• Advances in concrete construction
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• v.8 no.4
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• pp.321-333
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• 2019

The present study targets to access the consequence of utilization of coarse aggregates retrieved from waste concrete as a substitution of coarse fraction of natural aggregates and silica nano-particles as partial substitution of cement using principles of factorial design. Furthermore, procedures of design of experiments are employed to examine the effect of use of recycled aggregates and nano-silica. In this investigation, compressive strength found after at 7, 28, 90 and 365 days, split and flexural tensile strength, ultrasonic pulse velocity and rebound number and are chosen as responses, whereas the percentages of recycled coarse aggregates (RCA%) and nano-silica (NS(%)) are selected as factors. Analysis of Variance has been conducted on the experimental results for the selected responses with consideration the both factors, which indicates that RCA (%) and NS (%) have substantial impact on the various responses. However, the present analysis depicts that interaction between factors has considerable effect on the chosen parameters of concrete. Furthermore, validation experiments are carried to validate these models for compressive and tensile strength for 100% RCA and 1% NS. The results of comparative study indicates that that the error of the estimation determined using the relevant models are found to be small (±5%) in comparison with the analogous experimental results, which authenticates the calculated models.

• Advances in concrete construction
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• v.8 no.4
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• pp.277-283
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• 2019

In evaluating explosion-protection capacity, safety distance is broadly accepted as the distance at which detonation of a given explosive causes acceptable structural damage. Safety distance can be calculated based on structural response under blast loading and damage criteria. For the applicability of the safety distance, the minimum required stand-off distance should be given when the explosive size is assumed. However, because of the nature of structures, structural details and material characteristics differ, which requires sensitivity analysis of the safety distance. This study examines the safety-distance sensitivity from structural and material property variations. For the safety-distance calculation, a blast analysis module based on the Kingery and Bulmash formula, a structural response module based on a Single Degree of Freedom model, and damage criteria based on a support rotation angle were prepared. Sensitivity analysis was conducted for the Reinforced Concrete one-way slab with different thicknesses, reinforcement ratios, reinforcement yield strengths, and concrete compressive strengths. It was shown that slab thickness has the most significant influence on both inertial force and flexure resistance, but the compressive strength of the concrete is not relevant.

• Asian Journal of Business Environment
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• v.10 no.4
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• pp.5-13
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• 2020

Purpose: The purpose of this paper is to empirically investigate the relationship between government subsidies and research and development (R&D) investment of animal husbandry companies in China. The moderating effects of firm size, debt ratio, and firm profitability on this relationship are also examined. Research design, data and methodology: The analysis is based on 14 animal husbandry companies listed on the Shanghai and Shenzhen stock exchanges over the period of 2012-2016. Data are obtained from the China Stock Market & Accounting Research (CSMAR) database and the RESSET database, and multiple regression analysis is utilized with the aid of Stata. Results: The empirical results show that government subsidies can promote R&D investment of animal husbandry companies in China. In addition, firm size, debt ratio, and firm profitability have positive moderating effects on the relationship between government subsidies and R&D investment. Conclusions: Based on the results, the paper concludes that government subsidies play an important role in the process of R&D of China's animal husbandry companies. This paper recommends that managers of animal husbandry companies should enhance the utilization efficiency of government subsidies and put great emphasis on R&D investment. The policymakers should implement more incentives to encourage animal husbandry companies to invest more in R&D.

• Nutrition Research and Practice
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• v.4 no.5
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• pp.438-442
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• 2010

Rhemannie Radix Preparata (RRP) has been previously employed in traditional oriental medicine as a treatment for diabetic thirst and improving blood flow. The aim of this study was to evaluate its hypoglycemic control by assaying the activities of key enzymes of carbohydrate metabolism in streptozotocin-(STZ)-induced diabetic rats. Further, RRP extracts were prepared in water (RRPW), in 50% ethanol (RRP50), and in 100% ethanol (RRP100), respectively, and compared for their actions in diabetic rats. The oral treatment of RRP (5 mg/kg b.w./d) to diabetic rats for 21 days resulted in a significant decline in blood glucose by 67% compared to diabetic control rats (P < 0.05). The altered activities of glucokinase, glucose-6-phosphate dehydrogenase (G6PD), 6-phosphogluconate dehydrogenase (6PGD), and acetyl CoA carboxylase (ACC) in the livers of diabetic rats were reversed significantly to near-normal levels by the administration of RRP (P < 0.05). Among the three RRP extracts, RRP100 was the most effective in terms of hypoglycemic action. However, the administration of RRP to diabetic rats did not improve insulin production. The modulatory effects of RRP100 on the attenuation of carbohydrate enzyme activities appear to hold promise for widespread use for the treatment of diabetes in the future.

