• Title/Summary/Keyword: Acanthopanax senticosus $H_{ARMS}.$

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Vasodilation Effect of the Water Extract of Gingko biloba, Acanthopanax senticosus and Augmented Four-Substance Decoctions in Rat Thoracic Aorta (백과엽(白果葉) 및 자오가(刺五加) 가미사물탕(加味四物湯)이 백서(白鼠)의 흉부대동맥(胸部大動脈) 혈관이완(血管弛緩)에 미치는 영향)

  • Kim Hyung-Hwan;Park Soo-Yeon;Kang Soon-Ah;Kim Hong-Yeoul;Ahn Duk-Kyun;Park Seong-Kyu
    • Herbal Formula Science
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    • v.11 no.2
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    • pp.125-134
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    • 2003

  • We have examined the relaxational response to the water extract of Angelica gigas $N_{AKAI}$ (AG), Gingko biloba $L_{INNE}$ (GB), Acanthopanax senticosus $H_{ARMS}.$ (AP) and Augumented-Four-Substance Decoction (AG-FSD, GB-FSD, AP-FSD) in isolated thoracic aorta from sprague dawley(SD) rat. Rat thoracic aorta was investigated in vessel segments suspended for isometric tension recording by polygraph. Responses to AG, GB, AP and AG-FSD, GB-FSD, AP-FSD were investigated in vessels precontracted with 5-hydroxytryptamine(5-HT) were compared in vasodilation effect. We found that the thoracic aorta segments responded to AG, GB, AP and AG-FSD, GB-FSD, AP-FSD with a dose-dependent vasodilation. The 5-hydroxytryptamine induced contraction at $10^{-4}M$ were inhibited by 26.3%, 75.8%, 87.5% and 6.9%, 22.6%, 30.8% after addition of the 0.1 g/mL water extract of AG, GB, AP and AG-FSD, GB-FSD, AP-FSD. In conclusion, AG, GB, AP and AG-FSD, GB-FSD, AP-FSD induced relaxation in the isolated rat thoracic aorta were composed of dose-dependent relaxation. AP-FSD has very potent vasodilation.

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