• Title/Summary/Keyword: Accumulated Rate Method

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Development of Automated Diffusion Cell for Determining In Vitro Drug Release from Transdermal Device (경피흡수제형의 in vitro 약물방출실험을 위한 연속확산 장치의 개발)

  • Byun, Young-Rho;Choi, Young-Kweon;Jeong, Seo-Young;Kim, Young-Ha
    • YAKHAK HOEJI
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    • v.34 no.3
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    • pp.161-165
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    • 1990
  • An automated, simple, and reliable method was developed for determining in vitro drug release rate from transdermal delivery dosage forms. The patch is held in position in the heating block by sandwiching it between the middle plate and the bottom plate of diffusion cell. The dissolution profile of the commercially available transdermal scopolamine patch was determined over a 72-h period, and the results were compared with those obtained with other methods; paddle-over-disk method, reciprocating method, and diffusion cell method. It was demonstrated that the flow-through method is equivalent in terms of release rate profile and accumulated released drug amount over the lifetime of the dosage form tested. Also this method is simple, reliable and reproducible. Therefore, this technique can be used in a quality control for assuring product uniformity.

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Deciding the Maintenance Priority of Power Distribution System using Time-varying Failure Rate (시변 고장률을 이용한 배전계통 유지보수 우선순위 결정)

  • Lee, Hee-Tae;Moon, Jong-Fil;Kim, Jae-Chul
    • The Transactions of the Korean Institute of Electrical Engineers A
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    • v.55 no.11
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    • pp.476-484
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    • 2006
  • The failure prediction and preventive maintenance for the equipment of nuclear power plant area using reliability-centered maintenance have been grown. On the other hand, the maintenance for power distribution system consists of time-based maintenance mainly. In this paper, the new maintenance algorithms for power distribution system are developed considering reliability indices. First of all, Time-varying failure rates are extracted from data accumulated at KEPCO using exponential distribution function and weibull distribution function. Next, based on the extracted failure rate, reliability for real power distribution system is evaluated for applying the effective maintenance algorithm which is the analytic method deciding the maintenance point of time and searching the feeder affecting the specific customer. Also the algorithm deciding the maintenance priority order are presented based on sensitivity analysis and equipment investment plan are analyzed through the presented algorithm at real power distribution system.

Study on a Scheme of Investment Considering Customer Interruption Cost in Power Distribution System (정전비용을 고려한 배전계통 설비의 투자 계획 수립 방안연구)

  • Chu, Cheol-Min;Kim, Jae-Chul;Lee, Tae-Hee;Moon, Jong-Fil
    • Proceedings of the Korean Institute of IIIuminating and Electrical Installation Engineers Conference
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    • 2006.05a
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    • pp.365-369
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    • 2006
  • It is concentrated on a methodology to establish a scheme of investment on power distribution systems of components. This paper provides a methodology to estimate the scheme as using a customer interruption cost regarding reliability indices in power distribution systems. The proposed method basically uses the failure rate depending on time for explaining the deterioration of a component. Therefore, the theory of the sensitivity is used for deciding the precedence of the investment to consider an effect of each component's failure rate on the system reliability. After Estimating the sensitivity on component investment cost making incremental reliability level is produced by component's investment cost accumulated according to the precedence of the sensitivity. After that, the failure rate corresponding with reliability level on the curve of investment cost is used as producing the curve of customer interruption cost. Two curves have the crossing point that is proposed to acceptable reliability level for customer and utility. In this paper, the acceptable reliability level for customer with the utility is assessed to analyze customer interruption cost and sensitivity of reliability indices. In conclusion the result of investment based on this method is shown to the reliability level with two cost.