• Journal of the Korean Institute of Navigation
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• v.20 no.3
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• pp.1-11
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• 1996

The accuracy for determining fishing ground and for setting fishing gear location, and the repeatability of ship position vary depending on fishing methods. Especially, Loran-C has been served to give fisherman highly accurate ship's position, and a number of fishing vessel are equipped with it's receivers. In this paper, in order to evaluate the accuracy of Loran-C fix of Korean chain in Korean southeast coast, the authors examined and analyzed the data of the receiver of Loran-C(LC 90, Furuno) and GPS(AccNav $Sport^{TM}$, Eagle) measured automatically and continuously for 2 seconds at interval of 5minutes during 2hours from $11^{th}$ to $21^{st}$, July, 1996 at six observed points, that is, Pusan, Wolnae, Pangojin, Chongja, Kampo and Kuryongpo in Korean southeast coast. As the result obtained, Loran-C signals showed little fluctuation with good reprodutibility. Good stability of Loran-C signals was indicated by the small value of the standard deviation 0.064~0.094$\mu\textrm{s}$. Although determination of the observed position could not be completely accurate, the extent of the error was estimated smaller than 0.35 nautical mile.

• Journal of Microbiology and Biotechnology
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• v.19 no.1
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• pp.99-107
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• 2009

Strain PUPC1 produces an antifungal protease as well as plant growth promoting enzymes such as 1-aminocyclopropane-1-carboxylate (ACC) deaminase and phosphatase. Morphological, cultural, and physiological characteristics as well as 16S rRNA gene-sequence-based phylogenetic analysis confirmed the taxonomic affiliation of PUPC1 as Chryseobacterium aquaticum. The optimum growth of PUPC1 was observed at pH 6.0 and $30^{\circ}C$, and maximum protease production was observed in medium B amended with 1% tryptone, 0.5% sucrose, and 0.005% $MnCl_2$. The protease was purified by ammonium sulfate precipitation, Sephadex G-75 gel filtration chromatography, and electroelution from preparative SDS-PAGE. The protease had a molecular mass of 18.5 kDa. The optimum pH and temperature stability of the protease were pH 5.0-10.0 and temperature $40-70^{\circ}C$. Chryseobacterium aquaticum PUPC1 and its protease showed a broad-spectrum antifungal activity against phytopathogenic fungi. Strain PUPC1 also exhibited plant growth promoting traits. The objective of the present investigation was to isolate a strain for agricultural application for plant growth promotion and biocontrol of fungal diseases.

• The Korean Journal of Physiology and Pharmacology
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• v.14 no.5
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• pp.299-304
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• 2010

Losartan is a selective angiotensin II (Ang II) type 1 ($AT_1$) receptor antagonist which inhibits vascular smooth muscle cells (VSMCs) contraction and proliferation. We hypothesized that losartan may prevent cell proliferation by activating AMP-activated protein kinase (AMPK) in VSMCs. VSMCs were treated with various concentrations of losartan. AMPK activation was measured by Western blot analysis and cell proliferation was measured by MTT assay and flowcytometry. Losartan dose- and time-dependently increased the phosphorylation of AMPK and its downstream target, acetyl-CoA carboxylase (ACC) in VSMCs. Losartan also significantly decreased the Ang II- or 15% FBS-induced VSMC proliferation by inhibiting the expression of cell cycle associated proteins, such as p-Rb, cyclin D, and cyclin E. Compound C, a specific inhibitor of AMPK, or AMPK siRNA blocked the losartan-induced inhibition of cell proliferation and the $G_0/G_1$ cell cycle arrest. These data suggest that losartan-induced AMPK activation might attenuate Ang II-induced VSMC proliferation through the inhibition of cell cycle progression.

