호
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• pp.13-23
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• 1984

Acute renal failure refers to a rapid reduction in renal function that usually occurs in an individual with no known previous renal disease. Development of a complication of acue renal failure in critically ill surgical patients is not unusual, and it causes high morbidity and mortality. Acute renal failure can be divided as Pre-renal (functional), Renal (organic), and Post-renal (obstructive) azotemia according to their etiologies. Early recognition and proper correction of pre-renal conditions are utter most important to prevent an organic damage of kidney. These measures include correction of dehydration, treatment of sepsis, and institution of shock therapy. Prolonged exposure to ischemia or nephrotoxin may lead a kidney to permanent parenchymal damage. A differential diagnosis between functional and organic acute renal failure may not be simple in many clinical settings. Renal functional parameters, such as $FENa^+$ or renal failure index, are may be of help in these situations for the differential diagnosis. Provocative test utilyzing mannitol, loop diuretics and renovascular dilators after restoration of renal circulation will give further benefits for diagnosis or for prevention of functional failure from leading to organic renal failure. Converting enzyme blocker, dopamine, calcium channel blocker, and propranolol are also reported to have some degree of renal protection from bioenergetic renal insults. Once diagnosis of acute tubular necrosis has been made, all measures should be utilized to maintain the patient until renal tubular regeneration occurs. Careful regulation of fluid, electrolyte, and acid-base balance is primary goal. Hyperkalemia over 6.5 mEq/l is a medical emergency and it should be corrected immediately. Various dosing schedules for medicines excreting through kidney have been suggested but none was proved safe and accurate. Therefore blood level of specific medicines better be checked before each dose, especially digoxin and Aminoglycosides. Indication for application of ultrafiltration hemofilter or dialysis may be made by individual base.

• 자연과학논문집
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• 제7권
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• pp.53-58
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• 1995

우유와 쏘세지 등 몇가지 동물성 식품의 보존에 미치는 오골계 난백 lysozyme의 효과를 검토하기 위하여 이들을 0.05% lysozyme 으로 처리한 후 $20^{\circ}C$, $30^{\circ}C$ 및 $37^{\circ}C$에 저장하면서 경시적으로 이들의 pH와 휘발성 염기질소 함량 및 생균수의 변화를 조사 하였다. 생우유를 lysozyme 으로 처리하여 $20^{\circ}C$에서 48시간 저장 하였을 때 휘발성 염기질소 함량이 63mg%로 제일 낮아 보존효과가 있었고 $30^{\circ}C$에서는 lysozyme 과 glycine의 혼용처리시 그 보존효과가 상승하였다. 또한 시판우유와 어묵에서도 lysozyme처리에 의한 보존효과가 있었으며 특히 솔빈산을 첨가하지 않은 쏘세지에 lysozyme 을 처리하여 $5^{\circ}C$에 저장 하였을 때 휘발성 염기질소 함량이 약 150 mg%로 비교적 낮았다.

• Asian-Australasian Journal of Animal Sciences
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• 제30권8호
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• pp.1124-1134
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• 2017

Objective: This study explored the physico-chemical properties of late-incubation egg amniotic fluid and a potential in ovo feed (IOF) supplement. Methods: Amniotic fluid was collected from broiler breeders (Ross 308, 51 weeks and Cobb 500, 35 weeks) on day 17 after incubation. A mixture of high-quality soy protein supplement - Hamlet Protein AviStart (HPA) was serially diluted in MilliQ water to obtain solutions ranging from 150 to 9.375 mg/mL. The mixtures were heat-treated (0, 30, 60 minutes) in a waterbath ($80^{\circ}C$) and then centrifuged to obtain supernatants. The amniotic fluid and HPA supernatants were analysed for their physico-chemical properties. Results: Only viscosity and $K^+$ were significantly (p<0.05) different in both strains. Of all essential amino acids, leucine and lysine were in the highest concentration in both strains. The osmolality, viscosity and $pCO_2$ of the supernatants decreased (p<0.05) with decreasing HPA concentration. Heat treatment significantly (p<0.05) affected osmolality, pH, and $pCO_2$, of the supernatants. The interactions between HPA concentration and heat treatment were significant with regards to osmolality (p<0.01), pH (p<0.01), $pCO_2$ (p<0.05), glucose (p<0.05), lactate (p<0.01) and acid-base status (p<0.01) of HPA solutions. The $Ca^{2+}$, $K^+$, glucose, and lactate increased with increasing concentration of HPA solution. The protein content of HPA solutions decreased (p<0.05) with reduced HPA solution concentrations. The supernatant from 150 mg/mL HPA solution was richest in glutamic acid, aspartic acid, arginine and lysine. Amino acids concentrations were reduced (p<0.05) with each serial dilution but increased with longer heating. Conclusion: The values obtained in the primary solution (highest concentration) are close to the profiles of high-protein ingredients. This supplement, as a solution, hence, may be suitable for use as an IOF supplement and should be tested for this potential.

