• The Journal of Korean Society for School & Community Health Education
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• v.22 no.2
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• pp.53-64
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• 2021

Objectives: The objective of this study is to understand the factors having effects on the view of marriage of female university students, and also to present the reference data for establishing the measures for having the positive view of marriage of female university students. Methods: An online survey was conducted targeting total 254 female university students of two universities in Gyeonggi region, from October 1 st to November 13th 2020. The results of this study are as follows. Results: First, to the question related to the intent to marry, total 70% of them responded that they had intent to marry. In the time of marriage, they said they would marry when getting financially stable. The 30% of subjects said that they would choose non-marriage because they wanted to continuously enjoy free life and they did not want to bear burden related to childbirth and child-rearing. Second, in the results of analyzing differences in the view of marriage according to the general characteristics, the students with intent to marry showed the higher romantic view of marriage, instrumental view of marriage, and exclusive view of marriage than the students without intent to marry, which showed significant differences. Third, the view of marriage were the factors having the greatest effects on the intent to marry of female university students. Conclusion: Based on such results of this study, it would be necessary to focus on the policies that could positively change the view of marriage of female university students. It would be needed to establish the social·institutional support measures for work-life balance by reducing women's burden of childbirth and child-rearing. To the question about the time of marriage, the most subjects responded that they would do so when the economic ability and stable job were equipped. Thus, there should be the systematic youth employment support system that could help the students to quickly and stably enter society and to become financially independent after graduation. Also, for the formation of positive family relation, it would be necessary to develop·operate the educational programs for forming positive family relation and desirable communication methods for each subject(spouse, parents, children, siblings, and etc.).

• Proceedings of the Korean Society of Applied Pharmacology
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• 2002.07a
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• pp.113-113
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• 2002

Phylogenetically conserved Bcl-2 family proteins play a pivotal role in the regulation of apoptosis from virus to human. Members of the Bcl-2 family consist of antiapoptotic proteins such as Bcl-2, Bcl-xL, and Bcl-w, and proapoptotic proteins such as BAD, Bax, BOD, and Bok. It has been proposed that anti- and proapoptotic Bcl-2 proteins regulate cell death by binding to each other and forming heterodimers. A delicate balance between anti- and proapoptotic Bcl-2 family members exists in each cell and the relative concentration of these two groups of proteins determines whether the cell survives or undergoes apoptosis. Mcl-1 (Myeloid cell :leukemia-1) is a member of the Bcl-2 family proteins and was originally cloned as a differentiation-induced early gene that was activated in the human myeloblastic leukemia cell line, ML-1 . Mcl-1 is expressed in a wide variety of tissues and cells including neoplastic ones. We recently identified a short splicing variant of Mcl-1 short (Mcl-IS) and designated the known Mcl-1 as Mcl-1 long (Mcl-lL). Mcl-lL protein exhibits antiapoptotic activity and possesses the BH (Bcl-2 homology) 1, BH2, BH3, and transmembrane (TM) domains found in related Bcl-2 proteins. In contrast, Mcl-1 S is a BH3 domain-only proapoptotic protein that heterodimerizes with Mcl-lL. Although both Mc1-lL and Mcl-lS proteins contain BH domains fecund in other Bcl-2 family proteins, they are distinguished by their unusually long N-terminal sequences containing PEST (proline, glutamic acid, serine, and threonine) motifs, four pairs of arginine residues, and alanine- and glycine-rich regions. In addition, the expression pattern of Mcl-1 protein is different from that of Bcl-2 suggesting a unique role (or Mcl-1 in apoptosis regulation. Tankyrasel (TRF1-interacting, ankyrin-related ADP-related polymerasel) was originally isolated based on its binding to TRF 1 (telomeric repeat binding factor-1) and contains the sterile alpha motif (SAM) module, 24 ankyrin (ANK) repeats, and the catalytic domain of poly(adenosine diphosphate-ribose) polymerase (PARP). Previous studies showed that tankyrasel promotes telomere elongation in human cells presumably by inhibiting TRFI though its poly(ADP-ribosyl)action by tankyrasel . In addition, tankyrasel poly(ADP-ribosyl)ates Insulin-responsive amino peptidase (IRAP), a resident protein of GLUT4 vesicles, and insulin stimulates the PARP activity of tankyrase1 through its phosphorylation by mitogen-activated protein kinase (MAPK). ADP-ribosylation is a posttranslational modification that usually results in a loss of protein activity presumably by enhancing protein turnover. However, little information is available regarding the physiological function(s) of tankyrase1 other than as a PARP enzyme. In the present study, we found tankyrasel as a specific-binding protein of Mcl-1 Overexpression of tankyrasel led to the inhibition of both the apoptotic activity of Mel-lS and the survival action of Mcl-lL in mammalian cells. Unlike other known tankyrasel-interacting proteins, tankyrasel did not poly(ADP-ribosyl)ate either of the Mcl-1 proteins despite its ability to decrease Mcl-1 proteins expression following coexpression. Therefore, this study provides a novel mechanism to regulate Mcl-1-modulated apoptosis in which tankyrasel downregulates the expression of Mcl-1 proteins without the involvement of its ADP-ribosylation activity.

