• Journal of Gastric Cancer
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• 제3권1호
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• pp.26-32
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• 2003

Purpose: Genomic alterations and abnormal expression of the fragile histidine triad (FHIT) gene in gastric cancer were examined to determine whether the FHIT gene is actually a frequent target for alteration during gastric carcinogenesis. Materials and Methods: To correlate DNA and RNA lesions of the FHIT gene with the effect on FHIT protein expression, in 40 gastric cancers, we investigated the FHIT gene for loss of heterozygisity (LOH), aberrant transcripts, and protein expression. Results: Allelic loss at D3S1300 was detected in 7 of 38 ($19\%$) informative cases. Aberrant transcripts were observed in 20 of 40 ($50\%$) cases. Significant reduction of FHIT protein expression was observed in 22 of 40 ($55\%$) cases. Aberrant FHIT transcription was shown to be associated with loss of FHIT protein expression. However, aberrent FHIT transcripts themselves were not associated with any clinicopathological parameters, such as age, sex, tumor site, or clinical stage. Moreover, there was no association between the presence of LOH at D3S1300 and the expression of aberrant FHIT transcripts. Conclusion: The high frequency of aberrant FHIT transcripts, the significant rate of LOH at D3S1300, and the altered expression of the FHIT protein indicate that alterations of the FHIT gene can play an important role in gastric carcinogenesis.

• Toxicological Research
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• 제23권4호
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• pp.321-330
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• 2007

Garlic (Allium sativum L.) with the food supplement material and medicine was used traditionally in Asia and Europe. Epidemiological studies revealed that the intake of garlic reduced incidences of various cancer including digestive system. The present study was designed to investigate the effect of garlic ethanol extract on the development of colonic aberrant crypt foci (ACF) induced by 1,2-dimethylhydrazine (DMH) in male F344 rats. Five-week-old rats were given four times for two weeks to subcutaneous injections by DMH (30 mg/kg body weight) to induce ACF. The animals were divided into groups that fed diet containing garlic ethanol extract at five different doses (0.1, 0.2, 0.5, 2, 5%), respectively, animals were evaluated for the total number of ACF and total aberrant crypts (AC) per colon detected from methylene blue-stained rat colon. ACF were formed in animals in DMH-treated group. The feeding suppressed potently the appearance ACF in the colon of rats. Especially, fed diet containing garlic ethanol extract at intermediate dose (0.5%) significantly reduced the number of ACF and AC per colon (p < 0.05). Garlic ethanol extract inhibited DMH-induced overexpression of Activator Protein-1 (AP-1) and ${\beta}-catenin$ genes related to cell proliferation that also upregulated the expression of p21Waf1/Cip1 mRNA, a cell cycle-regulating gene. These results suggested that garlic ethanol extract may inhibit ACF formation, ${\beta}-catenin$ gene as the early preneoplastic marker of malignant potential in the process of colon carcinogenesis.

• 한국심리학회지 : 문화 및 사회문제
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• 제12권1호
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• pp.55-79
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• 2006

본 연구에서는 오류와 착오가 고령운전자의 운전행동에 어떠한 영향을 미치는지 알아보았다. 우선, 운전일탈행동의 구조와 문항의 신뢰도를 알아보기 위하여 456명의 운전자에게 운전일탈행동조사지(DBQ: Driver Behaviour Questionnaire)를 실시하였다. 그리고 883명의 운전자를 대상으로 운전일탈행동조사지를 실시하여 운전자들의 오류와 착오를 측정하였다. 참가자 가운데 만 25세 이하 청소년운전자와 만 65세 이상 고령운전자 325명을 대상으로 운전경력, 주행거리, 위반경험, 사고경험을 조사하였으며, 고령운전자의 자료는 1:1 인터뷰를 통하여 수집하였다. 그리고 운전일탈행동의 구조를 알아보고자 요인분석을 실시하고, 연령에 따른 운전일탈행동의 변화를 살펴보았다. 또한, 고령운전자와 청소년운전자를 대상으로 운전일탈행동과 운전경험과의 관계를 알아보았다. 그 결과, 운전일탈행동은 '위반', '오류', '착오'의 세 요인으로 이루어져 있었으며, 연령이 중가할수록 운전일탈행동은 감소하는 것으로 나타났다. 고령운전자와 청소년운전자 모두 운전경력이 많을수록 운전일탈행동은 적었으며, 고령운전자는 운전일탈행동 가운데 오류점수가 높고 청소년운전자는 위반점수가 높았다. 청소년운전자의 운전일탈행동은 주행거리, 위반경험과 상관관계가 있었고, 고령운전자의 운전일탈경험은 주행거리와 사고경험에 영향을 주고 있었으며, 특히 위반, 오류, 착오점수가 높을수록 고령운전자의 사고경험은 많았다.