• 한국작물학회지
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• 제35권3호
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• pp.248-253
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• 1990

자운영(Astragalus sinicus L. Line A) 종자의 발아와 묘신장을 네 온도(15, 25, 30 및 35$^{\circ}C$), 세 polyethylene glycol(PGE) 10,000(MW) 용액(0, 20 및 25g/100mg $H_2O$), 그리고 다섯수준의 황산(중량기준 conc. H$_2$SO$_4$ : Seeds; 0, 1:1 10분, 1:1 20분 1:1.5 10분 및 1:1.5 20분 침지)에 처리하여 측정한 결과를 요약하면 다음과 같다. 자운영의 발아율은 15$^{\circ}C$에서 가장 높았으나 묘장은 $25^{\circ}C$에서 가장 길었다. 발아율과 묘장 모두 PEG 무처리에서 25로 농도가 증가할수록 급격히 감소되었다. 15$^{\circ}C$의 PEG 20과 25에서는 다른 온도보다는 높은 발아율을 보였다. 황산처리효과에서는 발아율과 묘장 모두 황산무처리와 같거나 감소되었다. 그러나 PEG 무처리의 경우에는 황산:종자비율 1:1.5에서 10분간 침지시에 발아율이 가장 높았다. 본 시험의 결과로는 종자의 발아는 수분의 영향이 가장 큰 것으로 보였다.

• Preventive Nutrition and Food Science
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• 제10권1호
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• pp.17-21
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• 2005

This study was carried out to determine whether detection of minerals separated from irradiated mussel could be could be done by thermoluminescence (TL) method. After the minerals were separated by sodium polytungstate solution (2.0 g/mL) from irradiated mussel, organic compounds remaining in the minerals were removed by acid-base treatment and dried at 50℃ overnight, and then the minerals were measured through TL. The TL intensities of separated minerals at different irradiation doses during storage conditions of room and darkroom were obtained. TL intensity of first glow curves for minerals separated from irradiated mussel showed linear increase from the control to 5 kGy and slight increase from 5 kGy to 10 kGy. Since glow curve ratios of G2, G3 and G4, calculated from re-irradiated minerals measured immediately after irradiation and after storage of three months were over 0.5, detection of irradiation was possible. G1, which showed the glow curve ratios above 0.1, was classified as non-irradiated samples because the unique first glow curve was not found within the recommended temperature interval (150-230℃). Hence, on the basis of TL intensity, and glow curve ratio and shape, it is possible to correctly identify irradaited mussels after mineral separation during storage.

• 동력기계공학회지
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• 제5권3호
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• pp.88-94
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• 2001

Stellite 12 alloy-powders were overlaid on 410 stainless steel valve seat using plasma transferred arc(PTA) process. Variation of the microstructure, hardness, wear and corrosion of overlaid deposit with current change was investigated. The deposit showed hypoeutectic microstructure, which was consisted of primary cobalt dendrite and networked $M_7C_3$ type eutectic carbides. As current increased, the amount of eutectic carbide decreased and its dendritic secondary arm spacing increased. Hardness of the deposit was decreased with increase of current. Stress relief heat treatment at $600^{\circ}C$ for two hours resulted in slight increase of hardness in the deposit and showed uniform hardness distribution in base metal without any hardened layer in HAZ. Specific wear decreased with increase of sliding distance. The deposit of high hardness with a lot of eutectic carbide showed relatively low specific wear. Initial corrosion current density of the deposit in 0.1N sulfuric acid was lower than those of 410 stainless steel, and showed a little variation with PTA current.