• Journal of Korean Academy of Nursing
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• v.27 no.4
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• pp.933-942
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• 1997

There has recently been an increased interest in women's health from, various disciplines, with different perspectives presented according to each profession's academic background. This has led to many instances of incorrectly defining, or misinterpretation, of the issues even among professionals. Nurse scholars as well as practitioners who work in women's health care need to have a clear conceptual understanding of women's health in order to build a body of knowledge, delineate curricular activities, and set directions for professional nursing interventions. In addition, a conceptual model that may be directly utilized in practice is needed to maintain and promote women's health issues. The purpose of this study was to apply a Hybrid model, analyzing conceptual definitions and discussions related to women's health gathered from review of the literature. Further to compare analyticals the concepts and properties observed from field work, so as to present a final definition of women's health and, build a conceptual framework for a united comprehensive perspective on the concept as well as on nursing practice. Data collection and analysis consisted of a theoretical stage, field work stage, and final analysis. A heterogeneous group of professionals and lay persons, 39 in all, participated in the field work. Study findings Include several subconcepts under the concept of women's health : a woman's whole life, holistic health, quality of life, awareness of being a woman, individual nursing, self care ability, reproductive health, and family health. Thus, a comprehensive definition was built, 1. e., "Women's health care be defined as improvement in the quality of life of women through attainment of holistic health throughout the life span. With reproductive health at the core, the concept is directly related to family and national health, and includes taking care of one's own health based on awareness of being a woman and utilizing self care activities. Women's health care issues are unique and allow various responses, therefore women's health professionals need to apply individual approaches to reach solutions in attaining holistic health and improving quality of life." The constructual factors of women's health were found to be reproductive functions, diseases more common in woman, self actualization, mental health, women's health policies, sexuality, midlife changes, and marital relations, with each factor having more than three properties. Positive factors affecting women's health were found to be a normal childbearing process, a healthy lifestyle, active health management, health information, support, and resources, and interpersonal relationships. Negative factors were found to be overwhelming role stress, cultural oppression, gender inequality, distorted sexual identity, economic difficulties, misuse and/or abuse of substances, and stress. The model of women's health may be visualized as a balance scale set upon a woman's life, supporting 4 concentric circles. The innermost circle and second circle incorporate conceptual definitions of women's health, and the outer two circles represent the constructional factors and properties of women's health. Each circle has its own color that symbolizes the conceptual meaning. Positive and negative factors are represented as weights at either end of the scale, and are affected by nursing intervention, i. e., health and wellness increase when positive factors are stronger, whereas disease and illness increase when negative factors are stronger. This model is only a preliminary effort and requires much discussion and testing to be further developed. Continuous research is also required.

• Journal of Nutrition and Health
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• v.28 no.7
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• pp.653-674
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• 1995

This study was aimed at comparing the dietary patterns of university female students according to their residence type. As for subjects, one hundred and twenty students of Kongju national university were chosen as a total. They were devided into three groups ; those who live in family home, or university dormitory, or self-boarding house. In this study, intakes of food and nutrient and dietary behaviors of each group were investigated through two-day food records and questionnaire. The result was that mean daily intakes of calcium and iron were lower than RDAs in all groups. According to residence type, subjects of family home and self-boarding seemed to have more serious problem in the nutrients mentioned above considering the proportions of less than 2/3 of RDAs. Especially, iron status was poorer than any other nutrients in the aspects of this proportion and food source. Iron was taken largely from vegetable foods which were recognized as a source of low bioavailability of iron. The average distribution ratios of breakfast, lunch, dinner and snack to total calorie intake was 22, 29, 30 and 19. Thus, it proved that breakfast tended to be more negligent than any other meals, and that snack was an important means to give nutrients for subjects. This meal pattern might be one of the factor for the decrease of the dietary quality. Processed foods were founded to be an important source for providing nutrients. Percentages of calorie, carbohydrate and fat consumed by processed foods to total nutrients. Percentages of calorie, carbohydrate and fat consumed by processed foods to total nutrients intake were 30.6, 29.5 and 46.2. However, other nutrient intakes from processed foods such as vitamin and mineral were small. And processed foods which give nutrients were mainly cereal products like ra myon, bread, and milk and milk products. Consequently, processed foods seemed to be selected as a combinient substitute food which supply calorie to fill their hunger. According to the living type, dormitory students had them more frequently than any other groups. Food habit score was within the category of poor or fair. Particularly, the score of self-boarding students was the lowest of groups(p<0.05). The major dietary problems were small or overating, missing meal and irregular eating. The degree of these problems was a little different among groups(P<0.01). Nineteen kinds of food were consumed per day, and family home and self-boarding students had foods less variously than dormitory students(P<0.05). Proportions of skipping breakfast, lunch and dinner were 20.8, 12.5 and 8.3%. Accordingly, breakfast was missed more often than any other meals. And self-boarding students missed breakfast more often than any other groups. As a conclusion, subjects should take more calcium and iron, and eat diverse foods to improve their nutritional status. And it is also necessary that breakfast should be regarded more importantly, and that processed foods should be taken considering nutritional balance. In view of residence type, subjects of family home or self-boarding had more dietary problems than dormitory subjects. Thus, these results suggest that university female students might have low ability of meal management, and dietary patterns were different by their residence type. Therefore, nutrition education for them should be carried out with respect to dewelling environment.