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Determination of Sr-90 in the Vetebrae of Reference Korean (표준 한국인 척추골내의 Sr-90 함량 측정에 관한 연구)

  • Yung Jin Kim;Gook Hyun Chung
    • Nuclear Engineering and Technology
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    • v.16 no.3
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    • pp.131-135
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    • 1984
  • The determination of Sr-90 in 93 Korean vertebrae was carried out using modified method of tri-n-butyl phosphate extraction. As a result, the average content of Sr-90 in Korean vertebrae was 2.29 pCi/g Ca in the female and 1.73 pCi/g Ca in the male and the average level of both sexes was 2.01 pCi/g Ca, which was slightly higher than those of other countries. On the other hand, the Sr-90 injected into intraperitonal cavity of rat was accumulated in bones mostly and distributed evenly to various types of hones. The rate of accumulation and removal was not dependent on the amount of Sr-90 injected and over one half Sr-90 injected was accumulated in bones within one day and then it was removed gradually after two days from the injection.

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Reducing Exhaust Hydrocarbon at Gasoline Engine with Catalytic Converter using Synchronized Secondary Air Injection (촉매가 장착된 가솔린엔진에서 동기화된 2차공기분사에 의한 배기 탄화수소 저감)

  • 심현성;민경덕;정석호
    • Transactions of the Korean Society of Automotive Engineers
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    • v.9 no.2
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    • pp.67-74
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    • 2001
  • A synchronized secondaty air injection method has been developed to hydrocarbon emission by injecting secondary air intermittently into exhaust port. The method has been tested in a single cylinder spark-ignition engine operating at cold-steady / cold-start conditions. Effects of air injection timing, intake pressure and engine air-fuel ratio have been investigated at cold-steady condition. Also, hydrocarbon emission and exhaust gas temperature with catalytic conberter are compared with a continuous SAI method and base condition at cold-start condition. Resules show that hydrocarbon reduction rate and exhaust gas temperature are sensitive to the timing of synchronized SAI. At cold-steady condition, HC emission is minimum at engine air-fuel ratio of 10. At cold-start condition, the accumulated hydrocarbon emission during the first 120 s decreases about 56% and 22% with the synchronized and continuous SAI, respectively, compared to that of base condition.

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The Exploratory Study on the Financial Soundness of Public Pension : The Case of National Pension Scheme (공적연금 재정건전성에 대한 탐색적 고찰 : 국민연금을 중심으로)

  • Kwon, Moon-Il
    • Korean Journal of Social Welfare
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    • v.46
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    • pp.7-36
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    • 2001
  • The current benefit expenditure of National Pension Scheme is comparatively small, as it stands in the early stage in reference to the historical development. On the other hand, the current contribution rate of National Pension is set up beyond which is sufficient to cover the current benefit expenditure. Therefore, National Pension makes big surplus every year such that the size of accumulated fund increases very fast. Nevertheless, the apprehension of financial instability of National Pension prevails these days. If so, is it really well-grounded? In terms of the method of financing. public pension schemes of most of all nations in the world are based on pay-as you go or partial funding. Under these financing methods, financial soundness fundamentally depends on the power that the government is able to impose the burden which is equivalent to benefit expenditure and the attitude of the public which represents whether they will admit it or not. Under this perspective, the judgement of financial soundness of public pension can not be made arithmetically and technically only on the basis of the balance between receipts and expenditure but should be accomplished considering the very complex and diverse aspects. In these context, this paper defines what the financial soundness of public pension means specifically and presents the objective indices which help judge it, that is, implicit debt, cost rate, summarized cost rate, pension expenditure as percentage of GDP, and fund rate. Then, applying the indices, this paper analyzes the long-term financial situation of National Pension empirically and evaluates its financial soundness in exploratory perspective.

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Structure Detection of Transmission Frame Based on Accumulated Correlation for DVB-S2 System (DVB-S2 시스템에서 상관 누적을 이용한 전송프레임 구조 검출)

  • Jeon, Hanik;Oh, Deock-Gil
    • Journal of Satellite, Information and Communications
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    • v.10 no.2
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    • pp.109-114
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    • 2015
  • Frame synchronization is achieved by correlation between received symbols and a preamble pattern which is periodically appended at a frame header. In this paper, we deal with a frame detection method complaint with satellite-based DVB-S2 system. In DVB-S2, frame synchronization is performed under the low signal-to-noise ratio(SNR), a large frequency offset which can be up to 20% of a symbol transmission rate and unknown modulation schemes ranging from QPSK to 32-APSK. In this environment, we propose a method combining differential correlation based on SOF and PLSC with an accumulated correlation method for the detection of frame structures. In addition, detection performances about mean acquisition time(MAT) and detection error probability are evaluated via computer simulations.