• Rapid Communication in Photoscience
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• 제1권1호
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• pp.13-15
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• 2012

New porous $TiO_2$ nanostructures with shapes of pearl and rice were synthesized by hydrothermal treatment of $TiO_2$-liposome nanocomposites in acid and base solutions, respectively, as identified by scanning electron microscopy (SEM), transmission electron microscopy (TEM) images and large Brunauer-Emmett-Teller (BET) surface areas. The x-ray diffraction (XRD) patterns and selected area electron diffraction proved them to be well-defined anatase crystals. Their UV-visible reflectance absorption spectra were observed to have low band gap energy (3.03 and 3.07 eV, respectively), exhibiting surface absorption band in the visible range from 400 to 600 nm. The degradation of methylene blue (MB) over the $TiO_2$ nanostructures was observed upon visible-light irradiation, which was found to be very efficient as compared with any other conventional visible-light responsive $TiO_2$ nanostructures.

• Journal of Microbiology and Biotechnology
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• 제13권3호
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• pp.457-462
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• 2003

The complete nucleotide sequence of a plasmid, pMG1, isolated from Bifidobacterium longum MG1 has been determined. This plasmid, composed of 3,862 base pairs with 65.1% of G+C content. harbors two major open reading frames (ORF) encoding putative proteins of 29 kDa (ORF I) and 71 kDa (ORF II). ORF I showed relatively high amino acid sequence homology with replication proteins of other plasmids from Gr Im-positive and -negative bacteria. Upstream of ORF I, four sets of tandem repeat sequences resembling the iteron structure of related plasmids were found. S1 endonuclease treatment and Southern blot analysis revealed that pMG1 accumulates single-stranded DNA (ssDNA) intermediate, which indicate i the rolling circle replication (RCR) mechanism of this plasmid. Homology search indicated that ORF II encodes plasmid mobilization protein, and the presence of highly conserved oriT sequence in the upstream of this gene supported this assumption. RT-PCR showed that only ORF I is expressed in vivo. Based on these results, pMG 1 was exploited to construct a shuttle vector, pBES2. It was successfully transformed into Bifidobacterium and maintained stably.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2006년도 Spring Conference
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• pp.109-120
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• 2006

Alzheimer's disease (AD) is an age-related neurodegenerative disorder. The pathological hallmarks of AD are senile plaques and neurofibrillary tangles in the brain. Major component of senile plaques is amyloid beta peptide(A$\beta$) which is derived from amyloid precursor protein (APP). A$\beta$ is generated through the sequential cleavage of App by $\beta$ - and $\gamma$-secretases. $\beta$-secretase excises the ectodomain of APP ($\beta$-APPs) to leave a 99-amino acid long C-terminal fragment (APP-C99-CTF) in the membrane. $\gamma$-secretase then cleaves this membrane-tethered APP-CTF within the transmembrane domain, so releasing A$\beta$ peptides and APP-intracellular domain (AICD). Thus, $\beta$- and $\gamma$-secretase are regarded to perform the key steps in the pathogenesis of AD and have become important therapeutic targets in the prevention and treatment of AD. Enormous efforts have been focused to develop the amyloid beta related drug for cure of AD becuase A$\beta$ is believed to be one of the major causes of AD. since major pharmaceutical companies in world wide base compete to develop new drug for AD, we have to be careful to choose the drug target to success the tough race. In the present talk, possible drug targets based on basic research results will be discussed. These molecules should be a good target for development of new drug for AD and be less competitive to have a good shape for world wide competition.

• 상하수도학회지
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• 제27권1호
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• pp.121-128
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• 2013

The concern for dissolved phosphate in water/wastewater has been increasing because of the risk for eutrophication. A variety of conventional and advanced technologies were applied to meet the enforced new regulation of phosphate around the world. However, there still remained a lot of challenge because most introduced/developed method, for example, biological and physic-chemical treatment is not easy to satisfy the new regulation of phosphate in water. In order to meet the new regulation, the application of ion exchanger has been tried which showed that the removal efficiency for phosphate was strongly determined by in the presence of the competing ion, especially sulfate. As results, a new class of ion exchanger governed by ligand exchange was developed and investigated to increase the selectivity for phosphate. The current study using organic/inorganic anion exchanger developed with Lewis acid-base interaction confirms the selectivity for phosphate over sulfate. According to isotherm test and column test, the value of the maximum phosphate uptake (Q) showed 64 mg/g as $po{_4}^{3-}$ and the breakthrough for phosphate occurs after 1000 min and completely finishes at 2500 min, respectively.