• Journal of Yeungnam Medical Science
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• v.6 no.1
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• pp.121-131
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• 1989

The temperature-corrected values of blood gas analysis were compared to uncorrected values in 40 cases of open heart surgery under moderate hypothermic cardiopulmonary bypass. The results were as follows. 1. The corrected value of pH was significantly higher than uncorrected value, and it's relationship was ${\Delta}pH=-0.015$ ${\Delta}Temp+0.005$(r=0.81, P<(0.01). 2. The corrected value of $PCO_2$ was lower than uncorrected value, and it's relationship was ${\Delta}PCO_2=1.11$ ${\Delta}Temp+1.81$(r=0.50, P<0.01). 3. The corrected value of $PO_2$ was lower than uncorrected value, and it' s relationship was ${\Delta}PO_2=5.21$ ${\Delta}Temp-1.45$(r=0.32, P<0.01). But there was no clinical significance. 4. The corrected values of $HCO_{3^-}$, base excess, $CO_2$ content and oxygen saturation were similar with uncorrected values. In summery, the values of pH and $PCO_2$were significantly changed by temperature-correction. Because of the neutral point of water (pH=pOH) rises as temperature falls and it change in parallel with the changes in blood pH, a corrected pH of 7.4, $PaCO_2$ of 40mmHg during deep hypothermia would reflect a profound respiratory acidosis. Therefore, the use of the uncorrected value at $37^{\circ}C$ is more preferable and valid means of assessing acid-base management regardless of actual patient temperature.

• The Mathematical Education
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• v.61 no.3
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• pp.441-456
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• 2022

The purpose of the current study is to report a part of our larger project whose focus is to understand a relationship between students' units coordination and K-12 school mathematics. In particular, in this paper we report how students who exhibit distinct levels of units coordinations used their knowledge of proportion to solve quadratic function problems of the form y = ax². To this end, three 7th grade students all of whom assimiliated whole number problem situations with three levels of units but showed different levels for fraction problems were chosen. We carried out clinical interviews not only to understand their ability to coordinate units but to understand their problem solving process of proportion and the quadratic function problems. The analysis suggest that their abilities to coordinate units influenced their ways to solving proportion problems, and in turn influenced their ways to solve the specific form of quadratic functions. We have finalized our study by discussing how students' ability to construct and coordinate units, their proportion knowledge, and their knowledge associated with expressing the specific type of quadractic functions could be related.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2021.04a
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• pp.60-60
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• 2021

Non-alcoholic fatty liver disease (NAFLD), especially including non-alcoholic steatohepatitis (NASH) is one of the common diseases with 25% of prevalence globally, but there is no thera-peutic access available. Amomum villosum var. xanthioides (Wall. ex Baker) T.L.Wu & S.J.Chen (AX), which is a medicinal herb and traditionally used for treating digestive tract disorders in Asia countries. We aimed to examine pharmacological effects of ethyl acetate fraction of AX (AXEF) against ER stress-induced NASH mice model using C57/BL6J male mice by tunicamycin (TM, 2 mg/kg) injection focusing on the oxidative stress. Mice were orally administrated AXEF (12.5, 25, or 50 mg/kg), silymarin (50 mg/kg) or distilled water daily for 5 days, and outcomes for fatty liver, inflammation, and oxidative stress were measured in serum or liver tissue levels. AXEF drastically attenuated hepatic ER stress-induced NASH which were evidenced by decreases of li-pid droplet accumulations, serum liver enzymes, hepatic inflammations, and cell death signals in the hepatic tissue or serum levels. Interestingly, AXEF showed potent antioxidant effects by quenching of reactive oxidative stress and its final product of lipid peroxide in the hepatic tissue, specifically increase of metallothionein (MT). To confirm underlying actions of AXEF, we ob-served that AXEF increase MT1gene promoter activities in the physiological levels. Collectively, AXEF showed antioxidant properties on TM-induced ER stress of NASH by enhancement of MTs.

