• 한국분말재료학회지
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• 제25권2호
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• pp.104-108
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• 2018

Grain-growth behavior in the $95Na_{1/2}Bi_{1/2}TiO_3-5BaTiO_3$ (mole fraction, NBT-5BT) system has been investigated with the addition of $Na_2CO_3$. When $Na_2CO_3$ is added to NBT-5BT, the growth rate is higher than desired and grains are already impinging each other during the initial stage of sintering. The grain size decreases as the sintering temperature increases. With the addition of $Na_2CO_3$, a liquid phase infiltrates the interfaces between grains during sintering. The interface structure can be changed to be more faceted and the interface migration rate can increase due to fast material transport through the liquid phase. As the sintering temperature increases, the impingement of abnormal grains increases because the number of abnormal grains increases. Therefore, the average grain size of abnormal grains can be decreased as the temperature increases. The phenomenon can provide evidence that grain coarsening in NBT-5BT with addition of $Na_2CO_3$ is governed by the growth of facet planes, which would occur via mixed control.

• 정보보호학회논문지
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• 제29권6호
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• pp.1403-1412
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• 2019

터빈, 배관 및 저장탱크와 같은 물리장치들의 경우 노후화뿐만 아니라 제어장치에 대한 사이버공격으로 인해 PLC(Programmable Logic Controller)와 같은 제어시스템의 보호 및 상태감시기능이 동작하지 않는 경우, 피해파급력이 크고, 가동 중지 시 그 비용 손실 또한 매우 크다. 가동 중인 물리장치의 작동을 중지하지 않고 간접적으로 상태감시를 함으로써 가용성을 유지하기 위한 방안으로써 온도, 가속도, 전류 등을 간접적으로 감지하고, 데이터들을 Influx DB에 저장하여 실시간으로 감시하는 시스템을 설계 및 구현한다. 실제 구현된 시스템으로부터 데이터를 얻고 이를 이용하여 이상상태를 감지할 수 있음을 검증하였다. 간접적 실시간 감시시스템의 범용화를 통해 데이터를 축적해 활용하면, 추가비용 없이 가동을 중지하지 않고 사용할 수 있을 뿐만 아니라 미리 고장을 예측하고 필요한 경우에만 조치를 취하는 고장예지기술, 이상상태를 이중으로 감시하는 신뢰도 높은 건전성 관리 기술을 통해 유지보수비용과 위험도를 대폭적으로 감소시키고, 보안위협에 대한 대비가 가능하다.

• BMB Reports
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• 제40권4호
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• pp.467-474
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• 2007

Autosomal recessive polycystic kidney disease (ARPKD) is one of the important genetic disorders in pediatric practice. Mutation of the polycystic kidney and hepatic disease gene 1 (PKHD1) was identified as the cause of ARPKD. The gene encodes a 67-exon transcript for a large protein of 4074 amino acids termed fibrocystin, but its function remains unknown. The neoplastic-like in cystic epithelial proliferation and the epidermal growth factor/epidermal growth factor receptor (EGF/EGFR) axis overactivity are known as the most important characteristics of ARPKD. Since the misregulation of $Ca^{2+}$ signaling may lead to aberrant structure and function of the collecting ducts in kidney of rat with ARPKD, present study aimed to investigate the further mechanisms of abnormal proliferation of cystic cells by inhibition of PKHD1 expression. For this, a stable PKHD1-silenced HEK-293T cell line was established. Then cell proliferation rates, intracellular $Ca^{2+}$ concentration and extracellular signal-regulated kinase 1/2 (ERK1/2) activity were assessed after treatment with EGF, a calcium channel blocker and agonist, verapamil and Bay K8644. It was found that PKHD1-silenced HEK-293T cell lines were hyperproliferative to EGF stimulation. Also PKHD1-silencing lowered the intracellular $Ca^{2+}$ and caused EGF-induced ERK1/2 overactivation in the cells. An increase of intracellular $Ca^{2+}$ in PKHD1-silenced cells repressed the EGF-dependent ERK1/2 activation and the hyperproliferative response to EGF stimulation. Thus, inhibition of PKHD1 can cause EGF-induced excessive proliferation through decreasing intracellular $Ca^{2+}$ resulting in EGF-induced ERK1/2 activation. Our results suggest that the loss of fibrocystin may lead to abnormal proliferation in kidney epithelial cells and cyst formation in ARPKD by modulation of intracellular $Ca^{2+}$.

