• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6233-6239
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• 2013

Diabetes represents a serious health problem. In the diabetic state, alterations in metabolism, increased susceptibility to infections and immunological changes occur. The suppression of the immune response has been identified as a relevant factor that contributes to the increase in the rate of infections in these patients. At the same time, breast cancer is the most frequent malignant tumor in women. The molecular and cellular mechanisms underlying cancer development have revealed that immune cells functionally regulate epithelial cancer development and progression. Breastfeeding has been hypothesized to reduce the risk of breast cancer. However, early systematic reviews have not yielded consistent findings for this association. The demand for human milk is increasing due to the promotion and consumer acceptance of the health benefits of consuming a natural product rich in bioactive components. However, due to changes in glucose metabolism, the components of the milk from diabetic women are modified depending on the time of evaluation. In this literature review, we summarize important new findings revealing the paradoxical role of breastfeeding in preventing the onset of breast cancer in diabetic mothers. We hypothesized that the milk component production in diabetic mothers is affected by changes in glucose metabolism. Therefore, adequate maternal glycemic control and an adequate duration of breastfeeding for diabetic mothers are crucial to ensure that the immunity components are able to confer protection against breast cancer.

• 한국인터넷방송통신학회논문지
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• 제16권3호
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• pp.145-153
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• 2016

본 연구는 국내 케이블 TV의 디지털 전환 과정의 지체 요인을 분석하고 유료방송 시장의 경쟁 상황이 디지털 전환에 미치는 영향을 살펴보았다. 디지털 전환의 지체 요인은 케이블 TV 사업자의 의지 및 역량의 부족, 정책적 지원과 강제의 부재 및 시청자의 수용 의지와 관련된 요소로 나타났다. 아날로그 방송을 통하여 지속적인 수익을 올리며 유료방송시장에서 독점적 지위를 가지고 있던 케이블 TV 사업자는 추가적인 투자가 필요한 디지털 전환에 대하여 적극적으로 대처하지 못했다. 저소득층에 대한 지원이나 아날로그 케이블 TV 방송의 종료 기준 설정 부재 등 정책적인 뒷받침도 이루어지지 못했다. 디지털 상품에 대한 가격 저항감이나 조작의 편의성 선호 등 시청자의 수용 요인도 디지털 전환에 영향을 미쳤다. 2008년에 IPTV가 시장에 진입하며 유료방송시장에 실질적인 경쟁 상황이 형성되었으며 이는 케이블 TV 사업자의 디지털 전환 속도에 영향을 미친 것으로 나타났다.

• 한국조리학회지
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• 제16권3호
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• pp.307-316
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• 2010

본 논문의 목적은 자일리톨을 설탕 대체제로 사용하여 만든 머핀의 최적 배합을 개발하고자 함이다. 자일리톨을 첨가한 머핀의 특성은 높이, 부피, 무게, 비용적, 굽기 손실률, 영상분석, 색도와 관능검사에 의해 측정되었고, 저장기간 동안(0, 1, 3, 5일)의 머핀의 노화에 대한 자일리톨의 영향은 조직감 분석 기계에 의해 측정되었다. 자일리톨 첨가량이 증가할수록 머핀의 경도는 증가하였고, 저장기간 동안 유의적으로 증가하였다. 머핀 껍질의 명도(L값)는 자일리톨 첨가에 의해 유의적으로 증가하였다. 관능검사에서 자일리톨을 첨가하지 않은 대조구는 외관과 조직감에 가장 높은 수치를 보였다. 풍미, 맛과 전체적인 기호도에서는 자일리톨을 25% 첨가한 머핀이 가장 좋은 결과를 보였지만 대조구와는 유의적인 차이는 없었다.

• 대한토목학회논문집
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• 제32권2B호
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• pp.149-152
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• 2012

본 연구는 해상풍력발전기 기초 설계에 사용되는 IEC 61400-3, DNV-OS-J101, GL Wind, EUROCODE, AASHTO 및 국내 설계기준의 설계방법 및 안전율의 정도를 비교, 분석함으로써, 국내에서 해상풍력발전기 기초 설계시 필요한 제반사항을 제공하고자 한다. 해상풍력발전기 기초 설계에 관한 국내외 설계기준을 분석한 결과 설계법은 크게 설계접근법, 하중저항 설계법, 허용응력설계법을 적용하고 있으며, 각 설계법에 따른 안전율 정도를 분석한 결과 하중저항계수 설계법과 설계접근법은 거의 유사한 수준의 안전율을 확보하고 있는 반면, 허용응력설계법에서는 다소 보수적인 안전율을 적용하고 있어 해상풍력발전기 기초의 경제적 설계를 위한 국내 설계기준 개발이 필요할 것으로 판단된다.

