• The Korean Journal of Pesticide Science
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• v.14 no.4
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• pp.490-498
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• 2010

Isotianil is a fungicide which has prevention effects against rice blast disease. In order to register this new pesticide, the series of toxicity data on animal testing were reviewed to evaluate its hazards to consumers and to determine its acceptable daily intake. Isotianil was almost excreted by urine and feces. It has low acute oral toxicity while has no skin toxicity and ocular irritation. Its skin sensitization was evaluated as slight. Genotoxicity of parent compound and metabolite was negligible. Chronic toxicity tests on rats and dogs showed changes of hematology, clinical biochemistry and liver weight. It had no reproductive and teratogenic effects. The estimation of Acceptable Daily Intake(ADI) is based on the lowest no-observed adverse effect level (NOAEL). The lowest NOAEL of 2.83 mg/kg bw/day was found in the twelve-months rats study. The NOAEL was based on increased liver weight and treatment-related effect on clinica chemistry finding at the nest higher dose level of 2.83 mg/kg bw/day. Therefore, it is considered appropriated to apply an uncertainty factor of 100 to the NOAEL 2.83 mg/kg bw/day from the rat study, resulting in an ADI of 0.028 mg/kg bw/day.

• Korean Journal of Environmental Agriculture
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• v.41 no.4
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• pp.261-275
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• 2022

BACKGROUND: Prior to implementing a positive list system (PLS), there is a need to establish acceptable daily intake (ADI) and maximum residue limit (MRL) for veterinary drugs that have been approved a few decades ago in South Korea. On top of that, chronic dietary exposure assessment of veterinary drug residues should be performed to determine whether the use of these veterinary drugs would cause health concerns or not. METHODS AND RESULTS: To establish the ADI, the relevant toxicological data were collected from evaluation reports issued by international organizations. A slightly modified global estimate of chronic dietary exposure (GECDE) model was employed in the exposure assessment owing to the limited residual data. Therefore, only the ADI of ephedrine was established due to insufficient data for the other veterinary drugs. Thus, instead of ADI, the threshold of toxicological concern (TTC) value was used for the other drugs. Lastly, the hazard index (HI) was calculated, except for etizazole hydrochloride, due to the potential of mutagenicity. CONCLUSION(S): The HI values of ephedrine, menichlopholan, and anacolin were found to be as high as 6.4%, suggesting that chronic dietary exposure to the residues from these uses was unlikely to be a public health concern. Further research for exposure assessment of veterinary drug residues should be performed using up-todate Korean national health and nutrition examination survey (KNHANES) food consumption data. In addition, all relevant available data sources should be utilized for identifying the potentials of toxicity.

• Journal of Food Hygiene and Safety
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• v.16 no.1
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• pp.53-60
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• 2001

A study has been carried out to estimate the average daily intakes of sorbates, benzoates, and and esters of $\rho$-hydroxybenzoic acid commonly used in Korea. The estimation of daily intakes was based on individual dietary intakes in “National Health and Nutrition Survey in 1998”and the the contents of preservatives from 264 samples. Estimated daily intakes(EDI) of sorbates, benzoates, esters of $\rho$-hydroxybenzoic acid were 0.22, 0.015, and 0.004 mg/kg bw/day, respectively. When assuming the standard body weight of 55 kg for Korean, ratios to acceptable daily intake (ADI) of sorbates, benzoates, and esters of $\rho$-hydroxybenzoic acid were 0.88, 0.30, and 0.04%, respectively.

• Food Science and Industry
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• v.42 no.3
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• pp.2-7
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• 2009

• Korean Journal of Food Science and Technology
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• v.42 no.6
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• pp.762-767
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• 2010

This study evaluated daily intakes of BHT, BHA, and TBHQ in Korean. The daily intakes were estimated using both a dietary survey approach and food supply survey approach. In the dietary survey approach, individual dietary intake data from the Korea National Health and Nutrition Survey in 2005, as well as analytical results of BHT in 131 samples, BHA in 134 samples, and TBHQ in 104 samples, were used to assess daily intakes of the antioxidants. In the food supply survey approach, both total production amounts of BHT, BHA and TBHQ and maximum permitted levels of the antioxidants were used to calculate daily intakes. In the dietary survey results, the average daily intakes of BHT, BHA and TBHQ were 0.8, 0.5, and 0.3 ${\mu}g$/kg body weight/day, respectively, and below 0.2% of the ADI (acceptable daily intake) set by JECFA (Joint FAO/WHO Expert committee on Food Additives). In the food supply survey approach, the average daily intakes of BHT, BHA,and TBHQ were all 0.3 mg/kg body weight/day. The ratios of ADI were 97, 60, and 40%, respectively. According to these results, daily intakes of BHT, BHA, and TBHQ in Korean are lower than the ADI.

• Journal of Soil and Groundwater Environment
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• v.23 no.1
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• pp.63-73
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• 2018

Rice is a staple food source in Asian countries. In paddy field, rice plant can take up toxic elements through its roots from contaminated soils, and its leaves and grain can absorb the toxic elements deposited on the soil surface. A totla of 40 soil and polished rice samples were collected around four abandoned metal mines in Korea and analyzed for As, Cd, Cu, Pb and Zn by atomic absorption spectrophotometer (AAS). The average contents of As, Cd, Cu, Pb and Zn in rice grain grown on the contaminated soils were 0.247, 0.174, 4.694, 0.804 and 16.78 mg/kg, respectively. These levels are higher than worldwide average concentrations. Assuming the rice consumption of 169 g/day by overall households in Korea, the estimated daily intakes from the rices were found to be 33, 48, and 63% for As, Cd, and Pb, respectively, of the acceptable daily intake (ADI) suggested by the FAO/WHO Joint Food Additive and Contaminants Committee.