Developement and application of Statistical Hydrofracturing Data Processing Program (통계적 접근법에 의한 수압파쇄 자료해석용 전산 프로그램 개발 및 적용)

  • 류동우;최성웅;이희근
    • Tunnel and Underground Space
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    • v.6 no.3
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    • pp.209-222
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    • 1996
  • Shut-in pressure, reopenting pressure and fracture orientation are very important parameters to be evaluated precisely in in-situ stress measurement by hydraulic fracturing. Graphical methods on pressure-time curves have been conventionally used, even though these are seriously dependent on subjectivity of interpreters. So there have been many demands on new method to objectivity in determining parameters. We have developed integrated hydrofracturing data processing program (HYDFRAC), based on nonlinear regression analysis and can be invoked under the Window graphical user interface. HYDFRAC consiste of three routines, that is shut-in pressure routine, reopening pressure routine, and fracture delineation routine. Each of routines include independent modules according to parameter determination methods. Its application to field tests ensured both objectivity and facility in determining of hydraulic fracturing parameters. Determining shut-in pressures at each pressurization cycles, we adopted the exponential pressure-decay method(EPD method), the bilinear pressure-decay-rate method (PDR method), and the tangent intersection method in order to find the pressurization-cyclic tendency of shut-in pressures. The estimated pressure by PDR method exists in the range of the upper and lower values by EPD method, and lies near to the upper value more than the lower. Being the pressurization cycle increased, the range of upper and lower limits come to be stabilized gradually. By graphical superposition method and bilinear pressure-accumulated volume method, reopening pressures were determined. Vertical and inclined fracture attitudes were determined by applying the directional statistics and sinusoidal curve fitting, respectively. The results of evaluation of hydrofracturing parameters showed that statistical methods could enhance the objectivity better than graphical methods.

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Enhanced Electrokinetic remediation of low permeability soil contaminated with phenanthrene (Phenanthrene으로 오염된 저투수성 지반의 향상된 Electrokinetic 정화 처리)

  • 김강호;한상재;김수삼
    • Journal of Soil and Groundwater Environment
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    • v.7 no.4
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    • pp.3-9
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    • 2002
  • In this study, electrokinetic remediation tests were performed with spiked fine-grained soil by phenanthrene which is representative hydrophobic organic contaminant of petroleum hydrocarbon. And also, the enhanced method was used with surfactant concentration variation and elapsed time to achieve more higher removal efficiency than conventional electrokinetic treatment. In conventional electrokinetic treatment, most phenanthrene was not transported. But, in the enhanced method used by the surfactant, phenanthrene moved form anode to cathode region and accumulated in cathode region. Also, the transportation rate of phenanthrene was increased with surfactant concentration increasement and elapsed time.

The Pattern Segmentation of 3D Image Information Using FCM (FCM을 이용한 3차원 영상 정보의 패턴 분할)

  • Kim Eun-Seok;Joo Ki-See
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.10 no.5
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    • pp.871-876
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    • 2006
  • In this thesis, to accurately measure 3D face information using the spatial encoding patterns, the new algorithm to segment the pattern images from initial face pattern image is proposed. If the obtained images is non-homogeneous texture and ambiguous boundary pattern, the pattern segmentation is very difficult. Furthermore. the non-encoded areas by accumulated error are occurred. In this thesis, the FCM(fuzzy c-means) clustering method is proposed to enhance the robust encoding and segmentation rate under non-homogeneous texture and ambiguous boundary pattern. The initial parameters for experiment such as clustering class number, maximum repetition number, and error tolerance are set with 2, 100, 0.0001 respectively. The proposed pattern segmentation method increased 8-20% segmentation rate with conventional binary segmentation methods.