• Archives of Pharmacal Research
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• 제11권3호
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• pp.213-217
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• 1988

The effects of ethanol and acetaldehyde on monoamine oxidase activity in mouse liver mitochondrial fraction were studied. In vivo, a single dose of ethanol increased the hepatic monoamine oxidase activity compared to control group, and chronic ethanol consumption also increased the enzyme activity using tyramine, benzylamine or serotonin as substrate. Acetaldehyde, the metabolite of ethanol, significantly increased monoamine oxidase activity more than ethanol did. In contrast to the in vivo results, it was found that the monoamine oxidase activity was inhibited in vitro by ethanol or acetaldehyde in the dose-dependent manner.

• 동의생리병리학회지
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• 제24권1호
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• pp.96-101
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• 2010

The purpose of this study is to investigate the effect of water extract from Artemisiae Argi Folium Fermented with Sacchromyces cerevisiae (AFS) on hydrogen peroxide production within human hepatocyte HepG2 cells treated with gallic acid, EtOH, nicotine, acetaminophen, and acetaldehyde. AFS (0~400 ug/mL) was treated with gallic acid, EtOH, nicotine, acetaminophen, and acetaldehyde. And the intracellular productions of hydrogen peroxide were measured by dihydrorhodamine 123 (DHR) assay. AFS showed the restoration of the intracellular productions of hydrogen peroxide which were reduced by gallic acid, EtOH, nicotine, acetaminophen, and acetaldehyde in HepG2 Cells. AFS could be supposed to have the hepatoprotective effect related with hepatocytologic signaling activity against gallic acid, EtOH, nicotine, acetaminophen, and acetaldehyde.

• 한국대기환경학회지
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• 제20권4호
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• pp.515-521
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• 2004

The catalytic oxidation of volatile organic compounds (methanol. acetaldehyde) has been characterized using the copper phthalocyanine catalyst in a fixed bed flow reactor under atmospheric pressure. The catalytic activity for pretreatment conditions was examined by this reaction system. The catalytic activity was ordered as follows: metal free-PC＜Cu ($\alpha$)-PC＜Cu ($\beta$)-PC The formaldehyde, carbon monoxide as a partial oxidation product of methanol and acetaldehyde over Cu ($\alpha$)-PC catalyst were detected and the conversions of methanol and acetaldehyde were accomplished above 95% over Cu ($\alpha$) -PC, Cu ($\beta$) - PC catalyst at 35$0^{\circ}C$. The pretreated metal free -PC, Cu($\alpha$)-PC, Cu($\beta$)-PC catalysts have been characterised by TGA, EA and XRD analysis. The catalytic activity pretreated with air and $CH_3$OH mixture (P-4) or air only (P-5) was very excellent. XRD and EA results showed that Cu($\alpha$)-PC, Cu($\beta$)-PC were destroyed an(1 new metal oxide such as CuO were formed.

• 한국대기환경학회지
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• 제11권4호
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• pp.339-349
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• 1995

The purpose on this study is to optimize the chromatographic determination method of trace aldehydes in ambient air. Carbonyl compounds in urban air were trapped at $C_{18}$ DNPH-coated cartridges, and generated hydrazone derivatives were separated by HPLC and detected by UV-vis spectroscopic detector at 360nm. Formaldehyde and acetaldehyde compounds could be isolated from urban(Seoul) air with more than 95% collection efficiency. The analytical detection limits for formaldehyde and acetaldehyde are 0.06pp $b_{v}$, 0.08pp $b_{v}$ for 108 L air samples, respectively. The precision of this method are 3 .sim. 4%(RSD) for mutiple injection of hydrazone standards. Separation of seven dinitrophenylhydrazones could be achieved in appoximately 20 minutes operation time using $C_{18}$ column with apprepriate eluent. The method was applied to the analysis of aldehydes and ketone in Seoul ambient air. The 24-h ambient levels of formaldehyde, acetaldehyde reached up to 6 .sim. 14 and 3 .sim. 8ppbv, respectively. The daily average concentration ratio were 0.60 for acetaldehyde/formaldehyde.yde.

• 동의생리병리학회지
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• 제23권6호
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• pp.1379-1384
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• 2009

The purpose of this study is to investigate the effect of water extract from Artemisiae Argi Folium Fermented with Lactobacillus pentosus (AFL) on hydrogen peroxide production within human hepatocyte HepG2 cells treated with gallic acid, EtOH, nicotine, acetaminophen, and acetaldehyde. AFL (0~400 ug/mL) was treated with gallic acid, EtOH, nicotine, acetaminophen, and acetaldehyde. And the intracellular productions of hydrogen peroxide were measured by dihydrorhodamine 123 (DHR) assay. AFL showed the restoration of the intracellular productions of hydrogen peroxide which were reduced by gallic acid, EtOH, nicotine, acetaminophen, and acetaldehyde in HepG2 Cells. AFL could be supposed to have the hepatoprotective effect related with hepatocytologic signaling activity against gallic acid, EtOH, nicotine, acetaminophen, and acetaldehyde.

• 한국미생물·생명공학회지
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• 제13권3호
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• pp.233-237
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• 1985

C$_2$화합물 가운데 Ethanol, acetic acid 및 acetaldehyde을 공통적으로 동화할 수 있는 효모를 토양 및 하수 진흙으로부터 분리한 후 형태학적, 배양적 및 생리학적 특성을 고려하여 그 분류학적 위치를 검토하였다. 그 결과 분리효모는 다극 출아법에 의한 영양 증식을 하였으며 자낭포자를 형성하지 않고 또한 색소가 형성되지 않는 점으로 보아 Candida속에 속하였으며 Candida sp. JY-5로 명명하였다.