• The Journal of the Convergence on Culture Technology
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• v.8 no.1
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• pp.93-104
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• 2022

Based on the theoretical review of social cooperatives and the results of the fourth round of fact-finding, this study tried to discuss the sustainability of social co-operatives from the social, economic, and environmental aspects, focusing on the seven principles of co-operatives. The issue of sustainability is "a development that meets the needs of the present without compromising the ability of future generations to meet their own needs, the use of resources, the direction of investment, technological advances and institutional change in harmony with one another. as defined as "a process of change that advances the needs and desires of all future generations". It contains the meaning of connecting a sustainable society to future generations through harmony and balance, rather than opposing concepts of social value, environmental conservation, and economic growth. As a result of arranging the concept of social, economic, and environmental sustainability contained in sustainable development, and the seven principles of cooperatives and their connections, I would like to suggest the following about the sustainability of social cooperatives. First, efforts should be made for social contribution closely related to the local community. Second, it is necessary to create a profit model along with the public interest. Third, partnerships should be strengthened. When examining the public values and objectives that social cooperatives want to realize through this study, the three scopes of sustainable development are directly related to the role of important actors in pursuing social and economic values that social and economic organizations are facing. would. Therefore, the sustainability issue of social cooperatives is based on the concept that the goals and values pursued by social cooperatives are harmonious and balanced development in the environmental, social, and economic aspects, not only their own efforts but also the institutional support of the government. this will have to be presented.

• Journal of Environmental Health Sciences
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• v.46 no.3
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• pp.344-352
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• 2020

Objectives: Much attention has been paid to indoor air quality. Ventilation within schools is important because of indoor air quality and its effect on health and learning performance. In this study, we evaluated the carbon dioxide (CO₂) concentrations and ventilation rates in schools. Methods: This study measured the concentration of CO₂ in elementary, middle, and high school classrooms over six months. The seasons during the study were summer, fall, and winter. Sensor-based monitoring was used and the basic characteristics of the classroom were investigated. The body surface area of the students was used to calculate the CO₂ generation rate, and the air change per hour (ACH) was evaluated using mass balance modeling. Results: The average CO₂ concentration measured in most schools exceeded 1000 ppm. The ventilation rates varied from season to season. Compared to the recommended ventilation rate of 4.9 ACH, the roughly 3 ACH calculated in this study indicates that most schools possessed insufficient ventilation. Conclusions: The concentration of CO₂ in school classrooms could be an indicator of indoor air quality and can affect students' learning ability. In this study, CO₂ concentrations exceeding the standard indicate a lack of ventilation along with problems with indoor air quality. Therefore, appropriate improvements are needed to overcome these problems.

• The Journal of Korean Physical Therapy
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• v.12 no.1
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• pp.101-112
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• 2000

The aim of this study is to compared the cerebral palsy children with normal children in the exercise and cardio vascular ability after this study as the fundamental data fer mating programs for the cerebral palsy children. The test of this study is about twenty girls, the control group of the normal children(n=10) and the experiment group of cerebral palsy children(n=10). They were studied in four aspects which were the anthropometry, the medical check in the rest, the physical fitness or exercise roads test and the change of the target heart rate during exercise. The result were as follows : 1. The characteristic of the physical type : The control group is higher than the experiment group in the standing height and the body weight but their's little difference between them (p<0.05). The control group is lower than the experiment group in the body fat. 2. The characteristic of the medical check in the rest : The control group is higher than the experiment group in the vital capacity and flood expiratoryvolume one second. The control group is higher that the experiment group in the blood pressure of systolic and Diastolic. There's little difference between them(p<0.01). The control is lower than the experiment group in the heart pulse rate. There's little difference between them(p<0.005). 3. The characteristic of basic physical strength evaluation : The experiment group is the lowest dynamic muscular endurance, balance, agility and endurance which need to move the body with weight. The control group is much higher than the experiment group in the flexibility and muscle strength(Back strength). There's no difference between them(p<0.05). 4. The characteristics of the exercise stress last : The control group is higher than the experiment group in the endurance, the maximum of oxygen intake, endurance level and the out take of calory. There's little difference between them(p<0.01). 5. The characteristic of the change of the target heart rate during exercise : The control group is lower than the experiment group exchange of target heart rate, There's no difference them.