• Journal of Chest Surgery
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• v.24 no.1
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• pp.26-35
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• 1991

From January 1984 to June 1990, 188 patients have undergone cardiac valve replacement [114 MVR, 27 AVR, 47 Multiple valve replacement] with the St. Jude Medical prosthesis. The early mortality rate was 6.9%. The most common cause of early death was low output syndrome. There were no cases of valve-related early death. The risk factors for early death were advanced preoperative NYHA functional class [> IV], and prolonged ECC and ACC time. The 175 early survivors were followed-up for a total 372.7 patient-year over a period of 2 to 74 months [Mean $\pm$SD: 25.6$\pm$18.6 months]. During follow up, 12 patient died and late mortality rate was 6.9%. There were three valve-related late deaths: two were due to valve thrombosis and one was due to hemorrhage. Most late deaths [58%, 7/12] were from cardiac non-valvular causes. Valve-related complications occurred at a linearlized rate of 3.5% /pt-yr. Embolism occurred at a rate of 0.8% /pt-yr. There were three cases of valve thrombosis [0.8% /pt-yr: two fatal]. Hemorrhage due to anticoagulant occurred in 5 patients and a rate of 1.3% pt-yr [one fatal]. Five-year actuarial survival rate was 86.5 $\pm$5.1% and 97% of patient were in NYHA functional class I or II at three months postoperatively.

• Journal of Chest Surgery
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• v.22 no.2
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• pp.234-245
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• 1989

Between January 1984 and December 1986, sixty nine patients, aged 16 months to 25 years [mean age 10.05*6.40 years], underwent total correction of tetralogy of Fallot in Kyungpook national university hospital. In 66 hospital survivors, 30 patients were followed up for 12 to 48 months [mean 30.10*10.26 months]. These 30 patients were classified in two groups, TAP [transannular patch] and Non-TAP group. There were 9 patients in TAP group, and 21 in Non-TAP group. There were no significant differences between two groups in terms of age at operation, follow up duration, ACC time, and bypass time. All patients were evaluated by two dimensional echocardiography, Doppler echocardiography, standard 12-lead electrocardiography, and plain chest X-ray. Right ventricular systolic pressure, pulmonary arterial systolic pressure, pressure gradient between the right ventricle and the pulmonary artery, presence or absence of pulmonary regurgitation and its grading, fractional shortening of the left ventricle, and Qp/Qs in case of remnant ventricular septal defect were obtained by echocardiographic examination. Cardiothoracic ratio was measured by plain chest film, and ventricular dysrrhythmia was detected by electrocardiogram. Comparing the data between two groups, there was significant difference in incidence of postoperative pulmonary regurgitation [p< 0.05], 100%[9/9] in TAP group and 47.6 %[10/21] in Non-TAP group, but all the regurgitations were not severe. There were no significant differences in other comparisons, despite of higher incidence of cardiomegaly in TAP group [CT ratio: 59.3*5.3% VS 54.7*6, 4 %].

• The Korean Journal of Nuclear Medicine
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• v.39 no.2
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• pp.114-117
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• 2005

As the indication of percutaneous coronary intervention (PCI) has expanded to the more difficult and complicated cases, frequent restenosis is still expected after PCI. According to AHA/ACC guideline of the present time, routine use of myocardial perfusion single photon emission tomography (SPECT) is not recommended after coronary intervention, but symptom itself or exercise EKG is not enough for the detection of restensis or for the prediction of event-free survival. In high risk and/or symptomatic subjects, direct coronary angiography is required myocardial perfusion SPECT could detect restenosis in 79% of the patients if performed 2 to 9 months after PCI. Reversible perfusion decrease in the myocardial perfusion SPECT is known to be the major prognostic indicator of major adrerse cardiac event in PCI patients and also the prognosis is benign in the patients without reversible perfusion decrease. Though the cumulated specificity is 79% in the literature and optimal timing of myocardial perfusion SPECT is in controversy, SPECT is recommended even in asymptomatic patients at 3 to 9 months after PCI. Considering the evidences recently reported in the literature, myocardial perfusion SPECT is useful for risk stratification and detection of coronary artery restenosis requiring re-intervention in the asymptomatic patients after PCI.