• 대한약리학회지
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• 제25권1호
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• pp.87-91
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• 1989

본 실험에서는 ethanol 및 acetaldehyde가 유도하는 MAO 활성변동에 인삼 butanol 분획이 미치는 영향을 검토하였다. Ethanol(1 g/kg)을 mouse 복강내로 투여하였을 때 간장 중 MAO 활성이 현저히 증가하였으며 이러한 작용은 인삼butanol 분획 전처리로 개선되었다. 또한 pyrazole(200mg/kg)을 전처리하였을 때 ethanol에 의해 증가된 간장중 MAO활성이 정상수준으로 감소되었다. 만성적으로 ethanol을 투여한 경우에 있어서도 MAO활성이 증가되었으며 인삼 butaonl분획 전처리로 MAO 활성이 감소됨이 관찰되었다. Ethanol의 대사산물인 acetaldehyde(100mg/kg)을 복강내로 투여하고 관찰한 실험에서도 간장중 MAO활성이 현저하게 증가되었으며 인삼 butanol분획을 전처리함으로써 정상수준 가깝게 MAO활성이 감소되었다. 이 연구결과로 ethanol에 의한 간장중 MAO활성증가는 ethanol의 대사산물인 acetaldehyde에 기인된 것으로 생각되어지며 인삼 butanol분획이 acetaldehyde에 의해 유도되는 간장중 MAO활성 변동을 조절하고 있을 것으로 사료된다.

• 한국환경보건학회지
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• 제32권1호
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• pp.19-26
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• 2006

This study was undertaken to determine the concentrations of 15 aldehydes in air samples collected from 21 households including 9 atopy patient's homes and to assess the extent of exposure and risk for an individual due to inhalation. Of all the aldehydes identified in both indoor and outdoor environment, formaldehyde and acetaldehyde were the most abundant aldehydes, which were occupied $60\%\;and\;17\%$ of total amount, respectively. The geometric mean concentration of formaldehyde and acetaldehyde in indoor air were $170.5\pm1.9\;{\mu}g/m^3\;and\;47.3\pm1.5\;{\mu}g/m^3$, respectively. There existed a strong correlation between formaldehyde, acetaldehyde and other aldehydes. And the ratio of indoor and outdoor concentrations (I/O) exceeded 1.0 for almost every measured aldehydes except m-tolualdehyde... No associations were found between the level of aldehydes and either housing characteristics or living habits in most of the samples with only a few exception. And the concentrations of all aldehydes indoor air between atopy patient's homes and control homes were not significant(p>0.05). Formaldehyde and acetaldehyde exposures and risks were estimated by using the inhalation unit risk, mean concentrations and the 95th percentiles, and which were $2.6\times10^{-3}\;and\;1.1\times10^{-4}$, respectively. The mean and the 95th percentile risk estimates were 25 times higher for formaldehyde than for acetaldehyde in homes.

• 한국식품과학회지
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• 제25권2호
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• pp.136-141
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• 1993

본 연구에서는 우유에 탈지분유 또는 4종의 곡류(쌀, 보리, 밀, 옥수수)를 각각 첨가하고 젖산균(Lactobacillus acidophilus KCTC 2182)으로 발효하여 호상의 요구르트를 만든 후, 곡류의 첨가가 요구르트에서 생성되는 휘발성 향기성분의 종류와 함량에 미치는 영향을 조사하였다. Gas chromatograph를 사용하여 호상요구르트의 휘발성분을 분석한 결과, acetaldehyde, acetone, ethanol, diacetyl, butanol 및 acetoin의 6가지 취발성분이 탐지되었으며, 이 중에서 젖산균 발효에 의하여 생성된 것은 acetaldehyde, ethanol, diacetyl 및 acetoin 이었다. 곡류 첨가에 의하여 요구르트의 휘발성 향기성분의 전체적인 패턴에는 큰 변화가 없었다. 우유요구르트의 발효과정에 일어나는 휘발성 향기성분의 경시적인 변화를 보면, 젖산균 발효로 생성된 성분 가운데 acetoin과 ethanol은 발효 6시간까지 급격하게 증가한 후 그 이후에는 완만하게 증가하였고, diacetyl은 6시간까지 급격히 증가한 후 그 후부터는 감소하였으며, acetaldehyde는 발효 18시간부터 생성되기 시작하였다.

• 한국산업보건학회지
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• 제4권2호
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• pp.240-247
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• 1994

To identify normal levels of ethanol, acetaldehyde and alcohol dehydrogenase(ADH) activity in blood of Koreans, ethanol and acetaldehyde levels, activity of ADH in blood of Koreans, ethanol and acetaldehyde levels, activity of ADH in blood were measured in 97 subjects(male : 36, female : 61), 45 subjects(male : 21, female : 24) were not exposed to organic solvents and any other chemicals. Fifty two subjects(male : 15, female : 37) were exposed to organic solvents including toluene and xylene. The results were summerized as follows : 1. The blood ADH was not detected in exposed and non-exposed group. 2. The average blood ethanol level of non-exposed group was 0.0490 mg/dl, and exposed group was 0.0363 mg/dl. They were statistically significant(p<0.05). 3. The blood acetaldehyde levels in exposed group were significantly higher than that of non-exposed group was not statistically significant (p>0.05). 4. The average blood ethanol level of males in both groups was significantly higher than that of females, however, they were not statistically significant (p>0.05).