• BLOOD RESEARCH
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• 제53권4호
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• pp.281-287
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• 2018

Background Bone marrow involvement (BMI) affects the lymphoma stage, survival, and treatment. Bone marrow biopsy (BMB) and fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT) are useful techniques to detect BMI. Both have advantages and disadvantages. We aimed to identify factors that could be used to predict BMI with positive and negative results on PET/CT compare them with BMB in newly diagnosed patients with lymphoma. Methods We included 22 non-Hodgkin and 16 Hodgkin lymphoma patients in this single center study. All patients had PET/CT examination and BMB before treatment. BMI in BMB was reported as negative or positive. Bone marrow was classified into 3 types by FDG uptake on PT/CT; diffuse involvement, focal involvement, and normal bone marrow. Results PET/CT and BMB results were concordant (7 positive, 15 negative) in 22 patients (57%). We evaluated concordant and discordant patient characteristics and risk-stratified patients for BMI. Our findings suggest that patients with diffuse FDG uptake on PET/CT, especially patients with advanced age and low platelet and white blood cell counts, are likely to have BMI and could potentially forego BMB. Patients with negative PET/CT findings and no significant laboratory abnormalities are very unlikely to have BMI. Conclusion Our results suggest that BMI should not be decided solely based PET/CT or BMB findings. It is reasonable to use both diagnostic assays along with clinical and laboratory findings. PET/CT result, clinical and laboratory findings could be useful for predicting BMI in patient for whom BMB is contraindicated.

• 인터넷정보학회논문지
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• 제22권3호
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• pp.17-26
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• 2021

최근 COVID-19가 확산하고 외출 자제 권고와 같은 방역지침에 따라 집에서 생활하는 시간이 늘고 있다. 이에 따라 집에서 생활하는 1인 가구가 증가하고 있지만 1인 가구는 다인 가구보다 집 안에서 위급한 상황이 발생할 때 외부에 알리기 어렵다. 본 연구는 집안에서 발생하는 다양한 상황을 라이다, 영상, 음성 센서로 수집하고 센서에 따른 데이터를 각각의 알고리즘을 통해 분석하였다. 이를 이용해 위급상황 등의 비정상 패턴을 분석하여 사람의 이상징후를 탐지하는 연구를 진행했다. 각 센서에 따른 사람의 이상징후를 탐지하는 인공지능 알고리즘을 연구하였으며 센서에 따른 이상징후 탐지 정확도를 측정했다. 또한, 본 연구는 다양한 상황에 대한 센서의 탐지 가능 여부를 실험하여 센서 간의 장단점을 보완한 융합 방식을 제안한다.

• 한국전산구조공학회논문집
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• 제34권4호
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• pp.183-189
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• 2021

구조물에 장기적으로 발생하는 노후화를 정량적으로 파악하기 위해 상시진동 데이터를 활용한 일반화된 모니터링 시스템에 관한 연구가 세계적으로 활발히 수행중이다. 본 연구에서는 구조물에서 장기적으로 취득되는 동특성을 앙상블 학습에 활용하여 구조물의 이상을 감지하기 위한 보급형 엣지 컴퓨팅 시스템을 구축하였다. 시스템의 하드웨어는 라즈베리파이와 보급형 가속도계, 기울기센서, GPS RTK 모듈, 로라 모듈로 구성됐다. 실험실 규모의 구조물 모형 진동실험을 통해 동특성을 활용한 앙상블 학습의 구조물 이상감지를 검증하였으며, 실험을 기반으로 한 실시간 동특성 추출 분산처리 알고리즘을 라즈베리파이에 탑재하였다. 구축된 시스템을 하우징하고 포항시 행정복지센터에 설치하여 데이터를 취득함으로써 개발된 시스템의 현장 적용성을 검증하였다.

• Journal of Multimedia Information System
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• 제9권2호
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• pp.145-154
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• 2022

The authors are making a prototype flexible board of a radio-frequency transmitter for measuring an electromyogram (EMG) of a flying moth and plan to apply for an experimental station license from the Ministry of Internal Affairs and Communications of Japan in the summer of 2022. The goal is to create a continuous low-dose exposure standard that incorporates scientific and physiological functional assessments to replace the current standard based on lethal dose 50. This paper describes the technical evaluation of the hardware. The signal of a bipolar EMG electrode is amplified by an operational amplifier. This potential is added to a voltage-controlled crystal oscillator (27 MHz, bandwidth: 4 kHz), frequency-converted, and transmitted from an antenna about 10 cm long (diameter: 0.03 mm). The power source is a 1.55-V wristwatch battery that has a total weight of about 0.3 g (one dry battery and analog circuit) and an expected operating time of 20 minutes. The output power is -7 dBm and the effective isotropic radiated power is -40 dBm. The signal is received by a dual-whip antenna (2.15 dBi) at a distance of about 100 m from the moth. The link margin of the communication circuit is above 30 dB within 100 m. The concepts of this hardware and the measurement data are presented in this paper. This will be the first biological data transmission from a moth with an official license. In future, this telemetry system will improve the detection of physiological abnormalities of moths.