• Journal of Korean Society of Environmental Engineers
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• v.27 no.2
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• pp.151-157
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• 2005

A one-dimensional numerical model was developed to simulate vertical profiles of electron acceptors and their reduced species in benthic sediments. The model accounted for microbial degradation of organic matter and subsequent chemical reactions of interest using stoichiometric relationships. Depending on the dominant electron acceptors utilized by microorganisms, the benthic sediments were assumed to be vertically subdivided into six zones: (1) aerobic respiration, (2) denitrification, (3) manganese reduction, (4) iron reduction, (5) sulfate reduction, and (6) methanogenesis. The utilizations of electron acceptors in the biologically mediated oxidation of organic matter were represented by Monod-type expression. The mass balance equations formulated for the reactive transport of organic matter, electron acceptors, and their corresponding reduced species in the sediments were solved utilizing an iterative multistep numerical method. The ability of model to simulate a freshwater sediments system was tested by comparing simulation results against published data obtained from lake sediments. The simulation results reasonably agreed with field measurements for most species, except for ammonia. This result showed that the C/N ratio (106/16) in the sediments is lower than what the Redfield formula prescribes. Since accurate estimates of vertical profiles of electron acceptors and their reduced species are important to determine the mobility and bioavailability of trace metals in the sediments, the model has potential application to assess the stability of selected trace metals in the sediments.

• Experimental and Molecular Medicine
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• v.50 no.12
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• pp.12.1-12.14
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• 2018

Osteoporosis develops with high prevalence in both postmenopausal women and hypogonadal men. Osteoporosis results in significant morbidity, but no cure has been established. Mesenchymal stem cells (MSCs) critically contribute to bone homeostasis and possess potent immunomodulatory/anti-inflammatory capability. Here, we investigated the therapeutic efficacy of using an infusion of MSCs to treat sex hormone-deficient bone loss and its underlying mechanisms. In particular, we compared the impacts of MSC cytotherapy in the two genders with the aim of examining potential gender differences. Using the gonadectomy (GNX) model, we confirmed that the osteoporotic phenotypes were substantially consistent between female and male mice. Importantly, systemic MSC transplantation (MSCT) not only rescued trabecular bone loss in GNX mice but also restored cortical bone mass and bone quality. Unexpectedly, no differences were detected between the genders. Furthermore, MSCT demonstrated an equal efficiency in rectifying the bone remodeling balance in both genders of GNX animals, as proven by the comparable recovery of bone formation and parallel normalization of bone resorption. Mechanistically, using green fluorescent protein (GFP)-based cell-tracing, we demonstrated rapid engraftment but poor inhabitation of donor MSCs in the GNX recipient bone marrow of each gender. Alternatively, MSCT uniformly reduced the $CD3^+T$-cell population and suppressed the serum levels of inflammatory cytokines in reversing female and male GNX osteoporosis, which was attributed to the ability of the MSC to induce T-cell apoptosis. Immunosuppression in the microenvironment eventually led to functional recovery of endogenous MSCs, which resulted in restored osteogenesis and normalized behavior to modulate osteoclastogenesis. Collectively, these data revealed recipient sexually monomorphic responses to MSC therapy in gonadal steroid deficiency-induced osteoporosis via immunosuppression/anti-inflammation and resident stem cell recovery.

• (The)Study of the Eastern Classic
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• no.37
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• pp.345-375
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• 2009

In relation to body conception, the introduction of western medicine to Joseon Korea started off some points in disputes: the one was whether the western anatomy was positive or not, the other was whether the cognition was ruled by heart or brain. In the long run of these disputes, that who had clarified the change of body conception was Choi Han Kee. His new conception of body was characterized as follow: on the one hand, it emphasized the mechanical conception of body; on the other hand, it emphasized the cognitive ability of body. But that his conception of body had obscure points: that is, its mechanical conception was intervened by chi(神氣), and his doctrine of cognition searched for the origin of cognition in balance of chi of the body. He had set up this conception of body by the combination of western medicine and chi, but the combination did not seem to be perfect. This point had appeared again in his conception of physics that he thought the basis of medicine. He had pursed the combination of chemical element and chi, but it could not be accomplished successfully unless he had abandoned the organicist conception of chi. In conclusion, his new conception of body was not free from the suspicion of a incomplete tentative construction.