• Journal of Advanced Marine Engineering and Technology
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• 제37권8호
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• pp.946-952
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• 2013

선박의 Ro-Ro 구역이나 특별범주구역의 화재방호를 위해 설치하는 고정식 수계소화설비의 개발 및 실용화를 위해, 특히 방수량이 적으며 관련기준에서 요구하는 성능요건을 만족하는 미분무 노즐을 개발하고자 실물화재실험을 수행하였다. 본 설비의 화재시나리오는 크게 두 가지로 트럭화물화재와 승용차화재로 구분되며, 각각 고정 설치된 미분무 노즐과 화원과의 세 가지 위치에 대한 시나리오로 이루어져 있다. 모든 화재실험은 30분간 진행되었으며 천장부의 가스온도와 우드펠릿의 손상율, 타깃합판의 착화여부로 판단되었다. 본 논문은 두 가지 화재실험 중 조건이 더욱 까다로운 트럭화재용 미분무 노즐의 결과를 위주로 방수압력과 방수량, 미분무수의 유동특성에 따른 화재실험결과와 화재진압특성을 고찰하였으며, 수십 회의 반복실험 결과 분당 약 40 L의 유량을 가지는 저압 미분무 노즐로 Ro-Ro구역의 화재진압이 가능한 것으로 나타났다.

• 한국의학물리학회지:의학물리
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• 제29권2호
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• pp.53-58
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• 2018

This paper evaluates patient-specific quality assurance (PSQA) in the treatment of small and multiple tumors by the CyberKnife system with fixed collimators, using an ion chamber and EBT3 films. We selected 49 patients with single or multiple brain tumors, and the treatment plans include one to four targets with total volumes ranging from 0.12 cc to 3.74 cc. All PSQA deliveries were performed with a stereotactic dose verification phantom. The A16 microchamber (Standard Imaging, WI, USA) and Gafchromic EBT3 film (Ashland ISP Advanced Materials, NJ, USA) were inserted into the phantom to measure the point dose of the target and the dose distribution, respectively. The film was scanned 1 hr after irradiation by a film digitizer scanner and analyzed using RIT software (Radiological Imaging Technology, CO, USA). The acceptance criteria was <5% for the point dose measurement and >90% gamma passing rate using 3%/3 mm and relative dose difference, respectively. The point dose errors between the calculated and measured dose by the ion chamber were in the range of -17.5% to 8.03%. The mean point dose differences for 5 mm, 7.5 mm, and 10 mm fixed cone size was -11.1%, -4.1%, and -1.5%, respectively. The mean gamma passing rates for all cases was 96.1%. Although the maximum dose distribution of multiple targets was not shown in the film, gamma distribution showed that dose verification for multiple tumors can be performed. The use of the microchamber and EBT3 film made it possible to verify the dosimetric and mechanical accuracy of small and multiple targets. In particular, the correction factors should be applied to small fixed collimators less than 10 mm.

• 보건행정학회지
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• 제8권2호
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• pp.110-124
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• 1998

Determining of Strategic Business Units in the organization is a major critical process for improving the organizational performance. On increasing the demands for extension in function of health center, many health centers are trying to provide the various services. But most health center determined the kind and level of service without scientific considerations. The purposes of this study are to develope the model for determination of strategic business units in health center and to test the availability of implementation for it. Our model is rooted from the McKinsey matrix analysis of Product Portfolio Analysis which used widely in marketing field. We modified the evaluation criteria of the McKinsey matrix analysis for health care field appropriately. Our evaluation criteria are categorized into two concepts; contribution of service, availability of service. At first, in terms of contribution of service, market size, market growth rate, needs and demands of regional people, existences of alternative services in that region, correspondence with health policy. The other component, availability of service are included the availability of manpower, financial availability, the level of knowhow on service, acceptance of health care manpower. In the result of analysis, we could conclude that antismoking and antialcoholics education programs, health screening program are important strategically in that aspects of contributions and availability of services. Also, vaccination program is important in that aspect of service availability and diet and exercise program, health library are meaningful in the aspect of service contribution. Therefore, we think that efforts to investigate the evaluation criteria for priority setting or determination of service area in health center are useful challenges.