• 한국초지조사료학회지
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• 제42권3호
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• pp.201-207
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• 2022

Fescues, which are widely cultivated as grasses and forages around the world, are often naturally infected with the endophyte, Epichloë. This fungus, transmitted through seeds, imparts resistance to drying and herbivorous insects in its host without causing any external damage, thereby contributing to the adaptation of the host to the environment and maintaining a symbiosis. However, some endophytes, such as E. coenophialum synthesize ergovaline or lolitrem B, which accumulate in the plant and impart anti-mammalian properties. For example, when livestock consume excessive amounts of grass containing toxic endophytes, problems associated with neuromuscular abnormalities, such as convulsions, paralysis, high fever, decreased milk production, reproductive disorders, and even death, can occur. Therefore, pre-inoculation with non-toxic endogenous fungi or management with endophyte-free grass is important in preventing damage to livestock and producing high-quality forage. To date, the diagnosis of endophytes has been mainly performed by observation under a microscope following staining, or by performing an immune blot assay using a monoclonal antibody. Recently, the polymerase chain reaction (PCR)-based molecular diagnostic method is gaining importance in the fields of agriculture, livestock, and healthcare given the method's advantages. These include faster results, with greater accuracy and sensitivity than those obtained using conventional diagnostic methods. For the diagnosis of endophytes, the nested PCR method is the only available option developed; however, it is limited by the fact that the level of toxic alkaloid synthesis cannot be estimated. Therefore, in this study, we aimed to develop a triplex real-time PCR diagnostic method that can determine the presence or absence of endophyte infection using DNA extracted from seeds within 1 h, while simultaneously detecting easD and LtmC genes, which are related to toxic alkaloid synthesis. This new method was then also applied to real field samples.

• Clinical Pain
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• 제19권2호
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• pp.90-96
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• 2020

Objective: To investigate the diagnostic accuracy of two physical examinations (straight leg raise [SLR] and Bragard test) and electromyography (EMG) in patients with lumbosacral monoradiculopathy in acute and chronic state on confirmation of different diagnostic criteria (MRI vs MRI and diagnostic selective nerve root block [DSNRB]). Method: We identified 297 participants retrospectively from the departmental database. MRI evidence of L5 or S1 nerve root compression and a positive result in diagnostic SNRB served as reference standards. They were divided into two groups by the symptom duration: lasting more than 12 weeks in the chronic group and less than 12 weeks in the acute group. The diagnostic value of clinical tests and EMG were compared. Results: The clinical tests (SLR and Bragard test) done in acute stage on detection by MRI and DSNRB had the highest sensitivity (68%) compared to the chronic stage (63%), but sensitivity was low (57%) on confirmation of MRI alone. However, there was no significant difference on sensitivity and specificity of EMG regardless of reference standards and symptom duration. Electromyography was a significant predictor of neuropathic abnormalities on both acute (OR, 6.3; 95% CI, 2.4 to 16.7; p<0.01) and chronic (OR, 6.8; 95% CI, 2.9 to 16.3; p<0.01). Conclusion: In general, individual physical tests are easy to do and a combination of those tests could be a sensitive indicator of L5 or S1 radiculopathy. Furthermore, the use of provocation tests could provide useful information, especially in proceeding therapeutic selective nerve root block.

• 대한소아치과학회지
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• 제50권2호
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• pp.142-154
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• 2023

상악 견치는 기능과 외모에 있어서 중요한 역할을 하지만, 맹출 장애로 인해 문제를 일으키는 경우가 많다. 상악 견치의 매복은 비교적 흔하며 구조적 장애, 발달 이상, 공간 부족, 유전과 같은 다양한 요인에 의해 발생할 수 있다. 상악 견치의 구개측 매복은 서양인에게서 흔한 것으로 보고되지만 한국인에게는 순측 매복이 더 흔한 것으로 관찰된다. 순측으로 변위된 상악 견치의 경우, 치아 총생 및 골격성 부정교합이 보일 수 있으며, 측절치의 선천적 상실이나 과잉 측절치는 상악 견치의 구개측 매복 가능성을 높일 수 있다. 상악 견치 매복의 조기 발견 및 적절한 처치는 조화로운 치열 발달과 정상적인 치아 기능을 위해 중요하다. 본 종설을 통해 매복 상악 견치의 다양한 처치법을 제안하고 그 원리를 설명하고자 한다.