• Clinical Endoscopy
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• 제56권6호
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• pp.823-826
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• 2023

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제20권3호
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• pp.153-159
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• 2017

Purpose: Acid neutralization during chemical clearance is significantly prolonged in children with cystic fibrosis, compared to symptomatic children without cystic fibrosis. The absence of available reference values impeded identification of abnormal findings within individual patients with and without cystic fibrosis. The present study aimed to test the hypothesis that significantly more children with cystic fibrosis have acid neutralization durations during chemical clearance that fall outside the physiological range. Methods: Published reference value for acid neutralization duration during chemical clearance (determined using combined impedance/pH monitoring) was used to assess esophageal acid neutralization efficiency during chemical clearance in 16 children with cystic fibrosis (3 to < 18 years) and 16 age-matched children without cystic fibrosis. Results: Duration of acid neutralization during chemical clearance exceeded the upper end of the physiological range in 9 of 16 (56.3%) children with and in 3 of 16 (18.8%) children without cystic fibrosis (p=0.0412). The likelihood ratio for duration indicated that children with cystic fibrosis are 2.1-times more likely to have abnormal acid neutralization during chemical clearance, and children with abnormal acid neutralization during chemical clearance are 1.5-times more likely to have cystic fibrosis. Conclusion: Significantly more (but not all) children with cystic fibrosis have abnormally prolonged esophageal clearance of acid. Children with cystic fibrosis are more likely to have abnormal acid neutralization during chemical clearance. Additional studies involving larger sample sizes are needed to address the importance of genotype, esophageal motility, composition and volume of saliva, and gastric acidity on acid neutralization efficiency in cystic fibrosis children.

• 한국수산과학회지
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• 제41권4호
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• pp.294-300
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• 2008

Abnormal cooling of the Korean East Sea Water(KESW) in the East Sea before and after the 1982-1983 and 1997-1998 ENSO events is examined using bimonthly routine observation data from the National Fisheries Research and Development Institute of Korea for the period 1965 to 2002. The KESW, which occupies roughly a region between the Korean Peninsula and west of approximately $131^{\circ}E$, showed extreme cold-state years(1981 and 1996) prior to the two strongest ENSO events of the last half-century. Inter-annual bimonthly mean anomalies at 100 m in the KESW region were $-3.10^{\circ}C\;and\;-3.41^{\circ}C(SD=1.4^{\circ}C)$ in 1981 and 1996, respectively. These results suggest that extreme cooling of the KESW may be a prelude to very strong ENSO events through large-scale teleconnections.

• Journal of Hospice and Palliative Care
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• 제10권3호
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• pp.120-127
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• 2007

Bereavement is the state of loss resulting from death. Grief is the emotional response associated with loss, intense and acute sorrow resulting from loss. Complicated grief represent a pathological outcome involving social, physical, emotional, cognitive, spiritual morbidity. The common psychiatric disorders associated complicated grief or abnormal grief responses include clinical depression, anxiety disorders, alcohol abuse or other substance abuse, and dependence, psychotic disorders, and post-traumatic stress disorder (PTSD). Grief tasks involve a series of stage or phases following an important loss that gradually permit adjustment and recovery. Three phases of grief involve phase 1 (walking the edges), phase 2 (entering the depths), and phase 3 (reconnecting the world). For intervention to be effective they need to be individually tailored to abnormal grief reaction or unresolved grief reaction. Clear understandings of complicated grief, abnormal responses, factors increasing risk after bereavement will often enable us to prevent psychiatric disorders in bereaved patients.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2006년도 추계학술대회논문집
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• pp.556-561
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• 2006

In this study, the failure of the automotive clutch disk was investigated. During the process of power transmission, clutch disk plates did repeated work of releasing and engaging the pressure plate. The effects of unbalance rotation in the abnormal vibration and torque amplitude under engaged state were measured from this experiment. In order to reduce the unbalance, a modified clutch disk shape was developed. With a three-dimensional model of the stopper pin, to predict fatigue fracture, finite element analysis was carried out and evaluated the improvement of the new clutch disk.

• International Journal of Safety
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• 제11권1호
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• pp.26-32
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• 2012

This paper introduces a feasibility evaluation method for prognosis systems based on an empirical model in nuclear power plants. By exploiting the dynamical signature characterized by abnormal phenomena, the prognosis technique can be applied to detect the plant abnormal states prior to an unexpected plant trip. Early $operator^{\circ}{\emptyset}s$ awareness can extend available time for operation action; therefore, unexpected plant trip and time-consuming maintenance can be reduced. For the practical application in nuclear power plant, it is important not only to enhance the advantages of prognosis systems, but also to quantify the negative impact in prognosis, e.g., uncertainty. In order to apply these prognosis systems to real nuclear power plants, it is necessary to conduct a feasibility evaluation; the evaluation consists of 4 steps (: the development of an evaluation method, the development of selection criteria for the abnormal state, acquisition and signal processing, and an evaluation experiment). In this paper, we introduce the feasibility evaluation method and propose further study points for applying prognosis systems from KHNP's experiences in testing some prognosis technologies available in the market.

• Journal of Advanced Marine Engineering and Technology
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• 제30권2호
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• pp.247-252
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• 2006

Almost ship monitoring systems are event driven alarm system which warn only when the measurement value is over or under set point. These kinds of system cannot warn until signal is growing to abnormal state that the signal is over or under the set point. therefore cannot play a role for preventive maintenance system. This paper proposes fault diagnosis method which is able to diagnose and forecast the fault from present operating condition by analyzing monitored signals with present ship monitoring system without any additional sensors. By analyzing the data with high correlation coefficient(CC), correlation level of interactive data can be defined. Knowledge base of abnormal detection can be built by referring level of CC(Fault Detection CC. FDCC) to detect abnormal data among monitored data from monitoring system and knowledge base of diagnosis built by referring CC among interactive data for related machine each other to diagnose fault part.