• Journal of Pharmacopuncture
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• v.19 no.1
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• pp.59-69
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• 2016

Objectives: The mushroom Ganoderma lucidum has been widely used as a traditional herbal medicine for many years. Although several studies have focused on the anti-oxidative activity of this mushroom, the molecular mechanisms underlying its activity have not yet been clearly established. The present study investigated the cytoprotective effect of ethanol extract of Ganoderma lucidum (EGL) against oxidative stress (hydrogen peroxide, $H_2O_2$) and elucidated the underlying mechanisms in a C2C12 myoblast cell line. Methods: Oxidative stress markers were determined by using the comet assay to measure reactive oxygen species (ROS) generation and deoxyribonucleic acid (DNA) damage. Cell viability and Western blotting analyses were employed to evaluate the cellular response to EGL and $H_2O_2$ in C2C12 cells. Transfection with nuclear factor erythroid 2-related factor 2 (Nrf2)-specific small interfering ribonucleic acid (siRNA) was conducted to understand the relationship between Nrf2 expression and $H_2O_2$-induced growth inhibition. Results: The results showed that EGL effectively inhibited $H_2O_2$-induced growth and the generation of ROS. EGL markedly suppressed $H_2O_2$-induced comet-like DNA formation and phosphorylation of histone H2AX at serine 139 ($p-{\gamma}H2AX$), a widely used marker of DNA damage, suggesting that EGL prevented $H_2O_2$-induced DNA damage. Furthermore, the EGL treatment effectively induced the expression of Nrf2, as well as heme oxygenase-1 (HO-1), with parallel phosphorylation and nuclear translocation of Nrf2 in the C2C12 myoblasts. However, zinc protoporphyrin IX, a HO-1 inhibitor, significantly abolished the protective effects of EGL against $H_2O_2$-induced accumulation of ROS and reduced cell growth. Notably, transient transfection with Nrf2-specific siRNA attenuated the cytoprotective effects and HO-1 induction by EGL, indicating that EGL induced the expression of HO-1 in an Nrf2-dependent manner. Conclusion: Collectively, these results demonstrate that EGL augments the cellular anti-oxidant defense capacity through activation of Nrf2/HO-1, thereby protecting C2C12 myoblasts from $H_2O_2$-induced oxidative cytotoxicity.

• Magazine of the Korean Society of Agricultural Engineers
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• v.12 no.3
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• pp.2035-2042
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• 1970

Korean Janggi and Western plow to have developed for a long time in the east and west were tested and compared in their draft resistance. The charaderistic of Korean Janggi and plow to be able to make deep plowing, on of the most important factors influeneed the increased yield, were ofserved. The study was undertaken to obtain these basic factors' to device and construct the deep plowing Janggi. The results were as follow; 1. The draft resistance of Korean Janggi far less than that of plow and on the dry field, the influence of soil moisture contant to the draft resistance was larger in the Korean Janggi than in the western plow, but on the rice paddy, there was not differences between them. 2. The plow was more stable than that of Janggi in their operation. 3. The relation ship between the specific draft resistance and plowing depth was shown bygthe carved equation. $$K=Ax+\frac{B}{x}+C$$(K ; specific draft restance, x; plowing depth) A, B, C; Constant controled by soil and instrument factor) 4. Minimam values of the specific draft resistance were as follow; a. On the dry field; Korean Janggi; x = $8{\sim}14cm$ $4K=280{\sim}330gr/cm^2$$ Westean plow; x=$10{\sim}12cm$ $$K=480{\sim}490gr/cm^2$$ 6. On the rice paddy; Korean Janggi; x=$8{\sim}12cm$ $$K=255{\sim}280gr/cm^2$ Western plow; x=$7{\sim}10cm$ $$K=415{\sim}420grc/m^2$$

• Communications of the Korean Mathematical Society
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• v.12 no.3
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• pp.655-664
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• 1997

The existence and behavior of a bounded solution for a perturbed nonlinear differential equation of the type $$ (DE) x'(t) + Ax(t) \ni G(x(t)), t \in [0, \infty) $$ is considered. First, we consider the existence of a bounded solution with more simple assumptions using the concept of "the method of lines". Then we devote to study its behavior using recent results of almost non-expansive curve which is developed by Djafari Rouhani.i Rouhani.