• Korean Journal of Food Science and Technology
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• v.24 no.6
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• pp.563-567
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• 1992

Out of 74 food samples including pickled radish, soy sauce, Lactobacillus drinks, frozen sweets and snack confections, 60 samples were found to contain saccharin. The contents of sacchrain in terms of maximum and positive mean were 541, 306 ppm in pickled radish, 302, 153 ppm in soy sauce, 66, 37 ppm in Lactobacillus drinks, 90, 51 ppm in frozen sweets and 606, 285 ppm in snack confections, respectively. Most food items did not exceed the tolerance limit of saccharin while 70% of snack confections exceeded the limit, the average concentration being 2.9 times of the limit. Total daily intake of saccharin by Korean population for the period of $1985{\sim}1990$ was estimated to be $7{\sim}17\;mg/person$ from consumption data and $9{\sim}35\;mg/person$ from supply data. The intake level was $11{\sim}22%$ of acceptable daily intake for man (ADI) recommended by FAO/WHO whereas the level was slightly higher than that in USA or Japan. It is. therefore, judged that saccharin at the current pattern of usage will not exhibit any adverse effect on the safety of Korean population.

• Journal of the Korean Society of Food Science and Nutrition
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• v.43 no.4
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• pp.604-611
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• 2014

The purpose of this study was to assess the consumption of aspartame and acesulfame K, the most frequently utilized artificial sweeteners in Korea. The contents of aspartame and acesulfame K in processed foodstuffs were analyzed by HPLC, and daily intakes according to sex and age were estimated by applying the consumption data from the Korea National Health and Nutrition Examination Survey. Estimated daily intakes of aspartame and acesulfame K were 58.37 ${\mu}g/kg$ bw/day and 14.23 ${\mu}g/kg$ bw/day, respectively, in 2012. These amounts constituted 0.15% and 0.09% of the ADI (Acceptable Daily Intake) established by the JECFA (FAO/WHO Joint Expert Committee on Food Additives). Estimated daily intakes of aspartame and acesulfame K in the 95 percentile consumption group were 2,510.48 ${\mu}g/kg$ bw/day and 761.92 ${\mu}g/kg$ bw/day, respectively, and intake levels were 6.28% and 5.08% of the ADI, respectively. In conclusion, daily intake levels of artificial sweeteners were evaluated to be at safe levels.

• Journal of the Korean Society of Food Science and Nutrition
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• v.35 no.6
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• pp.690-697
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• 2006

This study has been carried out to estimate mean concentration and the daily intake of 2 artificial sweeteners (aspartame and sucralose) by analyzing food samples. Total number of samples was 755 and the number of samples detected for sweeteners was 33 (detection rate was 4.4%). Contribution rate to total estimated daily intake (%) of artificial sweeteners in food categories was high in candy for aspartame and sucralose. Total Estimated Daily Intakes $({\Sigma}EDI)$ for different age groups were high in $13{\sim}19$ years old for aspartame and $7{\sim}12$ years old for sucralose. Total estimated daily intakes $({\Sigma}EDI)$ of men and women were 5.10 mg/person/day and 4.88 mg/person/day, respectively. Total estimated daily intakes $({\Sigma}EDI)$ of artificial sweeteners were shown as follows; 3.75 mg/person/day for aspartame and 1.27 mg/person/day for sucralose, respectively and assuming a body weight of 55 kg. These values were ranged from $0.15{\sim}0.17%$ of acceptable daily intake (ADI) evaluated by FAO/WHO and $1.0{\sim}21.4%$ of theoretical maximum daily intake (TMDI), and therefore, judged to be safe.

• Journal of Nutrition and Health
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• v.45 no.6
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• pp.522-530
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• 2012

This study was performed in order to investigate the relationship between attention deficit hyperactivity disorder (ADHD), dietary habit and caffeine intake in upper-grade elementary school children. The total number of the study subjects was 237 students (111 boys and 126 girls), where 30 students (12.7%) were diagnosed as ADHD. The dietary habit score of the ADHD group was significantly lower than that of the normal group. In particular, the ADHD group had lower dietary scores in consuming daily breakfast, diverse foods, fruit and milk than those in the normal group. Meanwhile, the daily intake frequency of instant noodle (ramyeon) was significantly higher in the ADHD group than that in the normal group. The mean caffeine intake of the students was 42.95 mg and the proportion of students consuming more than the ADI (acceptable daily intake) was 11.8%. The caffeine intake of ADHD group (63.63 mg) tended to be higher than that of the normal group (39.95 mg); however, it was not significantly different. The ADHD score of the students was negatively related with the dietary habit score (r = -0.279, p < 0.01) but positively related with caffeine intake (r = 0.164, p < 0.05). The dietary habit score had a negative relationship with caffeine intake (r = -0.180, p < 0.01) and a positive relationship with height (r = 0.195, p < 0.01). Caffeine intake had a negative relationship with the height of the students (r = -0.171, p < 0.05). In conclusion, ADHD in children was related to poor dietary habit and high caffeine intake.