• 대한수의학회지
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• 제64권1호
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• pp.7.1-7.6
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• 2024

Bird species, particularly poultry and other bird types, including domestic pigeons, are susceptible to fowl pox, a contagious viral disease. The main goal of this study was to validate clinical avipoxvirus diagnoses using molecular analytical methods. The essential components of the investigation were the clinical signs, visible abnormalities, histological changes, and polymerase chain reaction analysis. Twenty out of 120 pigeons had clinical symptoms, which included yellowish crust or nodules near the feet, eyes, and beak. An erosive epidermal lesion and an epidermal acanthotic papular lesion with basal vacuolation were maculopapular evidence associated with significant epidermal hyperkeratosis, as confirmed by histological analysis. In addition, the results showed keratinocyte necrosis beneath the hyperkeratotic epidermal layer, together with superficial and deep dermal perivascular lymphocytic infiltration. In addition, the P4b core protein gene underwent phylogenetic analysis. The sequence analysis results indicated a high degree of similarity across the local strains, with just minor variations observed. Five sample sequences were selected and submitted to the NCBI database. These sequences were identified as OR187728, OR187729, OR187730, OR187731, and OR187732. All the various strains in this research may be classified under clade A of the chicken pox virus phylogenetic classification. This study presents the first description and characterization of pox virus infections in domestic pigeons inside the Basrah governorate.

• Korean Journal of Radiology
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• 제2권4호
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• pp.192-196
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• 2001

Objective: To compare conventional and diffusion-weighted MR imaging in terms of their depiction of the abnormalities occurring in Creutzfeldt-Jakob disease. Materials and Methods: We retrospectively analyzed the findings of conventional (T2-weighted and fluid-attenuated inversion recovery) and diffusion-weighted MR imaging in four patients with biopsy-proven Creutzfeldt-Jakob disease. The signal intensity of the lesion was classified by visual assessment as markedly high, slightly high, or isointense, relative to normal brain parenchyma. Results: Both conventional and diffusion-weighted MR images demonstrated bilateral high signal intensity in the basal ganglia in all four patients. Cortical lesions were observed on diffusion-weighted MR images in all four, and on fluid-attenuated inversion recovery MR images in one, but in no patient on T2-weighted images. Conventional MR images showed slightly high signal intensity in all lesions, while diffusion-weighted images showed markedly high signal intensity in most. Conclusion: Diffusion-weighted MR imaging is more sensitive than its conventional counterpart in the depiction of Creutzfeldt-Jakob disease, and permits better detection of the lesion in both the cerebral cortices and basal ganglia.

• 지능정보연구
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• 제27권3호
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• pp.57-73
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• 2021

ICT 인프라의 이상탐지를 통한 유지보수와 장애 예방이 중요해지고 있다. 장애 예방을 위해서 이상탐지에 대한 관심이 높아지고 있으며, 지금까지의 다양한 이상탐지 기법 중 최근 연구들에서는 딥러닝을 활용하고 있으며 오토인코더를 활용한 모델을 제안하고 있다. 이는 오토인코더가 다차원 다변량에 대해서도 효과적으로 처리가 가능하다는 것이다. 한편 학습 시에는 많은 컴퓨터 자원이 소모되지만 추론과정에서는 연산을 빠르게 수행할 수 있어 실시간 스트리밍 서비스가 가능하다. 본 연구에서는 기존 연구들과 달리 오토인코더에 2가지 요소를 가미하여 이상탐지의 성능을 높이고자 하였다. 먼저 다차원 데이터가 가지고 있는 속성별 특징을 최대한 부각하여 활용하기 위해 멀티모달 개념을 적용한 멀티모달 오토인코더를 적용하였다. CPU, Memory, network 등 서로 연관이 있는 지표들을 묶어 5개의 모달로 구성하여 학습 성능을 높이고자 하였다. 또한, 시계열 데이터의 특징을 데이터의 차원을 늘리지 않고 효과적으로 학습하기 위하여 조건부 오토인코더(conditional autoencoder) 구조를 활용하는 조건부 멀티모달 오토인코더(Conditional Multimodal Autoencoder, CMAE)를 제안하였다. 제안한 CAME 모델은 비교 실험을 통해 검증했으며, 기존 연구들에서 많이 활용된 오토인코더와 비교하여 AUC, Accuracy, Precision, Recall, F1-score의 성능 평가를 진행한 결과 유니모달 오토인코더(UAE)와 멀티모달 오토인코더(Multimodal Autoencoder, MAE)의 성능을 상회하는 결과를 얻어 이상탐지에 있어 효과적이라는 것을 확인하였다.