• International Journal of Computer Science & Network Security
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• v.24 no.1
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• pp.17-22
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• 2024

The objective of this work is to design a low cost yet fully functional 4-DOF articulate manipulator for educational applications. The design is based on general purpose, programmable smart servo motors namely the Dynamixel Ax-12. The mechanism for motion was developed by formulating the equations of kinematics and subsequent solutions for joint space variables. The trajectory of end-effector in joint variable space was determined by interpolation of a 3rd order polynomial. The solutions were verified through computer simulations and ultimately implemented on the hardware. Owing to the feedback from the built-in sensors, it is possible to correct the positioning error due to loading effects. The proposed solution offers an efficient and cost-effective platform to study the trajectory planning as well as dynamics of the manipulator.

• Journal of information and communication convergence engineering
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• v.8 no.5
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• pp.586-590
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• 2010

Medical technology is gradually being developed by applying information technologies. Especially, RFID technology is being used for precise disease history information of patients [4]. And in case the patient is far away, the patient can be treated using network communication of the internet [5][6]. The internet makes us to treat or operate the patient without being restricted to time or space. If the above technologies are made as a system, the patient can be treated or operated without being restricted to time or space. In this paper, we present a patient treatment system has been implemented with a system using RFID and network communication of the internet [1][2][3][4]. The system is driven as follows. First, the information of patient can be checked from a remote PC, if the tag that a patient has been read through a reader. And a remote treatment is performed by controlling robot's arm with a joystick using internet network [19][20][21]. The RFID system was implemented in frequency of 125 KHz [1]. The information of patient can be checked with PDA, PC and C-LCD using Bluetooth and WLAN [7][8][9][10]. For the treatment and operation of the patient, the robot's arm has been formed using AX-12 motor, joystick and two buttons [11][12][13][14][15] [17][18].

• Transactions of the Korean Society of Mechanical Engineers A
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• v.24 no.12
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• pp.2909-2916
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• 2000

6.5wt% Si steel is widely known as an excellent magnetic material because its magnetostriction is nearly zero. The AX magnetic properties as magnetostriction of 6.5% Si steel were evaluated and compared with those of conventional 3% Si steel sheet. In this paper, the fracture behavior of the poly crystals and single crystals of Fe-6.5wt%Si alloy has been observed. Single crystals were prepared by Floating Zone(FZ) method, which melts the alloy by the use of high temperature electron beam in pure argon gas condition. And the single crystals were annealed at 500$^{\circ}C$ and 700$^{\circ}C$ respectively and tensile tested at room temperature. According to the result, B2 phase has more good elongation than DO$_3$ phase. It was also found that the fracture surfaces of the single crystals have hairline facets in same direction, and the facets change the direction according to the single crystal phase.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.12
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• pp.4803-4812
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• 2015

Chronic alcohol and tobacco abuse plays a crucial role in the development of different liver associated disorders. Intake promotes the generation of reactive oxygen species within hepatic cells exposing their DNA to continuous oxidative stress which finally leads to DNA damage. However in response to such damage an entangled protective repair machinery comprising different repair proteins like ATM, ATR, H2AX, MRN complex becomes activated. Under abnormal conditions the excessive reactive oxygen species generation results in genetic predisposition of various genes (as ADH, ALDH, CYP2E1, GSTT1, GSTP1 and GSTM1) involved in xenobiotic metabolic pathways, associated with susceptibility to different liver related diseases such as fibrosis, cirrhosis and hepatocellular carcinoma. There is increasing evidence that the inflammatory process is inherently associated with many different cancer types, including hepatocellular carcinomas. The generated reactive oxygen species can also activate or repress epigenetic elements such as chromatin remodeling, non-coding RNAs (micro-RNAs), DNA (de) methylation and histone modification that affect gene expression, hence leading to various disorders. The present review provides comprehensive knowledge of different molecular mechanisms involved in gene polymorphism and their possible association with alcohol and tobacco consumption. The article also showcases the necessity of identifying novel diagnostic biomarkers for early cancer risk assessment among alcohol and tobacco users.