• 한국식품조리과학회지
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• 제30권5호
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• pp.620-630
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• 2014

Traditionally, the persimmon Gojongsi (Diospyros kaki Thunb) is peeled to make dried persimmons and the skins are thrown away. In this study, the quality characteristics of cookies containing persimmon peel powder were tested for recycling of the persimmon peels. The amounts of persimmon peel powder added to the cookies were about 0, 5, 7, 9 and 11%. The densities of the cookies of the control group and the persimmon peel powder containing experimental group were 1.25 and 1.25~1.37 respectively. The pH was 6.02 for the control group and 5.95~6.01 for the experimental group. Significant differences in the moisture content were observed between groups at 3.34 and 2.16~3.31 for the control and experimental groups, respectively (p<0.05). The spreadabilities and loss rates of the cookies increased with increasing amounts of persimmon peel powder (p<0.05). In contrast, the loss rates and leavening rate of the cookies decreased significantly with decreasing amounts of persimmon peel powder (p<0.05). The lightness of the cookies showed significant decrease (p<0.05), while the redness and yellowness increased with increasing amounts of persimmon peel powder. The hardness (kg) of the control group was 0.847 while that of the experimental group was 0.904~1.110. In the QDA, the results of sensory characteristic analysis showed that the experimental group earned 11% higher scores for color, flavor, taste, and bitterness, 7% higher for appearance and 9% higher for after taste. The consumer acceptance test revealed the experimental group to have a 7% more positive evaluation for color, favor, taste and texture than the control group. On the grounds of the experiment above, the optimal mixture ratio from the sensory test was found to be 7% persimmon peel powder in the cookies.

• 한국펄프종이공학회:학술대회논문집
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• 한국펄프종이공학회 2003년도 춘계학술발표논문집
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• pp.70-79
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• 2003

Paper coating can give smoothness surface and good printability to uncoated paper. Macro roughness of base paper would be decreasing its groove and grit in view of side. Nevertheless its improving effect for paper, some kind of problem is showing in the fine coated paper. Especially, back trap mottle is one of serious problems in printing with fine coated paper. Printers can not adjust conditions to overcome the problem. Also large amounts of paper can be rejected. There are many factors that influence back trap mottle. However it is not clear what the important parameters are in back trap mottle. Back trap mottle has some relationship with ink setting but good guidelines are not clear. Back trap mottle has been linked to non-uniform ink setting. We do not know how much variation in setting we can tolerate. Other mottle issues such as micro-picking and ink refusal are still common. This paper was prepared to identify correlation with ink setting and delta ink density obtained from experiment and then tried to find out some relationships with ink setting and back trap mottle. Basically fine calcium carbonate and ciay was used for main components and coarse calcium carbonate was mixed in two fine pigments to change its porosity and ink acceptance. Micro ink tack force at KRK printing tester was adapted to measure ink setting rate. KRK units were used for back trap mottle simulation and two printed samples were prepared to check delta ink density. Clay base coating has more fast ink setting time than calcium carbonate's though smoothness of clay was better than calcium carbonate. It could be explained by that clay has finer pore in its coating than calcium carbonate. DID(delta ink density) has shown a good correlation with ink setting time from micro ink tack. The total pore volume of coating layer did not match with ink setting and DID. From the results we might conclude coating that has fine pore size around 0.05 ${\mu}m$ can be exposed to high possibility of back trap mottle.

• 분석과학
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• 제28권1호
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• pp.1-7
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• 2015

4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco specific nitrosamine found only in tobacco products. The ability to monitor biomarker concentrations is very important in understanding environmental tobacco smoke (ETS). In this study, an efficient and sensitive method for the analysis of NNK in dust was developed and validated using liquid chromatography tandem mass spectrometry. Dust was collected with filter paper soaked in methanol. The standard solution and dust sample were diluted with 100 mM ammonium acetate and extracted using dichloromethane. Our calibration curves ranged from 25 to $10^4pg/mL$. Excellent linearity was obtained with correlation coefficient values between 0.9996 and 1.0000. The limit of detection (LOD) was 5 pg/mL ($S/N{\geq}3$) and the retention time was 10 min. The limit of quantification (LOQ) was 25 pg/mL, and the acceptance criteria was the rate of 98-103% (80-120% at levels up to $3{\times}LOQ$). The coefficient of variations (CV) was 2.8%. Accuracies determined from dust samples spiked with four different levels of NNK racurves ranged that from 25 to 104 pg/mL. Excellent linearity was obtained between 92.1% and 114%. The precision of the method was acceptable (5% of CV). The recovery rates of the whole analytical procedure at low, medium, and high levels were 105.7-116.5% for NNK. The carry-over effects during LC-MS/MS analysis were not observed for NNK. This manuscript summarizes the scientific evidence on the use of markers to measure ETS.