• 한국심리학회지 : 문화 및 사회문제
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• 제12권5호_spc
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• pp.149-167
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• 2006

고령화가 다른 국가에 비해 상대적으로 빠르게 진행되고 있는 상황에 대비한 고령운전자의 연구가 부족한 실정이다. 본 연구는 고령운전자의 교통사고 원인을 신체적 능력저하보다도 심리적 요인의 변화에 입각하여 고찰해 보려고 한다. - 고령운전자의 교통사고 고령운전자의 교통사고에서 가장 두드러지게 나타나는 행동적 특징은 좌회전시 발생하는 교통사고가 많다는 것이다. 그리고 사고장소에 따른 분석결과에 의하면, 교차로에서 발생하는 사고가 많다는 것이 확인되었다. - 고령운전자의 조심성과 보상행동 고령운전자의 조심성이 운전행동에 미치는 알아보기 위하여 운전자의 운전확신수준을 비교해 보았다 운전확신수준은 4개 요인으로 구분되었고, 고령운전자와 젊은 운전자의 운전확신수준 차이를 검증한 결과를 보면, 고령운전자의 운전확신수준이 젊은 운전자에 비해 현저하게 떨어지는 것을 알 수 있었다 그리고 좌회전을 선택시 소요되는 시간을 분석하여 고령운전자의 조심성을 이해하려고 하였다 고령운전자는 젊은 운전자에 비해 선택소요시간이 현저하게 길어진다는 사실을 발견하였다. - 고령운전자의 운전일탈행동 연령에 따른 운전일탈행동의 변화를 보면, 연령이 증가함에 따라 운전일탈행동의 위반, 오류, 착오의 평균 점수는 감소하는데, 각 요인이 감소하는 정도는 차이가 있었다. 위반점수는 연령의 증가에 따라 급격하게 감소하는 모습을 보이는데 비해 오류와 착오점수는 연령의 증가에 따라 완만하게 감소하는 경향을 보였다.

• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2005년도 생물공학의 동향(XVII)
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• pp.142-143
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• 2005

• Animal Systematics, Evolution and Diversity
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• 제1권1_2호
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• pp.79-86
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• 1985

한국산 똥풍뎅이과에 대한 모노그라프적 연구의 일부로서 우선 소순판이 큰 종류만을 다루었다. 이들은 총 3아과 6종 인데 이중 Aphodius brachysomus 는 신이형이 발견되어 이를 A. brachysomus ab. flavelytrus로 명명하였다.

• Journal of Chest Surgery
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• 제21권3호
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• pp.583-587
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• 1988

Bilateral coronary artery-pulmonary artery fistula is very uncommon congenital heart disease which occupy small percentage of all coronary arterio-venous fistulas. We experienced a case who was 52 years old female with bilateral coronary artery-pulmonary artery fistula. She complained exertional dyspnea k angina[coronary steal syndrome]. On physical examination, any cardiac murmur was not audible. There was no 0y step-up in right heart catheterization. But selective coronary angiography revealed tortuous aberrant vessels which originated from the canal branch of the right coronary artery k the left anterior descending coronary artery. Both aberrant vessels traversed the right ventricular outflow tract, and conjoined just proximal the pulmonic annulus and drained into the main pulmonary artery. The operation was performed under the extracorporeal circulation with beating heart. The procedures were suture-ligation of the draining orifice in main pulmonary artery & the feeding vessels on the right ventricular outflow tract. Postoperatively her complaints were completely disappeared and the selective coronary angiography revealed no left-to-right shunt.

• 한국임상수의학회:학술대회논문집
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• 한국임상수의학회 2008년도 추계학술대회
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• pp.192-192
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• 2008

• BMB Reports
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• 제46권1호
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• pp.9-16
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• 2013

In mammalian cells, aberrant transcripts harboring a premature termination codon (PTC) can be generated by abnormal or inefficient biogenesis of mRNAs or by somatic mutation. Truncated polypeptides synthesized from these aberrant transcripts could be toxic to normal cellular functions. However, mammalian cells have evolved sophisticated mechanisms for monitoring the quality of mRNAs. The faulty transcripts harboring PTC are subject to nonsense-mediated mRNA decay (NMD), nonsense-mediated translational repression (NMTR), nonsense-associated alternative splicing (NAS), or nonsense-mediated transcriptional gene silencing (NMTGS). In this review, we briefly outline the molecular characteristics of each pathway and suggest mRNA quality control mechanisms as a means to regulate normal gene expression.

• Natural Product Sciences
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• 제5권1호
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• pp.48-53
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• 1999

There are epidemiological evidences that the population with high fecal ${\beta}-glucuronidase$ activity has greater risk of colon cancer than the population with low fecal ${\beta}-glucuronidase$. This relationship was investigated by using the mouse-dimethylhydrazine colon carcinogenesis model and the extract of antler which was a ${\beta}-glucuronidase$ inhibitor. Mice with low fecal ${\beta}-glucuronidase$ activity induced by administration of water and Folch's fraction of antler had significantly fewer aberrant crypts after injections of 1,2-dimethylhydrazine (DMH) than mice treated with DMH alone. The result supports the hypothesis that the inhibitor of ${\beta}-glucuronidase$ such as antler extract can protect an animal against the induction of colon cancer.